TY  - JOUR
AU  - Su, Guo-Zhu
AU  - Wang, Shang-Yi
AU  - Yang, Xiu-Ying
AU  - Stevanović, Zora Dajić
AU  - Li, Na
AU  - Tanić, Nikola
AU  - Arsenijević, Nebojša
AU  - Yu, Shi-Shan
AU  - Li, Yong
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5165
AB  - Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B.
PB  - Oxford: Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.
VL  - 204
DO  - 10.1016/j.phytochem.2022.113458
SP  - 113458
ER  - 

@article{
author = "Su, Guo-Zhu and Wang, Shang-Yi and Yang, Xiu-Ying and Stevanović, Zora Dajić and Li, Na and Tanić, Nikola and Arsenijević, Nebojša and Yu, Shi-Shan and Li, Yong",
year = "2022",
abstract = "Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B.",
publisher = "Oxford: Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.",
volume = "204",
doi = "10.1016/j.phytochem.2022.113458",
pages = "113458"
}

Su, G., Wang, S., Yang, X., Stevanović, Z. D., Li, N., Tanić, N., Arsenijević, N., Yu, S.,& Li, Y.. (2022). Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.. in Phytochemistry
Oxford: Pergamon-Elsevier Science Ltd., 204, 113458.
https://doi.org/10.1016/j.phytochem.2022.113458

Su G, Wang S, Yang X, Stevanović ZD, Li N, Tanić N, Arsenijević N, Yu S, Li Y. Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.. in Phytochemistry. 2022;204:113458.
doi:10.1016/j.phytochem.2022.113458 .

Su, Guo-Zhu, Wang, Shang-Yi, Yang, Xiu-Ying, Stevanović, Zora Dajić, Li, Na, Tanić, Nikola, Arsenijević, Nebojša, Yu, Shi-Shan, Li, Yong, "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification." in Phytochemistry, 204 (2022):113458,
https://doi.org/10.1016/j.phytochem.2022.113458 . .

TY  - JOUR
AU  - Bošnjak-Neumüller, Jasna
AU  - Radaković, Milena
AU  - Djelić, Ninoslav
AU  - Vuković-Gačić, Branka
AU  - Stevanović, Zora Dajić
AU  - Kolarević, Stoimir
AU  - Mišić, Danijela
AU  - Stanković, Milan
AU  - Knežević-Vukčević, Jelena
AU  - Spremo-Potparević, Biljana
AU  - Stanimirović, Zoran
PY  - 2017
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28650332
UR  - http://www.pjps.pk/wp-content/uploads/pdfs/30/2/Supplementary/13-SUP-652.pdf
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3537
AB  - The success of antioxidant therapy in hyperthyroidism implies that disease is mediated by oxidative stress, which is known as one of the causing agents of ageing, degenerative diseases, and cancer. The main objective of our study was to determine possible protective effects of methanolic extract of N. rtanjensis in triiodothyronine (T3)-induced DNA breaks of human lymphocytes under in vitro conditions, based upon plant antioxidant capacity related to its phytochemical profile, mainly its polyphenolic complex. The total phenolic and flavonoid content and the antioxidant activity using in vitro 1,1-dyphenyl-2- picrylhydrazyl reagent (DPPH) was determined in methanolic extracts of plant leaves and flowers. The phenolic compound content of 62.73±1.80mg of GaA/g, exhibited solid antioxidant activity (IC50= 112.59±0.95μg/ml). The antigenotoxic activity of 0.2, 0.5 and 1.0mg/ml N. rtanjensis methanol extracts mixture with 100µM of T3 was studied in human lymphocytes in vitro using the Comet assay. It is supposed that the antigenotoxicity of N. rtanjensis methanol extracts was caused by high presence of chlorogenic acid, rosmarinic acid and rutin, all known as efficient antioxidant bioactive compounds, which were determined by ultrahigh-pressure liquid chromatograph with MS/MS Mass Spectroscopy (UHPLC/-HESI-MS / MS).
T2  - Pakistan Journal of Pharmaceutical Sciences
T1  - Nepeta rtanjensis (Lamiaceae), a plant endemic to the Balkans: Phenolic composition, antioxidant activity, and in vitro antigenotoxic effects in triiodothyronine-induced DNA damage in human lymphocytes.
IS  - 2(Suppl.)
VL  - 30
SP  - 625
EP  - 634
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_4504
ER  - 

@article{
author = "Bošnjak-Neumüller, Jasna and Radaković, Milena and Djelić, Ninoslav and Vuković-Gačić, Branka and Stevanović, Zora Dajić and Kolarević, Stoimir and Mišić, Danijela and Stanković, Milan and Knežević-Vukčević, Jelena and Spremo-Potparević, Biljana and Stanimirović, Zoran",
year = "2017",
abstract = "The success of antioxidant therapy in hyperthyroidism implies that disease is mediated by oxidative stress, which is known as one of the causing agents of ageing, degenerative diseases, and cancer. The main objective of our study was to determine possible protective effects of methanolic extract of N. rtanjensis in triiodothyronine (T3)-induced DNA breaks of human lymphocytes under in vitro conditions, based upon plant antioxidant capacity related to its phytochemical profile, mainly its polyphenolic complex. The total phenolic and flavonoid content and the antioxidant activity using in vitro 1,1-dyphenyl-2- picrylhydrazyl reagent (DPPH) was determined in methanolic extracts of plant leaves and flowers. The phenolic compound content of 62.73±1.80mg of GaA/g, exhibited solid antioxidant activity (IC50= 112.59±0.95μg/ml). The antigenotoxic activity of 0.2, 0.5 and 1.0mg/ml N. rtanjensis methanol extracts mixture with 100µM of T3 was studied in human lymphocytes in vitro using the Comet assay. It is supposed that the antigenotoxicity of N. rtanjensis methanol extracts was caused by high presence of chlorogenic acid, rosmarinic acid and rutin, all known as efficient antioxidant bioactive compounds, which were determined by ultrahigh-pressure liquid chromatograph with MS/MS Mass Spectroscopy (UHPLC/-HESI-MS / MS).",
journal = "Pakistan Journal of Pharmaceutical Sciences",
title = "Nepeta rtanjensis (Lamiaceae), a plant endemic to the Balkans: Phenolic composition, antioxidant activity, and in vitro antigenotoxic effects in triiodothyronine-induced DNA damage in human lymphocytes.",
number = "2(Suppl.)",
volume = "30",
pages = "625-634",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_4504"
}

Bošnjak-Neumüller, J., Radaković, M., Djelić, N., Vuković-Gačić, B., Stevanović, Z. D., Kolarević, S., Mišić, D., Stanković, M., Knežević-Vukčević, J., Spremo-Potparević, B.,& Stanimirović, Z.. (2017). Nepeta rtanjensis (Lamiaceae), a plant endemic to the Balkans: Phenolic composition, antioxidant activity, and in vitro antigenotoxic effects in triiodothyronine-induced DNA damage in human lymphocytes.. in Pakistan Journal of Pharmaceutical Sciences, 30(2(Suppl.)), 625-634.
https://hdl.handle.net/21.15107/rcub_agrospace_4504

Bošnjak-Neumüller J, Radaković M, Djelić N, Vuković-Gačić B, Stevanović ZD, Kolarević S, Mišić D, Stanković M, Knežević-Vukčević J, Spremo-Potparević B, Stanimirović Z. Nepeta rtanjensis (Lamiaceae), a plant endemic to the Balkans: Phenolic composition, antioxidant activity, and in vitro antigenotoxic effects in triiodothyronine-induced DNA damage in human lymphocytes.. in Pakistan Journal of Pharmaceutical Sciences. 2017;30(2(Suppl.)):625-634.
https://hdl.handle.net/21.15107/rcub_agrospace_4504 .

Bošnjak-Neumüller, Jasna, Radaković, Milena, Djelić, Ninoslav, Vuković-Gačić, Branka, Stevanović, Zora Dajić, Kolarević, Stoimir, Mišić, Danijela, Stanković, Milan, Knežević-Vukčević, Jelena, Spremo-Potparević, Biljana, Stanimirović, Zoran, "Nepeta rtanjensis (Lamiaceae), a plant endemic to the Balkans: Phenolic composition, antioxidant activity, and in vitro antigenotoxic effects in triiodothyronine-induced DNA damage in human lymphocytes." in Pakistan Journal of Pharmaceutical Sciences, 30, no. 2(Suppl.) (2017):625-634,
https://hdl.handle.net/21.15107/rcub_agrospace_4504 .