TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Kaluderovic, Milena R.
AU  - Mojić, Marija
AU  - Zmejkovski, Bojana B.
AU  - Hey-Hawkins, Evamarie
AU  - Vidaković, Melita
AU  - Grdović, Nevena
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1916
AB  - (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.
T2  - European Journal of Pharmacology
T1  - Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions
VL  - 760
DO  - 10.1016/j.ejphar.2015.04.012
SP  - 136
EP  - 144
ER  - 

@article{
author = "Bulatović, Mirna Z. and Kaluderovic, Milena R. and Mojić, Marija and Zmejkovski, Bojana B. and Hey-Hawkins, Evamarie and Vidaković, Melita and Grdović, Nevena and Kaluđerović, Goran N. and Mijatović, Sanja and Maksimović-Ivanić, Danijela",
year = "2015",
abstract = "(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.",
journal = "European Journal of Pharmacology",
title = "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions",
volume = "760",
doi = "10.1016/j.ejphar.2015.04.012",
pages = "136-144"
}

Bulatović, M. Z., Kaluderovic, M. R., Mojić, M., Zmejkovski, B. B., Hey-Hawkins, E., Vidaković, M., Grdović, N., Kaluđerović, G. N., Mijatović, S.,& Maksimović-Ivanić, D.. (2015). Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology, 760, 136-144.
https://doi.org/10.1016/j.ejphar.2015.04.012

Bulatović MZ, Kaluderovic MR, Mojić M, Zmejkovski BB, Hey-Hawkins E, Vidaković M, Grdović N, Kaluđerović GN, Mijatović S, Maksimović-Ivanić D. Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology. 2015;760:136-144.
doi:10.1016/j.ejphar.2015.04.012 .

Bulatović, Mirna Z., Kaluderovic, Milena R., Mojić, Marija, Zmejkovski, Bojana B., Hey-Hawkins, Evamarie, Vidaković, Melita, Grdović, Nevena, Kaluđerović, Goran N., Mijatović, Sanja, Maksimović-Ivanić, Danijela, "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions" in European Journal of Pharmacology, 760 (2015):136-144,
https://doi.org/10.1016/j.ejphar.2015.04.012 . .

TY  - JOUR
AU  - Kaluderovic, Milena R.
AU  - Mojić, Marija
AU  - Schreckenbach, Joachim P.
AU  - Maksimović-Ivanić, Danijela
AU  - Graf, Hans-Ludwig
AU  - Mijatović, Sanja
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2251
AB  - Autophagy plays an important role in embryogenesis, for the maintenance
   of tissue homeostasis and the elimination of damaged subcellular
   structures. Furthermore, autophagy could be a mode of physiological cell
   death and also be implicated in cell differentiation. Thus, we
   hypothesized that autophagy may have an impact on the differentiation of
   osteoblast cells influenced by various titanium-based surfaces.
   Interactions between smooth, commercially available pure titanium (Ti
   cp), rough Ticer, acid-etched Ti cp (SS) and M1-M3 (comprised of the
   monoclinic phase of sodium-titanium oxides and rutile; M2 contains
   amorphous calcium phosphates) and human osteoblast cells were
   investigated. Immunofluorescent staining was used for detecting
   autophagy, cell cluster formation and collagen type I (Col-1)
   expression. Flow cytometry was employed to identify autophagy, the
   production of endogenous nitric oxide (NO) and the size and granularity
   of the cells. Rough surfaces caused osteoblast differentiation via the
   autophagic-dependent PI3/Akt signalling pathway. These surfaces induced
   the formation of discrete populations of large, granular cells, i.e.
   mature osteoblasts. In addition, M1-M3 provoked the development of a
   third population of small, granular cells, responsible for cell cluster
   formation, which are important for the formation of bone noduli and
   mineralisation. The same surfaces induced faster osteoblast maturation
   and enhanced NO production, a hallmark of the already mentioned
   processes. Neither the mature osteoblasts nor the small cells appeared
   after the inhibition of autophagy. Inhibition of autophagy also
   prevented cell cluster formation. We demonstrate that autophagy plays an
   essential role in the osteoblast differentiation on titanium-based
   surfaces with rough topography. (C) 2015 S. Karger AG, Basel
T2  - Cells Tissues Organs
T1  - A Key Role of Autophagy in Osteoblast Differentiation on Titanium-Based
 Dental Implants
IS  - 3-4
VL  - 200
DO  - 10.1159/000434625
SP  - 265
EP  - 277
ER  - 

@article{
author = "Kaluderovic, Milena R. and Mojić, Marija and Schreckenbach, Joachim P. and Maksimović-Ivanić, Danijela and Graf, Hans-Ludwig and Mijatović, Sanja",
year = "2014",
abstract = "Autophagy plays an important role in embryogenesis, for the maintenance
   of tissue homeostasis and the elimination of damaged subcellular
   structures. Furthermore, autophagy could be a mode of physiological cell
   death and also be implicated in cell differentiation. Thus, we
   hypothesized that autophagy may have an impact on the differentiation of
   osteoblast cells influenced by various titanium-based surfaces.
   Interactions between smooth, commercially available pure titanium (Ti
   cp), rough Ticer, acid-etched Ti cp (SS) and M1-M3 (comprised of the
   monoclinic phase of sodium-titanium oxides and rutile; M2 contains
   amorphous calcium phosphates) and human osteoblast cells were
   investigated. Immunofluorescent staining was used for detecting
   autophagy, cell cluster formation and collagen type I (Col-1)
   expression. Flow cytometry was employed to identify autophagy, the
   production of endogenous nitric oxide (NO) and the size and granularity
   of the cells. Rough surfaces caused osteoblast differentiation via the
   autophagic-dependent PI3/Akt signalling pathway. These surfaces induced
   the formation of discrete populations of large, granular cells, i.e.
   mature osteoblasts. In addition, M1-M3 provoked the development of a
   third population of small, granular cells, responsible for cell cluster
   formation, which are important for the formation of bone noduli and
   mineralisation. The same surfaces induced faster osteoblast maturation
   and enhanced NO production, a hallmark of the already mentioned
   processes. Neither the mature osteoblasts nor the small cells appeared
   after the inhibition of autophagy. Inhibition of autophagy also
   prevented cell cluster formation. We demonstrate that autophagy plays an
   essential role in the osteoblast differentiation on titanium-based
   surfaces with rough topography. (C) 2015 S. Karger AG, Basel",
journal = "Cells Tissues Organs",
title = "A Key Role of Autophagy in Osteoblast Differentiation on Titanium-Based
 Dental Implants",
number = "3-4",
volume = "200",
doi = "10.1159/000434625",
pages = "265-277"
}

Kaluderovic, M. R., Mojić, M., Schreckenbach, J. P., Maksimović-Ivanić, D., Graf, H.,& Mijatović, S.. (2014). A Key Role of Autophagy in Osteoblast Differentiation on Titanium-Based
 Dental Implants. in Cells Tissues Organs, 200(3-4), 265-277.
https://doi.org/10.1159/000434625

Kaluderovic MR, Mojić M, Schreckenbach JP, Maksimović-Ivanić D, Graf H, Mijatović S. A Key Role of Autophagy in Osteoblast Differentiation on Titanium-Based
 Dental Implants. in Cells Tissues Organs. 2014;200(3-4):265-277.
doi:10.1159/000434625 .

Kaluderovic, Milena R., Mojić, Marija, Schreckenbach, Joachim P., Maksimović-Ivanić, Danijela, Graf, Hans-Ludwig, Mijatović, Sanja, "A Key Role of Autophagy in Osteoblast Differentiation on Titanium-Based
 Dental Implants" in Cells Tissues Organs, 200, no. 3-4 (2014):265-277,
https://doi.org/10.1159/000434625 . .