TY  - JOUR
AU  - Mijatović, Sanja
AU  - Bulatović, Mirna Z.
AU  - Mojić, Marija
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Maksimović-Ivanić, Danijela
AU  - Gomez-Ruiz, Santiago
AU  - Pinkas, Jiri
AU  - Horacek, Michal
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2247
AB  - The previously known complexes {[}Ti\{(Me2CMe2C)(eta(5)-C5H4)(2)\}Cl-2]
   (1), {[}Ti\{Me2C(eta(5)-C5H4)(2)\}Cl-2] (2), {[}Ti
   \{Me2Si(eta(5)-C5H4)(2)\}Cl-2] (4), {[}Ti\{MePhSi(eta(5)-C5H4)(2)\}Cl-2]
   (5) and {[}Ti\{MePhSi(eta(5)-C5Me4)(2)\}Cl-2] (6) have been prepared
   following reported procedures. The novel complex
   {[}Ti\{MePhC(eta(5)-C5H4)(2)\}Cl-2] (3) has been prepared and
   characterized. The cytotoxic activity of 1-6 has been tested after 72 h
   on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon
   cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic
   activity of complexes 1 and 6 compared to the reference compound
   ({[}Ti(eta(5)-C5H5)(2)\}Cl-2]). 1 and 6 have also been tested against
   primary normal mouse keratinocytes and lung fibroblasts. While viability
   of both type of primary cells was significantly less affected by 1 in
   comparison to the reference compound {[}Ti(eta(5)-C5H5)(2)Cl-2],
   compound 6 was completely nontoxic for nonmalignant cells, indicating a
   potential selectivity of this compound towards cancer cell lines. In
   addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining,
   detection of caspase activity and mitochondrial potential showed that 1
   and 6 were acting through inhibition of proliferation and subsequent
   induction of mitochondrial dependent apoptosis in colon cancer cell
   lines, HCT116 and SW620, which express low sensitivity to cisplatin.
   Compound 6 was found to be the leading drug in this group since it shows
   the fastest and most selective anticancer profile. (C) 2013 Elsevier
   B.V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes
VL  - 751
DO  - 10.1016/j.jorganchem.2013.07.059
SP  - 361
EP  - 367
ER  - 

@article{
author = "Mijatović, Sanja and Bulatović, Mirna Z. and Mojić, Marija and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Maksimović-Ivanić, Danijela and Gomez-Ruiz, Santiago and Pinkas, Jiri and Horacek, Michal and Kaluđerović, Goran N.",
year = "2014",
abstract = "The previously known complexes {[}Ti\{(Me2CMe2C)(eta(5)-C5H4)(2)\}Cl-2]
   (1), {[}Ti\{Me2C(eta(5)-C5H4)(2)\}Cl-2] (2), {[}Ti
   \{Me2Si(eta(5)-C5H4)(2)\}Cl-2] (4), {[}Ti\{MePhSi(eta(5)-C5H4)(2)\}Cl-2]
   (5) and {[}Ti\{MePhSi(eta(5)-C5Me4)(2)\}Cl-2] (6) have been prepared
   following reported procedures. The novel complex
   {[}Ti\{MePhC(eta(5)-C5H4)(2)\}Cl-2] (3) has been prepared and
   characterized. The cytotoxic activity of 1-6 has been tested after 72 h
   on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon
   cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic
   activity of complexes 1 and 6 compared to the reference compound
   ({[}Ti(eta(5)-C5H5)(2)\}Cl-2]). 1 and 6 have also been tested against
   primary normal mouse keratinocytes and lung fibroblasts. While viability
   of both type of primary cells was significantly less affected by 1 in
   comparison to the reference compound {[}Ti(eta(5)-C5H5)(2)Cl-2],
   compound 6 was completely nontoxic for nonmalignant cells, indicating a
   potential selectivity of this compound towards cancer cell lines. In
   addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining,
   detection of caspase activity and mitochondrial potential showed that 1
   and 6 were acting through inhibition of proliferation and subsequent
   induction of mitochondrial dependent apoptosis in colon cancer cell
   lines, HCT116 and SW620, which express low sensitivity to cisplatin.
   Compound 6 was found to be the leading drug in this group since it shows
   the fastest and most selective anticancer profile. (C) 2013 Elsevier
   B.V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes",
volume = "751",
doi = "10.1016/j.jorganchem.2013.07.059",
pages = "361-367"
}

Mijatović, S., Bulatović, M. Z., Mojić, M., Stošić-Grujičić, S., Miljković, Đ., Maksimović-Ivanić, D., Gomez-Ruiz, S., Pinkas, J., Horacek, M.,& Kaluđerović, G. N.. (2014). Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes. in Journal of Organometallic Chemistry, 751, 361-367.
https://doi.org/10.1016/j.jorganchem.2013.07.059

Mijatović S, Bulatović MZ, Mojić M, Stošić-Grujičić S, Miljković Đ, Maksimović-Ivanić D, Gomez-Ruiz S, Pinkas J, Horacek M, Kaluđerović GN. Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes. in Journal of Organometallic Chemistry. 2014;751:361-367.
doi:10.1016/j.jorganchem.2013.07.059 .

Mijatović, Sanja, Bulatović, Mirna Z., Mojić, Marija, Stošić-Grujičić, Stanislava, Miljković, Đorđe, Maksimović-Ivanić, Danijela, Gomez-Ruiz, Santiago, Pinkas, Jiri, Horacek, Michal, Kaluđerović, Goran N., "Study of the anticancer properties of methyl- and phenyl-substituted
 carbon- and silicon-bridged ansa-titanocene complexes" in Journal of Organometallic Chemistry, 751 (2014):361-367,
https://doi.org/10.1016/j.jorganchem.2013.07.059 . .

TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Bensing, Christian
AU  - Gomez-Ruiz, Santiago
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Mojić, Marija
AU  - Korac, Aleksandra
AU  - Golic, Igor
AU  - Perez-Quintanilla, Damian
AU  - Momčilović, Miljana
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2205
AB  - The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.
T2  - Angewandte Chemie-International Edition
T1  - Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment
IS  - 23
VL  - 53
DO  - 10.1002/anie.201400763
SP  - 5982
EP  - 5987
ER  - 

@article{
author = "Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Bensing, Christian and Gomez-Ruiz, Santiago and Steinborn, Dirk and Schmidt, Harry and Mojić, Marija and Korac, Aleksandra and Golic, Igor and Perez-Quintanilla, Damian and Momčilović, Miljana and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2014",
abstract = "The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.",
journal = "Angewandte Chemie-International Edition",
title = "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment",
number = "23",
volume = "53",
doi = "10.1002/anie.201400763",
pages = "5982-5987"
}

Bulatović, M. Z., Maksimović-Ivanić, D., Bensing, C., Gomez-Ruiz, S., Steinborn, D., Schmidt, H., Mojić, M., Korac, A., Golic, I., Perez-Quintanilla, D., Momčilović, M., Mijatović, S.,& Kaluđerović, G. N.. (2014). Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition, 53(23), 5982-5987.
https://doi.org/10.1002/anie.201400763

Bulatović MZ, Maksimović-Ivanić D, Bensing C, Gomez-Ruiz S, Steinborn D, Schmidt H, Mojić M, Korac A, Golic I, Perez-Quintanilla D, Momčilović M, Mijatović S, Kaluđerović GN. Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition. 2014;53(23):5982-5987.
doi:10.1002/anie.201400763 .

Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Bensing, Christian, Gomez-Ruiz, Santiago, Steinborn, Dirk, Schmidt, Harry, Mojić, Marija, Korac, Aleksandra, Golic, Igor, Perez-Quintanilla, Damian, Momčilović, Miljana, Mijatović, Sanja, Kaluđerović, Goran N., "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment" in Angewandte Chemie-International Edition, 53, no. 23 (2014):5982-5987,
https://doi.org/10.1002/anie.201400763 . .

TY  - JOUR
AU  - Ceballos-Torres, Jesus
AU  - del Hierro, Isabel
AU  - Prashar, Sanjiv
AU  - Fajardo, Mariano
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2139
AB  - Four alkenyl-substituted titanocene dichloride complexes
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H4(CMeR(CH2CH2CH=CH2))\}Cl-2] (R = Me (8),
   Ph (9)) and
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H3(CMeR(CH2CH2CH=CH2))(SiMe3)\}] (R = Me
   (10), Ph (11)) have been synthesized and characterized.
   The cytotoxic activity of 8-11 has been tested against human tumour cell
   lines from four different tissue origins {[}8505C (anaplastic thyroid
   cancer), DLD-1 (colon cancer), FaDu (head and neck cancer), A2780
   (ovarian cancer) and A549 (lung carcinoma)] and compared with those of
   the reference complexes {[}Ti(eta(5)-C5H5)(2)Cl-2] and cisplatin. The
   majority of the studied titanocene compounds are more active than the
   reference complex {[}Ti(eta(5)-C5H5)(2)Cl-2] indicating that the
   presence of alkenyl substituents leads to an increase in the cytotoxic
   activity. In addition, the presence of a trimethylsilyl group on the
   cyclopentadienyl ring also leads to an increase in the cytotoxic
   activity of 10 with respect to 8. The contrary is observed for 9 and 11
   (except on the DLD-1 cell line) with 9 (without -SiMe3) being more
   active than 11 (with -SiMe3). However, all synthesized complexes,
   exhibited lower cytotoxic activity than cisplatin.
   Stability and binding studies based on cyclic voltammetry and UV-visible
   spectroscopy have been carried out in order to explore possible
   interactions between titanocene derivatives and various intracellular
   molecules, such as the nitrogenous bases cytosine and thymine, the
   nucleotides adenosine and guanosine, and single-strand fish sperm DNA
   (FS-DNA). These experiments have allowed us to construct models to
   examine the interactions and action mechanisms of titanocene complexes
   inside the cells. In addition, this is one of the first studies on the
   interactions of titanocene derivatives with DNA fragments using cyclic
   voltammetry. (c) 2014 Elsevier B.V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity
VL  - 769
DO  - 10.1016/j.jorganchem.2014.06.031
SP  - 46
EP  - 57
ER  - 

@article{
author = "Ceballos-Torres, Jesus and del Hierro, Isabel and Prashar, Sanjiv and Fajardo, Mariano and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago",
year = "2014",
abstract = "Four alkenyl-substituted titanocene dichloride complexes
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H4(CMeR(CH2CH2CH=CH2))\}Cl-2] (R = Me (8),
   Ph (9)) and
   {[}Ti(eta(5)-C5H5)\{eta(5)-C5H3(CMeR(CH2CH2CH=CH2))(SiMe3)\}] (R = Me
   (10), Ph (11)) have been synthesized and characterized.
   The cytotoxic activity of 8-11 has been tested against human tumour cell
   lines from four different tissue origins {[}8505C (anaplastic thyroid
   cancer), DLD-1 (colon cancer), FaDu (head and neck cancer), A2780
   (ovarian cancer) and A549 (lung carcinoma)] and compared with those of
   the reference complexes {[}Ti(eta(5)-C5H5)(2)Cl-2] and cisplatin. The
   majority of the studied titanocene compounds are more active than the
   reference complex {[}Ti(eta(5)-C5H5)(2)Cl-2] indicating that the
   presence of alkenyl substituents leads to an increase in the cytotoxic
   activity. In addition, the presence of a trimethylsilyl group on the
   cyclopentadienyl ring also leads to an increase in the cytotoxic
   activity of 10 with respect to 8. The contrary is observed for 9 and 11
   (except on the DLD-1 cell line) with 9 (without -SiMe3) being more
   active than 11 (with -SiMe3). However, all synthesized complexes,
   exhibited lower cytotoxic activity than cisplatin.
   Stability and binding studies based on cyclic voltammetry and UV-visible
   spectroscopy have been carried out in order to explore possible
   interactions between titanocene derivatives and various intracellular
   molecules, such as the nitrogenous bases cytosine and thymine, the
   nucleotides adenosine and guanosine, and single-strand fish sperm DNA
   (FS-DNA). These experiments have allowed us to construct models to
   examine the interactions and action mechanisms of titanocene complexes
   inside the cells. In addition, this is one of the first studies on the
   interactions of titanocene derivatives with DNA fragments using cyclic
   voltammetry. (c) 2014 Elsevier B.V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity",
volume = "769",
doi = "10.1016/j.jorganchem.2014.06.031",
pages = "46-57"
}

Ceballos-Torres, J., del Hierro, I., Prashar, S., Fajardo, M., Mijatović, S., Maksimović-Ivanić, D., Kaluđerović, G. N.,& Gomez-Ruiz, S.. (2014). Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity. in Journal of Organometallic Chemistry, 769, 46-57.
https://doi.org/10.1016/j.jorganchem.2014.06.031

Ceballos-Torres J, del Hierro I, Prashar S, Fajardo M, Mijatović S, Maksimović-Ivanić D, Kaluđerović GN, Gomez-Ruiz S. Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity. in Journal of Organometallic Chemistry. 2014;769:46-57.
doi:10.1016/j.jorganchem.2014.06.031 .

Ceballos-Torres, Jesus, del Hierro, Isabel, Prashar, Sanjiv, Fajardo, Mariano, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Kaluđerović, Goran N., Gomez-Ruiz, Santiago, "Alkenyl-substituted titanocene dichloride complexes: Stability studies,
 binding and cytotoxicity" in Journal of Organometallic Chemistry, 769 (2014):46-57,
https://doi.org/10.1016/j.jorganchem.2014.06.031 . .

TY  - CONF
AU  - Bulatović, Mirna Z.
AU  - Bensing, C
AU  - Miljković, Đorđe
AU  - Mojić, Marija
AU  - Gomez-Ruiz, Santiago
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Kaluđerović, Goran N.
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/967
C3  - European Journal of Cancer
T1  - Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells
IS  - null
VL  - 49
SP  - 164
EP  - S174
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_967
ER  - 

@conference{
author = "Bulatović, Mirna Z. and Bensing, C and Miljković, Đorđe and Mojić, Marija and Gomez-Ruiz, Santiago and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Kaluđerović, Goran N.",
year = "2013",
journal = "European Journal of Cancer",
title = "Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells",
number = "null",
volume = "49",
pages = "164-S174",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_967"
}

Bulatović, M. Z., Bensing, C., Miljković, Đ., Mojić, M., Gomez-Ruiz, S., Mijatović, S., Maksimović-Ivanić, D.,& Kaluđerović, G. N.. (2013). Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells. in European Journal of Cancer, 49(null), 164-S174.
https://hdl.handle.net/21.15107/rcub_ibiss_967

Bulatović MZ, Bensing C, Miljković Đ, Mojić M, Gomez-Ruiz S, Mijatović S, Maksimović-Ivanić D, Kaluđerović GN. Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells. in European Journal of Cancer. 2013;49(null):164-S174.
https://hdl.handle.net/21.15107/rcub_ibiss_967 .

Bulatović, Mirna Z., Bensing, C, Miljković, Đorđe, Mojić, Marija, Gomez-Ruiz, Santiago, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Kaluđerović, Goran N., "Nanostructured silica functionalized with an organotin compound induces differentiation of B16 melanoma cells" in European Journal of Cancer, 49, no. null (2013):164-S174,
https://hdl.handle.net/21.15107/rcub_ibiss_967 .

TY  - GEN
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Maksimović-Ivanić, Danijela
AU  - Paschke, Reinhard
AU  - Mijatović, Sanja
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1225
T2  - Bioinorganic Chemistry and Applications
T1  - Metals in Medicine
IS  - null
VL  - null
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1225
ER  - 

@misc{
author = "Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Maksimović-Ivanić, Danijela and Paschke, Reinhard and Mijatović, Sanja",
year = "2012",
journal = "Bioinorganic Chemistry and Applications",
title = "Metals in Medicine",
number = "null",
volume = "null",
pages = "na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1225"
}

Kaluđerović, G. N., Gomez-Ruiz, S., Maksimović-Ivanić, D., Paschke, R.,& Mijatović, S.. (2012). Metals in Medicine. in Bioinorganic Chemistry and Applications, null(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1225

Kaluđerović GN, Gomez-Ruiz S, Maksimović-Ivanić D, Paschke R, Mijatović S. Metals in Medicine. in Bioinorganic Chemistry and Applications. 2012;null(null):null-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1225 .

Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Maksimović-Ivanić, Danijela, Paschke, Reinhard, Mijatović, Sanja, "Metals in Medicine" in Bioinorganic Chemistry and Applications, null, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1225 .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Zmejkovski, Bojana B
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojić, Marija
AU  - Steinborn, Dirk
AU  - Miljković, Đorđe
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava
AU  - Sabo, Tibor J
AU  - Maksimović-Ivanić, Danijela
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1223
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
IS  - 9
VL  - 4
EP  - 987
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1223
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatović, Sanja and Zmejkovski, Bojana B and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojić, Marija and Steinborn, Dirk and Miljković, Đorđe and Schmidt, Harry and Stošić-Grujičić, Stanislava and Sabo, Tibor J and Maksimović-Ivanić, Danijela",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
number = "9",
volume = "4",
pages = "987",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1223"
}

Kaluđerović, G. N., Mijatović, S., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojić, M., Steinborn, D., Miljković, Đ., Schmidt, H., Stošić-Grujičić, S., Sabo, T. J.,& Maksimović-Ivanić, D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics, 4(9).
https://hdl.handle.net/21.15107/rcub_ibiss_1223

Kaluđerović GN, Mijatović S, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojić M, Steinborn D, Miljković Đ, Schmidt H, Stošić-Grujičić S, Sabo TJ, Maksimović-Ivanić D. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):null-987.
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

Kaluđerović, Goran N., Mijatović, Sanja, Zmejkovski, Bojana B, Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojić, Marija, Steinborn, Dirk, Miljković, Đorđe, Schmidt, Harry, Stošić-Grujičić, Stanislava, Sabo, Tibor J, Maksimović-Ivanić, Danijela, "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

TY  - JOUR
AU  - Gomez-Ruiz, Santiago
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1224
AB  - The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.
T2  - Bioinorganic Chemistry and Applications
T1  - On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy
IS  - null
VL  - null
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1224
ER  - 

@article{
author = "Gomez-Ruiz, Santiago and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2012",
abstract = "The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.",
journal = "Bioinorganic Chemistry and Applications",
title = "On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy",
number = "null",
volume = "null",
pages = "na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1224"
}

Gomez-Ruiz, S., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2012). On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy. in Bioinorganic Chemistry and Applications, null(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1224

Gomez-Ruiz S, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy. in Bioinorganic Chemistry and Applications. 2012;null(null):null-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1224 .

Gomez-Ruiz, Santiago, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy" in Bioinorganic Chemistry and Applications, null, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1224 .