TY  - JOUR
AU  - Vukovic, Branislava
AU  - Lazic, Zoran
AU  - Avramov, Stevan
AU  - Pavlović, Maja
AU  - Čabrilo-Lazić, Milana
AU  - Malešević, Adam
AU  - Trifunović, Jovanka
AU  - Nikolić, Živorad
PY  - 2022
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0370-81792200047V
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5077
AB  - Introduction/Objective. Somatosensory evoked potentials are a neurophysiological tool for testing the effects of drugs in humans and animals. The aim of this study was to estimate the way that bromazepam and ibuprofen had on tooth pulp-evoked potentials (TPEPs) after non-painful stimuli, as well as to detect possible differences in this activity. Methods. Sixty young healthy subjects were included in the study. They were arranged into three groups: ibuprofen, bromazepam, and placebo. To record TPEPs response, dental pulp were electrically stimulated through intact enamel with non-painful stimuli. For stimulation and registration we used Xltek Protektor 32 system, software EPWorks, version 5.0 (Natus Medical Incorporated, Oakville, ON, Canada). The experiment consisted of two testing sessions. Five recordings were performed in each session. The first test session was before, and the second was 45 minutes after administration of a single dose of the ibuprofen (400 mg), bromazepam (1.5 mg) or placebo. Results. The results of the present study exhibit that both ibuprofen and bromazepam significantly increased all the latencies; ibuprofen decreased amplitudes of all the waves except the first one (p 0.05). Additionally, there were no significant differences in influence on TPEPs between bromazepam and ibuprofen (p > 0.05). Conclusion. Our study showed that both bromazepam and ibuprofen had the same influence on TPEPs after non-painful stimuli. That indicates that anxiolytic dose of bromazepam affects neurotransmission in the same manner as non-opioid analgesics ibuprofen.
PB  - Belgrade: Serbian Medical Society
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans
IS  - 5-6
VL  - 150
DO  - 10.2298/SARH220131047V
SP  - 267
EP  - 273
ER  - 

@article{
author = "Vukovic, Branislava and Lazic, Zoran and Avramov, Stevan and Pavlović, Maja and Čabrilo-Lazić, Milana and Malešević, Adam and Trifunović, Jovanka and Nikolić, Živorad",
year = "2022",
abstract = "Introduction/Objective. Somatosensory evoked potentials are a neurophysiological tool for testing the effects of drugs in humans and animals. The aim of this study was to estimate the way that bromazepam and ibuprofen had on tooth pulp-evoked potentials (TPEPs) after non-painful stimuli, as well as to detect possible differences in this activity. Methods. Sixty young healthy subjects were included in the study. They were arranged into three groups: ibuprofen, bromazepam, and placebo. To record TPEPs response, dental pulp were electrically stimulated through intact enamel with non-painful stimuli. For stimulation and registration we used Xltek Protektor 32 system, software EPWorks, version 5.0 (Natus Medical Incorporated, Oakville, ON, Canada). The experiment consisted of two testing sessions. Five recordings were performed in each session. The first test session was before, and the second was 45 minutes after administration of a single dose of the ibuprofen (400 mg), bromazepam (1.5 mg) or placebo. Results. The results of the present study exhibit that both ibuprofen and bromazepam significantly increased all the latencies; ibuprofen decreased amplitudes of all the waves except the first one (p 0.05). Additionally, there were no significant differences in influence on TPEPs between bromazepam and ibuprofen (p > 0.05). Conclusion. Our study showed that both bromazepam and ibuprofen had the same influence on TPEPs after non-painful stimuli. That indicates that anxiolytic dose of bromazepam affects neurotransmission in the same manner as non-opioid analgesics ibuprofen.",
publisher = "Belgrade: Serbian Medical Society",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans",
number = "5-6",
volume = "150",
doi = "10.2298/SARH220131047V",
pages = "267-273"
}

Vukovic, B., Lazic, Z., Avramov, S., Pavlović, M., Čabrilo-Lazić, M., Malešević, A., Trifunović, J.,& Nikolić, Ž.. (2022). Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans. in Srpski arhiv za celokupno lekarstvo
Belgrade: Serbian Medical Society., 150(5-6), 267-273.
https://doi.org/10.2298/SARH220131047V

Vukovic B, Lazic Z, Avramov S, Pavlović M, Čabrilo-Lazić M, Malešević A, Trifunović J, Nikolić Ž. Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans. in Srpski arhiv za celokupno lekarstvo. 2022;150(5-6):267-273.
doi:10.2298/SARH220131047V .

Vukovic, Branislava, Lazic, Zoran, Avramov, Stevan, Pavlović, Maja, Čabrilo-Lazić, Milana, Malešević, Adam, Trifunović, Jovanka, Nikolić, Živorad, "Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans" in Srpski arhiv za celokupno lekarstvo, 150, no. 5-6 (2022):267-273,
https://doi.org/10.2298/SARH220131047V . .

TY  - JOUR
AU  - Vuković, Branislava
AU  - Lazić, Zoran
AU  - Nikolić, Živorad
AU  - Kolar, Jovo
AU  - Avramov, Stevan
AU  - Cenić-Milošević, Desanka
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4188
AB  - Background/Aim. The sudden and excruciating pain that characterizes paroxysmal trigeminal neuralgia (PTN) has a negative effect on the wellbeing of the affected individuals, causing psychological distress. Salivary alpha-amylase (sAA) level represents an objective assessment of physical, physio-logical, and psychological stress. Evoked potentials (EPs) reflect nerve function and evaluate a functional aspect of the trigeminal nerve conduction. The aim of this study was to analyze possible modifications in painful impulses conduction related to sAA level by registering tooth pulp EPs in PTN patients. Methods. The study included ten PTN patients and twelve healthy subjects. The activity of sAA was measured using the Nipro Salivary Amylase Monitor. In order to record EPs response, the dental pulp of vital teeth was electrically stimulated through intact enamel. For stimulation and impulse registration, we used Xltek Protektor 32 system, software EPWorks, version 5.0. Results. The results obtained in PTN patients showed a higher number of waves and significantly shorter latencies and lower amplitudes N2-P2 a nd N 3-P3 at the neuralgic side c ompared to the healthy side of the same patient, as well as to the controls (p < 0.05). Moreover, latencies were significantly shorter in patients with higher sAA levels than in those with normal sAA levels (p < 0.05). Late latencies (N2 and P2) at the healthy side in patients with higher sAA levels were significantly shorter compared to patients whose sAA levels were normal (p < 0.05). Conclusion. This study showed that psychical stress associated with PTN probably further increased hyperexcitability and conduction velocity of the affected nerves. Moreover, it seems that anticipation of stressful pain even increases the conduction velocity of un-affected nerves at the thalamocortical level in PTN patients. However, in healthy individuals, stress itself had no influence on painful impulses conduction.
PB  - National Library of Serbia
T2  - Vojnosanitetski pregledMilitary Medical and Pharmaceutical Journal of Serbia
T1  - Salivary alpha-amylase and tooth pulp evoked potentials in paroxysmal trigeminal neuralgia patients
T1  - Salivarna alfa amilaza i evocirani potencijali zubne pulpe kod bolesnika sa paroksizmalnom trigeminalnom neuralgijomc
IS  - 2
VL  - 78
DO  - 10.2298/vsp190121053v
SP  - 223
EP  - 230
ER  - 

@article{
author = "Vuković, Branislava and Lazić, Zoran and Nikolić, Živorad and Kolar, Jovo and Avramov, Stevan and Cenić-Milošević, Desanka",
year = "2021",
abstract = "Background/Aim. The sudden and excruciating pain that characterizes paroxysmal trigeminal neuralgia (PTN) has a negative effect on the wellbeing of the affected individuals, causing psychological distress. Salivary alpha-amylase (sAA) level represents an objective assessment of physical, physio-logical, and psychological stress. Evoked potentials (EPs) reflect nerve function and evaluate a functional aspect of the trigeminal nerve conduction. The aim of this study was to analyze possible modifications in painful impulses conduction related to sAA level by registering tooth pulp EPs in PTN patients. Methods. The study included ten PTN patients and twelve healthy subjects. The activity of sAA was measured using the Nipro Salivary Amylase Monitor. In order to record EPs response, the dental pulp of vital teeth was electrically stimulated through intact enamel. For stimulation and impulse registration, we used Xltek Protektor 32 system, software EPWorks, version 5.0. Results. The results obtained in PTN patients showed a higher number of waves and significantly shorter latencies and lower amplitudes N2-P2 a nd N 3-P3 at the neuralgic side c ompared to the healthy side of the same patient, as well as to the controls (p < 0.05). Moreover, latencies were significantly shorter in patients with higher sAA levels than in those with normal sAA levels (p < 0.05). Late latencies (N2 and P2) at the healthy side in patients with higher sAA levels were significantly shorter compared to patients whose sAA levels were normal (p < 0.05). Conclusion. This study showed that psychical stress associated with PTN probably further increased hyperexcitability and conduction velocity of the affected nerves. Moreover, it seems that anticipation of stressful pain even increases the conduction velocity of un-affected nerves at the thalamocortical level in PTN patients. However, in healthy individuals, stress itself had no influence on painful impulses conduction.",
publisher = "National Library of Serbia",
journal = "Vojnosanitetski pregledMilitary Medical and Pharmaceutical Journal of Serbia",
title = "Salivary alpha-amylase and tooth pulp evoked potentials in paroxysmal trigeminal neuralgia patients, Salivarna alfa amilaza i evocirani potencijali zubne pulpe kod bolesnika sa paroksizmalnom trigeminalnom neuralgijomc",
number = "2",
volume = "78",
doi = "10.2298/vsp190121053v",
pages = "223-230"
}

Vuković, B., Lazić, Z., Nikolić, Ž., Kolar, J., Avramov, S.,& Cenić-Milošević, D.. (2021). Salivary alpha-amylase and tooth pulp evoked potentials in paroxysmal trigeminal neuralgia patients. in Vojnosanitetski pregledMilitary Medical and Pharmaceutical Journal of Serbia
National Library of Serbia., 78(2), 223-230.
https://doi.org/10.2298/vsp190121053v

Vuković B, Lazić Z, Nikolić Ž, Kolar J, Avramov S, Cenić-Milošević D. Salivary alpha-amylase and tooth pulp evoked potentials in paroxysmal trigeminal neuralgia patients. in Vojnosanitetski pregledMilitary Medical and Pharmaceutical Journal of Serbia. 2021;78(2):223-230.
doi:10.2298/vsp190121053v .

Vuković, Branislava, Lazić, Zoran, Nikolić, Živorad, Kolar, Jovo, Avramov, Stevan, Cenić-Milošević, Desanka, "Salivary alpha-amylase and tooth pulp evoked potentials in paroxysmal trigeminal neuralgia patients" in Vojnosanitetski pregledMilitary Medical and Pharmaceutical Journal of Serbia, 78, no. 2 (2021):223-230,
https://doi.org/10.2298/vsp190121053v . .