TY  - CONF
AU  - Ajdžanović, Vladimir
AU  - Jakovljević, Vladimir
AU  - Miler, Marko
AU  - Ristić, Nataša
AU  - Potrebić, Milica
AU  - Sretenović, Jasmina
AU  - Popovski Perčinić, Florina
AU  - Pendoski, Laze
AU  - Milošević, Verica
PY  - 2018
UR  - http://physiology.org.rs/4thCPS.php
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6035
AB  - The aim of this study was to investigate the immunohistomorphometric parameters of follicle-stimulating hormone (TSH) and luteinizing hormone (I.H) cells after testosterone application in an animal model of the andropause. Middle-aged Wistar rats were divided into orchidectomized (Or) and testosterone treated orchidectomized (OrxT) groups. Testosterone propionate (5 mg/kg b.m. (day) was administered for three weeks. while Or group received the vehicle alone.
Immunohistochemically stained FSH and I cells were subjected to the morphometric and optical density-related analysis. while circulating concentration of testosterone was measured by the immunoassay. Serum concentration of testosterone was increased (ps0.05) by 24 fold in comparison with Orx group.
Testosterone treatment did not cause significant changes of body mass or absolute and relative pituitary weights compared to Or group. The volume of FSH and LH cells was decreased (ps0.05) by 51.3% and 56.6% respectively, in comparison with Or rats. Relative volume density of FSI and LE cells was also decreased (p<0.05) by 54.0% and 72.8% respectively, compared to Or group. Results related to the optical density of gonadotropic cells were in line with the morphometric findings i.e. this parameter of FSH and LH cells was decreased (P«0.05) by 25.7% and 16.2% respectively, in comparison with Or rats. In conclusion. applied testosterone decreased morphometric parameters and optical density of gonadotropic cells in Or rats.
PB  - Belgrade : Serbian Physiological Society, 2018 (Lukovo : Galaksijanis)
C3  - Abstract book: 4th Congress of Physiological Sciences of Serbia with International Participation: Current Trends in Physiological Sciences: from cell signals to the biology of aging; 2018 Sep 19-23; Niš, Serbia
T1  - Testosterone effects on the pituitary gonadotropic cells in an animal model of the andropause
SP  - 118
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6035
ER  - 

@conference{
author = "Ajdžanović, Vladimir and Jakovljević, Vladimir and Miler, Marko and Ristić, Nataša and Potrebić, Milica and Sretenović, Jasmina and Popovski Perčinić, Florina and Pendoski, Laze and Milošević, Verica",
year = "2018",
abstract = "The aim of this study was to investigate the immunohistomorphometric parameters of follicle-stimulating hormone (TSH) and luteinizing hormone (I.H) cells after testosterone application in an animal model of the andropause. Middle-aged Wistar rats were divided into orchidectomized (Or) and testosterone treated orchidectomized (OrxT) groups. Testosterone propionate (5 mg/kg b.m. (day) was administered for three weeks. while Or group received the vehicle alone.
Immunohistochemically stained FSH and I cells were subjected to the morphometric and optical density-related analysis. while circulating concentration of testosterone was measured by the immunoassay. Serum concentration of testosterone was increased (ps0.05) by 24 fold in comparison with Orx group.
Testosterone treatment did not cause significant changes of body mass or absolute and relative pituitary weights compared to Or group. The volume of FSH and LH cells was decreased (ps0.05) by 51.3% and 56.6% respectively, in comparison with Or rats. Relative volume density of FSI and LE cells was also decreased (p<0.05) by 54.0% and 72.8% respectively, compared to Or group. Results related to the optical density of gonadotropic cells were in line with the morphometric findings i.e. this parameter of FSH and LH cells was decreased (P«0.05) by 25.7% and 16.2% respectively, in comparison with Or rats. In conclusion. applied testosterone decreased morphometric parameters and optical density of gonadotropic cells in Or rats.",
publisher = "Belgrade : Serbian Physiological Society, 2018 (Lukovo : Galaksijanis)",
journal = "Abstract book: 4th Congress of Physiological Sciences of Serbia with International Participation: Current Trends in Physiological Sciences: from cell signals to the biology of aging; 2018 Sep 19-23; Niš, Serbia",
title = "Testosterone effects on the pituitary gonadotropic cells in an animal model of the andropause",
pages = "118-118",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6035"
}

Ajdžanović, V., Jakovljević, V., Miler, M., Ristić, N., Potrebić, M., Sretenović, J., Popovski Perčinić, F., Pendoski, L.,& Milošević, V.. (2018). Testosterone effects on the pituitary gonadotropic cells in an animal model of the andropause. in Abstract book: 4th Congress of Physiological Sciences of Serbia with International Participation: Current Trends in Physiological Sciences: from cell signals to the biology of aging; 2018 Sep 19-23; Niš, Serbia
Belgrade : Serbian Physiological Society, 2018 (Lukovo : Galaksijanis)., 118-118.
https://hdl.handle.net/21.15107/rcub_ibiss_6035

Ajdžanović V, Jakovljević V, Miler M, Ristić N, Potrebić M, Sretenović J, Popovski Perčinić F, Pendoski L, Milošević V. Testosterone effects on the pituitary gonadotropic cells in an animal model of the andropause. in Abstract book: 4th Congress of Physiological Sciences of Serbia with International Participation: Current Trends in Physiological Sciences: from cell signals to the biology of aging; 2018 Sep 19-23; Niš, Serbia. 2018;:118-118.
https://hdl.handle.net/21.15107/rcub_ibiss_6035 .

Ajdžanović, Vladimir, Jakovljević, Vladimir, Miler, Marko, Ristić, Nataša, Potrebić, Milica, Sretenović, Jasmina, Popovski Perčinić, Florina, Pendoski, Laze, Milošević, Verica, "Testosterone effects on the pituitary gonadotropic cells in an animal model of the andropause" in Abstract book: 4th Congress of Physiological Sciences of Serbia with International Participation: Current Trends in Physiological Sciences: from cell signals to the biology of aging; 2018 Sep 19-23; Niš, Serbia (2018):118-118,
https://hdl.handle.net/21.15107/rcub_ibiss_6035 .