TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Bensing, Christian
AU  - Gomez-Ruiz, Santiago
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Mojić, Marija
AU  - Korac, Aleksandra
AU  - Golic, Igor
AU  - Perez-Quintanilla, Damian
AU  - Momčilović, Miljana
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2205
AB  - The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.
T2  - Angewandte Chemie-International Edition
T1  - Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment
IS  - 23
VL  - 53
DO  - 10.1002/anie.201400763
SP  - 5982
EP  - 5987
ER  - 

@article{
author = "Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Bensing, Christian and Gomez-Ruiz, Santiago and Steinborn, Dirk and Schmidt, Harry and Mojić, Marija and Korac, Aleksandra and Golic, Igor and Perez-Quintanilla, Damian and Momčilović, Miljana and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2014",
abstract = "The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.",
journal = "Angewandte Chemie-International Edition",
title = "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment",
number = "23",
volume = "53",
doi = "10.1002/anie.201400763",
pages = "5982-5987"
}

Bulatović, M. Z., Maksimović-Ivanić, D., Bensing, C., Gomez-Ruiz, S., Steinborn, D., Schmidt, H., Mojić, M., Korac, A., Golic, I., Perez-Quintanilla, D., Momčilović, M., Mijatović, S.,& Kaluđerović, G. N.. (2014). Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition, 53(23), 5982-5987.
https://doi.org/10.1002/anie.201400763

Bulatović MZ, Maksimović-Ivanić D, Bensing C, Gomez-Ruiz S, Steinborn D, Schmidt H, Mojić M, Korac A, Golic I, Perez-Quintanilla D, Momčilović M, Mijatović S, Kaluđerović GN. Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition. 2014;53(23):5982-5987.
doi:10.1002/anie.201400763 .

Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Bensing, Christian, Gomez-Ruiz, Santiago, Steinborn, Dirk, Schmidt, Harry, Mojić, Marija, Korac, Aleksandra, Golic, Igor, Perez-Quintanilla, Damian, Momčilović, Miljana, Mijatović, Sanja, Kaluđerović, Goran N., "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment" in Angewandte Chemie-International Edition, 53, no. 23 (2014):5982-5987,
https://doi.org/10.1002/anie.201400763 . .