TY  - JOUR
AU  - Vojnović-Milutinović, Danijela
AU  - Radovanović, Marina
AU  - Dinic, Jovana
AU  - Đorđević, Ana
AU  - Velickovic, Natasa
AU  - Elaković, Ivana
AU  - Matić, Gordana
AU  - Brkljačić, Jelena
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2273
AB  - Alterations in leptin and glucocorticoid signaling pathways in the
   hypothalamus of male and female rats subjected to a fructose-enriched
   diet were studied. The level of expression of the key components of the
   leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of
   cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway
   (glucocorticoid receptor /GR/, 11 beta-hydroxysteroid dehydrogenase type
   1 /11 beta HSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not
   differ between fructose-fed rats and control animals of both genders.
   However, in females, a fructose-enriched diet provoked increases in the
   adiposity index, plasma leptin and triglyceride concentrations, and
   displayed a tendency to decrease the leptin receptor (ObRb) protein and
   mRNA levels. In male rats, the fructose diet caused elevations in plasma
   non-esterified fatty acids and triglycerides, as well as in both plasma
   and hypothalamic leptin concentrations. Our results suggest that a
   fructose-enriched diet can induce hyperleptinemia in both female and
   male rats, but with a more pronounced effect on hypothalamic leptin
   sensitivity in females, probably contributing to the observed
   development of visceral adiposity.
T2  - Archives of Biological Sciences
T1  - Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats
IS  - 2
VL  - 66
DO  - 10.2298/ABS1402829M
SP  - 829
EP  - 839
ER  - 

@article{
author = "Vojnović-Milutinović, Danijela and Radovanović, Marina and Dinic, Jovana and Đorđević, Ana and Velickovic, Natasa and Elaković, Ivana and Matić, Gordana and Brkljačić, Jelena",
year = "2014",
abstract = "Alterations in leptin and glucocorticoid signaling pathways in the
   hypothalamus of male and female rats subjected to a fructose-enriched
   diet were studied. The level of expression of the key components of the
   leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of
   cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway
   (glucocorticoid receptor /GR/, 11 beta-hydroxysteroid dehydrogenase type
   1 /11 beta HSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not
   differ between fructose-fed rats and control animals of both genders.
   However, in females, a fructose-enriched diet provoked increases in the
   adiposity index, plasma leptin and triglyceride concentrations, and
   displayed a tendency to decrease the leptin receptor (ObRb) protein and
   mRNA levels. In male rats, the fructose diet caused elevations in plasma
   non-esterified fatty acids and triglycerides, as well as in both plasma
   and hypothalamic leptin concentrations. Our results suggest that a
   fructose-enriched diet can induce hyperleptinemia in both female and
   male rats, but with a more pronounced effect on hypothalamic leptin
   sensitivity in females, probably contributing to the observed
   development of visceral adiposity.",
journal = "Archives of Biological Sciences",
title = "Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats",
number = "2",
volume = "66",
doi = "10.2298/ABS1402829M",
pages = "829-839"
}

Vojnović-Milutinović, D., Radovanović, M., Dinic, J., Đorđević, A., Velickovic, N., Elaković, I., Matić, G.,& Brkljačić, J.. (2014). Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats. in Archives of Biological Sciences, 66(2), 829-839.
https://doi.org/10.2298/ABS1402829M

Vojnović-Milutinović D, Radovanović M, Dinic J, Đorđević A, Velickovic N, Elaković I, Matić G, Brkljačić J. Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats. in Archives of Biological Sciences. 2014;66(2):829-839.
doi:10.2298/ABS1402829M .

Vojnović-Milutinović, Danijela, Radovanović, Marina, Dinic, Jovana, Đorđević, Ana, Velickovic, Natasa, Elaković, Ivana, Matić, Gordana, Brkljačić, Jelena, "Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats" in Archives of Biological Sciences, 66, no. 2 (2014):829-839,
https://doi.org/10.2298/ABS1402829M . .