TY  - JOUR
AU  - Mihailović, Vladimir
AU  - Katanić Stanković, Jelena S.
AU  - Jurić, Tatjana
AU  - Srećković, Nikola
AU  - Mišić, Danijela
AU  - Šiler, Branislav
AU  - Monti, Daria Maria
AU  - Imbimbo, Paola
AU  - Nikles, Stefanie
AU  - Pan, San-Po
AU  - Bauer, Rudolf
PY  - 2020
UR  - https://www.sciencedirect.com/science/article/pii/S0926669019309847?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3562
AB  - Blackstonia perfoliata (L.) Huds. is known as a highly bitter secoiridoid glycosides-containing plant and as a possible substitute for some Gentianaceae plants in herbal preparations. Nevertheless, its bioactive properties are still unknown. The present study aimed to characterize both, secoiridoid glycosides and phenolic constituents, and to investigate antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities of B. perfoliata methanolic extract. The secoiridoid glycosides swertiamarin, gentiopicrin, and sweroside were found to be the dominant compounds of the extract, while 23 phenolic compounds were identified in much lower concentrations. Among phenolics, flavanols were the most abundant, which represents a unique feature among Gentianaceae species. The extract showed moderate to weak antioxidant activity with better performance in inhibition of lipid peroxidation than in free radical scavenging activities. The extract showed generally better antifungal properties compared with its antibacterial potential. Also, B. perfoliata demonstrated in vitro anti-inflammatory activity, the extract (50 μg/mL) showed inhibition of cyclooxigenases, COX-1 and COX-2, activities (19.65 and 48.02%, respectively). It also displayed biocompatibility on the immortalized and cancer cells, as no cytotoxic effect was observed. For the first time, the bioactive potential of this species was demonstrated, justifying its usage in pharmaceutical and food products as an alternative for some overexploited and endangered species from the Gentianaceae family.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds
VL  - 145
DO  - 10.1016/J.INDCROP.2019.111974
SP  - 111974
ER  - 

@article{
author = "Mihailović, Vladimir and Katanić Stanković, Jelena S. and Jurić, Tatjana and Srećković, Nikola and Mišić, Danijela and Šiler, Branislav and Monti, Daria Maria and Imbimbo, Paola and Nikles, Stefanie and Pan, San-Po and Bauer, Rudolf",
year = "2020",
abstract = "Blackstonia perfoliata (L.) Huds. is known as a highly bitter secoiridoid glycosides-containing plant and as a possible substitute for some Gentianaceae plants in herbal preparations. Nevertheless, its bioactive properties are still unknown. The present study aimed to characterize both, secoiridoid glycosides and phenolic constituents, and to investigate antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities of B. perfoliata methanolic extract. The secoiridoid glycosides swertiamarin, gentiopicrin, and sweroside were found to be the dominant compounds of the extract, while 23 phenolic compounds were identified in much lower concentrations. Among phenolics, flavanols were the most abundant, which represents a unique feature among Gentianaceae species. The extract showed moderate to weak antioxidant activity with better performance in inhibition of lipid peroxidation than in free radical scavenging activities. The extract showed generally better antifungal properties compared with its antibacterial potential. Also, B. perfoliata demonstrated in vitro anti-inflammatory activity, the extract (50 μg/mL) showed inhibition of cyclooxigenases, COX-1 and COX-2, activities (19.65 and 48.02%, respectively). It also displayed biocompatibility on the immortalized and cancer cells, as no cytotoxic effect was observed. For the first time, the bioactive potential of this species was demonstrated, justifying its usage in pharmaceutical and food products as an alternative for some overexploited and endangered species from the Gentianaceae family.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds",
volume = "145",
doi = "10.1016/J.INDCROP.2019.111974",
pages = "111974"
}

Mihailović, V., Katanić Stanković, J. S., Jurić, T., Srećković, N., Mišić, D., Šiler, B., Monti, D. M., Imbimbo, P., Nikles, S., Pan, S.,& Bauer, R.. (2020). Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds. in Industrial Crops and Products
Elsevier., 145, 111974.
https://doi.org/10.1016/J.INDCROP.2019.111974

Mihailović V, Katanić Stanković JS, Jurić T, Srećković N, Mišić D, Šiler B, Monti DM, Imbimbo P, Nikles S, Pan S, Bauer R. Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds. in Industrial Crops and Products. 2020;145:111974.
doi:10.1016/J.INDCROP.2019.111974 .

Mihailović, Vladimir, Katanić Stanković, Jelena S., Jurić, Tatjana, Srećković, Nikola, Mišić, Danijela, Šiler, Branislav, Monti, Daria Maria, Imbimbo, Paola, Nikles, Stefanie, Pan, San-Po, Bauer, Rudolf, "Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds" in Industrial Crops and Products, 145 (2020):111974,
https://doi.org/10.1016/J.INDCROP.2019.111974 . .

TY  - JOUR
AU  - Katanić Stanković, Jelena S.
AU  - Srećković, Nikola
AU  - Mišić, Danijela
AU  - Gašić, Uroš
AU  - Imbimbo, Paola
AU  - Monti, Daria Maria
AU  - Mihailović, Vladimir
PY  - 2020
UR  - https://www.sciencedirect.com/science/article/pii/S0926669019309422?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3523
AB  - The plants from genus Salvia, as one of the largest genus in Lamiaceae family, are frequently in use for various purposes, as foods, in cosmetic industry, or in traditional and official medicine. Salvia verticillata L. (liliac sage) is one of sidelined sage species with potential bioactivity, reported in traditional medicine. The aim of this study was to acquire a phytochemical profile of the methanol extract obtained from S. verticillata aerial parts and to evaluate its antioxidant, antimicrobial, and biocompatibility potential. Characteristic compounds of the genus Salvia, such as rosmarinic and caffeic acids, along with their derivatives (e.g. salvianolic and yunnaneic acids isomers) and flavonoids, have been identified by ultrahigh-performance Orbitrap metabolomic fingerprinting as the main phenolic metabolites in S. verticillata. The extract displayed moderate antimicrobial properties and significant antioxidant potential, with the half maximal inhibitory concentration values (IC50) ranging from 33 to 73 μg/mL. Importantly, full biocompatibility of the extract with eukaryotic cell lines was observed up to 72 h. The obtained results revealed the presence of polyphenolic bioactive compounds in S. verticillata extract with promising antioxidant potential and significant biocompatibility. In this regard, S. verticillata can find new perspectives of application as a food ingredient, in cosmetic and pharmaceutical industries, as it represents a valuable source of compounds with prominent health properties, with a special focus on rosmarinic acid.
T2  - Industrial Crops and Products
T1  - Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae) - A plant rich in rosmarinic acid
VL  - 143
DO  - 10.1016/J.INDCROP.2019.111932
SP  - 111932
ER  - 

@article{
author = "Katanić Stanković, Jelena S. and Srećković, Nikola and Mišić, Danijela and Gašić, Uroš and Imbimbo, Paola and Monti, Daria Maria and Mihailović, Vladimir",
year = "2020",
abstract = "The plants from genus Salvia, as one of the largest genus in Lamiaceae family, are frequently in use for various purposes, as foods, in cosmetic industry, or in traditional and official medicine. Salvia verticillata L. (liliac sage) is one of sidelined sage species with potential bioactivity, reported in traditional medicine. The aim of this study was to acquire a phytochemical profile of the methanol extract obtained from S. verticillata aerial parts and to evaluate its antioxidant, antimicrobial, and biocompatibility potential. Characteristic compounds of the genus Salvia, such as rosmarinic and caffeic acids, along with their derivatives (e.g. salvianolic and yunnaneic acids isomers) and flavonoids, have been identified by ultrahigh-performance Orbitrap metabolomic fingerprinting as the main phenolic metabolites in S. verticillata. The extract displayed moderate antimicrobial properties and significant antioxidant potential, with the half maximal inhibitory concentration values (IC50) ranging from 33 to 73 μg/mL. Importantly, full biocompatibility of the extract with eukaryotic cell lines was observed up to 72 h. The obtained results revealed the presence of polyphenolic bioactive compounds in S. verticillata extract with promising antioxidant potential and significant biocompatibility. In this regard, S. verticillata can find new perspectives of application as a food ingredient, in cosmetic and pharmaceutical industries, as it represents a valuable source of compounds with prominent health properties, with a special focus on rosmarinic acid.",
journal = "Industrial Crops and Products",
title = "Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae) - A plant rich in rosmarinic acid",
volume = "143",
doi = "10.1016/J.INDCROP.2019.111932",
pages = "111932"
}

Katanić Stanković, J. S., Srećković, N., Mišić, D., Gašić, U., Imbimbo, P., Monti, D. M.,& Mihailović, V.. (2020). Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae) - A plant rich in rosmarinic acid. in Industrial Crops and Products, 143, 111932.
https://doi.org/10.1016/J.INDCROP.2019.111932

Katanić Stanković JS, Srećković N, Mišić D, Gašić U, Imbimbo P, Monti DM, Mihailović V. Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae) - A plant rich in rosmarinic acid. in Industrial Crops and Products. 2020;143:111932.
doi:10.1016/J.INDCROP.2019.111932 .

Katanić Stanković, Jelena S., Srećković, Nikola, Mišić, Danijela, Gašić, Uroš, Imbimbo, Paola, Monti, Daria Maria, Mihailović, Vladimir, "Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae) - A plant rich in rosmarinic acid" in Industrial Crops and Products, 143 (2020):111932,
https://doi.org/10.1016/J.INDCROP.2019.111932 . .