TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Jakovljević, Branislava
AU  - Korovljev, Darinka
AU  - Simić, Svetlana
AU  - Čapo, Ivan
AU  - Podgorac, Jelena
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Rakić, Srđan
AU  - Petković, Branka
PY  - 2022
UR  - https://www.frontiersin.org/articles/10.3389/fphys.2021.810391/full
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4787
AB  - Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid
in the third trimester of pregnancy and it can be acute and chronic depending on
the duration. Published data suggest that during muscle development, in the stage
of late histochemical differentiation decreased mechanical loading cause decreased
expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the
case of chronic polyhydramnios, histochemical muscle differentiation could be affected
as a consequence of permanent decreased physical loading. Most affected would
be muscles which are the most active i.e., spine extensor muscles and muscles of
legs. Long-lasting decreased mechanical loading on muscle should cause decreased
expression of MHC type 1 leading to slow-to-fast transition, decreased number of
muscle fiber type I especially in extensor muscles of spine and legs. Additionally,
because MHC type 1 is present in all skeletal muscles it could lead to various degrees
of hypotrophy depending on constituting a percentage of MHC type 1 in affected
muscles. These changes in the case of preexisting muscle disorders have the potential
to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic
polyhydramnios is a rare opportunity to study the influence of reduced physical loading
on muscle development in the human fetus. Also, it could be a medical entity to examine
the influence of micro- and hypogravity conditions on the development of the fetal
muscular system during the last trimester of gestation.
PB  - Switzerland: Frontiers Media SA
T2  - Frontiers in Physiology
T1  - Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition
VL  - 12
DO  - 10.3389/fphys.2021.810391
SP  - 810391
ER  - 

@article{
author = "Sekulić, Slobodan and Jakovljević, Branislava and Korovljev, Darinka and Simić, Svetlana and Čapo, Ivan and Podgorac, Jelena and Martać, Ljiljana and Kesić, Srđan and Rakić, Srđan and Petković, Branka",
year = "2022",
abstract = "Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid
in the third trimester of pregnancy and it can be acute and chronic depending on
the duration. Published data suggest that during muscle development, in the stage
of late histochemical differentiation decreased mechanical loading cause decreased
expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the
case of chronic polyhydramnios, histochemical muscle differentiation could be affected
as a consequence of permanent decreased physical loading. Most affected would
be muscles which are the most active i.e., spine extensor muscles and muscles of
legs. Long-lasting decreased mechanical loading on muscle should cause decreased
expression of MHC type 1 leading to slow-to-fast transition, decreased number of
muscle fiber type I especially in extensor muscles of spine and legs. Additionally,
because MHC type 1 is present in all skeletal muscles it could lead to various degrees
of hypotrophy depending on constituting a percentage of MHC type 1 in affected
muscles. These changes in the case of preexisting muscle disorders have the potential
to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic
polyhydramnios is a rare opportunity to study the influence of reduced physical loading
on muscle development in the human fetus. Also, it could be a medical entity to examine
the influence of micro- and hypogravity conditions on the development of the fetal
muscular system during the last trimester of gestation.",
publisher = "Switzerland: Frontiers Media SA",
journal = "Frontiers in Physiology",
title = "Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition",
volume = "12",
doi = "10.3389/fphys.2021.810391",
pages = "810391"
}

Sekulić, S., Jakovljević, B., Korovljev, D., Simić, S., Čapo, I., Podgorac, J., Martać, L., Kesić, S., Rakić, S.,& Petković, B.. (2022). Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition. in Frontiers in Physiology
Switzerland: Frontiers Media SA., 12, 810391.
https://doi.org/10.3389/fphys.2021.810391

Sekulić S, Jakovljević B, Korovljev D, Simić S, Čapo I, Podgorac J, Martać L, Kesić S, Rakić S, Petković B. Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition. in Frontiers in Physiology. 2022;12:810391.
doi:10.3389/fphys.2021.810391 .

Sekulić, Slobodan, Jakovljević, Branislava, Korovljev, Darinka, Simić, Svetlana, Čapo, Ivan, Podgorac, Jelena, Martać, Ljiljana, Kesić, Srđan, Rakić, Srđan, Petković, Branka, "Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition" in Frontiers in Physiology, 12 (2022):810391,
https://doi.org/10.3389/fphys.2021.810391 . .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
AU  - Sekulić, Slobodan
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5745
AB  - Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu.
AB  - Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa
T1  - Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева
SP  - 369
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5745
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Martać, Ljiljana and Stojadinović, Gordana and Pešić, Vesna and Sekulić, Slobodan",
year = "2022",
abstract = "Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu., Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa, Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева",
pages = "369",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5745"
}

Podgorac, J., Petković, B., Martać, L., Stojadinović, G., Pešić, V.,& Sekulić, S.. (2022). Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745

Podgorac J, Petković B, Martać L, Stojadinović G, Pešić V, Sekulić S. Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

Podgorac, Jelena, Petković, Branka, Martać, Ljiljana, Stojadinović, Gordana, Pešić, Vesna, Sekulić, Slobodan, "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):369,
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

TY  - CONF
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5746
AB  - Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije.
AB  - Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina
T1  - Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина
SP  - 388
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5746
ER  - 

@conference{
author = "Kesić, Srđan and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Petković, Branka",
year = "2022",
abstract = "Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije., Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina, Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина",
pages = "388",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5746"
}

Kesić, S., Stojadinović, G., Martać, L., Sekulić, S.,& Petković, B.. (2022). Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746

Kesić S, Stojadinović G, Martać L, Sekulić S, Petković B. Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

Kesić, Srđan, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Petković, Branka, "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):388,
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Pešić, Vesna
PY  - 2022
UR  - https://kenesvm.azureedge.net/public/general/FENS2022.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5734
AB  - Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.
PB  - Federation of European Neuroscience Societies
C3  - E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
T1  - Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam
SP  - S02-173
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5734
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Pešić, Vesna",
year = "2022",
abstract = "Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.",
publisher = "Federation of European Neuroscience Societies",
journal = "E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France",
title = "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam",
pages = "S02-173",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5734"
}

Podgorac, J., Petković, B., Stojadinović, G., Martać, L., Sekulić, S.,& Pešić, V.. (2022). Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
Federation of European Neuroscience Societies., S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734

Podgorac J, Petković B, Stojadinović G, Martać L, Sekulić S, Pešić V. Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France. 2022;:S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

Podgorac, Jelena, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Pešić, Vesna, "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam" in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France (2022):S02-173,
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Lemajić-Komazec, Slobodanka
AU  - Sokolovac, Ivana
AU  - Topalidou, Anastasia
AU  - Gouni, Olga
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Keković, Goran
AU  - Redžek-Mudrinić, Tatjana
AU  - Čapo, Ivan
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32159401
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3635
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4772
AB  - Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.
PB  - Taylor and Francis Ltd
T2  - Fetal and Pediatric Pathology
T1  - Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation
IS  - 6
VL  - 40
DO  - 10.1080/15513815.2020.1737993
SP  - 674
EP  - 684
ER  - 

@article{
author = "Sekulić, Slobodan and Lemajić-Komazec, Slobodanka and Sokolovac, Ivana and Topalidou, Anastasia and Gouni, Olga and Petković, Branka and Martać, Ljiljana and Keković, Goran and Redžek-Mudrinić, Tatjana and Čapo, Ivan",
year = "2021",
abstract = "Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.",
publisher = "Taylor and Francis Ltd",
journal = "Fetal and Pediatric Pathology",
title = "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation",
number = "6",
volume = "40",
doi = "10.1080/15513815.2020.1737993",
pages = "674-684"
}

Sekulić, S., Lemajić-Komazec, S., Sokolovac, I., Topalidou, A., Gouni, O., Petković, B., Martać, L., Keković, G., Redžek-Mudrinić, T.,& Čapo, I.. (2021). Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology
Taylor and Francis Ltd., 40(6), 674-684.
https://doi.org/10.1080/15513815.2020.1737993

Sekulić S, Lemajić-Komazec S, Sokolovac I, Topalidou A, Gouni O, Petković B, Martać L, Keković G, Redžek-Mudrinić T, Čapo I. Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology. 2021;40(6):674-684.
doi:10.1080/15513815.2020.1737993 .

Sekulić, Slobodan, Lemajić-Komazec, Slobodanka, Sokolovac, Ivana, Topalidou, Anastasia, Gouni, Olga, Petković, Branka, Martać, Ljiljana, Keković, Goran, Redžek-Mudrinić, Tatjana, Čapo, Ivan, "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation" in Fetal and Pediatric Pathology, 40, no. 6 (2021):674-684,
https://doi.org/10.1080/15513815.2020.1737993 . .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Lemajić-Komazec, Slobodanka
AU  - Sokolovac, Ivana
AU  - Topalidou, Anastasia
AU  - Gouni, Olga
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Keković, Goran
AU  - Redžek-Mudrinić, Tatjana
AU  - Čapo, Ivan
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32159401
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3635
AB  - Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.
PB  - Taylor and Francis Ltd
T2  - Fetal and Pediatric Pathology
T1  - Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation
IS  - 6
VL  - 40
DO  - 10.1080/15513815.2020.1737993
SP  - 674
EP  - 684
ER  - 

@article{
author = "Sekulić, Slobodan and Lemajić-Komazec, Slobodanka and Sokolovac, Ivana and Topalidou, Anastasia and Gouni, Olga and Petković, Branka and Martać, Ljiljana and Keković, Goran and Redžek-Mudrinić, Tatjana and Čapo, Ivan",
year = "2021",
abstract = "Background: There is speculation that an immature vestibular system may be associated with breech presentation at delivery. Our aim was to determine whether syndromes with congenital inner ear malformations were accompanied by a higher frequency of breech presentation/malpresentations than in the general population (2%-3%). Methods: A review was conducted for published literature using PubMed/MEDLINE (1936-2016), to determine frequency of breech presentation and transverse lie in cases with congenital deafness (Michel aplasia, Wildervanck syndrome, Mondini-Alexander dysplasia, Waardenburg syndrome, CHARGE syndrome, Large vestibular aqueductal syndrome, Pendred syndrome, Oculo-aurico-vertebral spectrum, Jervel and Lange-Nielsen syndrome, Usher syndrome, and Scheibe dysplasia) and vestibular nerve aplasia. Results: Identified were total of 122 cases. The frequency of breech presentation was 1.64%, and of transverse lie 1.64%, giving a total of 3.28% malpresentations. Conclusion: The results of the study suggest that congenital malformations of the vestibular apparatus are not associated with the increased risk of breech presentation at delivery.",
publisher = "Taylor and Francis Ltd",
journal = "Fetal and Pediatric Pathology",
title = "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation",
number = "6",
volume = "40",
doi = "10.1080/15513815.2020.1737993",
pages = "674-684"
}

Sekulić, S., Lemajić-Komazec, S., Sokolovac, I., Topalidou, A., Gouni, O., Petković, B., Martać, L., Keković, G., Redžek-Mudrinić, T.,& Čapo, I.. (2021). Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology
Taylor and Francis Ltd., 40(6), 674-684.
https://doi.org/10.1080/15513815.2020.1737993

Sekulić S, Lemajić-Komazec S, Sokolovac I, Topalidou A, Gouni O, Petković B, Martać L, Keković G, Redžek-Mudrinić T, Čapo I. Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation. in Fetal and Pediatric Pathology. 2021;40(6):674-684.
doi:10.1080/15513815.2020.1737993 .

Sekulić, Slobodan, Lemajić-Komazec, Slobodanka, Sokolovac, Ivana, Topalidou, Anastasia, Gouni, Olga, Petković, Branka, Martać, Ljiljana, Keković, Goran, Redžek-Mudrinić, Tatjana, Čapo, Ivan, "Inner Ear Malformations in Congenital Deafness Are Not Associated with Increased Risk of Breech Presentation" in Fetal and Pediatric Pathology, 40, no. 6 (2021):674-684,
https://doi.org/10.1080/15513815.2020.1737993 . .

TY  - JOUR
AU  - Drljača, Jovana
AU  - Vejnović, Ana-Marija
AU  - Miljković, Dejan
AU  - Popović, Milan
AU  - Rakić, Dušica
AU  - Sekulić, Slobodan
AU  - Čapo, Ivan
AU  - Petković, Branka
PY  - 2020
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4473
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3655
AB  - The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress.
T2  - Archives of Biological Sciences
T1  - Changes in mouse thymus after exposure to tube-restraint stress
IS  - 1
VL  - 72
DO  - 10.2298/abs190716060d
SP  - 5
EP  - 11
ER  - 

@article{
author = "Drljača, Jovana and Vejnović, Ana-Marija and Miljković, Dejan and Popović, Milan and Rakić, Dušica and Sekulić, Slobodan and Čapo, Ivan and Petković, Branka",
year = "2020",
abstract = "The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress.",
journal = "Archives of Biological Sciences",
title = "Changes in mouse thymus after exposure to tube-restraint stress",
number = "1",
volume = "72",
doi = "10.2298/abs190716060d",
pages = "5-11"
}

Drljača, J., Vejnović, A., Miljković, D., Popović, M., Rakić, D., Sekulić, S., Čapo, I.,& Petković, B.. (2020). Changes in mouse thymus after exposure to tube-restraint stress. in Archives of Biological Sciences, 72(1), 5-11.
https://doi.org/10.2298/abs190716060d

Drljača J, Vejnović A, Miljković D, Popović M, Rakić D, Sekulić S, Čapo I, Petković B. Changes in mouse thymus after exposure to tube-restraint stress. in Archives of Biological Sciences. 2020;72(1):5-11.
doi:10.2298/abs190716060d .

Drljača, Jovana, Vejnović, Ana-Marija, Miljković, Dejan, Popović, Milan, Rakić, Dušica, Sekulić, Slobodan, Čapo, Ivan, Petković, Branka, "Changes in mouse thymus after exposure to tube-restraint stress" in Archives of Biological Sciences, 72, no. 1 (2020):5-11,
https://doi.org/10.2298/abs190716060d . .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Cvijanović, Milan
PY  - 2016
UR  - http://www.architalbiol.org/aib/article/view/154118
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2755
AB  - We used electrocortical spectral analysis and fractal methods for assessing the effects of unilateral, single brain injury on cerebellum. Cerebellar electrocortical activity was recorded in control state (before the injury) and after a single brain injury of the cerebellar cortex in anesthetized rats. We noticed that the mean power in gamma high-frequency domain (32-128 Hz) of the cerebellum, was increased after the first brain injury, while after a two-week recovery, it was larger than before the injury. The unilateral brain injury induced a permanent increase of the mild gamma activity in both the left and the right side of cerebellum cortex, but there was no further increase after the lesion was repeated. Our recent electrophysiological study on the cerebellum (Culic et al., 2005) suggested that the mean power spectra of the cerebellar cortical activity in the gamma frequency range might be the indicator of acute single focal brain injury. However, there is insufficient information on the effects of the repeated brain injury on the cerebellar electrocortical activity and morphology. There was no significant difference between the absolute and the relative mean power of the left and the right paravermal cortical activity (before, as well as, after the injury), in each of the animals tested afterwards, but there were differences between the left and the right side of cerebellum in experimental animals. Repeated injury of the cerebellar cortical areas, is strengthened by morphological changes in the cerebellar hemisphere, and shows a decrease in delta and an increase in gamma range.
T2  - Archives Italiennes de Biologie
T1  - Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum
IS  - 4
VL  - 154
DO  - 10.12871/00039829201441
SP  - 118
EP  - 124
ER  - 

@article{
author = "Martać, Ljiljana and Sekulić, Slobodan and Cvijanović, Milan",
year = "2016",
abstract = "We used electrocortical spectral analysis and fractal methods for assessing the effects of unilateral, single brain injury on cerebellum. Cerebellar electrocortical activity was recorded in control state (before the injury) and after a single brain injury of the cerebellar cortex in anesthetized rats. We noticed that the mean power in gamma high-frequency domain (32-128 Hz) of the cerebellum, was increased after the first brain injury, while after a two-week recovery, it was larger than before the injury. The unilateral brain injury induced a permanent increase of the mild gamma activity in both the left and the right side of cerebellum cortex, but there was no further increase after the lesion was repeated. Our recent electrophysiological study on the cerebellum (Culic et al., 2005) suggested that the mean power spectra of the cerebellar cortical activity in the gamma frequency range might be the indicator of acute single focal brain injury. However, there is insufficient information on the effects of the repeated brain injury on the cerebellar electrocortical activity and morphology. There was no significant difference between the absolute and the relative mean power of the left and the right paravermal cortical activity (before, as well as, after the injury), in each of the animals tested afterwards, but there were differences between the left and the right side of cerebellum in experimental animals. Repeated injury of the cerebellar cortical areas, is strengthened by morphological changes in the cerebellar hemisphere, and shows a decrease in delta and an increase in gamma range.",
journal = "Archives Italiennes de Biologie",
title = "Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum",
number = "4",
volume = "154",
doi = "10.12871/00039829201441",
pages = "118-124"
}

Martać, L., Sekulić, S.,& Cvijanović, M.. (2016). Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum. in Archives Italiennes de Biologie, 154(4), 118-124.
https://doi.org/10.12871/00039829201441

Martać L, Sekulić S, Cvijanović M. Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum. in Archives Italiennes de Biologie. 2016;154(4):118-124.
doi:10.12871/00039829201441 .

Martać, Ljiljana, Sekulić, Slobodan, Cvijanović, Milan, "Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum" in Archives Italiennes de Biologie, 154, no. 4 (2016):118-124,
https://doi.org/10.12871/00039829201441 . .

TY  - JOUR
AU  - Podgorac, Jelena
AU  - Čapo, Ivan
AU  - Sekulić, Slobodan
AU  - Pepelčević, Nenad
AU  - Martać, Ljiljana
AU  - Keković, Goran
PY  - 2012
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/516
AB  - Serotonin is, evolutionary, the oldest neurotransmitter. Ubiquitous distribution of serotonin in central nervous system, also implication in many physiological functions indicates significance of serotonergic system. Expression of the serotonin function is the most conditioned by the interaction with postsynaptic receptors. In this article, the classification of the serotonergic receptors and its role is reviewed. The expectations of future research are detection of new subpopulations of receptors, their functions and summation of knowledge in order to find new therapy and new manner in treatment of central nervous system disturbances, which imply serotonergic dysfunction.
AB  - Serotonin predstavlja jedan od evolutivno najstarijih neurotransmitrera. Njegova široka distribucija u centralnom nervnom sistemu i povezanost sa mnogobrojnim fiziološkim funkcijama ukazuje na značaj serotoninskog sistema. Karakter ispoljavanja serotonina u najvećoj meri određuje postsinaptički receptor sa kojim stupa u kontakt. U radu su prikazani do sada klasifikovani receptori i njihova uloga. Od budućih istraživanja očekuje se otkrivanje novih subpopulacija receptora, njihove uloge i sumacija saznanja u cilju pronalaženja novih lekova i načina lečenja uzrokovanih poremećajima serotinskog sistema CNS-a.
T2  - MD - Medical data
T1  - Funkcija serotoninskih receptora i njihov uticaj na ponašanje
T1  - Function of serotonin receptors and its role in the behavior
IS  - 2
VL  - 4
SP  - 167
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_516
ER  - 

@article{
author = "Podgorac, Jelena and Čapo, Ivan and Sekulić, Slobodan and Pepelčević, Nenad and Martać, Ljiljana and Keković, Goran",
year = "2012, 2012",
abstract = "Serotonin is, evolutionary, the oldest neurotransmitter. Ubiquitous distribution of serotonin in central nervous system, also implication in many physiological functions indicates significance of serotonergic system. Expression of the serotonin function is the most conditioned by the interaction with postsynaptic receptors. In this article, the classification of the serotonergic receptors and its role is reviewed. The expectations of future research are detection of new subpopulations of receptors, their functions and summation of knowledge in order to find new therapy and new manner in treatment of central nervous system disturbances, which imply serotonergic dysfunction., Serotonin predstavlja jedan od evolutivno najstarijih neurotransmitrera. Njegova široka distribucija u centralnom nervnom sistemu i povezanost sa mnogobrojnim fiziološkim funkcijama ukazuje na značaj serotoninskog sistema. Karakter ispoljavanja serotonina u najvećoj meri određuje postsinaptički receptor sa kojim stupa u kontakt. U radu su prikazani do sada klasifikovani receptori i njihova uloga. Od budućih istraživanja očekuje se otkrivanje novih subpopulacija receptora, njihove uloge i sumacija saznanja u cilju pronalaženja novih lekova i načina lečenja uzrokovanih poremećajima serotinskog sistema CNS-a.",
journal = "MD - Medical data",
title = "Funkcija serotoninskih receptora i njihov uticaj na ponašanje, Function of serotonin receptors and its role in the behavior",
number = "2",
volume = "4",
pages = "167-170",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_516"
}

Podgorac, J., Čapo, I., Sekulić, S., Pepelčević, N., Martać, L.,& Keković, G.. (2012). Funkcija serotoninskih receptora i njihov uticaj na ponašanje. in MD - Medical data, 4(2), 167-170.
https://hdl.handle.net/21.15107/rcub_ibiss_516

Podgorac J, Čapo I, Sekulić S, Pepelčević N, Martać L, Keković G. Funkcija serotoninskih receptora i njihov uticaj na ponašanje. in MD - Medical data. 2012;4(2):167-170.
https://hdl.handle.net/21.15107/rcub_ibiss_516 .

Podgorac, Jelena, Čapo, Ivan, Sekulić, Slobodan, Pepelčević, Nenad, Martać, Ljiljana, Keković, Goran, "Funkcija serotoninskih receptora i njihov uticaj na ponašanje" in MD - Medical data, 4, no. 2 (2012):167-170,
https://hdl.handle.net/21.15107/rcub_ibiss_516 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Ćulić, Milka
AU  - Stojadinović, Gordana
AU  - Spasić, Slađana
AU  - Sekulić, Slobodan
AU  - Lalošević, Dušan
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/333
AB  - The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.
AB  - Predmet ovog istraživanja je bio da se elektrofiziološki prouče efekti aluminijumske neurotoksičnosti. Animalni model neurodegenerativne demencije postignut je hroničnim tretmanom Wistar pacova sa aluminium hloridom u toku 4 nedelje u dozi od 2 mg/kg aluminijuma dnevno. Elektrofiziološko registrovanje levog i desnog somatosenzornog korteksa pacova tretiranih aluminijumom i kontrolnih pacova je vršeno pod Nembutalskom anestezijom. Analogno-digitalna konverzija registrovanih signala je izvršena pri frekvenciji semplovanja 256Hz. Spektralna analiza elektrokortikalne aktivnosti u trajanju od 120s (podeljena u epohe od 8s) je izvršena Furijeovom transformacijom, a fraktalna dimenzija ovih signala je izračunata Higučijevim algoritmom. Relativni spektri snage cerebralne aktivnosti u delta frekventnom opsegu su bili povećani, a u (8.1-15.0 Hz) frekventnom opsegu su bili smanjeni kod aluminijumom tretiranih životinja u odnosu na kontrolne. Srednja fraktalna dimenzija elektrokortikalne aktivnosti kod tretiranih pacova je manja - 1,290 u odnosu na srednju fraktalnu dimenziju elektrokortikalne aktivnosti kontrolnih pacova - 1,377. Spektralne i fraktalne karakteristike mogu biti elektrofiziološki znak razvitka neurodegenerativnih procesa kao kod Alchajmerove bolesti.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova
T1  - Effect of aluminium neurotoxicity on the rat brain electrocortical activity
IS  - 3
VL  - 42
SP  - 219
EP  - 225
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_333
ER  - 

@article{
author = "Martać, Ljiljana and Kesić, Srđan and Ćulić, Milka and Stojadinović, Gordana and Spasić, Slađana and Sekulić, Slobodan and Lalošević, Dušan",
year = "2006, 2006",
abstract = "The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia., Predmet ovog istraživanja je bio da se elektrofiziološki prouče efekti aluminijumske neurotoksičnosti. Animalni model neurodegenerativne demencije postignut je hroničnim tretmanom Wistar pacova sa aluminium hloridom u toku 4 nedelje u dozi od 2 mg/kg aluminijuma dnevno. Elektrofiziološko registrovanje levog i desnog somatosenzornog korteksa pacova tretiranih aluminijumom i kontrolnih pacova je vršeno pod Nembutalskom anestezijom. Analogno-digitalna konverzija registrovanih signala je izvršena pri frekvenciji semplovanja 256Hz. Spektralna analiza elektrokortikalne aktivnosti u trajanju od 120s (podeljena u epohe od 8s) je izvršena Furijeovom transformacijom, a fraktalna dimenzija ovih signala je izračunata Higučijevim algoritmom. Relativni spektri snage cerebralne aktivnosti u delta frekventnom opsegu su bili povećani, a u (8.1-15.0 Hz) frekventnom opsegu su bili smanjeni kod aluminijumom tretiranih životinja u odnosu na kontrolne. Srednja fraktalna dimenzija elektrokortikalne aktivnosti kod tretiranih pacova je manja - 1,290 u odnosu na srednju fraktalnu dimenziju elektrokortikalne aktivnosti kontrolnih pacova - 1,377. Spektralne i fraktalne karakteristike mogu biti elektrofiziološki znak razvitka neurodegenerativnih procesa kao kod Alchajmerove bolesti.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova, Effect of aluminium neurotoxicity on the rat brain electrocortical activity",
number = "3",
volume = "42",
pages = "219-225",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_333"
}

Martać, L., Kesić, S., Ćulić, M., Stojadinović, G., Spasić, S., Sekulić, S.,& Lalošević, D.. (2006). Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 219-225.
https://hdl.handle.net/21.15107/rcub_ibiss_333

Martać L, Kesić S, Ćulić M, Stojadinović G, Spasić S, Sekulić S, Lalošević D. Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):219-225.
https://hdl.handle.net/21.15107/rcub_ibiss_333 .

Martać, Ljiljana, Kesić, Srđan, Ćulić, Milka, Stojadinović, Gordana, Spasić, Slađana, Sekulić, Slobodan, Lalošević, Dušan, "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):219-225,
https://hdl.handle.net/21.15107/rcub_ibiss_333 .