TY  - CONF
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5834
AB  - MK-801 can mimic the cognitive, negative, psychotic, and physiological features of
schizophrenia, including increased hyperlocomotion and altered behavioral flexibility.
As N-methyl-D-aspartate (NMDA) receptor antagonist, it is widely used to test the
“glutamate hypofunction hypothesis of schizophrenia”. An extremely low-frequency
magnetic field (ELF-MF) can stimulate NMDA receptor activity, but its effect on
dysregulated glutamine transmission is unknown. Therefore, this study addresses the
effect of continuous exposure to ELF-MF (50 Hz, 0.5 mT) for 7 days on rat
psychomotor behavior induced by acute administration of MK-801 (0.25 mg/kg, i.p.).
During the experiment, adult male Wistar rats were placed near the on/off generator of
ELF-MF, injected with MK-801/saline immediately after 7-day sham/ELF-MF
exposure, and subjected to the open field test for 2 hours. Their behavior was analyzed
using the ANY-maze software and expressed as travel distance, time in movement,
and average speed while in motion in 30-min intervals. The results show that (1) acute
administration of 0.25 mg/kg MK-801 significantly increased travel distance and time
in movement from 60 to 120 min and average speed while in motion from 60 to 90
min compared with saline-injected animals; (2) 7-day exposure to ELF-MF had no
significant effect on the behavior of saline- and MK-801-injected animals compared
with the corresponding controls. Therefore, it can be concluded that this regime of
ELF-MF exposure does not affect the psychomotor behavior of rats caused by the
pharmacological modification of glutamine transmission with the applied MK-801
dose.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801
SP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5834
ER  - 

@conference{
author = "Kesić, Srđan and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Petković, Branka",
year = "2023",
abstract = "MK-801 can mimic the cognitive, negative, psychotic, and physiological features of
schizophrenia, including increased hyperlocomotion and altered behavioral flexibility.
As N-methyl-D-aspartate (NMDA) receptor antagonist, it is widely used to test the
“glutamate hypofunction hypothesis of schizophrenia”. An extremely low-frequency
magnetic field (ELF-MF) can stimulate NMDA receptor activity, but its effect on
dysregulated glutamine transmission is unknown. Therefore, this study addresses the
effect of continuous exposure to ELF-MF (50 Hz, 0.5 mT) for 7 days on rat
psychomotor behavior induced by acute administration of MK-801 (0.25 mg/kg, i.p.).
During the experiment, adult male Wistar rats were placed near the on/off generator of
ELF-MF, injected with MK-801/saline immediately after 7-day sham/ELF-MF
exposure, and subjected to the open field test for 2 hours. Their behavior was analyzed
using the ANY-maze software and expressed as travel distance, time in movement,
and average speed while in motion in 30-min intervals. The results show that (1) acute
administration of 0.25 mg/kg MK-801 significantly increased travel distance and time
in movement from 60 to 120 min and average speed while in motion from 60 to 90
min compared with saline-injected animals; (2) 7-day exposure to ELF-MF had no
significant effect on the behavior of saline- and MK-801-injected animals compared
with the corresponding controls. Therefore, it can be concluded that this regime of
ELF-MF exposure does not affect the psychomotor behavior of rats caused by the
pharmacological modification of glutamine transmission with the applied MK-801
dose.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801",
pages = "50",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5834"
}

Kesić, S., Stojadinović, G., Martać, L., Sekulić, S.,& Petković, B.. (2023). Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801. in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 50.
https://hdl.handle.net/21.15107/rcub_ibiss_5834

Kesić S, Stojadinović G, Martać L, Sekulić S, Petković B. Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801. in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:50.
https://hdl.handle.net/21.15107/rcub_ibiss_5834 .

Kesić, Srđan, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Petković, Branka, "Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801" in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):50,
https://hdl.handle.net/21.15107/rcub_ibiss_5834 .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Jovanović, Aleksandar
AU  - Živanović, Željko
AU  - Simić, Svetlana
AU  - Kesić, Srđan
AU  - Petković, Branka
AU  - Čapo, Ivan
AU  - van Loon, Jack J
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S2214552422000153
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4958
AB  - The International Space Station (ISS) has the possibility to perform experiments regarding rodent reproduction in microgravity. The musculoskeletal system at birth in precocial rodent species more resembles the human than that of altricial rodent species. For precocial rodent species with body weight ≤ 500 g (limit of ISS) determined were: adult body mass, newborn body mass, head-body length, tail length, existing variants (wild, domesticated, laboratory), single/group housing, dry food consumption/24 h, water intake/24 h, basal metabolic rate mlO2/g/h, environmental temperature, sand baths, urine output ml/24 h, fecal output g/24 h, size of fecal droplet, hair length, life span, length of oestrus cycle, duration of pregnancy, building nest, litter size, stage of musculoskeletal maturity at birth, and the duration of weaning. Characteristics were obtained by searching SCOPUS as well as the World Wide Web with key words for each of the species in English, Latin and, local language name. These characteristics were compared in order to find most appropriate species. Twelve precocial rodent species were identified. There is not enough data for Common yellow-toothed cavy, and Eastern spiny mouse. Inappropriate species were: Gundis, Dassie rat are a more demanding species for appropriate tending, litter size is small; Octodon degus requires sand baths as well as a nest during the first two weeks after delivery; muscle maturity of Spiny mouse at birth (myotubular stage), does not correspond to the human (late histochemical stage); Chinchilla requires separately housing, daily sand baths, has upper limit of weight. Possibility of keeping Southern mountain cavy as pet animal, short estrus, large litter size, absence of the need for nest and sand baths, makes this species the most promising candidates for experiments on ISS. If an experiment is planned with exposing gravid animals before term of the birth, then they might be kept together in the existing Rodent Habitat (USA). If an experiment with birth in microgravity is planned on ISS, the existing habitats do not provide conditions for such an experiment. It is necessary to develop habitats for separate keeping of pregnant animals to enable the following: 1. undisturbed delivery 2. prevent the possibility of hurting the newborns 3. ensure adequate post-partum maternal care and nursing.
T2  - Life Sciences in Space Research
T1  - Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculosketal development on international space station?
VL  - 33
DO  - 10.1016/j.lssr.2022.04.001
SP  - 48
EP  - 57
ER  - 

@article{
author = "Sekulić, Slobodan and Jovanović, Aleksandar and Živanović, Željko and Simić, Svetlana and Kesić, Srđan and Petković, Branka and Čapo, Ivan and van Loon, Jack J",
year = "2022",
abstract = "The International Space Station (ISS) has the possibility to perform experiments regarding rodent reproduction in microgravity. The musculoskeletal system at birth in precocial rodent species more resembles the human than that of altricial rodent species. For precocial rodent species with body weight ≤ 500 g (limit of ISS) determined were: adult body mass, newborn body mass, head-body length, tail length, existing variants (wild, domesticated, laboratory), single/group housing, dry food consumption/24 h, water intake/24 h, basal metabolic rate mlO2/g/h, environmental temperature, sand baths, urine output ml/24 h, fecal output g/24 h, size of fecal droplet, hair length, life span, length of oestrus cycle, duration of pregnancy, building nest, litter size, stage of musculoskeletal maturity at birth, and the duration of weaning. Characteristics were obtained by searching SCOPUS as well as the World Wide Web with key words for each of the species in English, Latin and, local language name. These characteristics were compared in order to find most appropriate species. Twelve precocial rodent species were identified. There is not enough data for Common yellow-toothed cavy, and Eastern spiny mouse. Inappropriate species were: Gundis, Dassie rat are a more demanding species for appropriate tending, litter size is small; Octodon degus requires sand baths as well as a nest during the first two weeks after delivery; muscle maturity of Spiny mouse at birth (myotubular stage), does not correspond to the human (late histochemical stage); Chinchilla requires separately housing, daily sand baths, has upper limit of weight. Possibility of keeping Southern mountain cavy as pet animal, short estrus, large litter size, absence of the need for nest and sand baths, makes this species the most promising candidates for experiments on ISS. If an experiment is planned with exposing gravid animals before term of the birth, then they might be kept together in the existing Rodent Habitat (USA). If an experiment with birth in microgravity is planned on ISS, the existing habitats do not provide conditions for such an experiment. It is necessary to develop habitats for separate keeping of pregnant animals to enable the following: 1. undisturbed delivery 2. prevent the possibility of hurting the newborns 3. ensure adequate post-partum maternal care and nursing.",
journal = "Life Sciences in Space Research",
title = "Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculosketal development on international space station?",
volume = "33",
doi = "10.1016/j.lssr.2022.04.001",
pages = "48-57"
}

Sekulić, S., Jovanović, A., Živanović, Ž., Simić, S., Kesić, S., Petković, B., Čapo, I.,& van Loon, J. J.. (2022). Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculosketal development on international space station?. in Life Sciences in Space Research, 33, 48-57.
https://doi.org/10.1016/j.lssr.2022.04.001

Sekulić S, Jovanović A, Živanović Ž, Simić S, Kesić S, Petković B, Čapo I, van Loon JJ. Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculosketal development on international space station?. in Life Sciences in Space Research. 2022;33:48-57.
doi:10.1016/j.lssr.2022.04.001 .

Sekulić, Slobodan, Jovanović, Aleksandar, Živanović, Željko, Simić, Svetlana, Kesić, Srđan, Petković, Branka, Čapo, Ivan, van Loon, Jack J, "Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculosketal development on international space station?" in Life Sciences in Space Research, 33 (2022):48-57,
https://doi.org/10.1016/j.lssr.2022.04.001 . .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Jakovljević, Branislava
AU  - Korovljev, Darinka
AU  - Simić, Svetlana
AU  - Čapo, Ivan
AU  - Podgorac, Jelena
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Rakić, Srđan
AU  - Petković, Branka
PY  - 2022
UR  - https://www.frontiersin.org/articles/10.3389/fphys.2021.810391/full
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4787
AB  - Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid
in the third trimester of pregnancy and it can be acute and chronic depending on
the duration. Published data suggest that during muscle development, in the stage
of late histochemical differentiation decreased mechanical loading cause decreased
expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the
case of chronic polyhydramnios, histochemical muscle differentiation could be affected
as a consequence of permanent decreased physical loading. Most affected would
be muscles which are the most active i.e., spine extensor muscles and muscles of
legs. Long-lasting decreased mechanical loading on muscle should cause decreased
expression of MHC type 1 leading to slow-to-fast transition, decreased number of
muscle fiber type I especially in extensor muscles of spine and legs. Additionally,
because MHC type 1 is present in all skeletal muscles it could lead to various degrees
of hypotrophy depending on constituting a percentage of MHC type 1 in affected
muscles. These changes in the case of preexisting muscle disorders have the potential
to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic
polyhydramnios is a rare opportunity to study the influence of reduced physical loading
on muscle development in the human fetus. Also, it could be a medical entity to examine
the influence of micro- and hypogravity conditions on the development of the fetal
muscular system during the last trimester of gestation.
PB  - Switzerland: Frontiers Media SA
T2  - Frontiers in Physiology
T1  - Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition
VL  - 12
DO  - 10.3389/fphys.2021.810391
SP  - 810391
ER  - 

@article{
author = "Sekulić, Slobodan and Jakovljević, Branislava and Korovljev, Darinka and Simić, Svetlana and Čapo, Ivan and Podgorac, Jelena and Martać, Ljiljana and Kesić, Srđan and Rakić, Srđan and Petković, Branka",
year = "2022",
abstract = "Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid
in the third trimester of pregnancy and it can be acute and chronic depending on
the duration. Published data suggest that during muscle development, in the stage
of late histochemical differentiation decreased mechanical loading cause decreased
expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the
case of chronic polyhydramnios, histochemical muscle differentiation could be affected
as a consequence of permanent decreased physical loading. Most affected would
be muscles which are the most active i.e., spine extensor muscles and muscles of
legs. Long-lasting decreased mechanical loading on muscle should cause decreased
expression of MHC type 1 leading to slow-to-fast transition, decreased number of
muscle fiber type I especially in extensor muscles of spine and legs. Additionally,
because MHC type 1 is present in all skeletal muscles it could lead to various degrees
of hypotrophy depending on constituting a percentage of MHC type 1 in affected
muscles. These changes in the case of preexisting muscle disorders have the potential
to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic
polyhydramnios is a rare opportunity to study the influence of reduced physical loading
on muscle development in the human fetus. Also, it could be a medical entity to examine
the influence of micro- and hypogravity conditions on the development of the fetal
muscular system during the last trimester of gestation.",
publisher = "Switzerland: Frontiers Media SA",
journal = "Frontiers in Physiology",
title = "Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition",
volume = "12",
doi = "10.3389/fphys.2021.810391",
pages = "810391"
}

Sekulić, S., Jakovljević, B., Korovljev, D., Simić, S., Čapo, I., Podgorac, J., Martać, L., Kesić, S., Rakić, S.,& Petković, B.. (2022). Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition. in Frontiers in Physiology
Switzerland: Frontiers Media SA., 12, 810391.
https://doi.org/10.3389/fphys.2021.810391

Sekulić S, Jakovljević B, Korovljev D, Simić S, Čapo I, Podgorac J, Martać L, Kesić S, Rakić S, Petković B. Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition. in Frontiers in Physiology. 2022;12:810391.
doi:10.3389/fphys.2021.810391 .

Sekulić, Slobodan, Jakovljević, Branislava, Korovljev, Darinka, Simić, Svetlana, Čapo, Ivan, Podgorac, Jelena, Martać, Ljiljana, Kesić, Srđan, Rakić, Srđan, Petković, Branka, "Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition" in Frontiers in Physiology, 12 (2022):810391,
https://doi.org/10.3389/fphys.2021.810391 . .

TY  - CONF
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5746
AB  - Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije.
AB  - Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina
T1  - Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина
SP  - 388
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5746
ER  - 

@conference{
author = "Kesić, Srđan and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Petković, Branka",
year = "2022",
abstract = "Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije., Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina, Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина",
pages = "388",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5746"
}

Kesić, S., Stojadinović, G., Martać, L., Sekulić, S.,& Petković, B.. (2022). Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746

Kesić S, Stojadinović G, Martać L, Sekulić S, Petković B. Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

Kesić, Srđan, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Petković, Branka, "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):388,
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

TY  - JOUR
AU  - Kesić, Srđan
PY  - 2021
UR  - https://link.springer.com/10.1007/s10441-021-09424-0
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4494
AB  - Some contemporary theorists such as Mazzocchi, Theise and Kafatos are convinced that the reformed complementarity may redefine how we might exploit the complexity theory in 21st-century life sciences research. However, the motives behind the profound re-invention of "biological complementarity" need to be substantiated with concrete shreds of evidence about this principle's applicability in real-life science experimentation, which we found missing in the literature. This paper discusses such pieces of evidence by confronting Bohr's complementarity and ion channel modeling practice. We examine whether and to what extent this principle might assist in developing ion channel models incorporating both deterministic and stochastic solutions. According to the "mutual exclusiveness of experimental setups" version of Bohr's complementarity, this principle is needed when two mutually exclusive perspectives or approaches are right, necessary in a particular context, and are not contradictory as they arise in mutually exclusive conditions (mutually exclusive experimental or modeling setups). A detailed examination of the modeling practice reveals that both solutions are often used simultaneously in a single ion channel model, suggesting that the opposite conceptual frameworks can coexist in the same modeling setup. We concluded that Bohr's complementarity might find applications in these complex modeling setups but only through its realistic phenomenological interpretation that allows applying different modes of description regardless of the nature of the underlying ion channel opening process. Also, we propose the combined use of complementarity and Complex thinking in building the multifaceted ion channel models. Overall, this paper's results support the efforts to establish a more general form of complementarity to meet today's complexity theory-inspired life sciences modeling demands.
PB  - Dordrecht: Springer Science and Business Media B.V.
T2  - Acta Biotheoretica
T1  - Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.
VL  - 69
DO  - 10.1007/s10441-021-09424-0
SP  - 723
EP  - 744
ER  - 

@article{
author = "Kesić, Srđan",
year = "2021",
abstract = "Some contemporary theorists such as Mazzocchi, Theise and Kafatos are convinced that the reformed complementarity may redefine how we might exploit the complexity theory in 21st-century life sciences research. However, the motives behind the profound re-invention of "biological complementarity" need to be substantiated with concrete shreds of evidence about this principle's applicability in real-life science experimentation, which we found missing in the literature. This paper discusses such pieces of evidence by confronting Bohr's complementarity and ion channel modeling practice. We examine whether and to what extent this principle might assist in developing ion channel models incorporating both deterministic and stochastic solutions. According to the "mutual exclusiveness of experimental setups" version of Bohr's complementarity, this principle is needed when two mutually exclusive perspectives or approaches are right, necessary in a particular context, and are not contradictory as they arise in mutually exclusive conditions (mutually exclusive experimental or modeling setups). A detailed examination of the modeling practice reveals that both solutions are often used simultaneously in a single ion channel model, suggesting that the opposite conceptual frameworks can coexist in the same modeling setup. We concluded that Bohr's complementarity might find applications in these complex modeling setups but only through its realistic phenomenological interpretation that allows applying different modes of description regardless of the nature of the underlying ion channel opening process. Also, we propose the combined use of complementarity and Complex thinking in building the multifaceted ion channel models. Overall, this paper's results support the efforts to establish a more general form of complementarity to meet today's complexity theory-inspired life sciences modeling demands.",
publisher = "Dordrecht: Springer Science and Business Media B.V.",
journal = "Acta Biotheoretica",
title = "Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.",
volume = "69",
doi = "10.1007/s10441-021-09424-0",
pages = "723-744"
}

Kesić, S.. (2021). Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.. in Acta Biotheoretica
Dordrecht: Springer Science and Business Media B.V.., 69, 723-744.
https://doi.org/10.1007/s10441-021-09424-0

Kesić S. Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.. in Acta Biotheoretica. 2021;69:723-744.
doi:10.1007/s10441-021-09424-0 .

Kesić, Srđan, "Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels." in Acta Biotheoretica, 69 (2021):723-744,
https://doi.org/10.1007/s10441-021-09424-0 . .

TY  - JOUR
AU  - Kesić, Srđan
PY  - 2021
UR  - https://link.springer.com/10.1007/s10441-021-09424-0
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4494
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4496
AB  - Some contemporary theorists such as Mazzocchi, Theise and Kafatos are convinced that the reformed complementarity may redefine how we might exploit the complexity theory in 21st-century life sciences research. However, the motives behind the profound re-invention of "biological complementarity" need to be substantiated with concrete shreds of evidence about this principle's applicability in real-life science experimentation, which we found missing in the literature. This paper discusses such pieces of evidence by confronting Bohr's complementarity and ion channel modeling practice. We examine whether and to what extent this principle might assist in developing ion channel models incorporating both deterministic and stochastic solutions. According to the "mutual exclusiveness of experimental setups" version of Bohr's complementarity, this principle is needed when two mutually exclusive perspectives or approaches are right, necessary in a particular context, and are not contradictory as they arise in mutually exclusive conditions (mutually exclusive experimental or modeling setups). A detailed examination of the modeling practice reveals that both solutions are often used simultaneously in a single ion channel model, suggesting that the opposite conceptual frameworks can coexist in the same modeling setup. We concluded that Bohr's complementarity might find applications in these complex modeling setups but only through its realistic phenomenological interpretation that allows applying different modes of description regardless of the nature of the underlying ion channel opening process. Also, we propose the combined use of complementarity and Complex thinking in building the multifaceted ion channel models. Overall, this paper's results support the efforts to establish a more general form of complementarity to meet today's complexity theory-inspired life sciences modeling demands.
PB  - Dordrecht: Springer Science and Business Media B.V.
T2  - Acta Biotheoretica
T1  - Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.
VL  - 69
DO  - 10.1007/s10441-021-09424-0
SP  - 723
EP  - 744
ER  - 

@article{
author = "Kesić, Srđan",
year = "2021",
abstract = "Some contemporary theorists such as Mazzocchi, Theise and Kafatos are convinced that the reformed complementarity may redefine how we might exploit the complexity theory in 21st-century life sciences research. However, the motives behind the profound re-invention of "biological complementarity" need to be substantiated with concrete shreds of evidence about this principle's applicability in real-life science experimentation, which we found missing in the literature. This paper discusses such pieces of evidence by confronting Bohr's complementarity and ion channel modeling practice. We examine whether and to what extent this principle might assist in developing ion channel models incorporating both deterministic and stochastic solutions. According to the "mutual exclusiveness of experimental setups" version of Bohr's complementarity, this principle is needed when two mutually exclusive perspectives or approaches are right, necessary in a particular context, and are not contradictory as they arise in mutually exclusive conditions (mutually exclusive experimental or modeling setups). A detailed examination of the modeling practice reveals that both solutions are often used simultaneously in a single ion channel model, suggesting that the opposite conceptual frameworks can coexist in the same modeling setup. We concluded that Bohr's complementarity might find applications in these complex modeling setups but only through its realistic phenomenological interpretation that allows applying different modes of description regardless of the nature of the underlying ion channel opening process. Also, we propose the combined use of complementarity and Complex thinking in building the multifaceted ion channel models. Overall, this paper's results support the efforts to establish a more general form of complementarity to meet today's complexity theory-inspired life sciences modeling demands.",
publisher = "Dordrecht: Springer Science and Business Media B.V.",
journal = "Acta Biotheoretica",
title = "Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.",
volume = "69",
doi = "10.1007/s10441-021-09424-0",
pages = "723-744"
}

Kesić, S.. (2021). Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.. in Acta Biotheoretica
Dordrecht: Springer Science and Business Media B.V.., 69, 723-744.
https://doi.org/10.1007/s10441-021-09424-0

Kesić S. Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels.. in Acta Biotheoretica. 2021;69:723-744.
doi:10.1007/s10441-021-09424-0 .

Kesić, Srđan, "Toward a More General Understanding of Bohr's Complementarity: Insights from Modeling of Ion Channels." in Acta Biotheoretica, 69 (2021):723-744,
https://doi.org/10.1007/s10441-021-09424-0 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3642
AB  - Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder
IS  - 4
VL  - 26
DO  - 10.2174/1381612826666200115094642
SP  - 466
EP  - 484
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Pešić, Vesna",
year = "2020",
abstract = "Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder",
number = "4",
volume = "26",
doi = "10.2174/1381612826666200115094642",
pages = "466-484"
}

Petković, B., Kesić, S.,& Pešić, V.. (2020). Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(4), 466-484.
https://doi.org/10.2174/1381612826666200115094642

Petković B, Kesić S, Pešić V. Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design. 2020;26(4):466-484.
doi:10.2174/1381612826666200115094642 .

Petković, Branka, Kesić, Srđan, Pešić, Vesna, "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder" in Current Pharmaceutical Design, 26, no. 4 (2020):466-484,
https://doi.org/10.2174/1381612826666200115094642 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://www.eurekaselect.com/180519/article
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32213154
UR  - https://radar.ibiss.bg.ac.rs/123456789/3879
AB  - BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
IS  - 31
VL  - 26
DO  - 10.2174/1381612826666200326125821
SP  - 3884
EP  - 3894
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
number = "31",
volume = "26",
doi = "10.2174/1381612826666200326125821",
pages = "3884-3894"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(31), 3884-3894.
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;26(31):3884-3894.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design, 26, no. 31 (2020):3884-3894,
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Spasić, Slađana Z.
AU  - Petković, Branka
AU  - Sekulić, Slobodan
AU  - Kesić, Srđan
PY  - 2020
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/5405
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4005
AB  - A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi’s fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis
IS  - 3
VL  - 72
DO  - 10.2298/ABS200524036S
SP  - 425
EP  - 432
ER  - 

@article{
author = "Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Spasić, Slađana Z. and Petković, Branka and Sekulić, Slobodan and Kesić, Srđan",
year = "2020",
abstract = "A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi’s fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis",
number = "3",
volume = "72",
doi = "10.2298/ABS200524036S",
pages = "425-432"
}

Stojadinović, G., Martać, L., Podgorac, J., Spasić, S. Z., Petković, B., Sekulić, S.,& Kesić, S.. (2020). The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences
Serbian Biological Society., 72(3), 425-432.
https://doi.org/10.2298/ABS200524036S

Stojadinović G, Martać L, Podgorac J, Spasić SZ, Petković B, Sekulić S, Kesić S. The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences. 2020;72(3):425-432.
doi:10.2298/ABS200524036S .

Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Spasić, Slađana Z., Petković, Branka, Sekulić, Slobodan, Kesić, Srđan, "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis" in Archives of Biological Sciences, 72, no. 3 (2020):425-432,
https://doi.org/10.2298/ABS200524036S . .

TY  - GEN
AU  - Kesić, Srđan
PY  - 2020
UR  - https://onlinelibrary.wiley.com/doi/abs/10.15252/embr.201949649
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6944899
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3581
AB  - The current focus on biomedical research has led to dearth of funding for basic research in evolution or ecology with the aim to better understand life.
T2  - EMBO reports
T1  - How to preserve the original mission of research in the omics era?
IS  - 1
VL  - 21
DO  - 10.15252/embr.201949649
SP  - e49649
ER  - 

@misc{
author = "Kesić, Srđan",
year = "2020",
abstract = "The current focus on biomedical research has led to dearth of funding for basic research in evolution or ecology with the aim to better understand life.",
journal = "EMBO reports",
title = "How to preserve the original mission of research in the omics era?",
number = "1",
volume = "21",
doi = "10.15252/embr.201949649",
pages = "e49649"
}

Kesić, S.. (2020). How to preserve the original mission of research in the omics era?. in EMBO reports, 21(1), e49649.
https://doi.org/10.15252/embr.201949649

Kesić S. How to preserve the original mission of research in the omics era?. in EMBO reports. 2020;21(1):e49649.
doi:10.15252/embr.201949649 .

Kesić, Srđan, "How to preserve the original mission of research in the omics era?" in EMBO reports, 21, no. 1 (2020):e49649,
https://doi.org/10.15252/embr.201949649 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3765
AB  - Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
DO  - 10.2174/1381612826666200326125821
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
doi = "10.2174/1381612826666200326125821"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd...
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design (2020),
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3642
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3665
AB  - Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder
IS  - 4
VL  - 26
DO  - 10.2174/1381612826666200115094642
SP  - 466
EP  - 484
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Pešić, Vesna",
year = "2020",
abstract = "Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well understood to what extent ribavirin per se contributes to changes in drug-related neurobehavioral disturbances, especially in the case of psychostimulant drugs such as amphetamine. It is now well-known that repeated amphetamine usage produces psychosis in humans and behavioral sensitization in animals. On the other hand, ribavirin has an affinity for adenosine A1 receptors that antagonistically modulate the activity of dopamine D1 receptors, which play a critical role in the development of behavioral sensitization. This review will focus on the current knowledge of neurochemical/neurobiological changes that exist in the psychostimulant drug-addicted brain itself and the antipsychotic-like efficiency of adenosine agonists. Particular attention will be paid to the potential side effects of ribavirin therapy, and the opportunities and challenges related to its application in already existing psychostimulant-use disorder.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder",
number = "4",
volume = "26",
doi = "10.2174/1381612826666200115094642",
pages = "466-484"
}

Petković, B., Kesić, S.,& Pešić, V.. (2020). Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(4), 466-484.
https://doi.org/10.2174/1381612826666200115094642

Petković B, Kesić S, Pešić V. Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. in Current Pharmaceutical Design. 2020;26(4):466-484.
doi:10.2174/1381612826666200115094642 .

Petković, Branka, Kesić, Srđan, Pešić, Vesna, "Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder" in Current Pharmaceutical Design, 26, no. 4 (2020):466-484,
https://doi.org/10.2174/1381612826666200115094642 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Pešić, Vesna
PY  - 2019
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641900018P
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/3970
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3400
AB  - Clinically-related basic studies on the behavioral effects of ribavirin treatment are still lacking despite its wide use as an antiviral medication. This paper considers the effects of low ribavirin doses (10, 20 and 30 mg/kg/day) on psychomotor activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced motor activity), and body weight gain in socially undisturbed adult male Wistar rats 24 h after the first, seventh and fourteenth once-a-day injection. Low doses of ribavirin were tested in an attempt to avoid the recognized systemic side effects related to high-dose usage. None of the singly applied ribavirin doses affected exploratory/spontaneous and AMPH-induced motor behavior (locomotion, stereotypy-like and vertical activity), however, body weight gain was significantly lower after treatment with 30 mg/kg of ribavirin. The 7- and 14-day treatments with 10 and 30 mg/kg/day of ribavirin significantly suppressed novelty-induced locomotion and body weight gain; the 14-day treatment with ribavirin at a dose of 30 mg/kg/ day decreased AMPH-induced stereotypy. These findings indicate that repeated application (up to 14 days) of low ribavirin doses results in low novelty-induced locomotion along with reduced weight gain, accentuating the existence of a U-shaped dose-response relationship with a prolonged duration of ribavirin treatment.
T2  - Archives of Biological Sciences
T1  - Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration
IS  - 2
VL  - 71
DO  - 10.2298/ABS190205018P
SP  - 357
EP  - 368
ER  - 

@article{
author = "Petković, Branka and Stojadinović, Gordana and Kesić, Srđan and Ristić, Slavica and Martać, Ljiljana and Podgorac, Jelena and Pešić, Vesna",
year = "2019",
abstract = "Clinically-related basic studies on the behavioral effects of ribavirin treatment are still lacking despite its wide use as an antiviral medication. This paper considers the effects of low ribavirin doses (10, 20 and 30 mg/kg/day) on psychomotor activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced motor activity), and body weight gain in socially undisturbed adult male Wistar rats 24 h after the first, seventh and fourteenth once-a-day injection. Low doses of ribavirin were tested in an attempt to avoid the recognized systemic side effects related to high-dose usage. None of the singly applied ribavirin doses affected exploratory/spontaneous and AMPH-induced motor behavior (locomotion, stereotypy-like and vertical activity), however, body weight gain was significantly lower after treatment with 30 mg/kg of ribavirin. The 7- and 14-day treatments with 10 and 30 mg/kg/day of ribavirin significantly suppressed novelty-induced locomotion and body weight gain; the 14-day treatment with ribavirin at a dose of 30 mg/kg/ day decreased AMPH-induced stereotypy. These findings indicate that repeated application (up to 14 days) of low ribavirin doses results in low novelty-induced locomotion along with reduced weight gain, accentuating the existence of a U-shaped dose-response relationship with a prolonged duration of ribavirin treatment.",
journal = "Archives of Biological Sciences",
title = "Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration",
number = "2",
volume = "71",
doi = "10.2298/ABS190205018P",
pages = "357-368"
}

Petković, B., Stojadinović, G., Kesić, S., Ristić, S., Martać, L., Podgorac, J.,& Pešić, V.. (2019). Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration. in Archives of Biological Sciences, 71(2), 357-368.
https://doi.org/10.2298/ABS190205018P

Petković B, Stojadinović G, Kesić S, Ristić S, Martać L, Podgorac J, Pešić V. Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration. in Archives of Biological Sciences. 2019;71(2):357-368.
doi:10.2298/ABS190205018P .

Petković, Branka, Stojadinović, Gordana, Kesić, Srđan, Ristić, Slavica, Martać, Ljiljana, Podgorac, Jelena, Pešić, Vesna, "Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration" in Archives of Biological Sciences, 71, no. 2 (2019):357-368,
https://doi.org/10.2298/ABS190205018P . .

TY  - JOUR
AU  - Kesić, Srđan
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S030698771930605X?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3449
AB  - This paper examines some methodological and epistemological issues underlying the ongoing "artificial" divide between pragmatic-systems biology and systems-theoretical biology. The pragmatic systems view of biology has encountered problems and constraints on its explanatory power because pragmatic systems biologists still tend to view systems as mere collections of parts, not as "emergent realities" produced by adaptive interactions between the constituting components. As such, they are incapable of characterizing the higher-level biological phenomena adequately. The attempts of systems-theoretical biologists to explain these "emergent realities" using mathematics also fail to produce satisfactory results. Given the increasing strategic importance of systems biology, both from theoretical and research perspectives, we suggest that additional epistemological and methodological insights into the possibility of further integration between traditional experimental studies and complex modeling are required. This integration will help to improve the currently underdeveloped pragmatic-systems biology and system-theoretical biology. The "epistemology of complexity," I contend, acts as a glue that connects and integrates different and sometimes opposing viewpoints, perspectives, streams, and practices, thus maintaining intellectual and research coherence of systems research of life. It allows scientists to shift the focus from traditional experimental research to integrated, modeling-based holistic practices capable of providing a comprehensive knowledge of organizing principles of living systems. It also opens the possibility of the development of new practical and theoretical foundations of systems biology to build a better understanding of complex organismic functions.
T2  - Medical Hypotheses
T1  - Rethinking the pragmatic systems biology and systems-theoretical biology divide: Toward a complexity-inspired epistemology of systems biomedicine.
VL  - 131
DO  - 10.1016/j.mehy.2019.109316
SP  - 109316
ER  - 

@article{
author = "Kesić, Srđan",
year = "2019",
abstract = "This paper examines some methodological and epistemological issues underlying the ongoing "artificial" divide between pragmatic-systems biology and systems-theoretical biology. The pragmatic systems view of biology has encountered problems and constraints on its explanatory power because pragmatic systems biologists still tend to view systems as mere collections of parts, not as "emergent realities" produced by adaptive interactions between the constituting components. As such, they are incapable of characterizing the higher-level biological phenomena adequately. The attempts of systems-theoretical biologists to explain these "emergent realities" using mathematics also fail to produce satisfactory results. Given the increasing strategic importance of systems biology, both from theoretical and research perspectives, we suggest that additional epistemological and methodological insights into the possibility of further integration between traditional experimental studies and complex modeling are required. This integration will help to improve the currently underdeveloped pragmatic-systems biology and system-theoretical biology. The "epistemology of complexity," I contend, acts as a glue that connects and integrates different and sometimes opposing viewpoints, perspectives, streams, and practices, thus maintaining intellectual and research coherence of systems research of life. It allows scientists to shift the focus from traditional experimental research to integrated, modeling-based holistic practices capable of providing a comprehensive knowledge of organizing principles of living systems. It also opens the possibility of the development of new practical and theoretical foundations of systems biology to build a better understanding of complex organismic functions.",
journal = "Medical Hypotheses",
title = "Rethinking the pragmatic systems biology and systems-theoretical biology divide: Toward a complexity-inspired epistemology of systems biomedicine.",
volume = "131",
doi = "10.1016/j.mehy.2019.109316",
pages = "109316"
}

Kesić, S.. (2019). Rethinking the pragmatic systems biology and systems-theoretical biology divide: Toward a complexity-inspired epistemology of systems biomedicine.. in Medical Hypotheses, 131, 109316.
https://doi.org/10.1016/j.mehy.2019.109316

Kesić S. Rethinking the pragmatic systems biology and systems-theoretical biology divide: Toward a complexity-inspired epistemology of systems biomedicine.. in Medical Hypotheses. 2019;131:109316.
doi:10.1016/j.mehy.2019.109316 .

Kesić, Srđan, "Rethinking the pragmatic systems biology and systems-theoretical biology divide: Toward a complexity-inspired epistemology of systems biomedicine." in Medical Hypotheses, 131 (2019):109316,
https://doi.org/10.1016/j.mehy.2019.109316 . .

TY  - JOUR
AU  - Spasić, Slađana Z.
AU  - Kesić, Srđan
PY  - 2019
UR  - https://www.frontiersin.org/article/10.3389/fphys.2019.00298/full
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6449720
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3364
PB  - Frontiers
T2  - Frontiers in physiology
T2  - Frontiers in Physiology
T1  - Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity.
VL  - 10
DO  - 10.3389/fphys.2019.00298
SP  - 298
ER  - 

@article{
author = "Spasić, Slađana Z. and Kesić, Srđan",
year = "2019",
publisher = "Frontiers",
journal = "Frontiers in physiology, Frontiers in Physiology",
title = "Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity.",
volume = "10",
doi = "10.3389/fphys.2019.00298",
pages = "298"
}

Spasić, S. Z.,& Kesić, S.. (2019). Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity.. in Frontiers in physiology
Frontiers., 10, 298.
https://doi.org/10.3389/fphys.2019.00298

Spasić SZ, Kesić S. Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity.. in Frontiers in physiology. 2019;10:298.
doi:10.3389/fphys.2019.00298 .

Spasić, Slađana Z., Kesić, Srđan, "Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity." in Frontiers in physiology, 10 (2019):298,
https://doi.org/10.3389/fphys.2019.00298 . .

TY  - JOUR
AU  - Kesić, Srđan
PY  - 2016
UR  - https://www.sciencedirect.com/science/article/pii/S1319562X15001485?via%3Dihub
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4992115
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3372
AB  - This study explores the conceptual history of systems biology and its impact on philosophical and scientific conceptions of reductionism, antireductionism and emergence. Development of systems biology at the beginning of 21st century transformed biological science. Systems biology is a new holistic approach or strategy how to research biological organisms, developed through three phases. The first phase was completed when molecular biology transformed into systems molecular biology. Prior to the second phase, convergence between applied general systems theory and nonlinear dynamics took place, hence allowing the formation of systems mathematical biology. The second phase happened when systems molecular biology and systems mathematical biology, together, were applied for analysis of biological data. Finally, after successful application in science, medicine and biotechnology, the process of the formation of modern systems biology was completed. Systems and molecular reductionist views on organisms were completely opposed to each other. Implications of systems and molecular biology on reductionist-antireductionist debate were quite different. The analysis of reductionism, antireductionism and emergence issues, in the era of systems biology, revealed the hierarchy between methodological, epistemological and ontological antireductionism. Primarily, methodological antireductionism followed from the systems biology. Only after, epistemological and ontological antireductionism could be supported.
T2  - Saudi Journal of Biological Sciences
T2  - Saudi Journal of Biological Sciences
T1  - Systems biology, emergence and antireductionism.
IS  - 5
VL  - 23
DO  - 10.1016/j.sjbs.2015.06.015
SP  - 584
EP  - 91
ER  - 

@article{
author = "Kesić, Srđan",
year = "2016",
abstract = "This study explores the conceptual history of systems biology and its impact on philosophical and scientific conceptions of reductionism, antireductionism and emergence. Development of systems biology at the beginning of 21st century transformed biological science. Systems biology is a new holistic approach or strategy how to research biological organisms, developed through three phases. The first phase was completed when molecular biology transformed into systems molecular biology. Prior to the second phase, convergence between applied general systems theory and nonlinear dynamics took place, hence allowing the formation of systems mathematical biology. The second phase happened when systems molecular biology and systems mathematical biology, together, were applied for analysis of biological data. Finally, after successful application in science, medicine and biotechnology, the process of the formation of modern systems biology was completed. Systems and molecular reductionist views on organisms were completely opposed to each other. Implications of systems and molecular biology on reductionist-antireductionist debate were quite different. The analysis of reductionism, antireductionism and emergence issues, in the era of systems biology, revealed the hierarchy between methodological, epistemological and ontological antireductionism. Primarily, methodological antireductionism followed from the systems biology. Only after, epistemological and ontological antireductionism could be supported.",
journal = "Saudi Journal of Biological Sciences, Saudi Journal of Biological Sciences",
title = "Systems biology, emergence and antireductionism.",
number = "5",
volume = "23",
doi = "10.1016/j.sjbs.2015.06.015",
pages = "584-91"
}

Kesić, S.. (2016). Systems biology, emergence and antireductionism.. in Saudi Journal of Biological Sciences, 23(5), 584-91.
https://doi.org/10.1016/j.sjbs.2015.06.015

Kesić S. Systems biology, emergence and antireductionism.. in Saudi Journal of Biological Sciences. 2016;23(5):584-91.
doi:10.1016/j.sjbs.2015.06.015 .

Kesić, Srđan, "Systems biology, emergence and antireductionism." in Saudi Journal of Biological Sciences, 23, no. 5 (2016):584-91,
https://doi.org/10.1016/j.sjbs.2015.06.015 . .

TY  - JOUR
AU  - Kesić, Srđan
AU  - Spasić, Slađana Z.
PY  - 2016
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0169260715302923
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3373
AB  - BACKGROUND AND OBJECTIVE For more than 20 years, Higuchi's fractal dimension (HFD), as a nonlinear method, has occupied an important place in the analysis of biological signals. The use of HFD has evolved from EEG and single neuron activity analysis to the most recent application in automated assessments of different clinical conditions. Our objective is to provide an updated review of the HFD method applied in basic and clinical neurophysiological research. METHODS This article summarizes and critically reviews a broad literature and major findings concerning the applications of HFD for measuring the complexity of neuronal activity during different neurophysiological conditions. The source of information used in this review comes from the PubMed, Scopus, Google Scholar and IEEE Xplore Digital Library databases. RESULTS The review process substantiated the significance, advantages and shortcomings of HFD application within all key areas of basic and clinical neurophysiology. Therefore, the paper discusses HFD application alone, combined with other linear or nonlinear measures, or as a part of automated methods for analyzing neurophysiological signals. CONCLUSIONS The speed, accuracy and cost of applying the HFD method for research and medical diagnosis make it stand out from the widely used linear methods. However, only a combination of HFD with other nonlinear methods ensures reliable and accurate analysis of a wide range of neurophysiological signals.
T2  - Computer Methods and Programs in Biomedicine
T2  - Computer Methods and Programs in Biomedicine
T1  - Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review.
VL  - 133
DO  - 10.1016/j.cmpb.2016.05.014
SP  - 55
EP  - 70
ER  - 

@article{
author = "Kesić, Srđan and Spasić, Slađana Z.",
year = "2016",
abstract = "BACKGROUND AND OBJECTIVE For more than 20 years, Higuchi's fractal dimension (HFD), as a nonlinear method, has occupied an important place in the analysis of biological signals. The use of HFD has evolved from EEG and single neuron activity analysis to the most recent application in automated assessments of different clinical conditions. Our objective is to provide an updated review of the HFD method applied in basic and clinical neurophysiological research. METHODS This article summarizes and critically reviews a broad literature and major findings concerning the applications of HFD for measuring the complexity of neuronal activity during different neurophysiological conditions. The source of information used in this review comes from the PubMed, Scopus, Google Scholar and IEEE Xplore Digital Library databases. RESULTS The review process substantiated the significance, advantages and shortcomings of HFD application within all key areas of basic and clinical neurophysiology. Therefore, the paper discusses HFD application alone, combined with other linear or nonlinear measures, or as a part of automated methods for analyzing neurophysiological signals. CONCLUSIONS The speed, accuracy and cost of applying the HFD method for research and medical diagnosis make it stand out from the widely used linear methods. However, only a combination of HFD with other nonlinear methods ensures reliable and accurate analysis of a wide range of neurophysiological signals.",
journal = "Computer Methods and Programs in Biomedicine, Computer Methods and Programs in Biomedicine",
title = "Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review.",
volume = "133",
doi = "10.1016/j.cmpb.2016.05.014",
pages = "55-70"
}

Kesić, S.,& Spasić, S. Z.. (2016). Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review.. in Computer Methods and Programs in Biomedicine, 133, 55-70.
https://doi.org/10.1016/j.cmpb.2016.05.014

Kesić S, Spasić SZ. Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review.. in Computer Methods and Programs in Biomedicine. 2016;133:55-70.
doi:10.1016/j.cmpb.2016.05.014 .

Kesić, Srđan, Spasić, Slađana Z., "Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review." in Computer Methods and Programs in Biomedicine, 133 (2016):55-70,
https://doi.org/10.1016/j.cmpb.2016.05.014 . .

TY  - JOUR
AU  - Spasić, Sladjana
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1998
UR  - https://www.sciencedirect.com/science/article/pii/S1095643314002499
AB  - To study the influence of a static magnetic field (SMF, 2 mT) and
   extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the
   neuronal population activity, the experiments were performed on adult
   longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a
   wavelet analysis of the local field potentials (LFPs), our study showed
   for the first time that the effects of prolonged and repeated exposure
   to the ELF MF on the LFPs were irreversible within investigated time
   frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was
   significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in
   comparison to the control value. The RWE of slower oscillations (1-2 Hz)
   was significantly decreased after the repeated exposures to either SnMF
   or SqMF. The SqMF induced decreasing of the faster waves in the range of
   64-128 Hz. However, we did not prove with presented methods that
   exposure to the SMF for 5 min produces any effects on the neuronal
   population activity. This study has proved the wavelet transform as a
   valuable tool for measuring the effects of SMF and ELF MF on the
   neuronal population activity in M. funereus antennal lobe.
T2  - Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology
T1  - Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis
VL  - 181
DO  - 10.1016/j.cbpa.2014.11.018
SP  - 27
EP  - 35
ER  - 

@article{
author = "Spasić, Sladjana and Kesić, Srđan and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2015",
abstract = "To study the influence of a static magnetic field (SMF, 2 mT) and
   extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the
   neuronal population activity, the experiments were performed on adult
   longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a
   wavelet analysis of the local field potentials (LFPs), our study showed
   for the first time that the effects of prolonged and repeated exposure
   to the ELF MF on the LFPs were irreversible within investigated time
   frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was
   significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in
   comparison to the control value. The RWE of slower oscillations (1-2 Hz)
   was significantly decreased after the repeated exposures to either SnMF
   or SqMF. The SqMF induced decreasing of the faster waves in the range of
   64-128 Hz. However, we did not prove with presented methods that
   exposure to the SMF for 5 min produces any effects on the neuronal
   population activity. This study has proved the wavelet transform as a
   valuable tool for measuring the effects of SMF and ELF MF on the
   neuronal population activity in M. funereus antennal lobe.",
journal = "Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology",
title = "Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis",
volume = "181",
doi = "10.1016/j.cbpa.2014.11.018",
pages = "27-35"
}

Spasić, S., Kesić, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2015). Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 181, 27-35.
https://doi.org/10.1016/j.cbpa.2014.11.018

Spasić S, Kesić S, Stojadinović G, Petković B, Todorović D. Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 2015;181:27-35.
doi:10.1016/j.cbpa.2014.11.018 .

Spasić, Sladjana, Kesić, Srđan, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis" in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 181 (2015):27-35,
https://doi.org/10.1016/j.cbpa.2014.11.018 . .

TY  - CONF
AU  - Kesić, Srđan
AU  - Spasić, Slađana
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4027
AB  - Based on a wavelet analysis, this study introduces the relative wavelet energy (RWE)
as a new measure for classification of the frequency bands of neuronal population activity
in insects. The RWE is used to explore the effects of static magnetic field (SMF,
2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on longhorn
beetle antennal lobe neuronal activity. To study the influence of SMF and ELF MF on
the neuronal population activity, the experiments were performed on adult longhorn
beetles Morimus funereus (Coleoptera, Cerambycidae). Our study, based on a wavelet
analysis of the local field potentials (LFPs), showed for the first time that the effects of
prolonged and repeated exposure to the ELF MF on the LFPs were irreversible. Compared
to the control, the RWE of 4-8 Hz frequency band was increased after repeatedly
applied sine ELF MF (SnMF)/square ELF MF (SqMF). On the other hand, the RWE of
slower oscillations (1-2 Hz) was significantly decreased after repeated exposures to both
applied ELF MF waveforms. The SqMF decreased the fastest 64-128 Hz frequency
band. However, exposure to the SMF didn't have any effects on the neuronal population
activity. This study, successfully demonstrated new and useful application of the RWE
method for classification of the frequency bands and measuring the effects of SMF and
ELF MF on the neuronal population activity in M. funereus antennal lobe.
PB  - Belgrade: Serbian Physiological Society
C3  - 3rd Congress of Physiological Sciences of Serbia With International Participation
T1  - Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
SP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4027
ER  - 

@conference{
author = "Kesić, Srđan and Spasić, Slađana and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2014",
abstract = "Based on a wavelet analysis, this study introduces the relative wavelet energy (RWE)
as a new measure for classification of the frequency bands of neuronal population activity
in insects. The RWE is used to explore the effects of static magnetic field (SMF,
2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on longhorn
beetle antennal lobe neuronal activity. To study the influence of SMF and ELF MF on
the neuronal population activity, the experiments were performed on adult longhorn
beetles Morimus funereus (Coleoptera, Cerambycidae). Our study, based on a wavelet
analysis of the local field potentials (LFPs), showed for the first time that the effects of
prolonged and repeated exposure to the ELF MF on the LFPs were irreversible. Compared
to the control, the RWE of 4-8 Hz frequency band was increased after repeatedly
applied sine ELF MF (SnMF)/square ELF MF (SqMF). On the other hand, the RWE of
slower oscillations (1-2 Hz) was significantly decreased after repeated exposures to both
applied ELF MF waveforms. The SqMF decreased the fastest 64-128 Hz frequency
band. However, exposure to the SMF didn't have any effects on the neuronal population
activity. This study, successfully demonstrated new and useful application of the RWE
method for classification of the frequency bands and measuring the effects of SMF and
ELF MF on the neuronal population activity in M. funereus antennal lobe.",
publisher = "Belgrade: Serbian Physiological Society",
journal = "3rd Congress of Physiological Sciences of Serbia With International Participation",
title = "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe",
pages = "126",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4027"
}

Kesić, S., Spasić, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2014). Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation
Belgrade: Serbian Physiological Society., 126.
https://hdl.handle.net/21.15107/rcub_ibiss_4027

Kesić S, Spasić S, Stojadinović G, Petković B, Todorović D. Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation. 2014;:126.
https://hdl.handle.net/21.15107/rcub_ibiss_4027 .

Kesić, Srđan, Spasić, Slađana, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe" in 3rd Congress of Physiological Sciences of Serbia With International Participation (2014):126,
https://hdl.handle.net/21.15107/rcub_ibiss_4027 .

TY  - JOUR
AU  - Kesić, Srđan
AU  - Nikolić, Ljiljana
AU  - Petković, Branka
AU  - Spasić, Slađana Z.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2270
AB  - The components of complex bioelectrical activity - action potential
   (AP), interspike interval (ISI) and the quiet interburst interval (IBI),
   along with the effects of 2.7 mT and 10 mT static magnetic fields, were
   identified and examined in the spontaneously active Br neuron of the
   subesophageal ganglion complex of the garden snail Helix pomatia by
   fractal analysis using Higuchi's fractal dimension (FD). The normalized
   mean of the empirical FD distributions of bursting activity of the Br
   neuron were formed under different experimental conditions: before
   (Control), during (MF), and after exposure to the static magnetic field
   (AMF). Using the fractal analysis method for the first time, a
   separation of the AP, ISI and IBI components was successfully achieved.
   Our results show that fractal analysis with deconvolution of the
   normalized mean of the empirical FD distributions into Gaussian
   functions is a useful tool for revealing the effects of magnetic fields
   on the complexity of neuronal bioelectric activity and its AP, ISI and
   IBI components.
T2  - Archives of Biological Sciences
T1  - Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail Br neuron
IS  - 2
VL  - 66
DO  - 10.2298/ABS1402563K
SP  - 563
EP  - 572
ER  - 

@article{
author = "Kesić, Srđan and Nikolić, Ljiljana and Petković, Branka and Spasić, Slađana Z.",
year = "2014",
abstract = "The components of complex bioelectrical activity - action potential
   (AP), interspike interval (ISI) and the quiet interburst interval (IBI),
   along with the effects of 2.7 mT and 10 mT static magnetic fields, were
   identified and examined in the spontaneously active Br neuron of the
   subesophageal ganglion complex of the garden snail Helix pomatia by
   fractal analysis using Higuchi's fractal dimension (FD). The normalized
   mean of the empirical FD distributions of bursting activity of the Br
   neuron were formed under different experimental conditions: before
   (Control), during (MF), and after exposure to the static magnetic field
   (AMF). Using the fractal analysis method for the first time, a
   separation of the AP, ISI and IBI components was successfully achieved.
   Our results show that fractal analysis with deconvolution of the
   normalized mean of the empirical FD distributions into Gaussian
   functions is a useful tool for revealing the effects of magnetic fields
   on the complexity of neuronal bioelectric activity and its AP, ISI and
   IBI components.",
journal = "Archives of Biological Sciences",
title = "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail Br neuron",
number = "2",
volume = "66",
doi = "10.2298/ABS1402563K",
pages = "563-572"
}

Kesić, S., Nikolić, L., Petković, B.,& Spasić, S. Z.. (2014). Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail Br neuron. in Archives of Biological Sciences, 66(2), 563-572.
https://doi.org/10.2298/ABS1402563K

Kesić S, Nikolić L, Petković B, Spasić SZ. Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail Br neuron. in Archives of Biological Sciences. 2014;66(2):563-572.
doi:10.2298/ABS1402563K .

Kesić, Srđan, Nikolić, Ljiljana, Petković, Branka, Spasić, Slađana Z., "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail Br neuron" in Archives of Biological Sciences, 66, no. 2 (2014):563-572,
https://doi.org/10.2298/ABS1402563K . .

TY  - JOUR
AU  - Kesić, Srđan
AU  - Nikolić, Ljiljana
AU  - Savić, Aleksandar G.
AU  - Petković, Branka
AU  - Spasić, Slađana Z.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2284
AB  - Aim of this study was to investigate the application of normalized mean
   of the empirical Higuchi fractal dimension (FD) distributions, as a new
   approach to analyze the spontaneous bioelectrical activity of garden
   snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of
   Br neuron bursting activity before and after the exposure to 10 mT
   static magnetic field (SMF) was observed by analyzing the following
   parameters: action potential (AP), interspike interval (ISI) and
   interbursting interval (IBI) components. Normalized mean of the
   empirical FD distributions were formed for the following experimental
   conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3,
   SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain
   without SMF induced increase in participation of AP and a decrease in
   participation of IBI components compared to the first control condition.
   However, in the presence of 10 mT SMF, ouabain-induced changes of
   measured parameters of Br neuron activity were less pronounced compared
   to the third control condition. We have shown that normalized mean of
   the empirical FD distributions is a useful method for detecting the
   changes in AP, ISI, and IBI components of complex bursting activity in
   altered physiological states.
T2  - General Physiology and Biophysics
T1  - Ouabain modulation of snail Br neuron bursting activity after the
 exposure to 10 mT static magnetic field revealed by Higuchi fractal
 dimension
IS  - 3
VL  - 33
DO  - 10.4149/gpb_2014010
SP  - 335
EP  - 344
ER  - 

@article{
author = "Kesić, Srđan and Nikolić, Ljiljana and Savić, Aleksandar G. and Petković, Branka and Spasić, Slađana Z.",
year = "2014",
abstract = "Aim of this study was to investigate the application of normalized mean
   of the empirical Higuchi fractal dimension (FD) distributions, as a new
   approach to analyze the spontaneous bioelectrical activity of garden
   snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of
   Br neuron bursting activity before and after the exposure to 10 mT
   static magnetic field (SMF) was observed by analyzing the following
   parameters: action potential (AP), interspike interval (ISI) and
   interbursting interval (IBI) components. Normalized mean of the
   empirical FD distributions were formed for the following experimental
   conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3,
   SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain
   without SMF induced increase in participation of AP and a decrease in
   participation of IBI components compared to the first control condition.
   However, in the presence of 10 mT SMF, ouabain-induced changes of
   measured parameters of Br neuron activity were less pronounced compared
   to the third control condition. We have shown that normalized mean of
   the empirical FD distributions is a useful method for detecting the
   changes in AP, ISI, and IBI components of complex bursting activity in
   altered physiological states.",
journal = "General Physiology and Biophysics",
title = "Ouabain modulation of snail Br neuron bursting activity after the
 exposure to 10 mT static magnetic field revealed by Higuchi fractal
 dimension",
number = "3",
volume = "33",
doi = "10.4149/gpb_2014010",
pages = "335-344"
}

Kesić, S., Nikolić, L., Savić, A. G., Petković, B.,& Spasić, S. Z.. (2014). Ouabain modulation of snail Br neuron bursting activity after the
 exposure to 10 mT static magnetic field revealed by Higuchi fractal
 dimension. in General Physiology and Biophysics, 33(3), 335-344.
https://doi.org/10.4149/gpb_2014010

Kesić S, Nikolić L, Savić AG, Petković B, Spasić SZ. Ouabain modulation of snail Br neuron bursting activity after the
 exposure to 10 mT static magnetic field revealed by Higuchi fractal
 dimension. in General Physiology and Biophysics. 2014;33(3):335-344.
doi:10.4149/gpb_2014010 .

Kesić, Srđan, Nikolić, Ljiljana, Savić, Aleksandar G., Petković, Branka, Spasić, Slađana Z., "Ouabain modulation of snail Br neuron bursting activity after the
 exposure to 10 mT static magnetic field revealed by Higuchi fractal
 dimension" in General Physiology and Biophysics, 33, no. 3 (2014):335-344,
https://doi.org/10.4149/gpb_2014010 . .

TY  - THES
AU  - Kesić, Srđan
PY  - 2014
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=2858
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:11066/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024734130
UR  - http://nardus.mpn.gov.rs/123456789/5286
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2391
AB  - Nelinearne i napredne statističke metode, pored linearnih metoda, zauzimaju sve
značajnije mesto u analizi fizioloških signala, posebno u svetlu nelinearnog i haotičnog
ponašanja bioloških sistema. Stoga je zajednička upotreba Higučijeve fraktalne dimenzije i
analize nezavisnih komponentata (ICA), značajan i nov pristup u analizi signala a posebno u
analizi aktivnosti jednog neurona. Najprepoznatljiviji tip spontane bioelektrične aktivnosti
neurona beskičmenjaka i kičmenjaka jeste pojava akcionih potencijala u paketićima.
U radu je po prvi put primenjen, jedinstven i inovativan pristup u razdvajanju
komponenata spontane bioelektrične aktivnosti Br neurona vinogradskog puža i to na akcione
potencijale (AP), intervale između akcionih potencijala (ISI) i tihe intervale bez aktivnosti (IBI)
uz pomoć Higučijeve fraktalne dimenzije i aproksimacije Gausovim funkcijama. Taj
metodološki pristup je omogućio praćenje uticaja konstantnog magnetnog polja i uabaina
inhibitora Na+/K+ pumpe na promene u kompleksnosti spontane bioelektrične aktivnosti Br
neurona. Sa druge strane, po prvi put je testirana upotreba ICA metode u različitim
eksperimentalnim uslovima po AP, ISI i IBI komponentama spontane bioelektrične aktivnosti.
Na taj način, u ovom radu demonstrirana je snaga zajedničke upotrebe navedenih metoda
uz predlog da se proširi njihova upotreba za potrebe analize spontano aktivnih neurona različitih
vrsta u fiziološkim i patološkim stanjima.
AB  - Nonlinear and advanced statistical methods, in addition to linear methods, occupy a
prominent place in the analysis of physiological signals, especially in light of the non-linear and
chaotic behavior of biological systems. Therefore, the use of Higuchi fractal dimension and
independent component analysis (ICA), reperesents a new approach to signal analysis, especially
regarding the activities of one neuron. The most recognizable type of spontaneous bioelectric
activity in neurons of invertebrates as well as vertebrates is the appearance of bursting activity.
This study presents a unique and innovative approach to the separation of the components
of spontaneous bioelectric activity of the garden snail Br neuron - action potential (AP),
interspike interval (ISI) and interburst interval (IBI), by using Higuchi’s fractal dimension and
Gaussian fitting functions. This methodological approach allows monitoring of the effect of
static magnetic field and the inhibitor of the Na+/K+ pump, ouabain, on the changes in the
complexity of the spontaneous bioelectric activity of the Br neuron. On the other hand, for the
first time ICA method was tested in different experimental conditions on AP, ISI and IBI
components of spontaneous bioelectric activity.
This study demonstrates the power of the common use of the above mentioned methods
and proposes to extend their use for the purpose of analyzing spontaneously active neurons of
different species in physiological and patological conditions.
PB  - Belgrade: University of Belgrade, Faculty of Biology
T2  - University of Belgrade, Faculty of Biology
T1  - Primena Higučijeve fraktalne dimenzije i metode nezavisnih komponenata u analizi spontane bioelektrične aktivnosti Br neurona vinogradskog puža pod delovanjem konstantnog magnetnog polja i uabaina
T1  - Application of Higuchi fractal dimension and indepenedent component method in analysis of garden snail Br neuron bursting activity modulated by static magnetic field and ouabain.
SP  - 1
EP  - 93
UR  - https://hdl.handle.net/21.15107/rcub_nardus_5286
ER  - 

@phdthesis{
author = "Kesić, Srđan",
year = "2014",
abstract = "Nelinearne i napredne statističke metode, pored linearnih metoda, zauzimaju sve
značajnije mesto u analizi fizioloških signala, posebno u svetlu nelinearnog i haotičnog
ponašanja bioloških sistema. Stoga je zajednička upotreba Higučijeve fraktalne dimenzije i
analize nezavisnih komponentata (ICA), značajan i nov pristup u analizi signala a posebno u
analizi aktivnosti jednog neurona. Najprepoznatljiviji tip spontane bioelektrične aktivnosti
neurona beskičmenjaka i kičmenjaka jeste pojava akcionih potencijala u paketićima.
U radu je po prvi put primenjen, jedinstven i inovativan pristup u razdvajanju
komponenata spontane bioelektrične aktivnosti Br neurona vinogradskog puža i to na akcione
potencijale (AP), intervale između akcionih potencijala (ISI) i tihe intervale bez aktivnosti (IBI)
uz pomoć Higučijeve fraktalne dimenzije i aproksimacije Gausovim funkcijama. Taj
metodološki pristup je omogućio praćenje uticaja konstantnog magnetnog polja i uabaina
inhibitora Na+/K+ pumpe na promene u kompleksnosti spontane bioelektrične aktivnosti Br
neurona. Sa druge strane, po prvi put je testirana upotreba ICA metode u različitim
eksperimentalnim uslovima po AP, ISI i IBI komponentama spontane bioelektrične aktivnosti.
Na taj način, u ovom radu demonstrirana je snaga zajedničke upotrebe navedenih metoda
uz predlog da se proširi njihova upotreba za potrebe analize spontano aktivnih neurona različitih
vrsta u fiziološkim i patološkim stanjima., Nonlinear and advanced statistical methods, in addition to linear methods, occupy a
prominent place in the analysis of physiological signals, especially in light of the non-linear and
chaotic behavior of biological systems. Therefore, the use of Higuchi fractal dimension and
independent component analysis (ICA), reperesents a new approach to signal analysis, especially
regarding the activities of one neuron. The most recognizable type of spontaneous bioelectric
activity in neurons of invertebrates as well as vertebrates is the appearance of bursting activity.
This study presents a unique and innovative approach to the separation of the components
of spontaneous bioelectric activity of the garden snail Br neuron - action potential (AP),
interspike interval (ISI) and interburst interval (IBI), by using Higuchi’s fractal dimension and
Gaussian fitting functions. This methodological approach allows monitoring of the effect of
static magnetic field and the inhibitor of the Na+/K+ pump, ouabain, on the changes in the
complexity of the spontaneous bioelectric activity of the Br neuron. On the other hand, for the
first time ICA method was tested in different experimental conditions on AP, ISI and IBI
components of spontaneous bioelectric activity.
This study demonstrates the power of the common use of the above mentioned methods
and proposes to extend their use for the purpose of analyzing spontaneously active neurons of
different species in physiological and patological conditions.",
publisher = "Belgrade: University of Belgrade, Faculty of Biology",
journal = "University of Belgrade, Faculty of Biology",
title = "Primena Higučijeve fraktalne dimenzije i metode nezavisnih komponenata u analizi spontane bioelektrične aktivnosti Br neurona vinogradskog puža pod delovanjem konstantnog magnetnog polja i uabaina, Application of Higuchi fractal dimension and indepenedent component method in analysis of garden snail Br neuron bursting activity modulated by static magnetic field and ouabain.",
pages = "1-93",
url = "https://hdl.handle.net/21.15107/rcub_nardus_5286"
}

Kesić, S.. (2014). Primena Higučijeve fraktalne dimenzije i metode nezavisnih komponenata u analizi spontane bioelektrične aktivnosti Br neurona vinogradskog puža pod delovanjem konstantnog magnetnog polja i uabaina. in University of Belgrade, Faculty of Biology
Belgrade: University of Belgrade, Faculty of Biology., 1-93.
https://hdl.handle.net/21.15107/rcub_nardus_5286

Kesić S. Primena Higučijeve fraktalne dimenzije i metode nezavisnih komponenata u analizi spontane bioelektrične aktivnosti Br neurona vinogradskog puža pod delovanjem konstantnog magnetnog polja i uabaina. in University of Belgrade, Faculty of Biology. 2014;:1-93.
https://hdl.handle.net/21.15107/rcub_nardus_5286 .

Kesić, Srđan, "Primena Higučijeve fraktalne dimenzije i metode nezavisnih komponenata u analizi spontane bioelektrične aktivnosti Br neurona vinogradskog puža pod delovanjem konstantnog magnetnog polja i uabaina" in University of Belgrade, Faculty of Biology (2014):1-93,
https://hdl.handle.net/21.15107/rcub_nardus_5286 .

TY  - JOUR
AU  - Spasić, Slađana Z.
AU  - Kalauzi, Aleksandar
AU  - Kesić, Srđan
AU  - Obradović, Milica
AU  - Šaponjić, Jasna
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1247
AB  - We used spectral analysis and Higuchi fractal dimension (FD) to correlate the EEG spectral characteristics of the sensorimotor cortex, hippocampus, and pons with their corresponding EEG signal complexities in anesthetized rats. We have explored the quantitative relationship between the mean FDs and EEG wide range high frequency (8-50 Hz) activity during ketamine/xylazine versus nembutal anesthesia at surgical plane. Using FD we detected distinct inter-structure complexity pattern and uncovered for the first time that the polygraphically and behaviorally defined anesthetized state at surgical plane as equal during experiment in two anesthetic regimens, is not the same with respect to the degree of neuronal activity (degree of generalized neuronal inhibition achieved) at different brain levels. Using the correlation of certain brain structure EEG spectral characteristics with their corresponding FDs, and the surrogate data modeling, we determined what particular frequency band contributes to EEG complexities in ketamine/xylazine versus nembutal anesthesia. In this study we have shown that the quantitative relationship between higher frequency EEG amplitude and EEG complexity is the best-modeled by surrogate data as a 3rd order polynomial. On the base of our EEG amplitude/EEG complexity relationship model, and the evidenced spectral differences in ketamine versus nembutal anesthesia we have proved that higher amplitudes of sigma, beta, and gamma frequency in ketamine anesthesia yields to higher FDs. (C) 2011 Elsevier Ltd. All rights reserved.
T2  - Journal of Theoretical Biology
T1  - Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats
IS  - null
VL  - 289
EP  - 166
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1247
ER  - 

@article{
author = "Spasić, Slađana Z. and Kalauzi, Aleksandar and Kesić, Srđan and Obradović, Milica and Šaponjić, Jasna",
year = "2011",
abstract = "We used spectral analysis and Higuchi fractal dimension (FD) to correlate the EEG spectral characteristics of the sensorimotor cortex, hippocampus, and pons with their corresponding EEG signal complexities in anesthetized rats. We have explored the quantitative relationship between the mean FDs and EEG wide range high frequency (8-50 Hz) activity during ketamine/xylazine versus nembutal anesthesia at surgical plane. Using FD we detected distinct inter-structure complexity pattern and uncovered for the first time that the polygraphically and behaviorally defined anesthetized state at surgical plane as equal during experiment in two anesthetic regimens, is not the same with respect to the degree of neuronal activity (degree of generalized neuronal inhibition achieved) at different brain levels. Using the correlation of certain brain structure EEG spectral characteristics with their corresponding FDs, and the surrogate data modeling, we determined what particular frequency band contributes to EEG complexities in ketamine/xylazine versus nembutal anesthesia. In this study we have shown that the quantitative relationship between higher frequency EEG amplitude and EEG complexity is the best-modeled by surrogate data as a 3rd order polynomial. On the base of our EEG amplitude/EEG complexity relationship model, and the evidenced spectral differences in ketamine versus nembutal anesthesia we have proved that higher amplitudes of sigma, beta, and gamma frequency in ketamine anesthesia yields to higher FDs. (C) 2011 Elsevier Ltd. All rights reserved.",
journal = "Journal of Theoretical Biology",
title = "Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats",
number = "null",
volume = "289",
pages = "166",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1247"
}

Spasić, S. Z., Kalauzi, A., Kesić, S., Obradović, M.,& Šaponjić, J.. (2011). Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats. in Journal of Theoretical Biology, 289(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1247

Spasić SZ, Kalauzi A, Kesić S, Obradović M, Šaponjić J. Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats. in Journal of Theoretical Biology. 2011;289(null):null-166.
https://hdl.handle.net/21.15107/rcub_ibiss_1247 .

Spasić, Slađana Z., Kalauzi, Aleksandar, Kesić, Srđan, Obradović, Milica, Šaponjić, Jasna, "Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats" in Journal of Theoretical Biology, 289, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1247 .

TY  - JOUR
AU  - Spasić, Slađana Z.
AU  - Kesić, Srđan
AU  - Kalauzi, Aleksandar
AU  - Šaponjić, Jasna
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1303
AB  - The complexity, entropy and other non-linear measures of the electroencephalogram ( EEG), such as Higuchi fractal dimension (FD), have been recently proposed as the measures of anesthesia depth and sedation. We hypothesized that during unconciousness in rats induced by the general anesthetics with opposite mechanism of action, behaviorally and poligraphically controlled as appropriately achieved stable anesthesia, we can detect distinct inter-structure brain dynamic using mean FDs. We used the surrogate data test for nonlinearity in order to establish the existence of nonlinear dynamics, and to justify the use of FD as a nonlinear measure in the time series analysis. The surrogate data of predefined probability distribution and autocorrelation properties have been generated using the algorithm of statically transformed autoregressive process (STAP). FD then is applied to quantify EEG signal complexity at the cortical, hippocampal and pontine level during stable general anesthesia (ketamine/xylazine or nembutal anesthesia). Our study showed for the first time that global neuronal inhibition caused by different mechanisms of anesthetic action induced distinct brain inter- structure complexity gradient in Sprague Dawley rats. EEG signal complexities were higher at cortical and hippocampal level in ketamine/ xylazine vs. nembutal anesthesia, with the dominance of hippocampal complexity. In nembutal anesthesia the complexity dominance moved to pontine level, and ponto- hippocampocortical decreasing complexity gradient was established. This study has proved the Higuchi fractal dimension as a valuable tool for measuring the anesthesia induced inter- structure EEG complexity.
T2  - Fractals-Complex Geometry Patterns and Scaling in Nature and Society
T1  - Different Anesthesia in Rat Induces Distinct Inter-Structure Brain Dynamic Detected By Higuchi Fractal Dimension
IS  - 1
VL  - 19
EP  - 123
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1303
ER  - 

@article{
author = "Spasić, Slađana Z. and Kesić, Srđan and Kalauzi, Aleksandar and Šaponjić, Jasna",
year = "2011",
abstract = "The complexity, entropy and other non-linear measures of the electroencephalogram ( EEG), such as Higuchi fractal dimension (FD), have been recently proposed as the measures of anesthesia depth and sedation. We hypothesized that during unconciousness in rats induced by the general anesthetics with opposite mechanism of action, behaviorally and poligraphically controlled as appropriately achieved stable anesthesia, we can detect distinct inter-structure brain dynamic using mean FDs. We used the surrogate data test for nonlinearity in order to establish the existence of nonlinear dynamics, and to justify the use of FD as a nonlinear measure in the time series analysis. The surrogate data of predefined probability distribution and autocorrelation properties have been generated using the algorithm of statically transformed autoregressive process (STAP). FD then is applied to quantify EEG signal complexity at the cortical, hippocampal and pontine level during stable general anesthesia (ketamine/xylazine or nembutal anesthesia). Our study showed for the first time that global neuronal inhibition caused by different mechanisms of anesthetic action induced distinct brain inter- structure complexity gradient in Sprague Dawley rats. EEG signal complexities were higher at cortical and hippocampal level in ketamine/ xylazine vs. nembutal anesthesia, with the dominance of hippocampal complexity. In nembutal anesthesia the complexity dominance moved to pontine level, and ponto- hippocampocortical decreasing complexity gradient was established. This study has proved the Higuchi fractal dimension as a valuable tool for measuring the anesthesia induced inter- structure EEG complexity.",
journal = "Fractals-Complex Geometry Patterns and Scaling in Nature and Society",
title = "Different Anesthesia in Rat Induces Distinct Inter-Structure Brain Dynamic Detected By Higuchi Fractal Dimension",
number = "1",
volume = "19",
pages = "123",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1303"
}

Spasić, S. Z., Kesić, S., Kalauzi, A.,& Šaponjić, J.. (2011). Different Anesthesia in Rat Induces Distinct Inter-Structure Brain Dynamic Detected By Higuchi Fractal Dimension. in Fractals-Complex Geometry Patterns and Scaling in Nature and Society, 19(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1303

Spasić SZ, Kesić S, Kalauzi A, Šaponjić J. Different Anesthesia in Rat Induces Distinct Inter-Structure Brain Dynamic Detected By Higuchi Fractal Dimension. in Fractals-Complex Geometry Patterns and Scaling in Nature and Society. 2011;19(1):null-123.
https://hdl.handle.net/21.15107/rcub_ibiss_1303 .

Spasić, Slađana Z., Kesić, Srđan, Kalauzi, Aleksandar, Šaponjić, Jasna, "Different Anesthesia in Rat Induces Distinct Inter-Structure Brain Dynamic Detected By Higuchi Fractal Dimension" in Fractals-Complex Geometry Patterns and Scaling in Nature and Society, 19, no. 1 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1303 .

TY  - JOUR
AU  - Kesić, Srđan
AU  - Kalauzi, Aleksandar
AU  - Radulovacki, Miodrag
AU  - Carley, David W
AU  - Šaponjić, Jasna
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1330
AB  - Sigma and theta frequency electroencephalogram (EEG) oscillations exhibit substantial and well-recognized shifts with transitions across sleep and wake states. We aimed in this study to test the changes in coupling between these characteristic oscillations of non-rapid-eye-movement (NREM)/rapid-eye-movement (REM) sleep within and between cortical and pontine EEGs following monoaminergic lesion, by using the Pearson's product-moment correlation coefficients. Experiments were performed in 14 adult, male Sprague Dawley rats chronically instrumented for sleep recording. We lesioned the dorsal raphe nucleus axon terminals in four rats using PCA neurotoxin (p-chloroamphetamine; Sigma-Aldrich, MO) administered as two intraperitoneal (IP) injections (6 mg/kg) 24 h apart. Lesioning of locus coeruleus axon terminals was performed in five rats using DSP-4 neurotoxin (N-2-chloroethyl-N-ethyl-2-bromobenzilamine; Sigma-Aldrich, MO) in a single IP dose of 50 mg/kg. Our previous study [Saponjic et al., Physiol Behav 90:1-10, 2007] demonstrated that these systemically induced monoaminergic lesions failed to produce significant changes in sleep/wake distribution from control conditions. The present study, by using spectral analysis and by examining the Pearson's correlation coefficients and their approximate probability density (APD) distribution profiles in control and lesion condition, demonstrates significant augmentation of the sigma/theta coupling strength, an inversion of cortical sigma/theta coupling direction and emergence of an additional sigma/theta coupling "mode" specific to the post-lesion state only within the cortex. By using the Pearson's correlation coefficients and their APD profiles, instead of classical sleep/wake distribution analysis, as a measure of direction and strength of sigma/theta coupling within and between cortex and pons, we were able to uncover the impact of a tonically decreased level of brain monoamines as altered strength and mode of coupling between sigma and theta oscillations. Specifically, a new mode of sigma/theta coupling emerged following lesion, which was specific to NREM sleep, suggests that loss of monoaminergic signaling interferes with NREM sleep consolidation. Our results also indicate an importance of monoamines in control of the sleep spindle and theta rhythm generators.
T2  - Sleep and Breathing
T1  - Coupling changes in cortical and pontine sigma and theta frequency oscillations following monoaminergic lesions in rat
IS  - 1
VL  - 15
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1330
ER  - 

@article{
author = "Kesić, Srđan and Kalauzi, Aleksandar and Radulovacki, Miodrag and Carley, David W and Šaponjić, Jasna",
year = "2011",
abstract = "Sigma and theta frequency electroencephalogram (EEG) oscillations exhibit substantial and well-recognized shifts with transitions across sleep and wake states. We aimed in this study to test the changes in coupling between these characteristic oscillations of non-rapid-eye-movement (NREM)/rapid-eye-movement (REM) sleep within and between cortical and pontine EEGs following monoaminergic lesion, by using the Pearson's product-moment correlation coefficients. Experiments were performed in 14 adult, male Sprague Dawley rats chronically instrumented for sleep recording. We lesioned the dorsal raphe nucleus axon terminals in four rats using PCA neurotoxin (p-chloroamphetamine; Sigma-Aldrich, MO) administered as two intraperitoneal (IP) injections (6 mg/kg) 24 h apart. Lesioning of locus coeruleus axon terminals was performed in five rats using DSP-4 neurotoxin (N-2-chloroethyl-N-ethyl-2-bromobenzilamine; Sigma-Aldrich, MO) in a single IP dose of 50 mg/kg. Our previous study [Saponjic et al., Physiol Behav 90:1-10, 2007] demonstrated that these systemically induced monoaminergic lesions failed to produce significant changes in sleep/wake distribution from control conditions. The present study, by using spectral analysis and by examining the Pearson's correlation coefficients and their approximate probability density (APD) distribution profiles in control and lesion condition, demonstrates significant augmentation of the sigma/theta coupling strength, an inversion of cortical sigma/theta coupling direction and emergence of an additional sigma/theta coupling "mode" specific to the post-lesion state only within the cortex. By using the Pearson's correlation coefficients and their APD profiles, instead of classical sleep/wake distribution analysis, as a measure of direction and strength of sigma/theta coupling within and between cortex and pons, we were able to uncover the impact of a tonically decreased level of brain monoamines as altered strength and mode of coupling between sigma and theta oscillations. Specifically, a new mode of sigma/theta coupling emerged following lesion, which was specific to NREM sleep, suggests that loss of monoaminergic signaling interferes with NREM sleep consolidation. Our results also indicate an importance of monoamines in control of the sleep spindle and theta rhythm generators.",
journal = "Sleep and Breathing",
title = "Coupling changes in cortical and pontine sigma and theta frequency oscillations following monoaminergic lesions in rat",
number = "1",
volume = "15",
pages = "47",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1330"
}

Kesić, S., Kalauzi, A., Radulovacki, M., Carley, D. W.,& Šaponjić, J.. (2011). Coupling changes in cortical and pontine sigma and theta frequency oscillations following monoaminergic lesions in rat. in Sleep and Breathing, 15(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1330

Kesić S, Kalauzi A, Radulovacki M, Carley DW, Šaponjić J. Coupling changes in cortical and pontine sigma and theta frequency oscillations following monoaminergic lesions in rat. in Sleep and Breathing. 2011;15(1):null-47.
https://hdl.handle.net/21.15107/rcub_ibiss_1330 .

Kesić, Srđan, Kalauzi, Aleksandar, Radulovacki, Miodrag, Carley, David W, Šaponjić, Jasna, "Coupling changes in cortical and pontine sigma and theta frequency oscillations following monoaminergic lesions in rat" in Sleep and Breathing, 15, no. 1 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1330 .