TY  - JOUR
AU  - Vranković, Jelena
AU  - Labus-Blagojević, Svetlana
AU  - Paunović, Momir
PY  - 2011
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/271
AB  - We investigated the expression of CYP1A in the foot, gill and visceral mass of the freshwater clam Corbicula fluminea in relation to polychlorinated biphenyls (PCBs) exposure. Different PCBs congeners were found in the foot and visceral mass, while the expression of CYP1A was observed only in the visceral mass. However the level of CYP1A expression in the visceral mass was not related to the level of PCBs present in the tissue. Our results indicate a higher rate of biotransformation and lower threshold of CYP1A induction in the visceral mass compared with other tissues.
T2  - Archives of Biological Sciences
T1  - Expression of cyp1a protein in the freshwater clam Corbicula fluminea (Müller)
IS  - 1
VL  - 63
SP  - 37
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_271
ER  - 

@article{
author = "Vranković, Jelena and Labus-Blagojević, Svetlana and Paunović, Momir",
year = "2011, 2011",
abstract = "We investigated the expression of CYP1A in the foot, gill and visceral mass of the freshwater clam Corbicula fluminea in relation to polychlorinated biphenyls (PCBs) exposure. Different PCBs congeners were found in the foot and visceral mass, while the expression of CYP1A was observed only in the visceral mass. However the level of CYP1A expression in the visceral mass was not related to the level of PCBs present in the tissue. Our results indicate a higher rate of biotransformation and lower threshold of CYP1A induction in the visceral mass compared with other tissues.",
journal = "Archives of Biological Sciences",
title = "Expression of cyp1a protein in the freshwater clam Corbicula fluminea (Müller)",
number = "1",
volume = "63",
pages = "37-42",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_271"
}

Vranković, J., Labus-Blagojević, S.,& Paunović, M.. (2011). Expression of cyp1a protein in the freshwater clam Corbicula fluminea (Müller). in Archives of Biological Sciences, 63(1), 37-42.
https://hdl.handle.net/21.15107/rcub_ibiss_271

Vranković J, Labus-Blagojević S, Paunović M. Expression of cyp1a protein in the freshwater clam Corbicula fluminea (Müller). in Archives of Biological Sciences. 2011;63(1):37-42.
https://hdl.handle.net/21.15107/rcub_ibiss_271 .

Vranković, Jelena, Labus-Blagojević, Svetlana, Paunović, Momir, "Expression of cyp1a protein in the freshwater clam Corbicula fluminea (Müller)" in Archives of Biological Sciences, 63, no. 1 (2011):37-42,
https://hdl.handle.net/21.15107/rcub_ibiss_271 .

TY  - CONF
AU  - Mihailović, Mirjana
AU  - Petrović, Miodrag
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Vidaković, Melita
AU  - Grigorov, Ilijana
AU  - Bogojević, Desanka
AU  - Ivanović-Matić, Svetlana
AU  - Martinović, Vesna
AU  - Arambašić Jovanović, Jelena
AU  - Joksimović, Danijela
AU  - Mihajlović, Ranđel
AU  - Labus-Blagojević, Svetlana
AU  - Poznanović, Goran
PY  - 2009
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5442
AB  - CYP1A is an established biomarker of fish exposure to PAHs and PCBs. The metallothioneins (MT)constitute a family of Cys-rich proteins that bind a wide range of metals and participate in their uptake,transport and regulation. The aim of this work was to detect changes in CYP1A and MT protein levelsin the hepatopancreas of two commercially important fish species: Mullus barbatus and Merlucciusmerluccius from three different types of locality in the Adriatic Sea (the open sea area of Platamuni,the port of Bar and Valdanos,) in winter. The relative concentration of CYP1A was highest in bothfish species from Bar. Chemical analysis of sea water did not reveal the presence of PAHs. Increasedconcentrations of PCBs were observed only in Bar. A species-specific and higher increase in the proteinconcentration of CYP1A was observed in Mullus barbatus compared to Merluccius merluccius. Thelevels of MT were highest in Merluccius merluccius from Bar and in Mullus barbatus from Valdanos.Induction of MT correlated with elevated concentrations of Pb and Cu, determined by chemicalanalysis of sea water from Valdanos and Bar, respectively. According to the examined parameters, thePlatamuni locality exhibited the lowest level of contamination.
PB  - Novi Sad: LECOTOX
C3  - Programme and Abstracts: 2nd Rep-lecotox workshop: Trends in ecological risk assessment; 2009 Sep 21-23; Novi Sad, Serbia
T1  - The expression of CYP1A and metallothionein in hepatopancreas of Merluccius merluccius and Mullus barbatus from the Adriatic Sea
SP  - 10
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5442
ER  - 

@conference{
author = "Mihailović, Mirjana and Petrović, Miodrag and Grdović, Nevena and Dinić, Svetlana and Uskoković, Aleksandra and Vidaković, Melita and Grigorov, Ilijana and Bogojević, Desanka and Ivanović-Matić, Svetlana and Martinović, Vesna and Arambašić Jovanović, Jelena and Joksimović, Danijela and Mihajlović, Ranđel and Labus-Blagojević, Svetlana and Poznanović, Goran",
year = "2009",
abstract = "CYP1A is an established biomarker of fish exposure to PAHs and PCBs. The metallothioneins (MT)constitute a family of Cys-rich proteins that bind a wide range of metals and participate in their uptake,transport and regulation. The aim of this work was to detect changes in CYP1A and MT protein levelsin the hepatopancreas of two commercially important fish species: Mullus barbatus and Merlucciusmerluccius from three different types of locality in the Adriatic Sea (the open sea area of Platamuni,the port of Bar and Valdanos,) in winter. The relative concentration of CYP1A was highest in bothfish species from Bar. Chemical analysis of sea water did not reveal the presence of PAHs. Increasedconcentrations of PCBs were observed only in Bar. A species-specific and higher increase in the proteinconcentration of CYP1A was observed in Mullus barbatus compared to Merluccius merluccius. Thelevels of MT were highest in Merluccius merluccius from Bar and in Mullus barbatus from Valdanos.Induction of MT correlated with elevated concentrations of Pb and Cu, determined by chemicalanalysis of sea water from Valdanos and Bar, respectively. According to the examined parameters, thePlatamuni locality exhibited the lowest level of contamination.",
publisher = "Novi Sad: LECOTOX",
journal = "Programme and Abstracts: 2nd Rep-lecotox workshop: Trends in ecological risk assessment; 2009 Sep 21-23; Novi Sad, Serbia",
title = "The expression of CYP1A and metallothionein in hepatopancreas of Merluccius merluccius and Mullus barbatus from the Adriatic Sea",
pages = "10",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5442"
}

Mihailović, M., Petrović, M., Grdović, N., Dinić, S., Uskoković, A., Vidaković, M., Grigorov, I., Bogojević, D., Ivanović-Matić, S., Martinović, V., Arambašić Jovanović, J., Joksimović, D., Mihajlović, R., Labus-Blagojević, S.,& Poznanović, G.. (2009). The expression of CYP1A and metallothionein in hepatopancreas of Merluccius merluccius and Mullus barbatus from the Adriatic Sea. in Programme and Abstracts: 2nd Rep-lecotox workshop: Trends in ecological risk assessment; 2009 Sep 21-23; Novi Sad, Serbia
Novi Sad: LECOTOX., 10.
https://hdl.handle.net/21.15107/rcub_ibiss_5442

Mihailović M, Petrović M, Grdović N, Dinić S, Uskoković A, Vidaković M, Grigorov I, Bogojević D, Ivanović-Matić S, Martinović V, Arambašić Jovanović J, Joksimović D, Mihajlović R, Labus-Blagojević S, Poznanović G. The expression of CYP1A and metallothionein in hepatopancreas of Merluccius merluccius and Mullus barbatus from the Adriatic Sea. in Programme and Abstracts: 2nd Rep-lecotox workshop: Trends in ecological risk assessment; 2009 Sep 21-23; Novi Sad, Serbia. 2009;:10.
https://hdl.handle.net/21.15107/rcub_ibiss_5442 .

Mihailović, Mirjana, Petrović, Miodrag, Grdović, Nevena, Dinić, Svetlana, Uskoković, Aleksandra, Vidaković, Melita, Grigorov, Ilijana, Bogojević, Desanka, Ivanović-Matić, Svetlana, Martinović, Vesna, Arambašić Jovanović, Jelena, Joksimović, Danijela, Mihajlović, Ranđel, Labus-Blagojević, Svetlana, Poznanović, Goran, "The expression of CYP1A and metallothionein in hepatopancreas of Merluccius merluccius and Mullus barbatus from the Adriatic Sea" in Programme and Abstracts: 2nd Rep-lecotox workshop: Trends in ecological risk assessment; 2009 Sep 21-23; Novi Sad, Serbia (2009):10,
https://hdl.handle.net/21.15107/rcub_ibiss_5442 .

TY  - CONF
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Bogojević, Desanka
AU  - Grdović, Nevena
AU  - Grigorov, Ilijana
AU  - Ivanović-Matić, Svetlana
AU  - Labus-Blagojević, Svetlana
AU  - Martinović, Vesna
AU  - Mihailović, Mirjana
AU  - Petrović, Miodrag
AU  - Uskoković, Aleksandra
AU  - Vidaković, Melita
AU  - Poznanović, Goran
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5636
AB  - CYP1A is a well-established biomarker of fish exposure to xenobiotics. Polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants in the aquatic environment. They induce a dose-dependent transcriptional induction of CYP1A genes and resulting increased concentrations of proteins. Our aim was to characterize the ecological impact of chemical contaminants in view of their toxicological potential. For that reasons the relative changes of CYP1A concentrations in the hepatopancreas of the Red mullet-Mullus barbatus, European hake-Merluccius merluccius and Tub gurnard-Trigla lucerna were examined in spring, at the mouth of the river Bojana. All species are of considerable commercial importance. In this work chemical analysis of seawater was performed and CYP1A induction was estimated by immunoblot analysis. Chemical analyses of seawater and sediment revealed the presence of anthracene, benzo(A)pyrene, pcb28 and pcb101. CYP1A was detected in the hepatic microsomal fraction in all examined fish species as an adaptive response to the slightly increased concentrations of PAHs and PCBs. It was shown in this study that CYP1A is a sensitive biomarker demonstrating that pollutants entered the organisms and elicited toxic effects at the critical target(s). The apparent initiation of the defense response in fish suggests that the contaminants present in seawater have an ecotoxicological potential. These findings could be interpreted as an early-warning signal for the deleterious effects of the pollutants.
PB  - Podgorica: Centre for Biodiversity of Montenegro
C3  - The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
T1  - The expression of CYP1A in the hepatopanceas of analysed fish species at the mouth of the river Bojana
SP  - 115
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5636
ER  - 

@conference{
author = "Dinić, Svetlana and Arambašić Jovanović, Jelena and Bogojević, Desanka and Grdović, Nevena and Grigorov, Ilijana and Ivanović-Matić, Svetlana and Labus-Blagojević, Svetlana and Martinović, Vesna and Mihailović, Mirjana and Petrović, Miodrag and Uskoković, Aleksandra and Vidaković, Melita and Poznanović, Goran",
year = "2006",
abstract = "CYP1A is a well-established biomarker of fish exposure to xenobiotics. Polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants in the aquatic environment. They induce a dose-dependent transcriptional induction of CYP1A genes and resulting increased concentrations of proteins. Our aim was to characterize the ecological impact of chemical contaminants in view of their toxicological potential. For that reasons the relative changes of CYP1A concentrations in the hepatopancreas of the Red mullet-Mullus barbatus, European hake-Merluccius merluccius and Tub gurnard-Trigla lucerna were examined in spring, at the mouth of the river Bojana. All species are of considerable commercial importance. In this work chemical analysis of seawater was performed and CYP1A induction was estimated by immunoblot analysis. Chemical analyses of seawater and sediment revealed the presence of anthracene, benzo(A)pyrene, pcb28 and pcb101. CYP1A was detected in the hepatic microsomal fraction in all examined fish species as an adaptive response to the slightly increased concentrations of PAHs and PCBs. It was shown in this study that CYP1A is a sensitive biomarker demonstrating that pollutants entered the organisms and elicited toxic effects at the critical target(s). The apparent initiation of the defense response in fish suggests that the contaminants present in seawater have an ecotoxicological potential. These findings could be interpreted as an early-warning signal for the deleterious effects of the pollutants.",
publisher = "Podgorica: Centre for Biodiversity of Montenegro",
journal = "The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro",
title = "The expression of CYP1A in the hepatopanceas of analysed fish species at the mouth of the river Bojana",
pages = "115",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5636"
}

Dinić, S., Arambašić Jovanović, J., Bogojević, D., Grdović, N., Grigorov, I., Ivanović-Matić, S., Labus-Blagojević, S., Martinović, V., Mihailović, M., Petrović, M., Uskoković, A., Vidaković, M.,& Poznanović, G.. (2006). The expression of CYP1A in the hepatopanceas of analysed fish species at the mouth of the river Bojana. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
Podgorica: Centre for Biodiversity of Montenegro., 115.
https://hdl.handle.net/21.15107/rcub_ibiss_5636

Dinić S, Arambašić Jovanović J, Bogojević D, Grdović N, Grigorov I, Ivanović-Matić S, Labus-Blagojević S, Martinović V, Mihailović M, Petrović M, Uskoković A, Vidaković M, Poznanović G. The expression of CYP1A in the hepatopanceas of analysed fish species at the mouth of the river Bojana. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro. 2006;:115.
https://hdl.handle.net/21.15107/rcub_ibiss_5636 .

Dinić, Svetlana, Arambašić Jovanović, Jelena, Bogojević, Desanka, Grdović, Nevena, Grigorov, Ilijana, Ivanović-Matić, Svetlana, Labus-Blagojević, Svetlana, Martinović, Vesna, Mihailović, Mirjana, Petrović, Miodrag, Uskoković, Aleksandra, Vidaković, Melita, Poznanović, Goran, "The expression of CYP1A in the hepatopanceas of analysed fish species at the mouth of the river Bojana" in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro (2006):115,
https://hdl.handle.net/21.15107/rcub_ibiss_5636 .

TY  - JOUR
AU  - Bogojević, Desanka
AU  - Grigorov, Ilijana
AU  - Vidaković, Melita
AU  - Ivanović Matić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Labus-Blagojević, Svetlana
AU  - Grdović, Nevena
AU  - Martinović, Vesna
AU  - Mihailović, Mirjana
AU  - Petrović, Miodrag
AU  - Poznanović, Goran
AU  - Uskoković, Aleksandra
AU  - Dinić, Svetlana
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/136
AB  - The expression of CYP1A, a biomarker for the presence of xenobiotic compounds, was examined in three fish species from the wider vicinity of Bar harbor in winter and spring. Induction of CYP1A was observed in winter and increased further in spring. Several PCBs were found in seawater in winter. They decreased below the limit of detection in spring, when the PAH fluorene was detected. It is concluded that the constant presence of CYP1A expression is probably due to pollutants in the environment, whereas increased expression of CYP1A in spring results from exposure of the fish to fluorene.
AB  - Ekspresija CYP1A, biomarkera na prisustvo ksenobiotika, posmatrana je u tri vrste riba ulovljenih sa šireg lokaliteta barske luke tokom zime i proleća. Indukcija CYP1A koja je uočena u zimskom periodu, dodatno je uvećana u prolećnom. Nekoliko PCB koji su pronađeni u morskoj vodi tokom zime, nije detektovano u proleće kada je otkriven PAH fluoren. Zaključeno je da je stalno prisustvo ekspresije CYP1A najverovatnije posledica prisustva polutanata u životnoj sredini; dodatno uvećanje ekspresije CYP1A u proleće posledica je izlaganja riba fluorenu.
T2  - Archives of Biological Sciences
T1  - Ekspresija CYP1A u hepatopankreasu Merluccius merluccius, Trigla lucerna i Liza ramada (pisces) u širem regionu luke Bar, Crna Gora
T1  - Expression of CYP1A in the hepatopancreas of Merluccius merluccius, Trigla lucerna, and Liza ramada (pisces) in the wider vicinity of Bar harbor Montenegro
IS  - 3
VL  - 58
DO  - 10.2298/ABS0603165M
SP  - 165
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_136
ER  - 

@article{
author = "Bogojević, Desanka and Grigorov, Ilijana and Vidaković, Melita and Ivanović Matić, Svetlana and Arambašić Jovanović, Jelena and Labus-Blagojević, Svetlana and Grdović, Nevena and Martinović, Vesna and Mihailović, Mirjana and Petrović, Miodrag and Poznanović, Goran and Uskoković, Aleksandra and Dinić, Svetlana",
year = "2006",
abstract = "The expression of CYP1A, a biomarker for the presence of xenobiotic compounds, was examined in three fish species from the wider vicinity of Bar harbor in winter and spring. Induction of CYP1A was observed in winter and increased further in spring. Several PCBs were found in seawater in winter. They decreased below the limit of detection in spring, when the PAH fluorene was detected. It is concluded that the constant presence of CYP1A expression is probably due to pollutants in the environment, whereas increased expression of CYP1A in spring results from exposure of the fish to fluorene., Ekspresija CYP1A, biomarkera na prisustvo ksenobiotika, posmatrana je u tri vrste riba ulovljenih sa šireg lokaliteta barske luke tokom zime i proleća. Indukcija CYP1A koja je uočena u zimskom periodu, dodatno je uvećana u prolećnom. Nekoliko PCB koji su pronađeni u morskoj vodi tokom zime, nije detektovano u proleće kada je otkriven PAH fluoren. Zaključeno je da je stalno prisustvo ekspresije CYP1A najverovatnije posledica prisustva polutanata u životnoj sredini; dodatno uvećanje ekspresije CYP1A u proleće posledica je izlaganja riba fluorenu.",
journal = "Archives of Biological Sciences",
title = "Ekspresija CYP1A u hepatopankreasu Merluccius merluccius, Trigla lucerna i Liza ramada (pisces) u širem regionu luke Bar, Crna Gora, Expression of CYP1A in the hepatopancreas of Merluccius merluccius, Trigla lucerna, and Liza ramada (pisces) in the wider vicinity of Bar harbor Montenegro",
number = "3",
volume = "58",
doi = "10.2298/ABS0603165M",
pages = "165-170",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_136"
}

Bogojević, D., Grigorov, I., Vidaković, M., Ivanović Matić, S., Arambašić Jovanović, J., Labus-Blagojević, S., Grdović, N., Martinović, V., Mihailović, M., Petrović, M., Poznanović, G., Uskoković, A.,& Dinić, S.. (2006). Ekspresija CYP1A u hepatopankreasu Merluccius merluccius, Trigla lucerna i Liza ramada (pisces) u širem regionu luke Bar, Crna Gora. in Archives of Biological Sciences, 58(3), 165-170.
https://doi.org/10.2298/ABS0603165M
https://hdl.handle.net/21.15107/rcub_ibiss_136

Bogojević D, Grigorov I, Vidaković M, Ivanović Matić S, Arambašić Jovanović J, Labus-Blagojević S, Grdović N, Martinović V, Mihailović M, Petrović M, Poznanović G, Uskoković A, Dinić S. Ekspresija CYP1A u hepatopankreasu Merluccius merluccius, Trigla lucerna i Liza ramada (pisces) u širem regionu luke Bar, Crna Gora. in Archives of Biological Sciences. 2006;58(3):165-170.
doi:10.2298/ABS0603165M
https://hdl.handle.net/21.15107/rcub_ibiss_136 .

Bogojević, Desanka, Grigorov, Ilijana, Vidaković, Melita, Ivanović Matić, Svetlana, Arambašić Jovanović, Jelena, Labus-Blagojević, Svetlana, Grdović, Nevena, Martinović, Vesna, Mihailović, Mirjana, Petrović, Miodrag, Poznanović, Goran, Uskoković, Aleksandra, Dinić, Svetlana, "Ekspresija CYP1A u hepatopankreasu Merluccius merluccius, Trigla lucerna i Liza ramada (pisces) u širem regionu luke Bar, Crna Gora" in Archives of Biological Sciences, 58, no. 3 (2006):165-170,
https://doi.org/10.2298/ABS0603165M .,
https://hdl.handle.net/21.15107/rcub_ibiss_136 .