TY  - JOUR
AU  - Ristic, Aleksandar J.
AU  - Sokic, Dragoslav
AU  - Bascarevic, Vladimir
AU  - Spasic, Snezana
AU  - Vojvodic, Nikola
AU  - Savic, Slobodan
AU  - Raicevic, Savo
AU  - Kovacevic, Masa
AU  - Savić, Danijela
AU  - Spasojevic, Ivan
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2214
AB  - An altered metal and electrolyte profile has been implicated in the
   pathologic mechanisms of chronic epilepsy; however, no study has
   comprehensively measured hippocampal concentrations of these elements in
   patients with mesial temporal lobe epilepsy and hippocampal sclerosis
   (mTLE-HS). We therefore analyzed hippocampi of 24 patients with
   drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior
   temporal lobe resection and amygdalohippocampectomy and 17 hippocampi
   obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years),
   using inductively coupled plasma optical emission spectrometry
   (ICP-OES). Epileptic hippocampi showed significantly lower
   concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control
   {[}C]: 3.57 +/- 0.33; p<0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409
   +/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61;
   p<0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/-
   25; p=0.010). Zinc, iron, calcium, and magnesium levels did not differ
   in HS and controls. In summary, copper and manganese levels are
   deficient, whereas iron level is unchanged in hippocampi from patients
   with mTLE-HS. Our results provide a basis for understanding the
   potential involvement of different metals and electrolytes in the
   pathology of HS. A PowerPoint slide summarizing this article is
   available for download in the Supporting Information section .
T2  - Epilepsia
T1  - Metals and electrolytes in sclerotic hippocampi in patients with
 drug-resistant mesial temporal lobe epilepsy
IS  - 5
VL  - 55
DO  - 10.1111/epi.12593
SP  - E34
EP  - E37
ER  - 

@article{
author = "Ristic, Aleksandar J. and Sokic, Dragoslav and Bascarevic, Vladimir and Spasic, Snezana and Vojvodic, Nikola and Savic, Slobodan and Raicevic, Savo and Kovacevic, Masa and Savić, Danijela and Spasojevic, Ivan",
year = "2014",
abstract = "An altered metal and electrolyte profile has been implicated in the
   pathologic mechanisms of chronic epilepsy; however, no study has
   comprehensively measured hippocampal concentrations of these elements in
   patients with mesial temporal lobe epilepsy and hippocampal sclerosis
   (mTLE-HS). We therefore analyzed hippocampi of 24 patients with
   drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior
   temporal lobe resection and amygdalohippocampectomy and 17 hippocampi
   obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years),
   using inductively coupled plasma optical emission spectrometry
   (ICP-OES). Epileptic hippocampi showed significantly lower
   concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control
   {[}C]: 3.57 +/- 0.33; p<0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409
   +/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61;
   p<0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/-
   25; p=0.010). Zinc, iron, calcium, and magnesium levels did not differ
   in HS and controls. In summary, copper and manganese levels are
   deficient, whereas iron level is unchanged in hippocampi from patients
   with mTLE-HS. Our results provide a basis for understanding the
   potential involvement of different metals and electrolytes in the
   pathology of HS. A PowerPoint slide summarizing this article is
   available for download in the Supporting Information section .",
journal = "Epilepsia",
title = "Metals and electrolytes in sclerotic hippocampi in patients with
 drug-resistant mesial temporal lobe epilepsy",
number = "5",
volume = "55",
doi = "10.1111/epi.12593",
pages = "E34-E37"
}

Ristic, A. J., Sokic, D., Bascarevic, V., Spasic, S., Vojvodic, N., Savic, S., Raicevic, S., Kovacevic, M., Savić, D.,& Spasojevic, I.. (2014). Metals and electrolytes in sclerotic hippocampi in patients with
 drug-resistant mesial temporal lobe epilepsy. in Epilepsia, 55(5), E34-E37.
https://doi.org/10.1111/epi.12593

Ristic AJ, Sokic D, Bascarevic V, Spasic S, Vojvodic N, Savic S, Raicevic S, Kovacevic M, Savić D, Spasojevic I. Metals and electrolytes in sclerotic hippocampi in patients with
 drug-resistant mesial temporal lobe epilepsy. in Epilepsia. 2014;55(5):E34-E37.
doi:10.1111/epi.12593 .

Ristic, Aleksandar J., Sokic, Dragoslav, Bascarevic, Vladimir, Spasic, Snezana, Vojvodic, Nikola, Savic, Slobodan, Raicevic, Savo, Kovacevic, Masa, Savić, Danijela, Spasojevic, Ivan, "Metals and electrolytes in sclerotic hippocampi in patients with
 drug-resistant mesial temporal lobe epilepsy" in Epilepsia, 55, no. 5 (2014):E34-E37,
https://doi.org/10.1111/epi.12593 . .