TY  - JOUR
AU  - Drakulic, Dunja
AU  - Stanojlovic, Milos
AU  - Nedeljkovic, Nadezda
AU  - Grkovic, Ivana
AU  - Velickovic, Natasa
AU  - Gusevac, Ivana
AU  - Mitrovic, Natasa
AU  - Buzadzic, Ivana
AU  - Horvat, Anica
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1982
AB  - Although dexamethasone (DEX), a synthetic glucocorticoid receptor (GR)
   analog with profound effects on energy metabolism, immune system, and
   hypothalamic-pituitary-adrenal axis, is widely used therapeutically, its
   impact on the brain is poorly understood. The aim of the present study
   was to explore the effect of repeated low-dose DEX administration on the
   activity and expression of the ectonucleotidase enzymes which hydrolyze
   and therefore control extracellular ATP and adenosine concentrations in
   the synaptic cleft. Ectonucleotidases tested were ectonucleoside
   triphosphate diphosphohydrolase 1-3 (NTPDase1-3) and
   ecto-5'-nucleotidase (eN), whereas the effects were evaluated in two
   brain areas that show different sensitivity to glucocorticoid action,
   hippocampus, and cerebral cortex. In the hippocampus, but not in
   cerebral cortex, modest level of neurodegenerative changes as well as
   increase in ATP, ADP, and AMP hydrolysis and upregulation of NTPDase1
   and eN mRNA expression ensued under the influence of DEX. The observed
   pattern of ectonucleotidase activation, which creates tissue volume with
   enhanced capacity for adenosine formation, is the hallmark of the
   response after different insults to the brain.
T2  - Journal of Molecular Neuroscience
T1  - Upregulation of Nucleoside Triphosphate Diphosphohydrolase-1 and
 Ecto-5'-Nucleotidase in Rat Hippocampus after Repeated Low-Dose
 Dexamethasone Administration
IS  - 4
VL  - 55
DO  - 10.1007/s12031-014-0452-y
SP  - 959
EP  - 967
ER  - 

@article{
author = "Drakulic, Dunja and Stanojlovic, Milos and Nedeljkovic, Nadezda and Grkovic, Ivana and Velickovic, Natasa and Gusevac, Ivana and Mitrovic, Natasa and Buzadzic, Ivana and Horvat, Anica",
year = "2015",
abstract = "Although dexamethasone (DEX), a synthetic glucocorticoid receptor (GR)
   analog with profound effects on energy metabolism, immune system, and
   hypothalamic-pituitary-adrenal axis, is widely used therapeutically, its
   impact on the brain is poorly understood. The aim of the present study
   was to explore the effect of repeated low-dose DEX administration on the
   activity and expression of the ectonucleotidase enzymes which hydrolyze
   and therefore control extracellular ATP and adenosine concentrations in
   the synaptic cleft. Ectonucleotidases tested were ectonucleoside
   triphosphate diphosphohydrolase 1-3 (NTPDase1-3) and
   ecto-5'-nucleotidase (eN), whereas the effects were evaluated in two
   brain areas that show different sensitivity to glucocorticoid action,
   hippocampus, and cerebral cortex. In the hippocampus, but not in
   cerebral cortex, modest level of neurodegenerative changes as well as
   increase in ATP, ADP, and AMP hydrolysis and upregulation of NTPDase1
   and eN mRNA expression ensued under the influence of DEX. The observed
   pattern of ectonucleotidase activation, which creates tissue volume with
   enhanced capacity for adenosine formation, is the hallmark of the
   response after different insults to the brain.",
journal = "Journal of Molecular Neuroscience",
title = "Upregulation of Nucleoside Triphosphate Diphosphohydrolase-1 and
 Ecto-5'-Nucleotidase in Rat Hippocampus after Repeated Low-Dose
 Dexamethasone Administration",
number = "4",
volume = "55",
doi = "10.1007/s12031-014-0452-y",
pages = "959-967"
}

Drakulic, D., Stanojlovic, M., Nedeljkovic, N., Grkovic, I., Velickovic, N., Gusevac, I., Mitrovic, N., Buzadzic, I.,& Horvat, A.. (2015). Upregulation of Nucleoside Triphosphate Diphosphohydrolase-1 and
 Ecto-5'-Nucleotidase in Rat Hippocampus after Repeated Low-Dose
 Dexamethasone Administration. in Journal of Molecular Neuroscience, 55(4), 959-967.
https://doi.org/10.1007/s12031-014-0452-y

Drakulic D, Stanojlovic M, Nedeljkovic N, Grkovic I, Velickovic N, Gusevac I, Mitrovic N, Buzadzic I, Horvat A. Upregulation of Nucleoside Triphosphate Diphosphohydrolase-1 and
 Ecto-5'-Nucleotidase in Rat Hippocampus after Repeated Low-Dose
 Dexamethasone Administration. in Journal of Molecular Neuroscience. 2015;55(4):959-967.
doi:10.1007/s12031-014-0452-y .

Drakulic, Dunja, Stanojlovic, Milos, Nedeljkovic, Nadezda, Grkovic, Ivana, Velickovic, Natasa, Gusevac, Ivana, Mitrovic, Natasa, Buzadzic, Ivana, Horvat, Anica, "Upregulation of Nucleoside Triphosphate Diphosphohydrolase-1 and
 Ecto-5'-Nucleotidase in Rat Hippocampus after Repeated Low-Dose
 Dexamethasone Administration" in Journal of Molecular Neuroscience, 55, no. 4 (2015):959-967,
https://doi.org/10.1007/s12031-014-0452-y . .