TY  - JOUR
AU  - Mirkov, Ivana
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Malešević, Anastasija
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6305
AB  - The importance of issues associated with urban/commensal rats and mice (property damage, management costs,
and health risks) press upon research on these animals. While the demography of commensal rodents is mostly
studied, the need for understanding factors influencing their natural morbidity/mortality is also stressed. In this
respect, more attention is expected to be paid to immunity, the physiological mechanism of defense against host
survival threats (pathogens, parasites, diseases). Commensal rats and mice carry numerous pathogens that evoke
diverse immune responses. The state of immunity in commensal house mice is studied in great detail, owing to
the use of laboratory strains in biomedical research. Because commensal rats are, compared to mice, carriers
of more zoonotic agents, rats’ immunity is studied mainly in that context. Some of these zoonotic agents cause
chronic, asymptomatic infections, which justified studies of immunological mechanisms of pathogen tolerance
versus clearance regulation in rats. Occurrence of some infections in specific tissues/organs pressed upon analysis
of local/regional immune responses and/or immunopathology. A survey of immunological activity/responses in
commensal rats is given in this review, with mention of existing data in commensal mice. It should throw some
light on the factors relevant to their morbidity and lifespan, supplementing the knowledge of commensal rodent
ecology.
PB  - John Wiley and Sons
T2  - Integrative Zoology
T1  - Physiological strategies in wild rodents: immune defenses of commensal rats
DO  - 10.1111/1749-4877.12766
SP  - 1
EP  - 21
ER  - 

@article{
author = "Mirkov, Ivana and Tucović, Dina and Kulaš, Jelena and Malešević, Anastasija and Kataranovski, Dragan and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2023",
abstract = "The importance of issues associated with urban/commensal rats and mice (property damage, management costs,
and health risks) press upon research on these animals. While the demography of commensal rodents is mostly
studied, the need for understanding factors influencing their natural morbidity/mortality is also stressed. In this
respect, more attention is expected to be paid to immunity, the physiological mechanism of defense against host
survival threats (pathogens, parasites, diseases). Commensal rats and mice carry numerous pathogens that evoke
diverse immune responses. The state of immunity in commensal house mice is studied in great detail, owing to
the use of laboratory strains in biomedical research. Because commensal rats are, compared to mice, carriers
of more zoonotic agents, rats’ immunity is studied mainly in that context. Some of these zoonotic agents cause
chronic, asymptomatic infections, which justified studies of immunological mechanisms of pathogen tolerance
versus clearance regulation in rats. Occurrence of some infections in specific tissues/organs pressed upon analysis
of local/regional immune responses and/or immunopathology. A survey of immunological activity/responses in
commensal rats is given in this review, with mention of existing data in commensal mice. It should throw some
light on the factors relevant to their morbidity and lifespan, supplementing the knowledge of commensal rodent
ecology.",
publisher = "John Wiley and Sons",
journal = "Integrative Zoology",
title = "Physiological strategies in wild rodents: immune defenses of commensal rats",
doi = "10.1111/1749-4877.12766",
pages = "1-21"
}

Mirkov, I., Tucović, D., Kulaš, J., Malešević, A., Kataranovski, D., Kataranovski, M.,& Popov Aleksandrov, A.. (2023). Physiological strategies in wild rodents: immune defenses of commensal rats. in Integrative Zoology
John Wiley and Sons., 1-21.
https://doi.org/10.1111/1749-4877.12766

Mirkov I, Tucović D, Kulaš J, Malešević A, Kataranovski D, Kataranovski M, Popov Aleksandrov A. Physiological strategies in wild rodents: immune defenses of commensal rats. in Integrative Zoology. 2023;:1-21.
doi:10.1111/1749-4877.12766 .

Mirkov, Ivana, Tucović, Dina, Kulaš, Jelena, Malešević, Anastasija, Kataranovski, Dragan, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Physiological strategies in wild rodents: immune defenses of commensal rats" in Integrative Zoology (2023):1-21,
https://doi.org/10.1111/1749-4877.12766 . .

TY  - CONF
AU  - Popović, Dušanka
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Malešević, Anastasija
AU  - Glamočlija, Jasmina
AU  - Soković Bajić, Svetlana
AU  - Brdarić, Emilija
AU  - Tolinački, Maja
AU  - Golić, Nataša
PY  - 2023
UR  - https://probiotics-prebiotics-newfood.com/wp-content/uploads/2023/09/Pogramme-web-07_09_2023.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6166
AB  - Objective:
The little data of the effect of pulmonary fungal infection on lung and
gut microbiota exist, thus aim of our study was to examine the effect of
Aspergillus fumigatus infection on bacterial homestasis in these organs in
Dark Agouti (DA) and Albino Oxford (AO) rats known to develop different
immune responce to the fungus.
Methods:
16S rRNA amplicon sequencing of the V3-V4 hypervariable region.
Enzyme-linked immunosorbent assay for cytokine content (IL-10, IL-6, TNF,
IL-1beta, IL-17 i IFN-gamma) in lung and gut homogenats, and plasma (IL-
6, IL-17, TNF). Myeloperoxidase, catalase, glutathione S-transferase and
content of reduced glutathione in lung homogenates.
Results:
No initial differences in lung bacterial microbiota between healthy DA
and AO rats exists, but A. fumigatus infection resulted in increase in
alpha diversity (without effect on bacterial composition) in both strains.
Changes in relative abundance at genus and species level were expressed
differently (increased in DA, decreased in AO). Dysbiosis in lung coincided
with increase of IFN-gamma, IL-17 and MPO in both strains, and increase
oxidative stress solely in DA. Gut inflammation was noted in both strains,
while bacterial dysbiosis only in DA.
Conclusions:
Pulmonary fungal infection resulted in bacterial dysbiosis in lung (in both
rat strains), and gut (solely in DA). Noted lung and gut inflammation in
these two rat strains, coexisted with different effects on bacterial
homeostasis, which could be due to different genetic background or
bacterial composition prior infection.
PB  - Roma: EMEC
C3  - 12th Probiotics, Prebiotics and New Foods: Nutraceuticals, Botanicals and Phytochemicals for Nutrition and Human, ANimal and Microbiota Health: 3rd Science and Business Symposium; 2023  Sep 16-19; Rome, Italy
T1  - The effect of pulmonary infection with Aspergillus fumigatus on lung and gut microbiota in Dark Agouti and Albino Oxford rats
SP  - 90
EP  - 90
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6166
ER  - 

@conference{
author = "Popović, Dušanka and Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Tucović, Dina and Kulaš, Jelena and Malešević, Anastasija and Glamočlija, Jasmina and Soković Bajić, Svetlana and Brdarić, Emilija and Tolinački, Maja and Golić, Nataša",
year = "2023",
abstract = "Objective:
The little data of the effect of pulmonary fungal infection on lung and
gut microbiota exist, thus aim of our study was to examine the effect of
Aspergillus fumigatus infection on bacterial homestasis in these organs in
Dark Agouti (DA) and Albino Oxford (AO) rats known to develop different
immune responce to the fungus.
Methods:
16S rRNA amplicon sequencing of the V3-V4 hypervariable region.
Enzyme-linked immunosorbent assay for cytokine content (IL-10, IL-6, TNF,
IL-1beta, IL-17 i IFN-gamma) in lung and gut homogenats, and plasma (IL-
6, IL-17, TNF). Myeloperoxidase, catalase, glutathione S-transferase and
content of reduced glutathione in lung homogenates.
Results:
No initial differences in lung bacterial microbiota between healthy DA
and AO rats exists, but A. fumigatus infection resulted in increase in
alpha diversity (without effect on bacterial composition) in both strains.
Changes in relative abundance at genus and species level were expressed
differently (increased in DA, decreased in AO). Dysbiosis in lung coincided
with increase of IFN-gamma, IL-17 and MPO in both strains, and increase
oxidative stress solely in DA. Gut inflammation was noted in both strains,
while bacterial dysbiosis only in DA.
Conclusions:
Pulmonary fungal infection resulted in bacterial dysbiosis in lung (in both
rat strains), and gut (solely in DA). Noted lung and gut inflammation in
these two rat strains, coexisted with different effects on bacterial
homeostasis, which could be due to different genetic background or
bacterial composition prior infection.",
publisher = "Roma: EMEC",
journal = "12th Probiotics, Prebiotics and New Foods: Nutraceuticals, Botanicals and Phytochemicals for Nutrition and Human, ANimal and Microbiota Health: 3rd Science and Business Symposium; 2023  Sep 16-19; Rome, Italy",
title = "The effect of pulmonary infection with Aspergillus fumigatus on lung and gut microbiota in Dark Agouti and Albino Oxford rats",
pages = "90-90",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6166"
}

Popović, D., Mirkov, I., Popov Aleksandrov, A., Tucović, D., Kulaš, J., Malešević, A., Glamočlija, J., Soković Bajić, S., Brdarić, E., Tolinački, M.,& Golić, N.. (2023). The effect of pulmonary infection with Aspergillus fumigatus on lung and gut microbiota in Dark Agouti and Albino Oxford rats. in 12th Probiotics, Prebiotics and New Foods: Nutraceuticals, Botanicals and Phytochemicals for Nutrition and Human, ANimal and Microbiota Health: 3rd Science and Business Symposium; 2023  Sep 16-19; Rome, Italy
Roma: EMEC., 90-90.
https://hdl.handle.net/21.15107/rcub_ibiss_6166

Popović D, Mirkov I, Popov Aleksandrov A, Tucović D, Kulaš J, Malešević A, Glamočlija J, Soković Bajić S, Brdarić E, Tolinački M, Golić N. The effect of pulmonary infection with Aspergillus fumigatus on lung and gut microbiota in Dark Agouti and Albino Oxford rats. in 12th Probiotics, Prebiotics and New Foods: Nutraceuticals, Botanicals and Phytochemicals for Nutrition and Human, ANimal and Microbiota Health: 3rd Science and Business Symposium; 2023  Sep 16-19; Rome, Italy. 2023;:90-90.
https://hdl.handle.net/21.15107/rcub_ibiss_6166 .

Popović, Dušanka, Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Tucović, Dina, Kulaš, Jelena, Malešević, Anastasija, Glamočlija, Jasmina, Soković Bajić, Svetlana, Brdarić, Emilija, Tolinački, Maja, Golić, Nataša, "The effect of pulmonary infection with Aspergillus fumigatus on lung and gut microbiota in Dark Agouti and Albino Oxford rats" in 12th Probiotics, Prebiotics and New Foods: Nutraceuticals, Botanicals and Phytochemicals for Nutrition and Human, ANimal and Microbiota Health: 3rd Science and Business Symposium; 2023  Sep 16-19; Rome, Italy (2023):90-90,
https://hdl.handle.net/21.15107/rcub_ibiss_6166 .