TY  - JOUR
AU  - Gašić, Uroš
AU  - Ćirić, Ivanka
AU  - Pejčić, Tomislav
AU  - Radenković, Dejan
AU  - Đorđević, Vladimir
AU  - Radulović, Siniša
AU  - Tešić, Živoslav
PY  - 2020
UR  - https://www.mdpi.com/2076-3921/9/6/547
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32585831
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC7346180
UR  - https://radar.ibiss.bg.ac.rs/123456789/3891
AB  - Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
PB  - MDPI AG
T2  - Antioxidants (Basel, Switzerland)
T1  - Polyphenols as Possible Agents for Pancreatic Diseases.
IS  - 6
VL  - 9
DO  - 10.3390/antiox9060547
SP  - 547
ER  - 

@article{
author = "Gašić, Uroš and Ćirić, Ivanka and Pejčić, Tomislav and Radenković, Dejan and Đorđević, Vladimir and Radulović, Siniša and Tešić, Živoslav",
year = "2020",
abstract = "Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.",
publisher = "MDPI AG",
journal = "Antioxidants (Basel, Switzerland)",
title = "Polyphenols as Possible Agents for Pancreatic Diseases.",
number = "6",
volume = "9",
doi = "10.3390/antiox9060547",
pages = "547"
}

Gašić, U., Ćirić, I., Pejčić, T., Radenković, D., Đorđević, V., Radulović, S.,& Tešić, Ž.. (2020). Polyphenols as Possible Agents for Pancreatic Diseases.. in Antioxidants (Basel, Switzerland)
MDPI AG., 9(6), 547.
https://doi.org/10.3390/antiox9060547

Gašić U, Ćirić I, Pejčić T, Radenković D, Đorđević V, Radulović S, Tešić Ž. Polyphenols as Possible Agents for Pancreatic Diseases.. in Antioxidants (Basel, Switzerland). 2020;9(6):547.
doi:10.3390/antiox9060547 .

Gašić, Uroš, Ćirić, Ivanka, Pejčić, Tomislav, Radenković, Dejan, Đorđević, Vladimir, Radulović, Siniša, Tešić, Živoslav, "Polyphenols as Possible Agents for Pancreatic Diseases." in Antioxidants (Basel, Switzerland), 9, no. 6 (2020):547,
https://doi.org/10.3390/antiox9060547 . .

TY  - JOUR
AU  - Devrnja, Nina
AU  - Anđelković, Boban
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Soković, Marina
AU  - Krstić Milošević, Dijana
AU  - Ristić, Mihailo
AU  - Ćalić, Dušica
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0254629916339928
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2721
AB  - Chemical composition of essential oil (EO) and methanol extracts (MEs) from different parts of Tanacetum vulgare L. plant was analyzed and investigated for potential biological activities and correlated with the main constituents detected in EO and MEs. The EO was characterized by a high content of oxygenated monoterpenes with trans-chrysanthenyl acetate as major compound. All MEs were characterized by neochlorogenic, 3,5-O-dicaffeoylquinic and caffeoylquinic acids. High phenolic content in MEs correlated to high antioxidant capacity, especially for roots. Tansy EO showed strong activity against the most of tested fungi and was efficient as bifonazole and ketoconazole, while the most sensitive bacteria were Gram-negative E. coli and E. cloacae. All MEs showed fungistatic and fungicidal effects against all of the eight tested fungi, but the antimicrobial activity was higher against Gram-positive bacteria. Additionally, shown for the first time, MEs of leaves and flowers exhibited a strong antiproliferative effect on human cervical adenocarcinoma (HeLa) cells, causing cell shrinkage and detachment. In the present study, the Tansy extracts and essential oil with low thujone content can provide a very promising and effective alternative in the field of antimicrobial applications and food preservation. The Tansy MEs possess a high antioxidant potential with phenolic acids being a major radical scavenging contributor with the proved antiproliferative activity to HeLa cells.
T2  - South African Journal of Botany
T1  - Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts
VL  - 111
DO  - 10.1016/j.sajb.2017.03.028
SP  - 212
EP  - 221
ER  - 

@article{
author = "Devrnja, Nina and Anđelković, Boban and Aranđelović, Sandra and Radulović, Siniša and Soković, Marina and Krstić Milošević, Dijana and Ristić, Mihailo and Ćalić, Dušica",
year = "2017",
abstract = "Chemical composition of essential oil (EO) and methanol extracts (MEs) from different parts of Tanacetum vulgare L. plant was analyzed and investigated for potential biological activities and correlated with the main constituents detected in EO and MEs. The EO was characterized by a high content of oxygenated monoterpenes with trans-chrysanthenyl acetate as major compound. All MEs were characterized by neochlorogenic, 3,5-O-dicaffeoylquinic and caffeoylquinic acids. High phenolic content in MEs correlated to high antioxidant capacity, especially for roots. Tansy EO showed strong activity against the most of tested fungi and was efficient as bifonazole and ketoconazole, while the most sensitive bacteria were Gram-negative E. coli and E. cloacae. All MEs showed fungistatic and fungicidal effects against all of the eight tested fungi, but the antimicrobial activity was higher against Gram-positive bacteria. Additionally, shown for the first time, MEs of leaves and flowers exhibited a strong antiproliferative effect on human cervical adenocarcinoma (HeLa) cells, causing cell shrinkage and detachment. In the present study, the Tansy extracts and essential oil with low thujone content can provide a very promising and effective alternative in the field of antimicrobial applications and food preservation. The Tansy MEs possess a high antioxidant potential with phenolic acids being a major radical scavenging contributor with the proved antiproliferative activity to HeLa cells.",
journal = "South African Journal of Botany",
title = "Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts",
volume = "111",
doi = "10.1016/j.sajb.2017.03.028",
pages = "212-221"
}

Devrnja, N., Anđelković, B., Aranđelović, S., Radulović, S., Soković, M., Krstić Milošević, D., Ristić, M.,& Ćalić, D.. (2017). Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts. in South African Journal of Botany, 111, 212-221.
https://doi.org/10.1016/j.sajb.2017.03.028

Devrnja N, Anđelković B, Aranđelović S, Radulović S, Soković M, Krstić Milošević D, Ristić M, Ćalić D. Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts. in South African Journal of Botany. 2017;111:212-221.
doi:10.1016/j.sajb.2017.03.028 .

Devrnja, Nina, Anđelković, Boban, Aranđelović, Sandra, Radulović, Siniša, Soković, Marina, Krstić Milošević, Dijana, Ristić, Mihailo, Ćalić, Dušica, "Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts" in South African Journal of Botany, 111 (2017):212-221,
https://doi.org/10.1016/j.sajb.2017.03.028 . .

TY  - JOUR
AU  - Skorić, Marijana
AU  - Gligorijević, Nevenka
AU  - Čavić, Milena
AU  - Todorović, Slađana
AU  - Janković, Radmila
AU  - Ristić, Mihailo
AU  - Mišić, Danijela
AU  - Radulović, Siniša
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0926669017301309
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2609
AB  - Nepeta rtanjensis Diklić & Milojević (fam. Lamiaceae) is an endemic, critically endangered plant, protected by the law in Serbia. Various biological activities have been ascribed to its major constituents, nepetalactones. In this study we describe for the first time cytotoxic activity of N. rtanjensis essential oil (EO), obtained from field cultivated plants, which was found to be especially rich in trans,cis-nepetalactone. MTT assays indicated that after 72 h of treatment the EO exhibited cytotoxic activity on investigated cancer cell lines: HeLa, K562, A549, LS-174 and MDA-MB-231. Normal cell line (MRC-5) was the least sensitive to the treatment and IC50 value for this cell line was not reached within the tested range of EO concentrations (up to 0.1 μL/mL). Analysis of morphological changes of treated cells confirmed the higher sensitivity of tumor cells than normal cells to the tested EO. Application of N. rtanjensis EO resulted in the appearance of morphological changes in tested cancer cell lines characteristic for apoptotic cell death, and induced perturbations of the cell cycle of HeLa cells. In addition, upregulation of Bax and p53, and downregulation of Bcl-2, and Skp2 genes, involved in apoptotic signalling cascades, confirmed an apoptosis-inducing effect of N. rtanjensis EO on HeLa cells. Presented results highlighted the potential of N. rtanjensis EO in anticancer therapy.
T2  - Industrial Crops and Products
T1  - Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action
VL  - 100
DO  - 10.1016/j.indcrop.2017.02.027
SP  - 163
EP  - 170
ER  - 

@article{
author = "Skorić, Marijana and Gligorijević, Nevenka and Čavić, Milena and Todorović, Slađana and Janković, Radmila and Ristić, Mihailo and Mišić, Danijela and Radulović, Siniša",
year = "2017",
abstract = "Nepeta rtanjensis Diklić & Milojević (fam. Lamiaceae) is an endemic, critically endangered plant, protected by the law in Serbia. Various biological activities have been ascribed to its major constituents, nepetalactones. In this study we describe for the first time cytotoxic activity of N. rtanjensis essential oil (EO), obtained from field cultivated plants, which was found to be especially rich in trans,cis-nepetalactone. MTT assays indicated that after 72 h of treatment the EO exhibited cytotoxic activity on investigated cancer cell lines: HeLa, K562, A549, LS-174 and MDA-MB-231. Normal cell line (MRC-5) was the least sensitive to the treatment and IC50 value for this cell line was not reached within the tested range of EO concentrations (up to 0.1 μL/mL). Analysis of morphological changes of treated cells confirmed the higher sensitivity of tumor cells than normal cells to the tested EO. Application of N. rtanjensis EO resulted in the appearance of morphological changes in tested cancer cell lines characteristic for apoptotic cell death, and induced perturbations of the cell cycle of HeLa cells. In addition, upregulation of Bax and p53, and downregulation of Bcl-2, and Skp2 genes, involved in apoptotic signalling cascades, confirmed an apoptosis-inducing effect of N. rtanjensis EO on HeLa cells. Presented results highlighted the potential of N. rtanjensis EO in anticancer therapy.",
journal = "Industrial Crops and Products",
title = "Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action",
volume = "100",
doi = "10.1016/j.indcrop.2017.02.027",
pages = "163-170"
}

Skorić, M., Gligorijević, N., Čavić, M., Todorović, S., Janković, R., Ristić, M., Mišić, D.,& Radulović, S.. (2017). Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action. in Industrial Crops and Products, 100, 163-170.
https://doi.org/10.1016/j.indcrop.2017.02.027

Skorić M, Gligorijević N, Čavić M, Todorović S, Janković R, Ristić M, Mišić D, Radulović S. Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action. in Industrial Crops and Products. 2017;100:163-170.
doi:10.1016/j.indcrop.2017.02.027 .

Skorić, Marijana, Gligorijević, Nevenka, Čavić, Milena, Todorović, Slađana, Janković, Radmila, Ristić, Mihailo, Mišić, Danijela, Radulović, Siniša, "Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action" in Industrial Crops and Products, 100 (2017):163-170,
https://doi.org/10.1016/j.indcrop.2017.02.027 . .