TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Tucović, Dina
AU  - Kulaš, Jelena
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Ninkov, Marina
AU  - Janković, Srđa
AU  - Kataranovski, Milena
PY  - 2021
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0165247821001644
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4664
AB  - Cadmium (Cd) represents a unique hazard because of the long biological half-life in humans (20-30 years). This metal accumulates in organs causing a continuum of responses, with organ disease/failure as extreme outcome. Some of the cellular and molecular alterations in target tissues can be related to immune-modulating potential of Cd. This metal may cause adverse responses in which components of the immune system function as both mediators and effectors of Cd tissue toxicity, which, in combination with Cd-induced alterations in homeostatic reparative activities may contribute to tissue dysfunction. In this work, current knowledge concerning inflammatory/autoimmune disease manifestations found to be related with cadmium exposure are summarized. Along with epidemiological evidence, animal and in vitro data are presented, with focus on cellular and molecular immune mechanisms potentially relevant for the disease susceptibility, disease promotion, or facilitating development of pre-existing pathologies.
PB  - Elsevier B.V.
T2  - Immunology Letters
T1  - Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.
VL  - 240
DO  - 10.1016/j.imlet.2021.10.003
SP  - 106
EP  - 122
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Tucović, Dina and Kulaš, Jelena and Zeljković, Milica and Popović, Dušanka and Ninkov, Marina and Janković, Srđa and Kataranovski, Milena",
year = "2021",
abstract = "Cadmium (Cd) represents a unique hazard because of the long biological half-life in humans (20-30 years). This metal accumulates in organs causing a continuum of responses, with organ disease/failure as extreme outcome. Some of the cellular and molecular alterations in target tissues can be related to immune-modulating potential of Cd. This metal may cause adverse responses in which components of the immune system function as both mediators and effectors of Cd tissue toxicity, which, in combination with Cd-induced alterations in homeostatic reparative activities may contribute to tissue dysfunction. In this work, current knowledge concerning inflammatory/autoimmune disease manifestations found to be related with cadmium exposure are summarized. Along with epidemiological evidence, animal and in vitro data are presented, with focus on cellular and molecular immune mechanisms potentially relevant for the disease susceptibility, disease promotion, or facilitating development of pre-existing pathologies.",
publisher = "Elsevier B.V.",
journal = "Immunology Letters",
title = "Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.",
volume = "240",
doi = "10.1016/j.imlet.2021.10.003",
pages = "106-122"
}

Popov Aleksandrov, A., Mirkov, I., Tucović, D., Kulaš, J., Zeljković, M., Popović, D., Ninkov, M., Janković, S.,& Kataranovski, M.. (2021). Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.. in Immunology Letters
Elsevier B.V.., 240, 106-122.
https://doi.org/10.1016/j.imlet.2021.10.003

Popov Aleksandrov A, Mirkov I, Tucović D, Kulaš J, Zeljković M, Popović D, Ninkov M, Janković S, Kataranovski M. Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.. in Immunology Letters. 2021;240:106-122.
doi:10.1016/j.imlet.2021.10.003 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Tucović, Dina, Kulaš, Jelena, Zeljković, Milica, Popović, Dušanka, Ninkov, Marina, Janković, Srđa, Kataranovski, Milena, "Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example." in Immunology Letters, 240 (2021):106-122,
https://doi.org/10.1016/j.imlet.2021.10.003 . .

TY  - JOUR
AU  - Kataranovski, Milena
AU  - Janković, Srđa J
AU  - Kataranovski, Dragan S.
AU  - Stošić, Jelena
AU  - Bogojević, Desanka
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1464
AB  - To examine the presence of gender differences in pro-inflammatory potential of cadmium in rats by comparing systemic inflammatory response to acute cadmium intoxication in animals of the two sexes. Methods Basic aspects of this response were evaluated, including plasma levels of inflammatory cytokines tumor necrosis factor (TNF) and interleukin-6 (IL-6) and of major rat acute phase protein alpha 2-macroglobulin (alpha2-M), as Soluble indicators of inflammation, and the number and activity of peripheral blood leukocytes, as cellular indicators of inflammation. Results Differential increases of IL-6 and alpha 2-M (higher in males than in females) in peripheral blood cell counts and types (leukocytosis and shift in the ratio of granulocytes to lymphocytes more pronounced in males vs females) and in levels of neutrophil priming (higher in males vs females) were noted. Conclusion The data document a more intense inflammatory response to cadmium administration in males. The sex differences in inflammatory effects of cadmium might be taken into consideration in studying the toxicity of this heavy metal.
T2  - Biomedical and Environmental Sciences
T1  - Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats
IS  - 1
VL  - 22
EP  - 7
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1464
ER  - 

@article{
author = "Kataranovski, Milena and Janković, Srđa J and Kataranovski, Dragan S. and Stošić, Jelena and Bogojević, Desanka",
year = "2009",
abstract = "To examine the presence of gender differences in pro-inflammatory potential of cadmium in rats by comparing systemic inflammatory response to acute cadmium intoxication in animals of the two sexes. Methods Basic aspects of this response were evaluated, including plasma levels of inflammatory cytokines tumor necrosis factor (TNF) and interleukin-6 (IL-6) and of major rat acute phase protein alpha 2-macroglobulin (alpha2-M), as Soluble indicators of inflammation, and the number and activity of peripheral blood leukocytes, as cellular indicators of inflammation. Results Differential increases of IL-6 and alpha 2-M (higher in males than in females) in peripheral blood cell counts and types (leukocytosis and shift in the ratio of granulocytes to lymphocytes more pronounced in males vs females) and in levels of neutrophil priming (higher in males vs females) were noted. Conclusion The data document a more intense inflammatory response to cadmium administration in males. The sex differences in inflammatory effects of cadmium might be taken into consideration in studying the toxicity of this heavy metal.",
journal = "Biomedical and Environmental Sciences",
title = "Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats",
number = "1",
volume = "22",
pages = "7",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1464"
}

Kataranovski, M., Janković, S. J., Kataranovski, D. S., Stošić, J.,& Bogojević, D.. (2009). Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats. in Biomedical and Environmental Sciences, 22(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1464

Kataranovski M, Janković SJ, Kataranovski DS, Stošić J, Bogojević D. Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats. in Biomedical and Environmental Sciences. 2009;22(1):null-7.
https://hdl.handle.net/21.15107/rcub_ibiss_1464 .

Kataranovski, Milena, Janković, Srđa J, Kataranovski, Dragan S., Stošić, Jelena, Bogojević, Desanka, "Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats" in Biomedical and Environmental Sciences, 22, no. 1 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1464 .