TY  - JOUR
AU  - Vukčević, Marija
AU  - Šerović, Katarina
AU  - Despot, Mateja
AU  - Nikolić-Kokić, Aleksandra
AU  - Vujović, Aleksandra
AU  - Nikolić, Milan
AU  - Blagojević, Duško
AU  - Jovanović, Tanja
AU  - Despot, Dragana
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6495
AB  - Background: Several vaccines against COVID-19 have been developed and licensed to
enhance the immune response against SARS-CoV-2. Similarly, previous infection with SARS-CoV-
2 has been shown to provide significant protection against severe infection and hospitalization.
Methods: We investigated the effect of three doses of the Sinopharm vaccine and SARS-CoV-2
infection on the specific immune response in 103 volunteers, measuring neutralizing antibodies, anti-
S1 IgG, anti-RBD IgM, anti-N IgM, anti-N IgG antibodies, and INF γ. Results: Our results showed
that the presence of cardiovascular diseases increased the level of anti-N-IgG antibodies, while
endocrinological diseases decreased the level of neutralizing antibodies and anti-N IgG antibodies,
suggesting that these diseases alter the effect of vaccine-induced immunity. In addition, there was a
significant decrease in anti-S1 IgG levels at 6 months and in anti-N IgG levels 18 months post-infection,
while neutralizing antibodies and INF γ levels were constant at 3, 6, and 18 months post-infection.
Conclusions: Our results confirm the emergence of hybrid immunity, which is the strongest and
most durable compared to natural immunity or vaccine-induced immunity. Significant positive
correlations were found between humoral and cellular immunity markers: neutralizing antibodies,
anti-S1 IgG and anti-N IgG antibodies, and INF γ, indicating a unique coordinated response specific
to COVID-19.
PB  - Basel: MDPI
T2  - Pharmaceuticals
T1  - Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity
IS  - 1
VL  - 17
DO  - 10.3390/ph17010122
SP  - 122
ER  - 

@article{
author = "Vukčević, Marija and Šerović, Katarina and Despot, Mateja and Nikolić-Kokić, Aleksandra and Vujović, Aleksandra and Nikolić, Milan and Blagojević, Duško and Jovanović, Tanja and Despot, Dragana",
year = "2024",
abstract = "Background: Several vaccines against COVID-19 have been developed and licensed to
enhance the immune response against SARS-CoV-2. Similarly, previous infection with SARS-CoV-
2 has been shown to provide significant protection against severe infection and hospitalization.
Methods: We investigated the effect of three doses of the Sinopharm vaccine and SARS-CoV-2
infection on the specific immune response in 103 volunteers, measuring neutralizing antibodies, anti-
S1 IgG, anti-RBD IgM, anti-N IgM, anti-N IgG antibodies, and INF γ. Results: Our results showed
that the presence of cardiovascular diseases increased the level of anti-N-IgG antibodies, while
endocrinological diseases decreased the level of neutralizing antibodies and anti-N IgG antibodies,
suggesting that these diseases alter the effect of vaccine-induced immunity. In addition, there was a
significant decrease in anti-S1 IgG levels at 6 months and in anti-N IgG levels 18 months post-infection,
while neutralizing antibodies and INF γ levels were constant at 3, 6, and 18 months post-infection.
Conclusions: Our results confirm the emergence of hybrid immunity, which is the strongest and
most durable compared to natural immunity or vaccine-induced immunity. Significant positive
correlations were found between humoral and cellular immunity markers: neutralizing antibodies,
anti-S1 IgG and anti-N IgG antibodies, and INF γ, indicating a unique coordinated response specific
to COVID-19.",
publisher = "Basel: MDPI",
journal = "Pharmaceuticals",
title = "Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity",
number = "1",
volume = "17",
doi = "10.3390/ph17010122",
pages = "122"
}

Vukčević, M., Šerović, K., Despot, M., Nikolić-Kokić, A., Vujović, A., Nikolić, M., Blagojević, D., Jovanović, T.,& Despot, D.. (2024). Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity. in Pharmaceuticals
Basel: MDPI., 17(1), 122.
https://doi.org/10.3390/ph17010122

Vukčević M, Šerović K, Despot M, Nikolić-Kokić A, Vujović A, Nikolić M, Blagojević D, Jovanović T, Despot D. Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity. in Pharmaceuticals. 2024;17(1):122.
doi:10.3390/ph17010122 .

Vukčević, Marija, Šerović, Katarina, Despot, Mateja, Nikolić-Kokić, Aleksandra, Vujović, Aleksandra, Nikolić, Milan, Blagojević, Duško, Jovanović, Tanja, Despot, Dragana, "Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity" in Pharmaceuticals, 17, no. 1 (2024):122,
https://doi.org/10.3390/ph17010122 . .

TY  - JOUR
AU  - Vukčević, Marija
AU  - Nikolić-Kokić, Aleksandra
AU  - Aleksić, Ivan
AU  - Todorović, Sanja
AU  - Oreščanin-Dušić, Zorana
AU  - Blagojević, Duško
AU  - Despot, Dragana
PY  - 2023
UR  - https://academic.oup.com/jee/advance-article/doi/10.1093/jee/toac190/6927190
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5386
AB  - Controlling the number of ticks as carriers of infectious diseases is very important. The process is sometimes compromised by activating the protective mechanisms of the tick itself. Glutathione-S-transferases activity (GSTs) was the subject of our investigation of tick abundance after pyrethroid treatment. We determined GSTs activity in ticks collected from six locations in Belgrade before and after pyrethroid treatment and correlated it with the number of ticks in the locations. The results showed that tick abundance correlated with GSTs activity. On the other hand, treatment efficiency was location-dependent, being similar in each particular location in both April (spring) and October (autumn). Our results suggest that GSTs activity reflects the influence of both present local allelochemicals from different environmental seasonal vegetation and applied pyrethroid. We can conclude that by evaluating GSTs activity in ticks from particular locations as well as during the treatment with acaricides tick removal practice could be improved.
T2  - Journal of Economic Entomology
T1  - Evaluation of Tick Abundance and Pyrethroid Resistance Via Determination of Glutathione-S-Transferases Activity
IS  - 1
VL  - 116
DO  - 10.1093/jee/toac190
SP  - 233
EP  - 239
ER  - 

@article{
author = "Vukčević, Marija and Nikolić-Kokić, Aleksandra and Aleksić, Ivan and Todorović, Sanja and Oreščanin-Dušić, Zorana and Blagojević, Duško and Despot, Dragana",
year = "2023",
abstract = "Controlling the number of ticks as carriers of infectious diseases is very important. The process is sometimes compromised by activating the protective mechanisms of the tick itself. Glutathione-S-transferases activity (GSTs) was the subject of our investigation of tick abundance after pyrethroid treatment. We determined GSTs activity in ticks collected from six locations in Belgrade before and after pyrethroid treatment and correlated it with the number of ticks in the locations. The results showed that tick abundance correlated with GSTs activity. On the other hand, treatment efficiency was location-dependent, being similar in each particular location in both April (spring) and October (autumn). Our results suggest that GSTs activity reflects the influence of both present local allelochemicals from different environmental seasonal vegetation and applied pyrethroid. We can conclude that by evaluating GSTs activity in ticks from particular locations as well as during the treatment with acaricides tick removal practice could be improved.",
journal = "Journal of Economic Entomology",
title = "Evaluation of Tick Abundance and Pyrethroid Resistance Via Determination of Glutathione-S-Transferases Activity",
number = "1",
volume = "116",
doi = "10.1093/jee/toac190",
pages = "233-239"
}

Vukčević, M., Nikolić-Kokić, A., Aleksić, I., Todorović, S., Oreščanin-Dušić, Z., Blagojević, D.,& Despot, D.. (2023). Evaluation of Tick Abundance and Pyrethroid Resistance Via Determination of Glutathione-S-Transferases Activity. in Journal of Economic Entomology, 116(1), 233-239.
https://doi.org/10.1093/jee/toac190

Vukčević M, Nikolić-Kokić A, Aleksić I, Todorović S, Oreščanin-Dušić Z, Blagojević D, Despot D. Evaluation of Tick Abundance and Pyrethroid Resistance Via Determination of Glutathione-S-Transferases Activity. in Journal of Economic Entomology. 2023;116(1):233-239.
doi:10.1093/jee/toac190 .

Vukčević, Marija, Nikolić-Kokić, Aleksandra, Aleksić, Ivan, Todorović, Sanja, Oreščanin-Dušić, Zorana, Blagojević, Duško, Despot, Dragana, "Evaluation of Tick Abundance and Pyrethroid Resistance Via Determination of Glutathione-S-Transferases Activity" in Journal of Economic Entomology, 116, no. 1 (2023):233-239,
https://doi.org/10.1093/jee/toac190 . .