TY  - JOUR
AU  - Nikolakopoulou, Angeliki M.
AU  - Montagne, Axel
AU  - Kisler, Kassandra
AU  - Dai, Zhonghua
AU  - Wang, Yaoming
AU  - Huuskonen, Mikko T.
AU  - Sagare, Abhay P.
AU  - Lazić, Divna
AU  - Sweeney, Melanie D.
AU  - Kong, Pan
AU  - Wang, Min
AU  - Owens, Nelly Chuqui
AU  - Lawson, Erica J.
AU  - Xie, Xiaochun
AU  - Zhao, Zhen
AU  - Zloković, Berislav V.
PY  - 2019
UR  - http://www.nature.com/articles/s41593-019-0434-z
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3388
AB  - Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable. Here we generate an inducible pericyte-specific Cre line and cross pericyte-specific Cre mice with iDTR mice carrying Cre-dependent human diphtheria toxin receptor. After pericyte ablation with diphtheria toxin, mice showed acute blood-brain barrier breakdown, severe loss of blood flow, and a rapid neuron loss that was associated with loss of pericyte-derived pleiotrophin (PTN), a neurotrophic growth factor. Intracerebroventricular PTN infusions prevented neuron loss in pericyte-ablated mice despite persistent circulatory changes. Silencing of pericyte-derived Ptn rendered neurons vulnerable to ischemic and excitotoxic injury. Our data demonstrate a rapid neurodegeneration cascade that links pericyte loss to acute circulatory collapse and loss of PTN neurotrophic support. These findings may have implications for the pathogenesis and treatment of neurological disorders that are associated with pericyte loss and/or neurovascular dysfunction.
T2  - Nature Neuroscience
T1  - Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.
IS  - 7
VL  - 22
DO  - 10.1038/s41593-019-0434-z
SP  - 1089
EP  - 1098
ER  - 

@article{
author = "Nikolakopoulou, Angeliki M. and Montagne, Axel and Kisler, Kassandra and Dai, Zhonghua and Wang, Yaoming and Huuskonen, Mikko T. and Sagare, Abhay P. and Lazić, Divna and Sweeney, Melanie D. and Kong, Pan and Wang, Min and Owens, Nelly Chuqui and Lawson, Erica J. and Xie, Xiaochun and Zhao, Zhen and Zloković, Berislav V.",
year = "2019",
abstract = "Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable. Here we generate an inducible pericyte-specific Cre line and cross pericyte-specific Cre mice with iDTR mice carrying Cre-dependent human diphtheria toxin receptor. After pericyte ablation with diphtheria toxin, mice showed acute blood-brain barrier breakdown, severe loss of blood flow, and a rapid neuron loss that was associated with loss of pericyte-derived pleiotrophin (PTN), a neurotrophic growth factor. Intracerebroventricular PTN infusions prevented neuron loss in pericyte-ablated mice despite persistent circulatory changes. Silencing of pericyte-derived Ptn rendered neurons vulnerable to ischemic and excitotoxic injury. Our data demonstrate a rapid neurodegeneration cascade that links pericyte loss to acute circulatory collapse and loss of PTN neurotrophic support. These findings may have implications for the pathogenesis and treatment of neurological disorders that are associated with pericyte loss and/or neurovascular dysfunction.",
journal = "Nature Neuroscience",
title = "Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.",
number = "7",
volume = "22",
doi = "10.1038/s41593-019-0434-z",
pages = "1089-1098"
}

Nikolakopoulou, A. M., Montagne, A., Kisler, K., Dai, Z., Wang, Y., Huuskonen, M. T., Sagare, A. P., Lazić, D., Sweeney, M. D., Kong, P., Wang, M., Owens, N. C., Lawson, E. J., Xie, X., Zhao, Z.,& Zloković, B. V.. (2019). Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.. in Nature Neuroscience, 22(7), 1089-1098.
https://doi.org/10.1038/s41593-019-0434-z

Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazić D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zloković BV. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.. in Nature Neuroscience. 2019;22(7):1089-1098.
doi:10.1038/s41593-019-0434-z .

Nikolakopoulou, Angeliki M., Montagne, Axel, Kisler, Kassandra, Dai, Zhonghua, Wang, Yaoming, Huuskonen, Mikko T., Sagare, Abhay P., Lazić, Divna, Sweeney, Melanie D., Kong, Pan, Wang, Min, Owens, Nelly Chuqui, Lawson, Erica J., Xie, Xiaochun, Zhao, Zhen, Zloković, Berislav V., "Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss." in Nature Neuroscience, 22, no. 7 (2019):1089-1098,
https://doi.org/10.1038/s41593-019-0434-z . .