TY  - JOUR
AU  - Tucović, Dina
AU  - Mirkov, Ivana
AU  - Kulaš, Jelena
AU  - Zeljković, Milica
AU  - Popović, Dušanka
AU  - Zolotarevski, Lidija
AU  - Đuđjić, Slađana
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2020
UR  - internal-pdf://Tucovic et al. - 2020 - Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and infla.pdf
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31924569
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3594
AB  - Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells' proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.
T2  - Environmental Toxicology and Pharmacology
T1  - Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.
VL  - 75
DO  - 10.1016/j.etap.2020.103326
SP  - 103326
ER  - 

@article{
author = "Tucović, Dina and Mirkov, Ivana and Kulaš, Jelena and Zeljković, Milica and Popović, Dušanka and Zolotarevski, Lidija and Đuđjić, Slađana and Mutić, Jelena and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2020",
abstract = "Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells' proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.",
journal = "Environmental Toxicology and Pharmacology",
title = "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.",
volume = "75",
doi = "10.1016/j.etap.2020.103326",
pages = "103326"
}

Tucović, D., Mirkov, I., Kulaš, J., Zeljković, M., Popović, D., Zolotarevski, L., Đuđjić, S., Mutić, J., Kataranovski, M.,& Popov Aleksandrov, A.. (2020). Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.. in Environmental Toxicology and Pharmacology, 75, 103326.
https://doi.org/10.1016/j.etap.2020.103326

Tucović D, Mirkov I, Kulaš J, Zeljković M, Popović D, Zolotarevski L, Đuđjić S, Mutić J, Kataranovski M, Popov Aleksandrov A. Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.. in Environmental Toxicology and Pharmacology. 2020;75:103326.
doi:10.1016/j.etap.2020.103326 .

Tucović, Dina, Mirkov, Ivana, Kulaš, Jelena, Zeljković, Milica, Popović, Dušanka, Zolotarevski, Lidija, Đuđjić, Slađana, Mutić, Jelena, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity." in Environmental Toxicology and Pharmacology, 75 (2020):103326,
https://doi.org/10.1016/j.etap.2020.103326 . .

TY  - JOUR
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Borković Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mutić, Jelena
AU  - Baščarević, Vladimir
AU  - Joković, Miloš
AU  - Pavlović, Slađan
PY  - 2020
UR  - https://www.termedia.pl/Association-between-oxidative-stress-biomarkers-and-concentrations-of-some-metal-ions-in-the-blood-of-patients-with-brain-tumors-and-hydrocephalus,19,37458,1,1.html
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3459
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3713
AB  - IntroductionAny substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.Material and methodsOur study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.ResultsThe higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.ConclusionsThere are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.
PB  - Termedia & Banach
T2  - Archives of Medical Science
T1  - Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus
IS  - 4
VL  - 16
DO  - 10.5114/aoms.2019.87409
SP  - 811
EP  - 819
ER  - 

@article{
author = "Vujotić, Ljiljana and Matić, Siniša and Borković Mitić, Slavica and Stojsavljević, Aleksandar and Mutić, Jelena and Baščarević, Vladimir and Joković, Miloš and Pavlović, Slađan",
year = "2020",
abstract = "IntroductionAny substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.Material and methodsOur study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.ResultsThe higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.ConclusionsThere are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.",
publisher = "Termedia & Banach",
journal = "Archives of Medical Science",
title = "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus",
number = "4",
volume = "16",
doi = "10.5114/aoms.2019.87409",
pages = "811-819"
}

Vujotić, L., Matić, S., Borković Mitić, S., Stojsavljević, A., Mutić, J., Baščarević, V., Joković, M.,& Pavlović, S.. (2020). Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science
Termedia & Banach., 16(4), 811-819.
https://doi.org/10.5114/aoms.2019.87409

Vujotić L, Matić S, Borković Mitić S, Stojsavljević A, Mutić J, Baščarević V, Joković M, Pavlović S. Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science. 2020;16(4):811-819.
doi:10.5114/aoms.2019.87409 .

Vujotić, Ljiljana, Matić, Siniša, Borković Mitić, Slavica, Stojsavljević, Aleksandar, Mutić, Jelena, Baščarević, Vladimir, Joković, Miloš, Pavlović, Slađan, "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus" in Archives of Medical Science, 16, no. 4 (2020):811-819,
https://doi.org/10.5114/aoms.2019.87409 . .

TY  - JOUR
AU  - Šuković, Danijela
AU  - Knežević, Bojana
AU  - Gašić, Uroš
AU  - Sredojević, Milica
AU  - Ćirić, Ivanka
AU  - Todić, Slavica
AU  - Mutić, Jelena
AU  - Tešić, Živoslav
PY  - 2020
UR  - https://www.mdpi.com/2304-8158/9/2/138
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3607
AB  - Vranac, an old autochthonous red grapevine variety of Montenegro, was first mentioned in a historical document published in the 15th century. As currently the study of indigenous varieties is of particular importance, the subject of this work was detailed characterization of phenolic compounds in the autochthonous grapevine variety Vranac, from the Montenegrin Podgorica subregion. Phenolic profiles of leaves, berries (skin, seeds, and pulp were examined separately) and young monovarietal wine were determined using ultra-high performance liquid chromatography (UHPLC) with linear trap quadrupole (LTQ)-Orbitrap XL mass spectrometry (MS). Total phenolic content (TPC) and radical scavenging activity (RSA) were higher for the grape seeds extracts, followed by extracts of grape skins and pulps. As expected, the total anthocyanin content (TAC) was higher in grape skin than in wine. A total of one hundred twenty nine compounds (forty two phenolic acids and their derivatives, twenty three flavan-3-ols, twenty one flavanols, five stilbenes and thirty eight anthocyanins) were identified in the investigated extracts. To our best knowledge, this is the first report of tentative identification of (epi)catechin 3-O-coumarate in grape seed and chalcan-flavan 3-ol dimers in wine and grape seed.
T2  - Foods (Basel, Switzerland)
T1  - Phenolic Profiles of Leaves, Grapes and Wine of Grapevine Variety Vranac (Vitisvinifera L.) from Montenegro.
IS  - 2
VL  - 9
DO  - 10.3390/foods9020138
SP  - 138
ER  - 

@article{
author = "Šuković, Danijela and Knežević, Bojana and Gašić, Uroš and Sredojević, Milica and Ćirić, Ivanka and Todić, Slavica and Mutić, Jelena and Tešić, Živoslav",
year = "2020",
abstract = "Vranac, an old autochthonous red grapevine variety of Montenegro, was first mentioned in a historical document published in the 15th century. As currently the study of indigenous varieties is of particular importance, the subject of this work was detailed characterization of phenolic compounds in the autochthonous grapevine variety Vranac, from the Montenegrin Podgorica subregion. Phenolic profiles of leaves, berries (skin, seeds, and pulp were examined separately) and young monovarietal wine were determined using ultra-high performance liquid chromatography (UHPLC) with linear trap quadrupole (LTQ)-Orbitrap XL mass spectrometry (MS). Total phenolic content (TPC) and radical scavenging activity (RSA) were higher for the grape seeds extracts, followed by extracts of grape skins and pulps. As expected, the total anthocyanin content (TAC) was higher in grape skin than in wine. A total of one hundred twenty nine compounds (forty two phenolic acids and their derivatives, twenty three flavan-3-ols, twenty one flavanols, five stilbenes and thirty eight anthocyanins) were identified in the investigated extracts. To our best knowledge, this is the first report of tentative identification of (epi)catechin 3-O-coumarate in grape seed and chalcan-flavan 3-ol dimers in wine and grape seed.",
journal = "Foods (Basel, Switzerland)",
title = "Phenolic Profiles of Leaves, Grapes and Wine of Grapevine Variety Vranac (Vitisvinifera L.) from Montenegro.",
number = "2",
volume = "9",
doi = "10.3390/foods9020138",
pages = "138"
}

Šuković, D., Knežević, B., Gašić, U., Sredojević, M., Ćirić, I., Todić, S., Mutić, J.,& Tešić, Ž.. (2020). Phenolic Profiles of Leaves, Grapes and Wine of Grapevine Variety Vranac (Vitisvinifera L.) from Montenegro.. in Foods (Basel, Switzerland), 9(2), 138.
https://doi.org/10.3390/foods9020138

Šuković D, Knežević B, Gašić U, Sredojević M, Ćirić I, Todić S, Mutić J, Tešić Ž. Phenolic Profiles of Leaves, Grapes and Wine of Grapevine Variety Vranac (Vitisvinifera L.) from Montenegro.. in Foods (Basel, Switzerland). 2020;9(2):138.
doi:10.3390/foods9020138 .

Šuković, Danijela, Knežević, Bojana, Gašić, Uroš, Sredojević, Milica, Ćirić, Ivanka, Todić, Slavica, Mutić, Jelena, Tešić, Živoslav, "Phenolic Profiles of Leaves, Grapes and Wine of Grapevine Variety Vranac (Vitisvinifera L.) from Montenegro." in Foods (Basel, Switzerland), 9, no. 2 (2020):138,
https://doi.org/10.3390/foods9020138 . .

TY  - JOUR
AU  - Vukojević, Vesna
AU  - Đurđić, Slađana
AU  - Stefanović, Violeta
AU  - Trifković, Jelena
AU  - Čakmak, Dragan
AU  - Perović, Veljko
AU  - Mutić, Jelena
PY  - 2019
UR  - http://link.springer.com/10.1007/s11356-018-3982-y
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3242
AB  - The mobility (fractionation) of rare earth elements (REEs) and their possible impacts on ecosystems are still relatively unknown. Soil samples were collected from two sites in central Serbia, an unpolluted mountain region (site 1) and a forest near a city (site 2). In order to investigate REE fractions (acid-soluble/exchangeable, reducible, oxidizable, and residual) in soils, BCR sequential extraction was performed. Additionally, the content of REEs was also determined in stipes and caps of the mushroom Macrolepiota procera, growing in the observed sites. Sc, Y, and lanthanide contents were determined by inductively coupled plasma mass spectrometry (ICP-MS), and results were subjected to multivariate data analysis. Application of pattern recognition technique revealed the existence of two distinguished clusters belonging to different geographical sites and determined by greater levels of Sc, Y, and lanthanides in Goč soil compared to Trstenik soil. Additionally, PCA analysis showed that REEs in soil were concentrated in two groups: the first consisted of elements belonging to light REEs and the second contained heavy REEs. These results suggest that the distribution of REEs in soils could indicate the geographical origin and type of soil. The bioconcentration factors and translocation factors for each REE were also calculated. This study provides baseline data on the rare earth element levels in the wild edible mushroom M. procera, growing in Serbia. In terms of bioconcentration and bioexclusion concept, Sc, Y, and REEs were bioexcluded in M. procera for both studied sites.
PB  - Springer Berlin Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Scandium, yttrium, and lanthanide contents in soil from Serbia and their accumulation in the mushroom Macrolepiota procera (Scop.) Singer.
DO  - 10.1007/s11356-018-3982-y
ER  - 

@article{
author = "Vukojević, Vesna and Đurđić, Slađana and Stefanović, Violeta and Trifković, Jelena and Čakmak, Dragan and Perović, Veljko and Mutić, Jelena",
year = "2019",
abstract = "The mobility (fractionation) of rare earth elements (REEs) and their possible impacts on ecosystems are still relatively unknown. Soil samples were collected from two sites in central Serbia, an unpolluted mountain region (site 1) and a forest near a city (site 2). In order to investigate REE fractions (acid-soluble/exchangeable, reducible, oxidizable, and residual) in soils, BCR sequential extraction was performed. Additionally, the content of REEs was also determined in stipes and caps of the mushroom Macrolepiota procera, growing in the observed sites. Sc, Y, and lanthanide contents were determined by inductively coupled plasma mass spectrometry (ICP-MS), and results were subjected to multivariate data analysis. Application of pattern recognition technique revealed the existence of two distinguished clusters belonging to different geographical sites and determined by greater levels of Sc, Y, and lanthanides in Goč soil compared to Trstenik soil. Additionally, PCA analysis showed that REEs in soil were concentrated in two groups: the first consisted of elements belonging to light REEs and the second contained heavy REEs. These results suggest that the distribution of REEs in soils could indicate the geographical origin and type of soil. The bioconcentration factors and translocation factors for each REE were also calculated. This study provides baseline data on the rare earth element levels in the wild edible mushroom M. procera, growing in Serbia. In terms of bioconcentration and bioexclusion concept, Sc, Y, and REEs were bioexcluded in M. procera for both studied sites.",
publisher = "Springer Berlin Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Scandium, yttrium, and lanthanide contents in soil from Serbia and their accumulation in the mushroom Macrolepiota procera (Scop.) Singer.",
doi = "10.1007/s11356-018-3982-y"
}

Vukojević, V., Đurđić, S., Stefanović, V., Trifković, J., Čakmak, D., Perović, V.,& Mutić, J.. (2019). Scandium, yttrium, and lanthanide contents in soil from Serbia and their accumulation in the mushroom Macrolepiota procera (Scop.) Singer.. in Environmental Science and Pollution Research
Springer Berlin Heidelberg..
https://doi.org/10.1007/s11356-018-3982-y

Vukojević V, Đurđić S, Stefanović V, Trifković J, Čakmak D, Perović V, Mutić J. Scandium, yttrium, and lanthanide contents in soil from Serbia and their accumulation in the mushroom Macrolepiota procera (Scop.) Singer.. in Environmental Science and Pollution Research. 2019;.
doi:10.1007/s11356-018-3982-y .

Vukojević, Vesna, Đurđić, Slađana, Stefanović, Violeta, Trifković, Jelena, Čakmak, Dragan, Perović, Veljko, Mutić, Jelena, "Scandium, yttrium, and lanthanide contents in soil from Serbia and their accumulation in the mushroom Macrolepiota procera (Scop.) Singer." in Environmental Science and Pollution Research (2019),
https://doi.org/10.1007/s11356-018-3982-y . .

TY  - JOUR
AU  - Kulaš, Jelena
AU  - Ninkov, Marina
AU  - Tucović, Dina
AU  - Popov Aleksandrov, Aleksandra
AU  - Ukropina, Mirela
AU  - Cakić Milošević, Maja
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
PY  - 2019
UR  - http://www.besjournal.com/en/article/doi/10.3967/bes2019.068
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3470
AB  - OBJECTIVE The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response. METHODS Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated. RESULTS Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. CONCLUSION The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.
PB  - Biomedical and Environmental Sciences
T2  - Biomedical and Environmental Sciences
T1  - Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.
IS  - 7
VL  - 32
DO  - 10.3967/bes2019.068
SP  - 508
EP  - 519
ER  - 

@article{
author = "Kulaš, Jelena and Ninkov, Marina and Tucović, Dina and Popov Aleksandrov, Aleksandra and Ukropina, Mirela and Cakić Milošević, Maja and Mutić, Jelena and Kataranovski, Milena and Mirkov, Ivana",
year = "2019",
abstract = "OBJECTIVE The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response. METHODS Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated. RESULTS Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. CONCLUSION The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.",
publisher = "Biomedical and Environmental Sciences",
journal = "Biomedical and Environmental Sciences",
title = "Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.",
number = "7",
volume = "32",
doi = "10.3967/bes2019.068",
pages = "508-519"
}

Kulaš, J., Ninkov, M., Tucović, D., Popov Aleksandrov, A., Ukropina, M., Cakić Milošević, M., Mutić, J., Kataranovski, M.,& Mirkov, I.. (2019). Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.. in Biomedical and Environmental Sciences
Biomedical and Environmental Sciences., 32(7), 508-519.
https://doi.org/10.3967/bes2019.068

Kulaš J, Ninkov M, Tucović D, Popov Aleksandrov A, Ukropina M, Cakić Milošević M, Mutić J, Kataranovski M, Mirkov I. Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.. in Biomedical and Environmental Sciences. 2019;32(7):508-519.
doi:10.3967/bes2019.068 .

Kulaš, Jelena, Ninkov, Marina, Tucović, Dina, Popov Aleksandrov, Aleksandra, Ukropina, Mirela, Cakić Milošević, Maja, Mutić, Jelena, Kataranovski, Milena, Mirkov, Ivana, "Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats." in Biomedical and Environmental Sciences, 32, no. 7 (2019):508-519,
https://doi.org/10.3967/bes2019.068 . .

TY  - JOUR
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Borković Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mutić, Jelena
AU  - Baščarević, Vladimir
AU  - Joković, Miloš
AU  - Pavlović, Slađan
PY  - 2019
UR  - https://www.termedia.pl/Association-between-oxidative-stress-biomarkers-and-concentrations-of-some-metal-ions-in-the-blood-of-patients-with-brain-tumors-and-hydrocephalus,19,37458,1,1.html
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3459
AB  - Introduction
Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.

Material and methods
Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.

Results
The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.

Conclusions
There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.
PB  - Termedia & Banach
T2  - Archives of Medical Science
T1  - Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus
DO  - 10.5114/aoms.2019.87409
ER  - 

@article{
author = "Vujotić, Ljiljana and Matić, Siniša and Borković Mitić, Slavica and Stojsavljević, Aleksandar and Mutić, Jelena and Baščarević, Vladimir and Joković, Miloš and Pavlović, Slađan",
year = "2019",
abstract = "Introduction
Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.

Material and methods
Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.

Results
The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.

Conclusions
There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.",
publisher = "Termedia & Banach",
journal = "Archives of Medical Science",
title = "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus",
doi = "10.5114/aoms.2019.87409"
}

Vujotić, L., Matić, S., Borković Mitić, S., Stojsavljević, A., Mutić, J., Baščarević, V., Joković, M.,& Pavlović, S.. (2019). Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science
Termedia & Banach..
https://doi.org/10.5114/aoms.2019.87409

Vujotić L, Matić S, Borković Mitić S, Stojsavljević A, Mutić J, Baščarević V, Joković M, Pavlović S. Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science. 2019;.
doi:10.5114/aoms.2019.87409 .

Vujotić, Ljiljana, Matić, Siniša, Borković Mitić, Slavica, Stojsavljević, Aleksandar, Mutić, Jelena, Baščarević, Vladimir, Joković, Miloš, Pavlović, Slađan, "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus" in Archives of Medical Science (2019),
https://doi.org/10.5114/aoms.2019.87409 . .

TY  - JOUR
AU  - Tucović, Dina
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Kulaš, Jelena
AU  - Zolotarevski, Lidija
AU  - Vukojević, Vesna
AU  - Mutić, Jelena
AU  - Tatalović, Nikola
AU  - Kataranovski, Milena
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0147651318307231?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3126
AB  - Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30-day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies.
T2  - Ecotoxicology and Environmental Safety
T1  - Oral cadmium exposure affects skin immune reactivity in rats.
VL  - 164
DO  - 10.1016/j.ecoenv.2018.07.117
SP  - 12
EP  - 20
ER  - 

@article{
author = "Tucović, Dina and Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Kulaš, Jelena and Zolotarevski, Lidija and Vukojević, Vesna and Mutić, Jelena and Tatalović, Nikola and Kataranovski, Milena",
year = "2018",
abstract = "Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30-day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies.",
journal = "Ecotoxicology and Environmental Safety",
title = "Oral cadmium exposure affects skin immune reactivity in rats.",
volume = "164",
doi = "10.1016/j.ecoenv.2018.07.117",
pages = "12-20"
}

Tucović, D., Popov Aleksandrov, A., Mirkov, I., Ninkov, M., Kulaš, J., Zolotarevski, L., Vukojević, V., Mutić, J., Tatalović, N.,& Kataranovski, M.. (2018). Oral cadmium exposure affects skin immune reactivity in rats.. in Ecotoxicology and Environmental Safety, 164, 12-20.
https://doi.org/10.1016/j.ecoenv.2018.07.117

Tucović D, Popov Aleksandrov A, Mirkov I, Ninkov M, Kulaš J, Zolotarevski L, Vukojević V, Mutić J, Tatalović N, Kataranovski M. Oral cadmium exposure affects skin immune reactivity in rats.. in Ecotoxicology and Environmental Safety. 2018;164:12-20.
doi:10.1016/j.ecoenv.2018.07.117 .

Tucović, Dina, Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Kulaš, Jelena, Zolotarevski, Lidija, Vukojević, Vesna, Mutić, Jelena, Tatalović, Nikola, Kataranovski, Milena, "Oral cadmium exposure affects skin immune reactivity in rats." in Ecotoxicology and Environmental Safety, 164 (2018):12-20,
https://doi.org/10.1016/j.ecoenv.2018.07.117 . .

TY  - JOUR
AU  - Vlahović, Milena
AU  - Matić, Dragana
AU  - Mutić, Jelena
AU  - Trifković, Jelena
AU  - Đurđić, Slađana
AU  - Perić Mataruga, Vesna
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1532045617301205
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2790
AB  - Bioaccumulation and excretion of heavy metals in insects is only partially clarified. We have investigated cadmium accumulation in the feces, head and integument of Lymantria dispar (Lepidoptera: Lymantriidae) larvae exposed to chronic dietary intake of cadmium. The aim of the experiment was to establish modalities of metal accumulation, primarily cadmium, as well as changes in fitness traits in two insect populations receiving 50 or 100 μg Cd/g dry food. The egg-masses originated from two localities: a protected nature reserve (unpolluted population) and an area near a busy highway (polluted population) in Serbia. At both added dietary levels cadmium concentration was highest in feces. Small alterations in metal concentrations after both cadmium treatments were detected in the integument. It was established that irrespective of population origin, the modality of decline of larval mass and relative growth rate (RGR) was similar. Concentrations of Cu and Zn in the integument were approximately the same regardless of dietary cadmium intake. However, cadmium accumulation in the examined tissues, as well as variability of fitness traits depended on population origin and cadmium concentration. In larvae from both populations not given contaminated food the head was the organ with the greatest accumulation of trace elements. Our results reveal how invasive phytophagous insects cope with high metal concentrations in their food by body mass (RGR) reduction and energy allocation towards processes that enable accumulation of cadmium and other trace elements in different tissues.
PB  - Elsevier Inc.
T2  - Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
T1  - Influence of dietary cadmium exposure on fitness traits and its accumulation (with an overview on trace elements) in Lymantria dispar larvae
VL  - 200
DO  - 10.1016/j.cbpc.2017.06.003
SP  - 27
EP  - 33
ER  - 

@article{
author = "Vlahović, Milena and Matić, Dragana and Mutić, Jelena and Trifković, Jelena and Đurđić, Slađana and Perić Mataruga, Vesna",
year = "2017",
abstract = "Bioaccumulation and excretion of heavy metals in insects is only partially clarified. We have investigated cadmium accumulation in the feces, head and integument of Lymantria dispar (Lepidoptera: Lymantriidae) larvae exposed to chronic dietary intake of cadmium. The aim of the experiment was to establish modalities of metal accumulation, primarily cadmium, as well as changes in fitness traits in two insect populations receiving 50 or 100 μg Cd/g dry food. The egg-masses originated from two localities: a protected nature reserve (unpolluted population) and an area near a busy highway (polluted population) in Serbia. At both added dietary levels cadmium concentration was highest in feces. Small alterations in metal concentrations after both cadmium treatments were detected in the integument. It was established that irrespective of population origin, the modality of decline of larval mass and relative growth rate (RGR) was similar. Concentrations of Cu and Zn in the integument were approximately the same regardless of dietary cadmium intake. However, cadmium accumulation in the examined tissues, as well as variability of fitness traits depended on population origin and cadmium concentration. In larvae from both populations not given contaminated food the head was the organ with the greatest accumulation of trace elements. Our results reveal how invasive phytophagous insects cope with high metal concentrations in their food by body mass (RGR) reduction and energy allocation towards processes that enable accumulation of cadmium and other trace elements in different tissues.",
publisher = "Elsevier Inc.",
journal = "Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology",
title = "Influence of dietary cadmium exposure on fitness traits and its accumulation (with an overview on trace elements) in Lymantria dispar larvae",
volume = "200",
doi = "10.1016/j.cbpc.2017.06.003",
pages = "27-33"
}

Vlahović, M., Matić, D., Mutić, J., Trifković, J., Đurđić, S.,& Perić Mataruga, V.. (2017). Influence of dietary cadmium exposure on fitness traits and its accumulation (with an overview on trace elements) in Lymantria dispar larvae. in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
Elsevier Inc.., 200, 27-33.
https://doi.org/10.1016/j.cbpc.2017.06.003

Vlahović M, Matić D, Mutić J, Trifković J, Đurđić S, Perić Mataruga V. Influence of dietary cadmium exposure on fitness traits and its accumulation (with an overview on trace elements) in Lymantria dispar larvae. in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;200:27-33.
doi:10.1016/j.cbpc.2017.06.003 .

Vlahović, Milena, Matić, Dragana, Mutić, Jelena, Trifković, Jelena, Đurđić, Slađana, Perić Mataruga, Vesna, "Influence of dietary cadmium exposure on fitness traits and its accumulation (with an overview on trace elements) in Lymantria dispar larvae" in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 200 (2017):27-33,
https://doi.org/10.1016/j.cbpc.2017.06.003 . .

TY  - JOUR
AU  - Prokić, Marko
AU  - Borković-Mitić, Slavica
AU  - Krizmanić, Imre
AU  - Mutić, Jelena
AU  - Vukojević, Vesna
AU  - Nasia, Mohamed
AU  - Gavrić, Jelena
AU  - Despotović, Svetlana
AU  - Gavrilović, Branka
AU  - Radovanović, Tijana
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5931
AB  - Heavy metal pollution of the aquatic environment is of great concern worldwide. Heavy metals are
capable of inducing oxidative stress by increasing the formation of reactive oxygen species (ROS), and
directly affecting the antioxidant defense system (AOS) in living organisms. The frog Pelophylax kl. esculentus is a semiaquatic species with semipermeable skin and a complex lifecycle, and represents a
potentially useful bioindicator organism. The aim of this study was to investigate the accumulation of
several heavy metals (Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb and Zn), and their effects on selected parameters of the
AOS, including the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), glutathione reductase (GR), phase II biotransformation enzyme glutathione-S-transferase (GST), the
total glutathione (GSH) contents and sulfhydryl (SH) group concentrations, as well as cholinesterases
(ChEs) activities in the liver, skin and muscle of P. kl. esculentus. Frog samples were collected at two sites
(the Danube–Tisza–Danube canal (DTDC) and the river Ponjavica) in Serbia, which are characterized by
different levels of metal pollution. Differences between the metal contents in different tissues showed
that the skin of frogs from the DTDC accumulated statistically higher concentrations of Cd, Cu, Pb and Zn,
while only the Fe concentration was lower. No significant differences between metal concentrations in
muscle tissues of frogs from the DTDC and Ponjavica were observed. Examination of the parameters of
the AOS revealed that frogs from the DTDC had higher concentrations of GSH in the liver and of SH
groups in the skin and muscle, whereas the activities of the antioxidative enzymes SOD, GHS-Px and GR
in the liver and of GR in the skin were lower than in frogs from the Ponjavica. The relationship between
metal concentrations and AOS parameters showed the highest number of correlations with GSH, GR and
CAT, and with Ni, Zn, Hg, Cr and Cd. Based on the results in this study, we concluded that increased
concentrations of heavy metals in frog tissues can alter the AOS, which leads to higher concentrations of
GSH and SH groups and lower activities of antioxidative enzymes. The response of the AOS to metal
pollutants allowed us to make a distinction between different frog tissues, and to conclude that the liver
and skin are more suitable for assessing metal-induced oxidative stress in frogs than muscle.
PB  - San Diego: Academic Press Inc.
T2  - Ecotoxicology and Environmental Safety
T1  - Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution
VL  - 128
DO  - 10.1016/j.ecoenv.2016.02.005
SP  - 21
EP  - 29
ER  - 

@article{
author = "Prokić, Marko and Borković-Mitić, Slavica and Krizmanić, Imre and Mutić, Jelena and Vukojević, Vesna and Nasia, Mohamed and Gavrić, Jelena and Despotović, Svetlana and Gavrilović, Branka and Radovanović, Tijana and Pavlović, Slađan and Saičić, Zorica",
year = "2016",
abstract = "Heavy metal pollution of the aquatic environment is of great concern worldwide. Heavy metals are
capable of inducing oxidative stress by increasing the formation of reactive oxygen species (ROS), and
directly affecting the antioxidant defense system (AOS) in living organisms. The frog Pelophylax kl. esculentus is a semiaquatic species with semipermeable skin and a complex lifecycle, and represents a
potentially useful bioindicator organism. The aim of this study was to investigate the accumulation of
several heavy metals (Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb and Zn), and their effects on selected parameters of the
AOS, including the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), glutathione reductase (GR), phase II biotransformation enzyme glutathione-S-transferase (GST), the
total glutathione (GSH) contents and sulfhydryl (SH) group concentrations, as well as cholinesterases
(ChEs) activities in the liver, skin and muscle of P. kl. esculentus. Frog samples were collected at two sites
(the Danube–Tisza–Danube canal (DTDC) and the river Ponjavica) in Serbia, which are characterized by
different levels of metal pollution. Differences between the metal contents in different tissues showed
that the skin of frogs from the DTDC accumulated statistically higher concentrations of Cd, Cu, Pb and Zn,
while only the Fe concentration was lower. No significant differences between metal concentrations in
muscle tissues of frogs from the DTDC and Ponjavica were observed. Examination of the parameters of
the AOS revealed that frogs from the DTDC had higher concentrations of GSH in the liver and of SH
groups in the skin and muscle, whereas the activities of the antioxidative enzymes SOD, GHS-Px and GR
in the liver and of GR in the skin were lower than in frogs from the Ponjavica. The relationship between
metal concentrations and AOS parameters showed the highest number of correlations with GSH, GR and
CAT, and with Ni, Zn, Hg, Cr and Cd. Based on the results in this study, we concluded that increased
concentrations of heavy metals in frog tissues can alter the AOS, which leads to higher concentrations of
GSH and SH groups and lower activities of antioxidative enzymes. The response of the AOS to metal
pollutants allowed us to make a distinction between different frog tissues, and to conclude that the liver
and skin are more suitable for assessing metal-induced oxidative stress in frogs than muscle.",
publisher = "San Diego: Academic Press Inc.",
journal = "Ecotoxicology and Environmental Safety",
title = "Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution",
volume = "128",
doi = "10.1016/j.ecoenv.2016.02.005",
pages = "21-29"
}

Prokić, M., Borković-Mitić, S., Krizmanić, I., Mutić, J., Vukojević, V., Nasia, M., Gavrić, J., Despotović, S., Gavrilović, B., Radovanović, T., Pavlović, S.,& Saičić, Z.. (2016). Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution. in Ecotoxicology and Environmental Safety
San Diego: Academic Press Inc.., 128, 21-29.
https://doi.org/10.1016/j.ecoenv.2016.02.005

Prokić M, Borković-Mitić S, Krizmanić I, Mutić J, Vukojević V, Nasia M, Gavrić J, Despotović S, Gavrilović B, Radovanović T, Pavlović S, Saičić Z. Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution. in Ecotoxicology and Environmental Safety. 2016;128:21-29.
doi:10.1016/j.ecoenv.2016.02.005 .

Prokić, Marko, Borković-Mitić, Slavica, Krizmanić, Imre, Mutić, Jelena, Vukojević, Vesna, Nasia, Mohamed, Gavrić, Jelena, Despotović, Svetlana, Gavrilović, Branka, Radovanović, Tijana, Pavlović, Slađan, Saičić, Zorica, "Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution" in Ecotoxicology and Environmental Safety, 128 (2016):21-29,
https://doi.org/10.1016/j.ecoenv.2016.02.005 . .

TY  - CONF
AU  - Đorđević, Vladimir
AU  - Prokić, Marko
AU  - Pavlović, Slađan
AU  - Radovanović, Tijana
AU  - Gavrilović, Branka
AU  - Mutić, Jelena
AU  - Buha, Aleksandra
AU  - Knežević, Djordje
AU  - Jovanović, Sanja
AU  - Borković Mitić, Slavica
PY  - 2016
UR  - https://www.imi.hr/en/2016/03/10/crotox-2016-book-of-abstracts/
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3507
AB  - Pancreatic cancer (PC) is one of the most aggressive types of cancer and a worldwide health treat. However, it is rather unclear which environmental pollutants can be linked to PC development. Exposure to toxic metals through various sources can be one of the risk factors, especially having in mind that some toxic metals can induce oxidative stress, which has already been associated with the pathogenesis of PC. The aim of this study was to investigate the levels of cadmium (Cd) and lead (Pb), toxic metals of great environmental concern known to induce oxidative stress, in the blood of PC patients and healthy control subjects, as well as to examine the following biomarkers of oxidative stress: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), glutathione (GSH), sulfhydrylgroups (SH), and lipid peroxides (TBARS) in blood. Blood samples were obtained from 15 PC patients and 7 healthy subjects. The present study demonstrated a significant increase in Pb concentrations in patients with carcinoma when compared to healthy subjects (p<0.05), while no significant differences were observed in Cd levels. The activities of SOD and CAT, as well as the concentration of SH groups, were significantly higher in people with PC compared with controls (p<0.05) proving oxidative stress induction in the blood of PC patients. This work contributes to a better understanding of the potential role of metal-induced oxidative stress in PC aetiology. However, confirmation of these pilot findings in a larger study is needed.
PB  - Croatian Society of Toxicology
C3  - Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1)
T1  - The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.
SP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3507
ER  - 

@conference{
author = "Đorđević, Vladimir and Prokić, Marko and Pavlović, Slađan and Radovanović, Tijana and Gavrilović, Branka and Mutić, Jelena and Buha, Aleksandra and Knežević, Djordje and Jovanović, Sanja and Borković Mitić, Slavica",
year = "2016",
abstract = "Pancreatic cancer (PC) is one of the most aggressive types of cancer and a worldwide health treat. However, it is rather unclear which environmental pollutants can be linked to PC development. Exposure to toxic metals through various sources can be one of the risk factors, especially having in mind that some toxic metals can induce oxidative stress, which has already been associated with the pathogenesis of PC. The aim of this study was to investigate the levels of cadmium (Cd) and lead (Pb), toxic metals of great environmental concern known to induce oxidative stress, in the blood of PC patients and healthy control subjects, as well as to examine the following biomarkers of oxidative stress: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), glutathione (GSH), sulfhydrylgroups (SH), and lipid peroxides (TBARS) in blood. Blood samples were obtained from 15 PC patients and 7 healthy subjects. The present study demonstrated a significant increase in Pb concentrations in patients with carcinoma when compared to healthy subjects (p<0.05), while no significant differences were observed in Cd levels. The activities of SOD and CAT, as well as the concentration of SH groups, were significantly higher in people with PC compared with controls (p<0.05) proving oxidative stress induction in the blood of PC patients. This work contributes to a better understanding of the potential role of metal-induced oxidative stress in PC aetiology. However, confirmation of these pilot findings in a larger study is needed.",
publisher = "Croatian Society of Toxicology",
journal = "Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1)",
title = "The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.",
pages = "47",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3507"
}

Đorđević, V., Prokić, M., Pavlović, S., Radovanović, T., Gavrilović, B., Mutić, J., Buha, A., Knežević, D., Jovanović, S.,& Borković Mitić, S.. (2016). The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.. in Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1)
Croatian Society of Toxicology., 47.
https://hdl.handle.net/21.15107/rcub_ibiss_3507

Đorđević V, Prokić M, Pavlović S, Radovanović T, Gavrilović B, Mutić J, Buha A, Knežević D, Jovanović S, Borković Mitić S. The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.. in Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1). 2016;:47.
https://hdl.handle.net/21.15107/rcub_ibiss_3507 .

Đorđević, Vladimir, Prokić, Marko, Pavlović, Slađan, Radovanović, Tijana, Gavrilović, Branka, Mutić, Jelena, Buha, Aleksandra, Knežević, Djordje, Jovanović, Sanja, Borković Mitić, Slavica, "The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results." in Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1) (2016):47,
https://hdl.handle.net/21.15107/rcub_ibiss_3507 .

TY  - JOUR
AU  - Borković Mitić, Slavica
AU  - Prokić, Marko
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Trifković, Jelena
AU  - Gavrić, Jelena
AU  - Despotović, Svetlana
AU  - Gavrilović, Branka
AU  - Radovanović, Tijana
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
PY  - 2016
UR  - http://www.springer.com/tdm
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2468
AB  - To understand the effect of metals on the marsh frog Pelophylax ridibundus and the possible environment-induced changes in oxidative stress enzymes, we determined the concentrations of 18 metals: Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, In, Li, Mn, Ni, Pb, Sr, and Zn, in the tissues (liver, skin, and muscle) and water samples collected from different locations in Serbia. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), acetylcholinesterase (AChE), and changes in concentrations of reduced glutathione (GSH) and sulfhydryl groups (SH) were analyzed in the tissues of the sampled frogs. The concentrations of Al, Cd, Co, Cr, Cu, Fe, Ga, Hg, and Ni were highest in the liver, whereas those of Ba, Ca, Li, Mn, Pb, Sr, and Zn were highest in the skin. Hg correlated positively with liver SOD (in frogs from Danube-Tisza-Danube Canal (DTD)), muscle CAT (DTD), and muscle GST Ponjavica River (PO); Pb demonstrated a strong positive correlation with liver GR in frogs from Mt. Fruška Gora (FG); Cd only exhibited a positive correlation with AChE in the skin of frogs from DTD. In the skin, Zn correlated positively with AChE (DTD), SH groups (PO), and CAT (FG), and negatively with CAT, GST, and SH in the liver of frogs from DTD. Examination of these oxidative stress biomarkers, together with analysis of metal accumulation in the liver and skin of marsh frogs, provides a powerful tool for the assessment of metal pollution.
PB  - Springer Nature
T2  - Environmental Science and Pollution Research
T1  - Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus)
IS  - 10
VL  - 23
DO  - 10.13039/501100004564
SP  - 9649
EP  - 9659
ER  - 

@article{
author = "Borković Mitić, Slavica and Prokić, Marko and Krizmanić, Imre I. and Mutić, Jelena and Trifković, Jelena and Gavrić, Jelena and Despotović, Svetlana and Gavrilović, Branka and Radovanović, Tijana and Pavlović, Slađan and Saičić, Zorica",
year = "2016",
abstract = "To understand the effect of metals on the marsh frog Pelophylax ridibundus and the possible environment-induced changes in oxidative stress enzymes, we determined the concentrations of 18 metals: Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, In, Li, Mn, Ni, Pb, Sr, and Zn, in the tissues (liver, skin, and muscle) and water samples collected from different locations in Serbia. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), acetylcholinesterase (AChE), and changes in concentrations of reduced glutathione (GSH) and sulfhydryl groups (SH) were analyzed in the tissues of the sampled frogs. The concentrations of Al, Cd, Co, Cr, Cu, Fe, Ga, Hg, and Ni were highest in the liver, whereas those of Ba, Ca, Li, Mn, Pb, Sr, and Zn were highest in the skin. Hg correlated positively with liver SOD (in frogs from Danube-Tisza-Danube Canal (DTD)), muscle CAT (DTD), and muscle GST Ponjavica River (PO); Pb demonstrated a strong positive correlation with liver GR in frogs from Mt. Fruška Gora (FG); Cd only exhibited a positive correlation with AChE in the skin of frogs from DTD. In the skin, Zn correlated positively with AChE (DTD), SH groups (PO), and CAT (FG), and negatively with CAT, GST, and SH in the liver of frogs from DTD. Examination of these oxidative stress biomarkers, together with analysis of metal accumulation in the liver and skin of marsh frogs, provides a powerful tool for the assessment of metal pollution.",
publisher = "Springer Nature",
journal = "Environmental Science and Pollution Research",
title = "Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus)",
number = "10",
volume = "23",
doi = "10.13039/501100004564",
pages = "9649-9659"
}

Borković Mitić, S., Prokić, M., Krizmanić, I. I., Mutić, J., Trifković, J., Gavrić, J., Despotović, S., Gavrilović, B., Radovanović, T., Pavlović, S.,& Saičić, Z.. (2016). Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus). in Environmental Science and Pollution Research
Springer Nature., 23(10), 9649-9659.
https://doi.org/10.13039/501100004564

Borković Mitić S, Prokić M, Krizmanić II, Mutić J, Trifković J, Gavrić J, Despotović S, Gavrilović B, Radovanović T, Pavlović S, Saičić Z. Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus). in Environmental Science and Pollution Research. 2016;23(10):9649-9659.
doi:10.13039/501100004564 .

Borković Mitić, Slavica, Prokić, Marko, Krizmanić, Imre I., Mutić, Jelena, Trifković, Jelena, Gavrić, Jelena, Despotović, Svetlana, Gavrilović, Branka, Radovanović, Tijana, Pavlović, Slađan, Saičić, Zorica, "Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus)" in Environmental Science and Pollution Research, 23, no. 10 (2016):9649-9659,
https://doi.org/10.13039/501100004564 . .