TY  - JOUR
AU  - Matić, Miloš M.
AU  - Paunović, Milica G.
AU  - Milošević, Marija D.
AU  - Ognjanović, Branka I.
AU  - Saičić, Zorica
PY  - 2019
UR  - https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1587451
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3309
AB  - Acetaminophen is widely used as an over-the-counter analgesic and antipyretic drug. The aim of the present study was to investigate the pro-oxidative effects of acetaminophen (300 mg/kg/day i.p.) and antioxidative effects of β-glucan (4 mg/kg/day i.p.) and/or vitamin C (100 mg/kg/day i.p.) on the blood parameters of treated rats. After 3 days of treatment, hematological and parameters of redox status were measured. Exposure of rats to acetaminophen caused significant changes in some hematological parameters and the glutathione redox cycle, leading to an increased concentration of oxidative stress parameters and the formation of lipid peroxidation, while the activities of antioxidant enzymes were decreased. Administration of β-glucan and/or vitamin C reduced lipid peroxidation and restored the levels of examined hematological and oxidative stress parameters and improved the activities of antioxidant enzymes. Obtained results demonstrated that acetaminophen has significant pro-oxidative effects and may disrupt redox balance in blood of rats, while the combination of β-glucan and/or vitamin C amplified the antioxidant defense potential and exhibited a strong hematoprotective activity against acetaminophen-induced toxicity. Therefore, β-glucan and vitamin C co-treatment may be a promising therapeutic option for the treatment of acute acetaminophen hematotoxicity.
T2  - Drug and Chemical Toxicology
T1  - Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats.
DO  - 10.1080/01480545.2019.1587451
ER  - 

@article{
author = "Matić, Miloš M. and Paunović, Milica G. and Milošević, Marija D. and Ognjanović, Branka I. and Saičić, Zorica",
year = "2019",
abstract = "Acetaminophen is widely used as an over-the-counter analgesic and antipyretic drug. The aim of the present study was to investigate the pro-oxidative effects of acetaminophen (300 mg/kg/day i.p.) and antioxidative effects of β-glucan (4 mg/kg/day i.p.) and/or vitamin C (100 mg/kg/day i.p.) on the blood parameters of treated rats. After 3 days of treatment, hematological and parameters of redox status were measured. Exposure of rats to acetaminophen caused significant changes in some hematological parameters and the glutathione redox cycle, leading to an increased concentration of oxidative stress parameters and the formation of lipid peroxidation, while the activities of antioxidant enzymes were decreased. Administration of β-glucan and/or vitamin C reduced lipid peroxidation and restored the levels of examined hematological and oxidative stress parameters and improved the activities of antioxidant enzymes. Obtained results demonstrated that acetaminophen has significant pro-oxidative effects and may disrupt redox balance in blood of rats, while the combination of β-glucan and/or vitamin C amplified the antioxidant defense potential and exhibited a strong hematoprotective activity against acetaminophen-induced toxicity. Therefore, β-glucan and vitamin C co-treatment may be a promising therapeutic option for the treatment of acute acetaminophen hematotoxicity.",
journal = "Drug and Chemical Toxicology",
title = "Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats.",
doi = "10.1080/01480545.2019.1587451"
}

Matić, M. M., Paunović, M. G., Milošević, M. D., Ognjanović, B. I.,& Saičić, Z.. (2019). Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats.. in Drug and Chemical Toxicology.
https://doi.org/10.1080/01480545.2019.1587451

Matić MM, Paunović MG, Milošević MD, Ognjanović BI, Saičić Z. Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats.. in Drug and Chemical Toxicology. 2019;.
doi:10.1080/01480545.2019.1587451 .

Matić, Miloš M., Paunović, Milica G., Milošević, Marija D., Ognjanović, Branka I., Saičić, Zorica, "Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats." in Drug and Chemical Toxicology (2019),
https://doi.org/10.1080/01480545.2019.1587451 . .

TY  - JOUR
AU  - Milošević, Marija D.
AU  - Paunović, Milica G.
AU  - Matić, Miloš M.
AU  - Ognjanović, Branka I.
AU  - Saičić, Zorica
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0753332218311636?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3100
AB  - Excessive use of organophosphate insecticides, including fenitrothion (FNT) can cause detrimental consequences in non-target organisms. Selenium (Se) and vitamin C (Vit C) possess protective abilities against various toxic compounds due to their antioxidative properties. Accordingly, the aim of the present study was to examine the possible ameliorative effects of Se and Vit C in hepatotoxicity induced by FNT. For the purpose of this study, male Wistar albino rats were divided into control and groups treated with Se (0.5 mg/kg b.w, as Na2SeO3) and Vit C (100 mg/kg b.w), FNT (20 mg/kg b.w) and FNT in cotreatment with Se and Vit C for 30 days. The current data showed a reduction in absolute and relative liver weight after FNT administration. Increased activities of liver enzymes (AST, ALT, ALP, LDH and GGT) indicated liver damage. FNT alone caused significant alterations in biochemical parameters (glucose and total bilirubin). Elevation in LPO level along with decreased activities of antioxidant enzymes (SOD, CAT, GSH-Px) and GSH content reflected the presence of oxidative stress. Coadministration of FNT with Se and Vit C exhibited hepatoprotective role confirmed by reduction of oxidative stress levels and restoration in the values of examined parameters. Because of their beneficial effects, Se and Vit C may be used in reducing injuries caused by pesticides.
T2  - Biomedicine & Pharmacotherapy
T1  - Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver.
VL  - 106
DO  - 10.1016/j.biopha.2018.06.132
SP  - 232
EP  - 238
ER  - 

@article{
author = "Milošević, Marija D. and Paunović, Milica G. and Matić, Miloš M. and Ognjanović, Branka I. and Saičić, Zorica",
year = "2018",
abstract = "Excessive use of organophosphate insecticides, including fenitrothion (FNT) can cause detrimental consequences in non-target organisms. Selenium (Se) and vitamin C (Vit C) possess protective abilities against various toxic compounds due to their antioxidative properties. Accordingly, the aim of the present study was to examine the possible ameliorative effects of Se and Vit C in hepatotoxicity induced by FNT. For the purpose of this study, male Wistar albino rats were divided into control and groups treated with Se (0.5 mg/kg b.w, as Na2SeO3) and Vit C (100 mg/kg b.w), FNT (20 mg/kg b.w) and FNT in cotreatment with Se and Vit C for 30 days. The current data showed a reduction in absolute and relative liver weight after FNT administration. Increased activities of liver enzymes (AST, ALT, ALP, LDH and GGT) indicated liver damage. FNT alone caused significant alterations in biochemical parameters (glucose and total bilirubin). Elevation in LPO level along with decreased activities of antioxidant enzymes (SOD, CAT, GSH-Px) and GSH content reflected the presence of oxidative stress. Coadministration of FNT with Se and Vit C exhibited hepatoprotective role confirmed by reduction of oxidative stress levels and restoration in the values of examined parameters. Because of their beneficial effects, Se and Vit C may be used in reducing injuries caused by pesticides.",
journal = "Biomedicine & Pharmacotherapy",
title = "Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver.",
volume = "106",
doi = "10.1016/j.biopha.2018.06.132",
pages = "232-238"
}

Milošević, M. D., Paunović, M. G., Matić, M. M., Ognjanović, B. I.,& Saičić, Z.. (2018). Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver.. in Biomedicine & Pharmacotherapy, 106, 232-238.
https://doi.org/10.1016/j.biopha.2018.06.132

Milošević MD, Paunović MG, Matić MM, Ognjanović BI, Saičić Z. Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver.. in Biomedicine & Pharmacotherapy. 2018;106:232-238.
doi:10.1016/j.biopha.2018.06.132 .

Milošević, Marija D., Paunović, Milica G., Matić, Miloš M., Ognjanović, Branka I., Saičić, Zorica, "Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver." in Biomedicine & Pharmacotherapy, 106 (2018):232-238,
https://doi.org/10.1016/j.biopha.2018.06.132 . .

TY  - JOUR
AU  - Milošević, Marija D.
AU  - Paunović, Milica G.
AU  - Matić, Miloš M.
AU  - Ognjanović, Branka I.
AU  - Saičić, Zorica
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1382668917302740
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2863
AB  - Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5 mg/kg b.w.) and vitamin C (100 mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20 mg/kg b.w) for 30 days. Fenitrothion caused changes in body weight, food and water intake, and some haematological and biochemical parameters. Fenitrothion altered the glutathione redox status (GSH and GSSG) and decreased activity of antioxidant enzymes (GSH-Px, GST, SOD and CAT), leading to a lipid peroxidation. Selenium and vitamin C, by improving the activity of antioxidants, reduced oxidative stress and a lipid peroxidation, maintaining the values of examined parameters to optimal levels. Therefore, selenium and vitamin C could be useful in providing protection of exposed non-target organisms including people from fenitrothion.
T2  - Environmental Toxicology and Pharmacology
T1  - The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats
VL  - 56
DO  - 10.1016/j.etap.2017.09.016
SP  - 204
EP  - 209
ER  - 

@article{
author = "Milošević, Marija D. and Paunović, Milica G. and Matić, Miloš M. and Ognjanović, Branka I. and Saičić, Zorica",
year = "2017",
abstract = "Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5 mg/kg b.w.) and vitamin C (100 mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20 mg/kg b.w) for 30 days. Fenitrothion caused changes in body weight, food and water intake, and some haematological and biochemical parameters. Fenitrothion altered the glutathione redox status (GSH and GSSG) and decreased activity of antioxidant enzymes (GSH-Px, GST, SOD and CAT), leading to a lipid peroxidation. Selenium and vitamin C, by improving the activity of antioxidants, reduced oxidative stress and a lipid peroxidation, maintaining the values of examined parameters to optimal levels. Therefore, selenium and vitamin C could be useful in providing protection of exposed non-target organisms including people from fenitrothion.",
journal = "Environmental Toxicology and Pharmacology",
title = "The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats",
volume = "56",
doi = "10.1016/j.etap.2017.09.016",
pages = "204-209"
}

Milošević, M. D., Paunović, M. G., Matić, M. M., Ognjanović, B. I.,& Saičić, Z.. (2017). The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats. in Environmental Toxicology and Pharmacology, 56, 204-209.
https://doi.org/10.1016/j.etap.2017.09.016

Milošević MD, Paunović MG, Matić MM, Ognjanović BI, Saičić Z. The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats. in Environmental Toxicology and Pharmacology. 2017;56:204-209.
doi:10.1016/j.etap.2017.09.016 .

Milošević, Marija D., Paunović, Milica G., Matić, Miloš M., Ognjanović, Branka I., Saičić, Zorica, "The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats" in Environmental Toxicology and Pharmacology, 56 (2017):204-209,
https://doi.org/10.1016/j.etap.2017.09.016 . .

TY  - JOUR
AU  - Matić, Miloš M.
AU  - Milošević, Marija D.
AU  - Paunović, Milica G.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2016
UR  - http://www.pmf.kg.ac.rs/KJS/images/volumes/vol38/kjs38maticmilosevic135.pdf
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2616
AB  - Paracetamol (acetaminophen) is widely used as an ov er-the-counter analgesic and antipyretic drug. The aim of this stu dy was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β -glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative s tress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure of rats to paracetamol caused changes of some haematological parameters (R BCs count, Hb concentration, Ht value and WBCs count), suggesting that the paraceta mol induced haematotoxicity. Paracetamol reduced serum total protein (TP), album in and globulin, while increased alanine aminotransferase (ALT), aspartate aminotran sferase (AST) and lactate dehydrogenase (LDH) activities compared to the cont rol. The results indicate that paracetamol is led to significant decrease in the c oncentration of Na + and K + and increase of Ca 2+ in the serum compared to the control. Coadministra tion of vitamin C and β -glucan with paracetamol reversed these changes of haematol ogical and biochemical parameters and diminished the toxic effects of paracetamol. Th e obtained results indicated that the concentration of LPO in erythrocytes significantly increased in, while the concentration of GSH significantly decreased in the group treated with paracetamol compared to control group. Coadministration of vitamin C and β -glucan with paracetamol reversed paracetamol-induced alterations in these oxidative stress parameters. This study suggests that paracetamol has significant prooxidative effec ts and may disrupt oxidant/antioxidant balance in erythrocytes. Furthermore, coadministrat ion with vitamin C and β -glucan have protective effects on paracetamol-induced oxidative damage and haematotoxicity.
T2  - Kragujevac Journal of Science
T1  - Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan
VL  - 38
SP  - 135
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_2616
ER  - 

@article{
author = "Matić, Miloš M. and Milošević, Marija D. and Paunović, Milica G. and Ognjanović, Branka I. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2016",
abstract = "Paracetamol (acetaminophen) is widely used as an ov er-the-counter analgesic and antipyretic drug. The aim of this stu dy was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β -glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative s tress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure of rats to paracetamol caused changes of some haematological parameters (R BCs count, Hb concentration, Ht value and WBCs count), suggesting that the paraceta mol induced haematotoxicity. Paracetamol reduced serum total protein (TP), album in and globulin, while increased alanine aminotransferase (ALT), aspartate aminotran sferase (AST) and lactate dehydrogenase (LDH) activities compared to the cont rol. The results indicate that paracetamol is led to significant decrease in the c oncentration of Na + and K + and increase of Ca 2+ in the serum compared to the control. Coadministra tion of vitamin C and β -glucan with paracetamol reversed these changes of haematol ogical and biochemical parameters and diminished the toxic effects of paracetamol. Th e obtained results indicated that the concentration of LPO in erythrocytes significantly increased in, while the concentration of GSH significantly decreased in the group treated with paracetamol compared to control group. Coadministration of vitamin C and β -glucan with paracetamol reversed paracetamol-induced alterations in these oxidative stress parameters. This study suggests that paracetamol has significant prooxidative effec ts and may disrupt oxidant/antioxidant balance in erythrocytes. Furthermore, coadministrat ion with vitamin C and β -glucan have protective effects on paracetamol-induced oxidative damage and haematotoxicity.",
journal = "Kragujevac Journal of Science",
title = "Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan",
volume = "38",
pages = "135-146",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_2616"
}

Matić, M. M., Milošević, M. D., Paunović, M. G., Ognjanović, B. I., Štajn, A. Š.,& Saičić, Z.. (2016). Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan. in Kragujevac Journal of Science, 38, 135-146.
https://hdl.handle.net/21.15107/rcub_ibiss_2616

Matić MM, Milošević MD, Paunović MG, Ognjanović BI, Štajn AŠ, Saičić Z. Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan. in Kragujevac Journal of Science. 2016;38:135-146.
https://hdl.handle.net/21.15107/rcub_ibiss_2616 .

Matić, Miloš M., Milošević, Marija D., Paunović, Milica G., Ognjanović, Branka I., Štajn, Andraš Š., Saičić, Zorica, "Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan" in Kragujevac Journal of Science, 38 (2016):135-146,
https://hdl.handle.net/21.15107/rcub_ibiss_2616 .