TY  - JOUR
AU  - Prokić, Marko
AU  - Borković Mitić, Slavica
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena J.
AU  - Gavrić, Jelena
AU  - Despotović, Svetlana
AU  - Gavrilović, Branka
AU  - Radovanović, Tijana
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1532045617301370
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2827
AB  - In spring, frogs from temperate regions are faced with arousal-induced oxidative stress and exposure to various xenobiotics from the environment. The question is whether pollutants can significantly modify the antioxidative defense system (AOS) response of hibernators during recovery from hibernation. If this assumption is true, we would then expect different patterns of seasonal variations in the AOS between individuals exposed to different levels of pollution. To examine this assumption, we determined the relationship between seasonal variations of accumulated metals and AOS parameters in the skin and muscle of two frog species from the Pelophylax esculentus complex (P. ridibundus and P. esculentus) inhabiting two localities (the Danube-Tisza-Danube canal and the Ponjavica River) with different levels of pollution during pre- and post-hibernation periods, respectively autumn and spring. Our results showed that even though there were differences in the concentrations of accumulated metals and AOS parameters between localities and species, the frogs displayed almost the same patterns of AOS variations during seasons, with a higher AOS response observed in spring. The parameters SH groups, GSH, GR and SOD had been contributed most rather than others. Our findings indicate that oxidative stress during the post-hibernation period was mainly caused by the organisms’ recovery from hibernation, as the result of natural selection acting on the AOS, and that the accumulated metals did not significantly modify the AOS response. The present study provides new insight into the biological and physiological cellular responses of frogs to arousal stress.
T2  - Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
T1  - Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals
VL  - 202
DO  - 10.1016/j.cbpc.2017.07.006
SP  - 19
EP  - 25
ER  - 

@article{
author = "Prokić, Marko and Borković Mitić, Slavica and Krizmanić, Imre I. and Mutić, Jelena J. and Gavrić, Jelena and Despotović, Svetlana and Gavrilović, Branka and Radovanović, Tijana and Pavlović, Slađan and Saičić, Zorica",
year = "2017",
abstract = "In spring, frogs from temperate regions are faced with arousal-induced oxidative stress and exposure to various xenobiotics from the environment. The question is whether pollutants can significantly modify the antioxidative defense system (AOS) response of hibernators during recovery from hibernation. If this assumption is true, we would then expect different patterns of seasonal variations in the AOS between individuals exposed to different levels of pollution. To examine this assumption, we determined the relationship between seasonal variations of accumulated metals and AOS parameters in the skin and muscle of two frog species from the Pelophylax esculentus complex (P. ridibundus and P. esculentus) inhabiting two localities (the Danube-Tisza-Danube canal and the Ponjavica River) with different levels of pollution during pre- and post-hibernation periods, respectively autumn and spring. Our results showed that even though there were differences in the concentrations of accumulated metals and AOS parameters between localities and species, the frogs displayed almost the same patterns of AOS variations during seasons, with a higher AOS response observed in spring. The parameters SH groups, GSH, GR and SOD had been contributed most rather than others. Our findings indicate that oxidative stress during the post-hibernation period was mainly caused by the organisms’ recovery from hibernation, as the result of natural selection acting on the AOS, and that the accumulated metals did not significantly modify the AOS response. The present study provides new insight into the biological and physiological cellular responses of frogs to arousal stress.",
journal = "Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology",
title = "Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals",
volume = "202",
doi = "10.1016/j.cbpc.2017.07.006",
pages = "19-25"
}

Prokić, M., Borković Mitić, S., Krizmanić, I. I., Mutić, J. J., Gavrić, J., Despotović, S., Gavrilović, B., Radovanović, T., Pavlović, S.,& Saičić, Z.. (2017). Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals. in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 202, 19-25.
https://doi.org/10.1016/j.cbpc.2017.07.006

Prokić M, Borković Mitić S, Krizmanić II, Mutić JJ, Gavrić J, Despotović S, Gavrilović B, Radovanović T, Pavlović S, Saičić Z. Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals. in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;202:19-25.
doi:10.1016/j.cbpc.2017.07.006 .

Prokić, Marko, Borković Mitić, Slavica, Krizmanić, Imre I., Mutić, Jelena J., Gavrić, Jelena, Despotović, Svetlana, Gavrilović, Branka, Radovanović, Tijana, Pavlović, Slađan, Saičić, Zorica, "Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals" in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 202 (2017):19-25,
https://doi.org/10.1016/j.cbpc.2017.07.006 . .