TY  - CONF
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5834
AB  - MK-801 can mimic the cognitive, negative, psychotic, and physiological features of
schizophrenia, including increased hyperlocomotion and altered behavioral flexibility.
As N-methyl-D-aspartate (NMDA) receptor antagonist, it is widely used to test the
“glutamate hypofunction hypothesis of schizophrenia”. An extremely low-frequency
magnetic field (ELF-MF) can stimulate NMDA receptor activity, but its effect on
dysregulated glutamine transmission is unknown. Therefore, this study addresses the
effect of continuous exposure to ELF-MF (50 Hz, 0.5 mT) for 7 days on rat
psychomotor behavior induced by acute administration of MK-801 (0.25 mg/kg, i.p.).
During the experiment, adult male Wistar rats were placed near the on/off generator of
ELF-MF, injected with MK-801/saline immediately after 7-day sham/ELF-MF
exposure, and subjected to the open field test for 2 hours. Their behavior was analyzed
using the ANY-maze software and expressed as travel distance, time in movement,
and average speed while in motion in 30-min intervals. The results show that (1) acute
administration of 0.25 mg/kg MK-801 significantly increased travel distance and time
in movement from 60 to 120 min and average speed while in motion from 60 to 90
min compared with saline-injected animals; (2) 7-day exposure to ELF-MF had no
significant effect on the behavior of saline- and MK-801-injected animals compared
with the corresponding controls. Therefore, it can be concluded that this regime of
ELF-MF exposure does not affect the psychomotor behavior of rats caused by the
pharmacological modification of glutamine transmission with the applied MK-801
dose.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801
SP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5834
ER  - 

@conference{
author = "Kesić, Srđan and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Petković, Branka",
year = "2023",
abstract = "MK-801 can mimic the cognitive, negative, psychotic, and physiological features of
schizophrenia, including increased hyperlocomotion and altered behavioral flexibility.
As N-methyl-D-aspartate (NMDA) receptor antagonist, it is widely used to test the
“glutamate hypofunction hypothesis of schizophrenia”. An extremely low-frequency
magnetic field (ELF-MF) can stimulate NMDA receptor activity, but its effect on
dysregulated glutamine transmission is unknown. Therefore, this study addresses the
effect of continuous exposure to ELF-MF (50 Hz, 0.5 mT) for 7 days on rat
psychomotor behavior induced by acute administration of MK-801 (0.25 mg/kg, i.p.).
During the experiment, adult male Wistar rats were placed near the on/off generator of
ELF-MF, injected with MK-801/saline immediately after 7-day sham/ELF-MF
exposure, and subjected to the open field test for 2 hours. Their behavior was analyzed
using the ANY-maze software and expressed as travel distance, time in movement,
and average speed while in motion in 30-min intervals. The results show that (1) acute
administration of 0.25 mg/kg MK-801 significantly increased travel distance and time
in movement from 60 to 120 min and average speed while in motion from 60 to 90
min compared with saline-injected animals; (2) 7-day exposure to ELF-MF had no
significant effect on the behavior of saline- and MK-801-injected animals compared
with the corresponding controls. Therefore, it can be concluded that this regime of
ELF-MF exposure does not affect the psychomotor behavior of rats caused by the
pharmacological modification of glutamine transmission with the applied MK-801
dose.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801",
pages = "50",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5834"
}

Kesić, S., Stojadinović, G., Martać, L., Sekulić, S.,& Petković, B.. (2023). Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801. in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 50.
https://hdl.handle.net/21.15107/rcub_ibiss_5834

Kesić S, Stojadinović G, Martać L, Sekulić S, Petković B. Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801. in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:50.
https://hdl.handle.net/21.15107/rcub_ibiss_5834 .

Kesić, Srđan, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Petković, Branka, "Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801" in Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):50,
https://hdl.handle.net/21.15107/rcub_ibiss_5834 .

TY  - JOUR
AU  - Podgorac, Jelena
AU  - Sekulić, Slobodan
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Pešić, Vesna
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9557044
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5169
AB  - Clinical findings show that the use of valproic acid (VPA) during pregnancy increases the risk of birth defects and autism spectrum disorder in offspring. Although there is a consensus that monitoring of potential long-term outcomes of VPA exposure is needed, especially in undiagnosed individuals, preclinical studies addressing this issue are rare. The present study examined the effects of continuous intrauterine exposure to a wide dose range of VPA (50, 100, 200, and 400 mg/kg/day) on the physical and behavioral response in peripubertal mice as a rodent model of adolescence. Body weight and the hot plate test [on postnatal days (PND) 25 and 32], the elevated plus-maze test (on PND35), and the open field test (on PND40) served to examine physical growth, the supraspinal reflex response to a painful thermal stimulus and conditional learning, anxiety-like/risk-assessment behavior, as well as novelty-induced psychomotor activity, respectively. VPA exposure produced the following responses: (i) a negative effect on body weight, except for the dose of 100 mg/kg/day in both sexes; (ii) an increase in the percentage of animals that responded to the thermal stimulus above the defined cut-off time interval and the response latency in both sexes; (iii) dose-specific changes within sexes in behavior provoked by a novel anxiogenic environment, i.e., in females less anxiety-like/risk-assessment behavior in response to the lowest exposure dose, and in males more pronounced anxiety-like/risk-assessment behavior after exposure to the highest dose and 100 mg/kg/day; (iv) dose-specific changes within sexes in novelty-induced psychomotor activity, i.e., in females a decrease in stereotypy-like activity along with an increase in rearing, and in males a decrease in stereotypy-like activity only. These findings show that continuous intrauterine exposure to VPA produces maladaptive functioning in different behavioral domains in adolescence and that the consequences are delicate to assess as they are dose-related within sexes.
PB  - Lausanne: Frontiers Media S.A.
T2  - Frontiers in Behavioral Neuroscience
T1  - The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes
VL  - 16
DO  - 10.3389/fnbeh.2022.982811
SP  - 982811
ER  - 

@article{
author = "Podgorac, Jelena and Sekulić, Slobodan and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Pešić, Vesna",
year = "2022",
abstract = "Clinical findings show that the use of valproic acid (VPA) during pregnancy increases the risk of birth defects and autism spectrum disorder in offspring. Although there is a consensus that monitoring of potential long-term outcomes of VPA exposure is needed, especially in undiagnosed individuals, preclinical studies addressing this issue are rare. The present study examined the effects of continuous intrauterine exposure to a wide dose range of VPA (50, 100, 200, and 400 mg/kg/day) on the physical and behavioral response in peripubertal mice as a rodent model of adolescence. Body weight and the hot plate test [on postnatal days (PND) 25 and 32], the elevated plus-maze test (on PND35), and the open field test (on PND40) served to examine physical growth, the supraspinal reflex response to a painful thermal stimulus and conditional learning, anxiety-like/risk-assessment behavior, as well as novelty-induced psychomotor activity, respectively. VPA exposure produced the following responses: (i) a negative effect on body weight, except for the dose of 100 mg/kg/day in both sexes; (ii) an increase in the percentage of animals that responded to the thermal stimulus above the defined cut-off time interval and the response latency in both sexes; (iii) dose-specific changes within sexes in behavior provoked by a novel anxiogenic environment, i.e., in females less anxiety-like/risk-assessment behavior in response to the lowest exposure dose, and in males more pronounced anxiety-like/risk-assessment behavior after exposure to the highest dose and 100 mg/kg/day; (iv) dose-specific changes within sexes in novelty-induced psychomotor activity, i.e., in females a decrease in stereotypy-like activity along with an increase in rearing, and in males a decrease in stereotypy-like activity only. These findings show that continuous intrauterine exposure to VPA produces maladaptive functioning in different behavioral domains in adolescence and that the consequences are delicate to assess as they are dose-related within sexes.",
publisher = "Lausanne: Frontiers Media S.A.",
journal = "Frontiers in Behavioral Neuroscience",
title = "The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes",
volume = "16",
doi = "10.3389/fnbeh.2022.982811",
pages = "982811"
}

Podgorac, J., Sekulić, S., Petković, B., Stojadinović, G., Martać, L.,& Pešić, V.. (2022). The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes. in Frontiers in Behavioral Neuroscience
Lausanne: Frontiers Media S.A.., 16, 982811.
https://doi.org/10.3389/fnbeh.2022.982811

Podgorac J, Sekulić S, Petković B, Stojadinović G, Martać L, Pešić V. The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes. in Frontiers in Behavioral Neuroscience. 2022;16:982811.
doi:10.3389/fnbeh.2022.982811 .

Podgorac, Jelena, Sekulić, Slobodan, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Pešić, Vesna, "The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes" in Frontiers in Behavioral Neuroscience, 16 (2022):982811,
https://doi.org/10.3389/fnbeh.2022.982811 . .

TY  - CONF
AU  - Milićević, Katarina
AU  - Lazarević, Milica
AU  - Momčilović, Miljana
AU  - Todorović, Nataša
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Nikolić, Ljiljana
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5504
AB  - Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system (CNS)
characterized by infiltration of lymphocytes that leads to myelin damage and neurodegeneration.
The complex interaction between CNS-infiltrating immune cells (CNS-IIC) and astrocytes is an
important contributor to the disease progression. Here, we investigate how naïve astrocytes respond
to autoreactive immune cells present in the CNS at different stages of the disease. For this purpose,
CNS-IICs were isolated from the spinal cords of rats with experimental autoimmune
encephalomyelitis at onset, late-onset and the peak of the disease. Naïve astrocytes, isolated from
the spinal cords of wild-type rat pups, responded to brief bath application of CNS-IIC by robust
elevation of intracellular Ca2+ independently of the disease stage. Our data suggest that direct
contact between astrocytes and CNS-IICs induces Ca2+ changes in astrocytes and points to the new
aspect of cell-cell interactions in the propagation of neuroinflammatory response in CNS
autoimmunity.
PB  - Belgrade: Society of Physical Chemists of Serbia
C3  - Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
T1  - Naïve astrocytes react to CNS-infiltrated immune cells
SP  - 267
EP  - 270
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5504
ER  - 

@conference{
editor = "Čupić, Željko, Anić, Slobodan",
author = "Milićević, Katarina and Lazarević, Milica and Momčilović, Miljana and Todorović, Nataša and Petković, Branka and Stojadinović, Gordana and Nikolić, Ljiljana",
year = "2022",
abstract = "Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system (CNS)
characterized by infiltration of lymphocytes that leads to myelin damage and neurodegeneration.
The complex interaction between CNS-infiltrating immune cells (CNS-IIC) and astrocytes is an
important contributor to the disease progression. Here, we investigate how naïve astrocytes respond
to autoreactive immune cells present in the CNS at different stages of the disease. For this purpose,
CNS-IICs were isolated from the spinal cords of rats with experimental autoimmune
encephalomyelitis at onset, late-onset and the peak of the disease. Naïve astrocytes, isolated from
the spinal cords of wild-type rat pups, responded to brief bath application of CNS-IIC by robust
elevation of intracellular Ca2+ independently of the disease stage. Our data suggest that direct
contact between astrocytes and CNS-IICs induces Ca2+ changes in astrocytes and points to the new
aspect of cell-cell interactions in the propagation of neuroinflammatory response in CNS
autoimmunity.",
publisher = "Belgrade: Society of Physical Chemists of Serbia",
journal = "Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia",
title = "Naïve astrocytes react to CNS-infiltrated immune cells",
pages = "267-270",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5504"
}

Čupić, Ž., Anić, S., Milićević, K., Lazarević, M., Momčilović, M., Todorović, N., Petković, B., Stojadinović, G.,& Nikolić, L.. (2022). Naïve astrocytes react to CNS-infiltrated immune cells. in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
Belgrade: Society of Physical Chemists of Serbia., 267-270.
https://hdl.handle.net/21.15107/rcub_ibiss_5504

Čupić Ž, Anić S, Milićević K, Lazarević M, Momčilović M, Todorović N, Petković B, Stojadinović G, Nikolić L. Naïve astrocytes react to CNS-infiltrated immune cells. in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia. 2022;:267-270.
https://hdl.handle.net/21.15107/rcub_ibiss_5504 .

Čupić, Željko, Anić, Slobodan, Milićević, Katarina, Lazarević, Milica, Momčilović, Miljana, Todorović, Nataša, Petković, Branka, Stojadinović, Gordana, Nikolić, Ljiljana, "Naïve astrocytes react to CNS-infiltrated immune cells" in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia (2022):267-270,
https://hdl.handle.net/21.15107/rcub_ibiss_5504 .

TY  - CONF
AU  - Nikolić, Ljiljana
AU  - Vidović, Marija
AU  - Todorović, Nataša
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Bogdanović Pristov, Jelena
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5508
AB  - Investigating membrane properties of plants is a challenging task, considering that success of
experiments is highly dependent on the possibility to isolate metabolically active protoplasts that
can withstand membrane current recordings. The aim of the present work is to obtain viable
protoplasts derived from root cells of Pisum sativum that can be used for the whole-cell patchclamp. We designed the procedure of the pea protoplasts isolation that delivers stable protoplasts
with preserved membrane integrity suitable for electrophysiological experiments. We applied a
custom approach for patch-clamping protoplasts using a microscope with a movable microscope
stage. We recorded prominent inward and prominent outward types of membrane current profiles of
protoplasts. Obtained data indicate that optimized isolation protocol and custom system for patchclamping, can be applied to study membrane properties of root protoplasts.
PB  - Belgrade: Society of Physical Chemists of Serbia
C3  - Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
T1  - Protoplast patch-clamping using an upright microscope with a movable stage
SP  - 271
EP  - 274
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5508
ER  - 

@conference{
editor = "Čupić, Željko, Anić, Slobodan",
author = "Nikolić, Ljiljana and Vidović, Marija and Todorović, Nataša and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Bogdanović Pristov, Jelena",
year = "2022",
abstract = "Investigating membrane properties of plants is a challenging task, considering that success of
experiments is highly dependent on the possibility to isolate metabolically active protoplasts that
can withstand membrane current recordings. The aim of the present work is to obtain viable
protoplasts derived from root cells of Pisum sativum that can be used for the whole-cell patchclamp. We designed the procedure of the pea protoplasts isolation that delivers stable protoplasts
with preserved membrane integrity suitable for electrophysiological experiments. We applied a
custom approach for patch-clamping protoplasts using a microscope with a movable microscope
stage. We recorded prominent inward and prominent outward types of membrane current profiles of
protoplasts. Obtained data indicate that optimized isolation protocol and custom system for patchclamping, can be applied to study membrane properties of root protoplasts.",
publisher = "Belgrade: Society of Physical Chemists of Serbia",
journal = "Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia",
title = "Protoplast patch-clamping using an upright microscope with a movable stage",
pages = "271-274",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5508"
}

Čupić, Ž., Anić, S., Nikolić, L., Vidović, M., Todorović, N., Petković, B., Stojadinović, G., Martać, L.,& Bogdanović Pristov, J.. (2022). Protoplast patch-clamping using an upright microscope with a movable stage. in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
Belgrade: Society of Physical Chemists of Serbia., 271-274.
https://hdl.handle.net/21.15107/rcub_ibiss_5508

Čupić Ž, Anić S, Nikolić L, Vidović M, Todorović N, Petković B, Stojadinović G, Martać L, Bogdanović Pristov J. Protoplast patch-clamping using an upright microscope with a movable stage. in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia. 2022;:271-274.
https://hdl.handle.net/21.15107/rcub_ibiss_5508 .

Čupić, Željko, Anić, Slobodan, Nikolić, Ljiljana, Vidović, Marija, Todorović, Nataša, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Bogdanović Pristov, Jelena, "Protoplast patch-clamping using an upright microscope with a movable stage" in Proceedings: Physical Chemistry 2022, Vol. 1.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia (2022):271-274,
https://hdl.handle.net/21.15107/rcub_ibiss_5508 .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
AU  - Sekulić, Slobodan
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5745
AB  - Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu.
AB  - Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa
T1  - Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева
SP  - 369
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5745
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Martać, Ljiljana and Stojadinović, Gordana and Pešić, Vesna and Sekulić, Slobodan",
year = "2022",
abstract = "Valproinska kiselina (VPK) je lek izbora u terapiji epilepsija kod trudnica, iako može uzrokovati različite poremećaje kod potomstva.1 Naša prethodna istraživanja su pokazala usporen somatski razvoj i odloženo sazrevanje motoričkog sistema u ranom postnatalnom periodu kod potomaka miševa koji su prenatalno kontinuirano izlagani VPK.2 Sa ciljem da proširimo saznanja vezana za model i procenimo dugotrajnost posledica VPK, u ovoj studiji ispitivali smo karakteristike psihomotornog ponašanja adolescentnih i odraslih mužjaka miševa u odgovoru na novu sredinu. Ženke su kontinuirano injecirane rastvorom VPK (50, 100 ili 400 mg/kg/dan; subkutano) tokom celog perioda gestacije. Potomstvo muškog pola starosti 6 nedelja (adolescenti) i 12 nedelja (odrasli) je ispitivano u testu otvorenog polja (open field test) u cilju procene lokomotorne, stereotipne i vertikalne aktivnosti. Rezultati ukazuju da tretman VPK: (1) nema uticaja na lokomotornu i vertikalnu aktivnost adolescentnih i odraslih jedinki, (2) smanjuje stereotipnu aktivnost adolescentnih jedinki u dozi od 100 i 400 mg/kg/dan. Dobijeni rezultati ukazuju da prenatalno kontinuirano izlaganje VPK ima dugotrajne posledice kod potomstva muškog pola, narušavajući očekivani odgovor adolescentnih jedinki na novu sredinu. Izostanak efekta kod odraslih jedinki se može objasniti spontanim dovođenjem sistema u ravnotežu usled maturacionih promena, što ipak ostaje da se dodatno proceni u drugim testovima zasnovanim na spontanom odgovoru na novu sredinu., Валпроинска киселина (ВПК) је лек избора у терапији епилепсија код трудница,
иако може узроковати различите поремећаје код потомства.1 Наша претходна
истраживања су показала успорен соматски развој и одложено сазревање
моторичког система у раном постнаталном периоду код потомака мишева који су
пренатално континуирано излагани ВПК.2 Са циљем да проширимо сазнања везана
за модел и проценимо дуготрајност последица ВПК, у овој студији испитивали смо
карактеристике психомоторног понашања адолесцентних и одраслих мужјака
мишева у одговору на нову средину. Женке су континуирано ињециране раствором
ВПК (50, 100 или 400 мг/кг/дан; субкутано) током целог периода гестације.
Потомство мушког пола старости 6 недеља (адолесценти) и 12 недеља (одрасли) је
испитивано у тесту отвореног поља (open field test) у циљу процене локомоторне,
стереотипне и вертикалне активности. Резултати указују да третман ВПК: (1) нема
утицаја на локомоторну и вертикалну активност адолесцентних и одраслих
јединки, (2) смањује стереотипну активност адолесцентних јединки у дози од 100 и
400 мг/кг/дан. Добијени резултати указују да пренатално континуирано излагање
ВПК има дуготрајне последице код потомства мушког пола, нарушавајући
очекивани одговор адолесцентних јединки на нову средину. Изостанак ефекта код
одраслих јединки се може објаснити спонтаним довођењем система у равнотежу
услед матурационих промена, што ипак остаје да се додатно процени у другим
тестовима заснованим на спонтаном одговору на нову средину.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa, Утицај континуираног излагања валпроинској киселини током пренаталног развоја на психомоторно понашање адолесцентних и одраслих мужјака мишева",
pages = "369",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5745"
}

Podgorac, J., Petković, B., Martać, L., Stojadinović, G., Pešić, V.,& Sekulić, S.. (2022). Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745

Podgorac J, Petković B, Martać L, Stojadinović G, Pešić V, Sekulić S. Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:369.
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

Podgorac, Jelena, Petković, Branka, Martać, Ljiljana, Stojadinović, Gordana, Pešić, Vesna, Sekulić, Slobodan, "Uticaj kontinuiranog izlaganja valproinskoj kiselini tokom prenatalnog razvoja na psihomotorno ponašanje adolescentnih i odraslih mužjaka miševa" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):369,
https://hdl.handle.net/21.15107/rcub_ibiss_5745 .

TY  - CONF
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5746
AB  - Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije.
AB  - Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina
T1  - Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина
SP  - 388
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5746
ER  - 

@conference{
author = "Kesić, Srđan and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Petković, Branka",
year = "2022",
abstract = "Akutna primena dizocilpina (MK-801), antagoniste glutaminskih N-metil-D-aspartatnih (NMDA) receptora, prouzrokuje psihotične simptome slične šizofreniji kod pacova.1 Ekstremno niskofrekventno magnetno polje (ENF-MP), kao fizički faktor životne sredine, može stimulisati aktivnost NMDA receptora,2 mada ovaj efekat ENF-MP u uslovima disregulisane glutaminske transmisije nije poznat. Stoga, ova studija se bavi uticajem kontinuiranog izlaganja ENF-MP (50 Hz, 0,5 mT) u toku 7 dana na psihomotorno ponašanje pacova izazvano akutnom primenom MK-801 (0,1 mg/kg, i.p.). U toku eksperimenta odrasli mužjaci Wistar pacova postavljeni su u blizini uključenog/isključenog ENF-MP generatora, neposredno nakon prestanka izlaganja injecirani MK-801/fiziološkim rastvorom i podvrgnuti testu otvorenog polja (open field test) u toku 2 sata. ANY-maze softverom je urađena analiza lokomotorne i stereotipne aktivnosti. Pokazano je da: (1) 7-dnevno kontinuirano izlaganje ENF-MP nema uticaja, dok akutna primena MK-801 značajno povećava lokomotornu i stereotipnu aktivnost pacova od 60. do 90. min registracije ponašanja; (2) 7- dnevno kontinuirano izlaganje ENF-MP značajno intenzivira efekte izazvane akutnom primenom MK-801 od 60. do 120. min registracije ponašanja. Dobijeni rezultati ukazuju na modulatorni uticaj kontinuiranog izlaganja ENF-MP pomenutih karakteristika na glutaminsku transmisiju, koji dolazi do izražaja u uslovima njene farmakološke manipulacije., Акутна примена дизоцилпина (MK-801), антагонисте глутаминских Н-метил-Д-
аспартатних (NMDA) рецептора, проузрокује психотичне симптоме сличне
шизофренији код пацова.1 Екстремно нискофреквентно магнетно поље (ЕНФ-МП),
као физички фактор животне средине, може стимулисати активност NMDA
рецептора,2 мада овај ефекат ЕНФ-МП у условима дисрегулисане глутаминске
трансмисије није познат. Стога, ова студија се бави утицајем континуираног
излагања ЕНФ-МП (50 Hz, 0,5 mT) у току 7 дана на психомоторно понашање
пацова изазвано акутном применом MK-801 (0,1 mg/kg, и.п.). У току експеримента
одрасли мужјаци Wistar пацова постављени су у близини укљученог/искљученог
ЕНФ-МП генератора, непосредно након престанка излагања инјецирани MK-
801/физиолошким раствором и подвргнути тесту отвореног поља (open field test) у
току 2 сата. ANY-maze софтвером je урађена анализa локомоторне и стереотипне
активности. Показано је да: (1) 7-дневно континуирано излагање ЕНФ-МП нема
утицаја, док акутна примена МK-801 значајно повећава локомоторну и
стереотипну активност пацова од 60. до 90. мин регистрације понашања; (2) 7-
дневно континуирано излагање ЕНФ-МП значајно интензивира ефекте изазване
акутном применом МK-801 од 60. до 120. мин регистрације понашања. Добијени
резултати указују на модулаторни утицај континуираног излагања ЕНФ-МП
поменутих карактеристика на глутаминску трансмисију, који долази до изражаја у
условима њене фармаколошке манипулације.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina, Утицај магнетног поља (50 Hz, 0,5 mT) на психомоторно понашање пацова изазвано акутном применом дизоцилпина",
pages = "388",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5746"
}

Kesić, S., Stojadinović, G., Martać, L., Sekulić, S.,& Petković, B.. (2022). Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746

Kesić S, Stojadinović G, Martać L, Sekulić S, Petković B. Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:388.
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

Kesić, Srđan, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Petković, Branka, "Uticaj magnetnog polja (50 Hz, 0,5 mT) na psihomotorno ponašanje pacova izazvano akutnom primenom dizocilpina" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):388,
https://hdl.handle.net/21.15107/rcub_ibiss_5746 .

TY  - CONF
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Pešić, Vesna
PY  - 2022
UR  - https://kenesvm.azureedge.net/public/general/FENS2022.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5734
AB  - Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.
PB  - Federation of European Neuroscience Societies
C3  - E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
T1  - Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam
SP  - S02-173
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5734
ER  - 

@conference{
author = "Podgorac, Jelena and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Sekulić, Slobodan and Pešić, Vesna",
year = "2022",
abstract = "Aims: Levetiracetam (LEV), which belongs to a new generation of antiepileptic drugs, has been recognized as a relatively safe antiepileptic therapy, according to studies on neurodevelopmental outcomes in children exposed to LEV in utero, although some animal studies reported skeletal abnormalities. This study deals with the influence of prenatal exposure to LEV in the doses that cover therapeutic range in humans on gross skeletal structure and anxiety-like behavior in adolescent mice. Methods: Adult 8-weeks old female NMRI mice were randomly divided into four groups and treated subcutaneously during breeding and gestation with saline (control) or LEV in the doses of 158 mg/kg/day (LEV-158), 211 mg/kg/day (LEV-211), or 316 mg/kg/day (LEV-316). After delivery, each female with the progeny was housed separately. Weaning and separation by sex were done on the 20th postnatal day (P20). The elevated plus-maze test was used to assess the anxiety-like behavior in both male and female offspring on P37. Results: Females and males in the LEV-158 and LEV-316 group displayed less anxiety-like behavior compared to the control, while in the LEV-211 group such behavior was not observed. Sex-related differences in anxiety-like behavior were not detected within any LEV group, as well as visible skeletal malformations. Conclusion: The findings in the mouse model suggest that prenatal exposure to LEV could be associated with less anxiety-like behavior in adolescence, paying attention to the U-shaped dose-response and highlighting the behavioral outcomes of small LEV doses.",
publisher = "Federation of European Neuroscience Societies",
journal = "E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France",
title = "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam",
pages = "S02-173",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5734"
}

Podgorac, J., Petković, B., Stojadinović, G., Martać, L., Sekulić, S.,& Pešić, V.. (2022). Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France
Federation of European Neuroscience Societies., S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734

Podgorac J, Petković B, Stojadinović G, Martać L, Sekulić S, Pešić V. Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam. in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France. 2022;:S02-173.
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

Podgorac, Jelena, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Sekulić, Slobodan, Pešić, Vesna, "Anxiety-like behavior in adolescent mice prenatally exposed to different doses of levetiracetam" in E-Book of Abstracts: FENS Forum 2022; 2022 Jul 9-13; Paris, France (2022):S02-173,
https://hdl.handle.net/21.15107/rcub_ibiss_5734 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
PY  - 2022
UR  - https://www.primescholars.com/articles/aluminium-neurotoxicity-and-neuroprotection.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5736
AB  - Aluminium is considered to be the most widely distributed metal in nature and industry and is extensively used in products and processes associated with human activity. Contamination may occur by air, water, food, additives, medicaments, vaccines, cosmetics, agrochemicals, etc. Aluminium is recognized as a highly neurotoxic element in animals and humans connected with several diseases such as Alzheimer’s and Parkinson’s disease, neurodegenerative motor disorders, encephalopathy, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and autism. There are many animal models in rats developed to investigate aluminium neurotoxicity. Nevertheless, molecular mechanisms of its action are not yet resolved, and mechanisms of damage and safety concentrations are still much discussed. The brain is the most susceptible system to damages provoked by aluminium exposure, such as oxidative stress, iron dyshomeostasis, changes in neurotransmission, immunologic alteration and pro-inflammation, genotoxicity, transformation and peptide denaturation, changes in enzyme activity, membrane perturbation, apoptosis, necrosis, and dysplasia. A novel investigation of aluminium neurotoxicity includes the assessment of neuroprotection and the identification of new substances as potential drugs.
PB  - London: Prime Scholars
T2  - Journal of Heavy Metal Toxicity and Diseases
T1  - Aluminium neurotoxicity and neuroprotection
IS  - 4
VL  - 7
DO  - 10.21767/2473-6457.22.7.4.11
SP  - 11
ER  - 

@article{
author = "Martać, Ljiljana and Podgorac, Jelena and Petković, Branka and Stojadinović, Gordana",
year = "2022",
abstract = "Aluminium is considered to be the most widely distributed metal in nature and industry and is extensively used in products and processes associated with human activity. Contamination may occur by air, water, food, additives, medicaments, vaccines, cosmetics, agrochemicals, etc. Aluminium is recognized as a highly neurotoxic element in animals and humans connected with several diseases such as Alzheimer’s and Parkinson’s disease, neurodegenerative motor disorders, encephalopathy, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and autism. There are many animal models in rats developed to investigate aluminium neurotoxicity. Nevertheless, molecular mechanisms of its action are not yet resolved, and mechanisms of damage and safety concentrations are still much discussed. The brain is the most susceptible system to damages provoked by aluminium exposure, such as oxidative stress, iron dyshomeostasis, changes in neurotransmission, immunologic alteration and pro-inflammation, genotoxicity, transformation and peptide denaturation, changes in enzyme activity, membrane perturbation, apoptosis, necrosis, and dysplasia. A novel investigation of aluminium neurotoxicity includes the assessment of neuroprotection and the identification of new substances as potential drugs.",
publisher = "London: Prime Scholars",
journal = "Journal of Heavy Metal Toxicity and Diseases",
title = "Aluminium neurotoxicity and neuroprotection",
number = "4",
volume = "7",
doi = "10.21767/2473-6457.22.7.4.11",
pages = "11"
}

Martać, L., Podgorac, J., Petković, B.,& Stojadinović, G.. (2022). Aluminium neurotoxicity and neuroprotection. in Journal of Heavy Metal Toxicity and Diseases
London: Prime Scholars., 7(4), 11.
https://doi.org/10.21767/2473-6457.22.7.4.11

Martać L, Podgorac J, Petković B, Stojadinović G. Aluminium neurotoxicity and neuroprotection. in Journal of Heavy Metal Toxicity and Diseases. 2022;7(4):11.
doi:10.21767/2473-6457.22.7.4.11 .

Martać, Ljiljana, Podgorac, Jelena, Petković, Branka, Stojadinović, Gordana, "Aluminium neurotoxicity and neuroprotection" in Journal of Heavy Metal Toxicity and Diseases, 7, no. 4 (2022):11,
https://doi.org/10.21767/2473-6457.22.7.4.11 . .

TY  - CONF
AU  - Nikolić, Ljiljana
AU  - Savić, Danijela
AU  - Korać Jačić, Jelena
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Bogdanović Pristov, Jelena
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5509
AB  - Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target
for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine
effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically
evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not
affect inward currents. Our results thus provide fine resolution and time frame for targeting ion
channel activity that is crucial in pharmacological investigations.
PB  - Belgrade: Society of Physical Chemists of Serbia
C3  - Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
T1  - Membrane currents of C6 cells in pharmacological investigation
SP  - 589
EP  - 592
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5509
ER  - 

@conference{
author = "Nikolić, Ljiljana and Savić, Danijela and Korać Jačić, Jelena and Petković, Branka and Stojadinović, Gordana and Martać, Ljiljana and Bogdanović Pristov, Jelena",
year = "2022",
abstract = "Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target
for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine
effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically
evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not
affect inward currents. Our results thus provide fine resolution and time frame for targeting ion
channel activity that is crucial in pharmacological investigations.",
publisher = "Belgrade: Society of Physical Chemists of Serbia",
journal = "Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia",
title = "Membrane currents of C6 cells in pharmacological investigation",
pages = "589-592",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5509"
}

Nikolić, L., Savić, D., Korać Jačić, J., Petković, B., Stojadinović, G., Martać, L.,& Bogdanović Pristov, J.. (2022). Membrane currents of C6 cells in pharmacological investigation. in Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia
Belgrade: Society of Physical Chemists of Serbia., 589-592.
https://hdl.handle.net/21.15107/rcub_ibiss_5509

Nikolić L, Savić D, Korać Jačić J, Petković B, Stojadinović G, Martać L, Bogdanović Pristov J. Membrane currents of C6 cells in pharmacological investigation. in Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia. 2022;:589-592.
https://hdl.handle.net/21.15107/rcub_ibiss_5509 .

Nikolić, Ljiljana, Savić, Danijela, Korać Jačić, Jelena, Petković, Branka, Stojadinović, Gordana, Martać, Ljiljana, Bogdanović Pristov, Jelena, "Membrane currents of C6 cells in pharmacological investigation" in Proceedings: Physical Chemistry 2022, Vol. 2.: 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry; 2022 Sep 26-30; Belgrade, Serbia (2022):589-592,
https://hdl.handle.net/21.15107/rcub_ibiss_5509 .

TY  - CONF
AU  - AlJamal, Kamal
AU  - Stojadinović, Gordana
AU  - Živić, Miroslav
AU  - Todorović, Nataša
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4711
AB  - The chloride channel VRAC has been implicated in apoptosis, proliferation, transport of organic acids and regulatory volume decrease. Regulated by RAS/cGMP and by the ionic strength, it mediates efflux of anions (Cl-, glutamate, gluthatione, taurine, cGAMP). Knowing that chloride transport activity, mediated by NKCC, is indispensable for axon growth, we hypothesized that VRAC could have a role in neurite elongation mechanism. Experimental treatments compared to control were: VRAC selective inhibitor DCPIB (10 µM); BpV (phen) (80 nM), an inhibitor of PTEN. Axon growth was measured on cultured 
dissociated dorsal root ganglia neonatal neurons fixed 24h after treatment and immunostained with anti-neurofilament H (NF-H) phosphorylated antibody. FIJI Simple Neurite Tracer was used for morphometry of individual neurons. 24h post treatment, total neurite length compared to control was decreased by BpV (p=0.0058) and to a lesser extent by DCPIB. In all measured parameters related to the degree of branching, BpV group neurons had small dispersion of values. In addition, DCPIB treated cells had 
larger fractal dimension (<0.05) than control neurons. The effect of DCPIB is mostly related to an increase in Fractal Dimension parameter, according to Principal Component Analysis. The increase in the number of primary branches per increment of cable length is significantly smaller in DCPIB group than in control and BpV -treated neurons. The DCPIB effect demonstrates that an anion current, presumably VRAC, has 
a role in the process of proper branching and directional elongation of neonatal DRG neurites.
C3  - EMBO Workshop Axons 2021: Structure and function
T1  - Morphometric comparison of neurite outgrowth in rat DRG cultures treated with DCPIB and BpV
SP  - 74
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4711
ER  - 

@conference{
author = "AlJamal, Kamal and Stojadinović, Gordana and Živić, Miroslav and Todorović, Nataša",
year = "2021",
abstract = "The chloride channel VRAC has been implicated in apoptosis, proliferation, transport of organic acids and regulatory volume decrease. Regulated by RAS/cGMP and by the ionic strength, it mediates efflux of anions (Cl-, glutamate, gluthatione, taurine, cGAMP). Knowing that chloride transport activity, mediated by NKCC, is indispensable for axon growth, we hypothesized that VRAC could have a role in neurite elongation mechanism. Experimental treatments compared to control were: VRAC selective inhibitor DCPIB (10 µM); BpV (phen) (80 nM), an inhibitor of PTEN. Axon growth was measured on cultured 
dissociated dorsal root ganglia neonatal neurons fixed 24h after treatment and immunostained with anti-neurofilament H (NF-H) phosphorylated antibody. FIJI Simple Neurite Tracer was used for morphometry of individual neurons. 24h post treatment, total neurite length compared to control was decreased by BpV (p=0.0058) and to a lesser extent by DCPIB. In all measured parameters related to the degree of branching, BpV group neurons had small dispersion of values. In addition, DCPIB treated cells had 
larger fractal dimension (<0.05) than control neurons. The effect of DCPIB is mostly related to an increase in Fractal Dimension parameter, according to Principal Component Analysis. The increase in the number of primary branches per increment of cable length is significantly smaller in DCPIB group than in control and BpV -treated neurons. The DCPIB effect demonstrates that an anion current, presumably VRAC, has 
a role in the process of proper branching and directional elongation of neonatal DRG neurites.",
journal = "EMBO Workshop Axons 2021: Structure and function",
title = "Morphometric comparison of neurite outgrowth in rat DRG cultures treated with DCPIB and BpV",
pages = "74",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4711"
}

AlJamal, K., Stojadinović, G., Živić, M.,& Todorović, N.. (2021). Morphometric comparison of neurite outgrowth in rat DRG cultures treated with DCPIB and BpV. in EMBO Workshop Axons 2021: Structure and function, 74.
https://hdl.handle.net/21.15107/rcub_ibiss_4711

AlJamal K, Stojadinović G, Živić M, Todorović N. Morphometric comparison of neurite outgrowth in rat DRG cultures treated with DCPIB and BpV. in EMBO Workshop Axons 2021: Structure and function. 2021;:74.
https://hdl.handle.net/21.15107/rcub_ibiss_4711 .

AlJamal, Kamal, Stojadinović, Gordana, Živić, Miroslav, Todorović, Nataša, "Morphometric comparison of neurite outgrowth in rat DRG cultures treated with DCPIB and BpV" in EMBO Workshop Axons 2021: Structure and function (2021):74,
https://hdl.handle.net/21.15107/rcub_ibiss_4711 .

TY  - CONF
AU  - Todorović, Nataša
AU  - Stojadinović, Gordana
AU  - AlJamal, Kamal
AU  - Živić, Miroslav
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4678
AB  - Unlike the neurons in the CNS, the peripheral neurons have certain intrinsic regenerative capacity. 
After injury, peripheral neurons can switch to a cellular “state for growth”, with the expression profiles 
similar to early developmental stages. 
We looked at the changes of morphometric parameters induced in young peripheral neurons with 
treatments that in adult neurons have growth-stimulatory effect. The experimental treatments compared 
to control were: BpV (phen), an inhibitor of PTEN; and bFGF, basic fibroblast growth factor. The 
neurite growth was measured on cultured dissociated dorsal root ganglia neonatal neurons fixed 24h 
after treatment and immunostained with anti-neurofilament H (NF-H) phosphorylated antibody. FIJI 
Simple Neurite Tracer was used for morphometry of individual neurons. 24h post treatment, compared 
to control, total neurite length, length of primary and length of terminal branches, were increased by 
bFGF but not by BpV treatment. In all measured parameters related to the degree of branching, BpV treated neurons had small dispersion of values and small mean values, reminiscent of literature data 
stating that BpV treated neurons are elongated and less branched. However, the BpV did not have a 
positive influence on neurite elongation, as was reported on adult neurons. In contrast, bFGF stimulated 
elongation of young neurons in the manner similar to the effects described on the adult neurons.
PB  - Kragujevac, Serbia: Institute for Information Technologies, University of Kragujevac
C3  - 1st International Conference on Chemo and BioInformatics, ICCBIKG 2021; 2021 Oct 26-27; Kragujevac, Serbia
T1  - The morphometric study of the effects of bisperoxovanadium (bpv(phen)) on neonatal drg neurons in culture
DO  - 10.46793/ICCBI21.214T
SP  - 214
EP  - 217
ER  - 

@conference{
author = "Todorović, Nataša and Stojadinović, Gordana and AlJamal, Kamal and Živić, Miroslav",
year = "2021",
abstract = "Unlike the neurons in the CNS, the peripheral neurons have certain intrinsic regenerative capacity. 
After injury, peripheral neurons can switch to a cellular “state for growth”, with the expression profiles 
similar to early developmental stages. 
We looked at the changes of morphometric parameters induced in young peripheral neurons with 
treatments that in adult neurons have growth-stimulatory effect. The experimental treatments compared 
to control were: BpV (phen), an inhibitor of PTEN; and bFGF, basic fibroblast growth factor. The 
neurite growth was measured on cultured dissociated dorsal root ganglia neonatal neurons fixed 24h 
after treatment and immunostained with anti-neurofilament H (NF-H) phosphorylated antibody. FIJI 
Simple Neurite Tracer was used for morphometry of individual neurons. 24h post treatment, compared 
to control, total neurite length, length of primary and length of terminal branches, were increased by 
bFGF but not by BpV treatment. In all measured parameters related to the degree of branching, BpV treated neurons had small dispersion of values and small mean values, reminiscent of literature data 
stating that BpV treated neurons are elongated and less branched. However, the BpV did not have a 
positive influence on neurite elongation, as was reported on adult neurons. In contrast, bFGF stimulated 
elongation of young neurons in the manner similar to the effects described on the adult neurons.",
publisher = "Kragujevac, Serbia: Institute for Information Technologies, University of Kragujevac",
journal = "1st International Conference on Chemo and BioInformatics, ICCBIKG 2021; 2021 Oct 26-27; Kragujevac, Serbia",
title = "The morphometric study of the effects of bisperoxovanadium (bpv(phen)) on neonatal drg neurons in culture",
doi = "10.46793/ICCBI21.214T",
pages = "214-217"
}

Todorović, N., Stojadinović, G., AlJamal, K.,& Živić, M.. (2021). The morphometric study of the effects of bisperoxovanadium (bpv(phen)) on neonatal drg neurons in culture. in 1st International Conference on Chemo and BioInformatics, ICCBIKG 2021; 2021 Oct 26-27; Kragujevac, Serbia
Kragujevac, Serbia: Institute for Information Technologies, University of Kragujevac., 214-217.
https://doi.org/10.46793/ICCBI21.214T

Todorović N, Stojadinović G, AlJamal K, Živić M. The morphometric study of the effects of bisperoxovanadium (bpv(phen)) on neonatal drg neurons in culture. in 1st International Conference on Chemo and BioInformatics, ICCBIKG 2021; 2021 Oct 26-27; Kragujevac, Serbia. 2021;:214-217.
doi:10.46793/ICCBI21.214T .

Todorović, Nataša, Stojadinović, Gordana, AlJamal, Kamal, Živić, Miroslav, "The morphometric study of the effects of bisperoxovanadium (bpv(phen)) on neonatal drg neurons in culture" in 1st International Conference on Chemo and BioInformatics, ICCBIKG 2021; 2021 Oct 26-27; Kragujevac, Serbia (2021):214-217,
https://doi.org/10.46793/ICCBI21.214T . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://www.eurekaselect.com/180519/article
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32213154
UR  - https://radar.ibiss.bg.ac.rs/123456789/3879
AB  - BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
IS  - 31
VL  - 26
DO  - 10.2174/1381612826666200326125821
SP  - 3884
EP  - 3894
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "BACKGROUND Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy. OBJECTIVE We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal. METHOD The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals' motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too. RESULTS The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested. CONCLUSION Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
number = "31",
volume = "26",
doi = "10.2174/1381612826666200326125821",
pages = "3884-3894"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd.., 26(31), 3884-3894.
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;26(31):3884-3894.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design, 26, no. 31 (2020):3884-3894,
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Spasić, Slađana Z.
AU  - Petković, Branka
AU  - Sekulić, Slobodan
AU  - Kesić, Srđan
PY  - 2020
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/5405
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4005
AB  - A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi’s fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis
IS  - 3
VL  - 72
DO  - 10.2298/ABS200524036S
SP  - 425
EP  - 432
ER  - 

@article{
author = "Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Spasić, Slađana Z. and Petković, Branka and Sekulić, Slobodan and Kesić, Srđan",
year = "2020",
abstract = "A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi’s fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis",
number = "3",
volume = "72",
doi = "10.2298/ABS200524036S",
pages = "425-432"
}

Stojadinović, G., Martać, L., Podgorac, J., Spasić, S. Z., Petković, B., Sekulić, S.,& Kesić, S.. (2020). The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences
Serbian Biological Society., 72(3), 425-432.
https://doi.org/10.2298/ABS200524036S

Stojadinović G, Martać L, Podgorac J, Spasić SZ, Petković B, Sekulić S, Kesić S. The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences. 2020;72(3):425-432.
doi:10.2298/ABS200524036S .

Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Spasić, Slađana Z., Petković, Branka, Sekulić, Slobodan, Kesić, Srđan, "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis" in Archives of Biological Sciences, 72, no. 3 (2020):425-432,
https://doi.org/10.2298/ABS200524036S . .

TY  - JOUR
AU  - Petković, Branka
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Pavković, Željko
AU  - Podgorac, Jelena
AU  - Stojadinović, Gordana
AU  - Pešić, Vesna
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3765
AB  - Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.
PB  - Bentham Science Publishers Ltd.
T2  - Current Pharmaceutical Design
T1  - A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats
DO  - 10.2174/1381612826666200326125821
ER  - 

@article{
author = "Petković, Branka and Kesić, Srđan and Ristić, Slavica and Pavković, Željko and Podgorac, Jelena and Stojadinović, Gordana and Pešić, Vesna",
year = "2020",
abstract = "Background: Psychotic states related to psychostimulant misuse in patients with hepatitis C virus infection may complicate acceptance and reaction to antiviral treatment. This observation equally applies to widely used ribavirin therapy.
Objective: We examined psychomotor and body weight gain response to low ribavirin doses after cessation of intermittent amphetamine treatment in adult rats to assess its role in neurobehavioral outcome during psychostimulant withdrawal.
Method: The model of amphetamine-induced (1.5 mg/kg/day, i.p., 7 consecutive days) motor sensitization and affected body weight gain was established in adult male Wistar rats. Then, additional cohort of amphetamine-sensitized rats was subjected to saline (0.9% NaCl; 1 mL/kg/day; i.p.) or ribavirin (10, 20 and 30 mg/kg/day, i.p.) treatment for 7 consecutive days. Animals’ motor activity in a novel environment was monitored after the 1st and the 7th saline/ribavirin injection. Body weight gain was calculated as appropriate. Determination and quantification of ribavirin in the brain tissue were performed too.
Results: The 1st application of ribavirin to amphetamine-sensitized rats affected/decreased their novelty-induced motor activity only at a dose of 30 mg/kg. After the 7th application, ribavirin 30 mg/kg/day still decreased while 10 and 20 mg/kg/day increased novelty-induced motor activity. These behavioral effects coincided with the time required to reach maximum ribavirin concentration in the brain. Body weight gain during withdrawal was not influenced by any of the doses tested.
Conclusion: Ribavirin displays central effects that in repeated treatment, depending on the applied dose, could significantly influence psychomotor response but not body weight gain during psychostimulant/amphetamine withdrawal.",
publisher = "Bentham Science Publishers Ltd.",
journal = "Current Pharmaceutical Design",
title = "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats",
doi = "10.2174/1381612826666200326125821"
}

Petković, B., Kesić, S., Ristić, S., Pavković, Ž., Podgorac, J., Stojadinović, G.,& Pešić, V.. (2020). A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design
Bentham Science Publishers Ltd...
https://doi.org/10.2174/1381612826666200326125821

Petković B, Kesić S, Ristić S, Pavković Ž, Podgorac J, Stojadinović G, Pešić V. A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. in Current Pharmaceutical Design. 2020;.
doi:10.2174/1381612826666200326125821 .

Petković, Branka, Kesić, Srđan, Ristić, Slavica, Pavković, Željko, Podgorac, Jelena, Stojadinović, Gordana, Pešić, Vesna, "A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats" in Current Pharmaceutical Design (2020),
https://doi.org/10.2174/1381612826666200326125821 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Stojadinović, Gordana
AU  - Kesić, Srđan
AU  - Ristić, Slavica
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Pešić, Vesna
PY  - 2019
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641900018P
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/3970
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3400
AB  - Clinically-related basic studies on the behavioral effects of ribavirin treatment are still lacking despite its wide use as an antiviral medication. This paper considers the effects of low ribavirin doses (10, 20 and 30 mg/kg/day) on psychomotor activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced motor activity), and body weight gain in socially undisturbed adult male Wistar rats 24 h after the first, seventh and fourteenth once-a-day injection. Low doses of ribavirin were tested in an attempt to avoid the recognized systemic side effects related to high-dose usage. None of the singly applied ribavirin doses affected exploratory/spontaneous and AMPH-induced motor behavior (locomotion, stereotypy-like and vertical activity), however, body weight gain was significantly lower after treatment with 30 mg/kg of ribavirin. The 7- and 14-day treatments with 10 and 30 mg/kg/day of ribavirin significantly suppressed novelty-induced locomotion and body weight gain; the 14-day treatment with ribavirin at a dose of 30 mg/kg/ day decreased AMPH-induced stereotypy. These findings indicate that repeated application (up to 14 days) of low ribavirin doses results in low novelty-induced locomotion along with reduced weight gain, accentuating the existence of a U-shaped dose-response relationship with a prolonged duration of ribavirin treatment.
T2  - Archives of Biological Sciences
T1  - Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration
IS  - 2
VL  - 71
DO  - 10.2298/ABS190205018P
SP  - 357
EP  - 368
ER  - 

@article{
author = "Petković, Branka and Stojadinović, Gordana and Kesić, Srđan and Ristić, Slavica and Martać, Ljiljana and Podgorac, Jelena and Pešić, Vesna",
year = "2019",
abstract = "Clinically-related basic studies on the behavioral effects of ribavirin treatment are still lacking despite its wide use as an antiviral medication. This paper considers the effects of low ribavirin doses (10, 20 and 30 mg/kg/day) on psychomotor activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced motor activity), and body weight gain in socially undisturbed adult male Wistar rats 24 h after the first, seventh and fourteenth once-a-day injection. Low doses of ribavirin were tested in an attempt to avoid the recognized systemic side effects related to high-dose usage. None of the singly applied ribavirin doses affected exploratory/spontaneous and AMPH-induced motor behavior (locomotion, stereotypy-like and vertical activity), however, body weight gain was significantly lower after treatment with 30 mg/kg of ribavirin. The 7- and 14-day treatments with 10 and 30 mg/kg/day of ribavirin significantly suppressed novelty-induced locomotion and body weight gain; the 14-day treatment with ribavirin at a dose of 30 mg/kg/ day decreased AMPH-induced stereotypy. These findings indicate that repeated application (up to 14 days) of low ribavirin doses results in low novelty-induced locomotion along with reduced weight gain, accentuating the existence of a U-shaped dose-response relationship with a prolonged duration of ribavirin treatment.",
journal = "Archives of Biological Sciences",
title = "Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration",
number = "2",
volume = "71",
doi = "10.2298/ABS190205018P",
pages = "357-368"
}

Petković, B., Stojadinović, G., Kesić, S., Ristić, S., Martać, L., Podgorac, J.,& Pešić, V.. (2019). Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration. in Archives of Biological Sciences, 71(2), 357-368.
https://doi.org/10.2298/ABS190205018P

Petković B, Stojadinović G, Kesić S, Ristić S, Martać L, Podgorac J, Pešić V. Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration. in Archives of Biological Sciences. 2019;71(2):357-368.
doi:10.2298/ABS190205018P .

Petković, Branka, Stojadinović, Gordana, Kesić, Srđan, Ristić, Slavica, Martać, Ljiljana, Podgorac, Jelena, Pešić, Vesna, "Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration" in Archives of Biological Sciences, 71, no. 2 (2019):357-368,
https://doi.org/10.2298/ABS190205018P . .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Petković, Branka
PY  - 2017
UR  - http://www.doiserbia.nb.rs/issue.aspx?issueid=3008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3773
AB  - Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2–3 months old rats weighing 200 – 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity.
AB  - Uvod. U eksperimentima je uporedo registrovana elektrokortikalna aktivnost parijetalne kore velikog mozga, kao i aktivnost kore malog mozga. Cilj je da se uporedi njihova spontana aktivnost jer se registrovanje vrši u anesteziji. Materijal i metode. U istraživanju smo koristili pacove starosti 2 - 3 meseca, telesne mase 200 - 350 g. Formirane su dve grupe pacova sa istim karakteristikama. Kod prve grupe, koju cinilo je 15 pacova (kontrolna grupa) ispitivanje je rađeno u anesteziji, zabeležene su promene spektralne snage u skladu sa obimom frekvencije. Druga grupa od 30 pacova je ispitivana pod istim eksperimentalnim uslovima, ali su pacovi tretirani rastvorom aluminijum hlorid heksahidrata, ili 1.5 % rastvorom aluminijum hlorid heksahidrata per os. Diskusija. Promena spontane aktivnosti malog mozga u uslovima intoksikacije aluminijumom je poređena sa kontrolnim vrednostima. Pokazano je da lezija i neurotoksičnost u uslovima stabilne anestezije dovode do desinhronizacije aktivnosti malog mozga. Ovo je opisano promenom fraktalne dimenzije elektrokortikalne aktivnosti. Pretpostavka je da se inhibicija izazvana anestetikom kompenzuje u uslovima intoksikacije aluminijumom. Zaključak. Mali mozak ima ulogu u kompenzaciji putem promene spontane aktivnosti. Ovakav odgovor podrazumeva povećanje vrednosti fraktalne dimenzije elektrokortikalne aktivnosti malog mozga koja je u uslovima neurotoksičnosti smanjena.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva
T2  - Medical Review
T1  - Spontaneous cerebellar activity and its role in neurotoxicity
T1  - Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti
IS  - 9-10
VL  - 70
DO  - 10.2298/MPNS1710283M
SP  - 283
EP  - 289
ER  - 

@article{
author = "Martać, Ljiljana and Stojadinović, Gordana and Petković, Branka",
year = "2017",
abstract = "Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2–3 months old rats weighing 200 – 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity., Uvod. U eksperimentima je uporedo registrovana elektrokortikalna aktivnost parijetalne kore velikog mozga, kao i aktivnost kore malog mozga. Cilj je da se uporedi njihova spontana aktivnost jer se registrovanje vrši u anesteziji. Materijal i metode. U istraživanju smo koristili pacove starosti 2 - 3 meseca, telesne mase 200 - 350 g. Formirane su dve grupe pacova sa istim karakteristikama. Kod prve grupe, koju cinilo je 15 pacova (kontrolna grupa) ispitivanje je rađeno u anesteziji, zabeležene su promene spektralne snage u skladu sa obimom frekvencije. Druga grupa od 30 pacova je ispitivana pod istim eksperimentalnim uslovima, ali su pacovi tretirani rastvorom aluminijum hlorid heksahidrata, ili 1.5 % rastvorom aluminijum hlorid heksahidrata per os. Diskusija. Promena spontane aktivnosti malog mozga u uslovima intoksikacije aluminijumom je poređena sa kontrolnim vrednostima. Pokazano je da lezija i neurotoksičnost u uslovima stabilne anestezije dovode do desinhronizacije aktivnosti malog mozga. Ovo je opisano promenom fraktalne dimenzije elektrokortikalne aktivnosti. Pretpostavka je da se inhibicija izazvana anestetikom kompenzuje u uslovima intoksikacije aluminijumom. Zaključak. Mali mozak ima ulogu u kompenzaciji putem promene spontane aktivnosti. Ovakav odgovor podrazumeva povećanje vrednosti fraktalne dimenzije elektrokortikalne aktivnosti malog mozga koja je u uslovima neurotoksičnosti smanjena.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva",
journal = "Medical Review",
title = "Spontaneous cerebellar activity and its role in neurotoxicity, Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti",
number = "9-10",
volume = "70",
doi = "10.2298/MPNS1710283M",
pages = "283-289"
}

Martać, L., Stojadinović, G.,& Petković, B.. (2017). Spontaneous cerebellar activity and its role in neurotoxicity. in Medical Review
Društvo lekara Vojvodine Srpskog lekarskog društva., 70(9-10), 283-289.
https://doi.org/10.2298/MPNS1710283M

Martać L, Stojadinović G, Petković B. Spontaneous cerebellar activity and its role in neurotoxicity. in Medical Review. 2017;70(9-10):283-289.
doi:10.2298/MPNS1710283M .

Martać, Ljiljana, Stojadinović, Gordana, Petković, Branka, "Spontaneous cerebellar activity and its role in neurotoxicity" in Medical Review, 70, no. 9-10 (2017):283-289,
https://doi.org/10.2298/MPNS1710283M . .

TY  - JOUR
AU  - Spasić, Sladjana
AU  - Kesić, Srđan
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1998
UR  - https://www.sciencedirect.com/science/article/pii/S1095643314002499
AB  - To study the influence of a static magnetic field (SMF, 2 mT) and
   extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the
   neuronal population activity, the experiments were performed on adult
   longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a
   wavelet analysis of the local field potentials (LFPs), our study showed
   for the first time that the effects of prolonged and repeated exposure
   to the ELF MF on the LFPs were irreversible within investigated time
   frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was
   significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in
   comparison to the control value. The RWE of slower oscillations (1-2 Hz)
   was significantly decreased after the repeated exposures to either SnMF
   or SqMF. The SqMF induced decreasing of the faster waves in the range of
   64-128 Hz. However, we did not prove with presented methods that
   exposure to the SMF for 5 min produces any effects on the neuronal
   population activity. This study has proved the wavelet transform as a
   valuable tool for measuring the effects of SMF and ELF MF on the
   neuronal population activity in M. funereus antennal lobe.
T2  - Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology
T1  - Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis
VL  - 181
DO  - 10.1016/j.cbpa.2014.11.018
SP  - 27
EP  - 35
ER  - 

@article{
author = "Spasić, Sladjana and Kesić, Srđan and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2015",
abstract = "To study the influence of a static magnetic field (SMF, 2 mT) and
   extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the
   neuronal population activity, the experiments were performed on adult
   longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a
   wavelet analysis of the local field potentials (LFPs), our study showed
   for the first time that the effects of prolonged and repeated exposure
   to the ELF MF on the LFPs were irreversible within investigated time
   frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was
   significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in
   comparison to the control value. The RWE of slower oscillations (1-2 Hz)
   was significantly decreased after the repeated exposures to either SnMF
   or SqMF. The SqMF induced decreasing of the faster waves in the range of
   64-128 Hz. However, we did not prove with presented methods that
   exposure to the SMF for 5 min produces any effects on the neuronal
   population activity. This study has proved the wavelet transform as a
   valuable tool for measuring the effects of SMF and ELF MF on the
   neuronal population activity in M. funereus antennal lobe.",
journal = "Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology",
title = "Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis",
volume = "181",
doi = "10.1016/j.cbpa.2014.11.018",
pages = "27-35"
}

Spasić, S., Kesić, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2015). Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 181, 27-35.
https://doi.org/10.1016/j.cbpa.2014.11.018

Spasić S, Kesić S, Stojadinović G, Petković B, Todorović D. Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 2015;181:27-35.
doi:10.1016/j.cbpa.2014.11.018 .

Spasić, Sladjana, Kesić, Srđan, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Effects of the static and ELF magnetic fields on the neuronal population
 activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
 revealed by wavelet analysis" in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 181 (2015):27-35,
https://doi.org/10.1016/j.cbpa.2014.11.018 . .

TY  - CONF
AU  - Kesić, Srđan
AU  - Spasić, Slađana
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4027
AB  - Based on a wavelet analysis, this study introduces the relative wavelet energy (RWE)
as a new measure for classification of the frequency bands of neuronal population activity
in insects. The RWE is used to explore the effects of static magnetic field (SMF,
2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on longhorn
beetle antennal lobe neuronal activity. To study the influence of SMF and ELF MF on
the neuronal population activity, the experiments were performed on adult longhorn
beetles Morimus funereus (Coleoptera, Cerambycidae). Our study, based on a wavelet
analysis of the local field potentials (LFPs), showed for the first time that the effects of
prolonged and repeated exposure to the ELF MF on the LFPs were irreversible. Compared
to the control, the RWE of 4-8 Hz frequency band was increased after repeatedly
applied sine ELF MF (SnMF)/square ELF MF (SqMF). On the other hand, the RWE of
slower oscillations (1-2 Hz) was significantly decreased after repeated exposures to both
applied ELF MF waveforms. The SqMF decreased the fastest 64-128 Hz frequency
band. However, exposure to the SMF didn't have any effects on the neuronal population
activity. This study, successfully demonstrated new and useful application of the RWE
method for classification of the frequency bands and measuring the effects of SMF and
ELF MF on the neuronal population activity in M. funereus antennal lobe.
PB  - Belgrade: Serbian Physiological Society
C3  - 3rd Congress of Physiological Sciences of Serbia With International Participation
T1  - Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
SP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4027
ER  - 

@conference{
author = "Kesić, Srđan and Spasić, Slađana and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2014",
abstract = "Based on a wavelet analysis, this study introduces the relative wavelet energy (RWE)
as a new measure for classification of the frequency bands of neuronal population activity
in insects. The RWE is used to explore the effects of static magnetic field (SMF,
2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on longhorn
beetle antennal lobe neuronal activity. To study the influence of SMF and ELF MF on
the neuronal population activity, the experiments were performed on adult longhorn
beetles Morimus funereus (Coleoptera, Cerambycidae). Our study, based on a wavelet
analysis of the local field potentials (LFPs), showed for the first time that the effects of
prolonged and repeated exposure to the ELF MF on the LFPs were irreversible. Compared
to the control, the RWE of 4-8 Hz frequency band was increased after repeatedly
applied sine ELF MF (SnMF)/square ELF MF (SqMF). On the other hand, the RWE of
slower oscillations (1-2 Hz) was significantly decreased after repeated exposures to both
applied ELF MF waveforms. The SqMF decreased the fastest 64-128 Hz frequency
band. However, exposure to the SMF didn't have any effects on the neuronal population
activity. This study, successfully demonstrated new and useful application of the RWE
method for classification of the frequency bands and measuring the effects of SMF and
ELF MF on the neuronal population activity in M. funereus antennal lobe.",
publisher = "Belgrade: Serbian Physiological Society",
journal = "3rd Congress of Physiological Sciences of Serbia With International Participation",
title = "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe",
pages = "126",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4027"
}

Kesić, S., Spasić, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2014). Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation
Belgrade: Serbian Physiological Society., 126.
https://hdl.handle.net/21.15107/rcub_ibiss_4027

Kesić S, Spasić S, Stojadinović G, Petković B, Todorović D. Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation. 2014;:126.
https://hdl.handle.net/21.15107/rcub_ibiss_4027 .

Kesić, Srđan, Spasić, Slađana, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe" in 3rd Congress of Physiological Sciences of Serbia With International Participation (2014):126,
https://hdl.handle.net/21.15107/rcub_ibiss_4027 .

TY  - THES
AU  - Stojadinović, Gordana
PY  - 2013
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=878
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:7281/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024622514
UR  - http://nardus.mpn.gov.rs/123456789/2122
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2420
AB  - Odlučili smo se za istraživanje pojave epileptičnih napada kod pacova, izazvanih etarskim uljem kamforovog
drveta ili njegovim glavnim konstituentom 1,8-sineolom. Eksperimenti su izvedeni na odraslim pacovima
muškog pola Wistar soja. Operativni zahvati i akutna registrovanja elektrofizioloških signala su obavljeni
pod Nembutal anestezijom. Registrovani su lokalni potencijali polja kore velikog i malog mozga u uslovima
pre i 1 h posle intraperitonealne (i.p.) administracije etarskog ulja kamforovog drveta ili 1,8-sineola.
Pacovima je intraperitonealno ubrizgavano etarsko ulje kamforovog drveta (150-750 μl/kg t.m., u 1 ml
fiziološkog rastvora i.p.) ili 1,8-sineol (300-500 μl/kg t.m., u 1 ml fiziološkog rastvora, i.p.). Digitalizovani
elektrokortikalni signali (frekvence semplovanja: 256 Hz) su analizirani uz pomoć brze Furijeove
transformacije, a potom je izračunavana vrednost fraktalne dimenzije (FD) i Hurstovog eksponenta (H).
Etarsko ulje kamforovog drveta (≥450 μl/kg t.m.) ili 1,8-sineol (≥300 μl/kg t.m.) indukuju epileptičnu
aktivnost sa pojavom pojedinačnih i grupnih šiljaka velike amplitude u elektrokortikogramu sa povremenim
kloničnim konvulzijama ekstremiteta, 3-15 minuta nakon administracije supstanci. Na velikom mozgu,
nakon administracije etarskog ulja kamforovog drveta, kao i 1,8-sineola, u epohama sa epileptičnom
aktivnošću, bio je prisutan veliki porast ukupne snage kao i povećanje relativne snage u delta (0,1-4,0 Hz)
frekventnom opsegu, odnosno smanjenje relativne snage u teta (4,1-8,0 Hz), alfa (8,1-15,0 Hz), beta (15,1-
32,0 Hz) i gama (32,1-128,0 Hz) frekventnim opsezima. Potvrđeno je dominantno učešće delta (0,1-4,0 Hz)
frekventnog opsega a vrednost relativne snage se kretala od 47 do 87 %. Na malom mozgu, u epohama sa
epileptičnom aktivnošću, relativne snage frekventnih opsega su se različito ponašale u odnosu na veliki
mozak i različito nakon administracije 1,8-sineola u odnosu na etarsko ulje kamforovog drveta. Razlike
između velikog i malog mozga, kao i razlike u delovanju etarskog ulja kamforovog drveta i 1,8-sineola, bile
su izraženije u parametrima fraktalne analize. Na velikom mozgu pacova, nakon administracije etarskog ulja
kamforovog drveta, u epohama sa epileptičnom aktivnošću, postoji povećanje vrednosti FD u odnosu na
kontrolu, a na malom mozgu smanjenje. Suprotno, nakon administracije 1,8-sineola postoji smanjenje
vrednosti FD na velikom, odnosno povećanje na malom mozgu. Postojala je i dozna zavisnost odgovora
nakon administracije etarskog ulja kamforovog drveta, odnosno 1,8-sineola. Na velikom mozgu, povećanje
doze etarskog ulja kamforovog drveta, odnosno 1,8-sineola, u epohama sa epileptičnom aktivnošću, praćeno
je povećanjem relativne snage delta (0,1-4,0 Hz) frekventnog opsega, odnosno smanjenjem relativne snage
teta (4,1-8,0 Hz), alfa (8,1-15,0 Hz), beta (15,1-32,0 Hz) i gama (32,1-128,0 Hz) frekventnih opsega.
Suprotno, na malom mozgu, povećanje doze etarskog ulja kamforovog drveta u epohama sa epileptičnom
aktivnošću, praćeno je smanjenjem relativne snage delta (0,1-4,0 Hz), odnosno povećanjem relativne snage
teta (4,1-8,0 Hz), alfa (8,1-15,0 Hz) i beta (15,1-32,0 Hz) frekventnih opsega. Na malom mozgu, povećanje
doze 1,8-sineola u epohama sa epileptičnom aktivnošću, praćeno je povećanjem relativne snage teta (4,1-8,0
Hz), odnosno smanjenjem relativne snage gama (32,1-128,0 Hz) frekventnog opsega. I na velikom i na
malom mozgu pacova, promene vrednosti FD negativno su korelisane sa povećanjem doze kako etarskog ulja
kamforovog drveta tako i 1,8-sineola. Neophodno je dalje ispitati doznu zavisnost svakog konstituenta
etarskog ulja kamforovog drveta na aktivnost mozga kako bi se rasvetlila sigurna upotreba etarskih ulja
biljaka koje sadrže ove terpenoide.
AB  - We investigated the rat brain activity in acute seizures evoked by camphor tree essential oil or its main
constituent 1,8-cineole. The experiments were performed on adult male Wistar rats. The surgery and acute
electrophysiological recordings were performed under pentobarbital sodium anesthesia. Local field potentials
of cerebral and cerebellar parietal cortex were recorded before and 1 h after intraperitoneal (i.p.) camphor
essential oil or 1,8-cineole administration. The rats were intraperitoneally injected with camphor essential oil
(150-750 μl/kg b.w., in 1 ml of saline, i.p.) or 1,8-cineole (300-500 μl/kg b.w., in 1 ml of saline, i.p.). The
digitized electrocortical signals (sampling frequency: 256 Hz) were analyzed by the Fast Fourier Transform,
and were calculated Fractal dimension (FD) and Hurst exponent (H) also. Camphor essential oil (≥450 μl/kg
b.w.) and 1,8-cineole (≥300 μl/kg b.w.) induced seizure-like activity with single and multiple spiking of high
amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions, 3-15 min after their
administration. On the cerebrum, after camphor essential oil and 1,8-cineole administration, in epochs with
epileptic activity, there was high increase in total power and an increase in relative power in delta (0,1-4,0
Hz) frequency range, as well as a decrease in relative power in theta (4,1-8,0 Hz), alpha (8,1-15,0 Hz), beta
(15,1-32,0 Hz) and gamma (32,1-128,0 Hz) frequency ranges. It was confirmed the dominant presence of the
delta (0,1- 4,0 Hz) frequency range and the values of the relative power ranged from 47 to 87 %. On the
cerebellum, in epochs with epileptic activity, the relative power of the frequency ranges were behaving
differently than cerebrum, as well as after administration of 1,8-cineole compared to the camphor essential
oil. The differences between the cerebrum and cerebellum, as well as differences in the activities of the
camphor essential oil and 1,8-cineole, were more pronounced in the parameters of fractal analysis. On the
cerebrum, after camphor essential oil aministration, in epochs with epileptic activity, there was an increase in
the FD value compared to the control, and the decrease on the cerebellum. In contrast, after 1,8-cineole
administration there was a decrease in FD value on the cerebrum, and increase on the cerebellum. There was
a dose dependence of response after the camphor essential oil and 1,8-cineole administration. On the
cerebrum, increasing the dose of the camphor essential oil and 1,8-cineole, in epochs with epileptic activity,
correlated with an increase in relative power in delta (0,1 to 4,0 Hz) frequency range and a decrease in
relative power in theta (4,1-8,0 Hz), alpha (8,1-15,0 Hz), beta (15,1-32,0 Hz) and gamma (32,1-128,0 Hz)
frequency ranges. In contrast, on the cerebellum, increasing the dose of the camphor essential oil in epochs
with epileptic activity, correlated with a decrease in relative power in delta (0,1 to 4,0 Hz) and increase in
relative power in theta (4,1 to 8,0 Hz), alpha (8,1 to 15,0 Hz) and beta (15,1 to 32,0 Hz) frequency ranges. On
the cerebellum, increasing the dose of 1,8-cineole, in epochs with epileptic activity, correlated with an
increase in relative power in theta (4,1-8,0 Hz) and a decrease in relative power in gamma (32,1-128,0 Hz)
frequency range. On the cerebrum and cerebellum, FD changes were negatively correlated with campor
essential oil and 1,8-cineole doses increasing. It is necessary to investigate further the dose dependent
effectiveness of each terpenoid constituent of camhor essential oil on the brain activity in order to elucidate
the relative safety of the usage of essential oils with these terpenoids.
PB  - Belgrade: University of Belgrade, Faculty of Biology
T2  - University of Belgrade, Faculty of Biology
T1  - Spektralne i fraktalne karakteristike električne aktivnosti mozga pacova pod akutnim uticajem etarskog ulja kamforovog drveta
T1  - Spectral and fractal characteristics of rat brain electrical activity after acute camphor tree essential oil administration
SP  - 1
EP  - 133
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2122
ER  - 

@phdthesis{
author = "Stojadinović, Gordana",
year = "2013",
abstract = "Odlučili smo se za istraživanje pojave epileptičnih napada kod pacova, izazvanih etarskim uljem kamforovog
drveta ili njegovim glavnim konstituentom 1,8-sineolom. Eksperimenti su izvedeni na odraslim pacovima
muškog pola Wistar soja. Operativni zahvati i akutna registrovanja elektrofizioloških signala su obavljeni
pod Nembutal anestezijom. Registrovani su lokalni potencijali polja kore velikog i malog mozga u uslovima
pre i 1 h posle intraperitonealne (i.p.) administracije etarskog ulja kamforovog drveta ili 1,8-sineola.
Pacovima je intraperitonealno ubrizgavano etarsko ulje kamforovog drveta (150-750 μl/kg t.m., u 1 ml
fiziološkog rastvora i.p.) ili 1,8-sineol (300-500 μl/kg t.m., u 1 ml fiziološkog rastvora, i.p.). Digitalizovani
elektrokortikalni signali (frekvence semplovanja: 256 Hz) su analizirani uz pomoć brze Furijeove
transformacije, a potom je izračunavana vrednost fraktalne dimenzije (FD) i Hurstovog eksponenta (H).
Etarsko ulje kamforovog drveta (≥450 μl/kg t.m.) ili 1,8-sineol (≥300 μl/kg t.m.) indukuju epileptičnu
aktivnost sa pojavom pojedinačnih i grupnih šiljaka velike amplitude u elektrokortikogramu sa povremenim
kloničnim konvulzijama ekstremiteta, 3-15 minuta nakon administracije supstanci. Na velikom mozgu,
nakon administracije etarskog ulja kamforovog drveta, kao i 1,8-sineola, u epohama sa epileptičnom
aktivnošću, bio je prisutan veliki porast ukupne snage kao i povećanje relativne snage u delta (0,1-4,0 Hz)
frekventnom opsegu, odnosno smanjenje relativne snage u teta (4,1-8,0 Hz), alfa (8,1-15,0 Hz), beta (15,1-
32,0 Hz) i gama (32,1-128,0 Hz) frekventnim opsezima. Potvrđeno je dominantno učešće delta (0,1-4,0 Hz)
frekventnog opsega a vrednost relativne snage se kretala od 47 do 87 %. Na malom mozgu, u epohama sa
epileptičnom aktivnošću, relativne snage frekventnih opsega su se različito ponašale u odnosu na veliki
mozak i različito nakon administracije 1,8-sineola u odnosu na etarsko ulje kamforovog drveta. Razlike
između velikog i malog mozga, kao i razlike u delovanju etarskog ulja kamforovog drveta i 1,8-sineola, bile
su izraženije u parametrima fraktalne analize. Na velikom mozgu pacova, nakon administracije etarskog ulja
kamforovog drveta, u epohama sa epileptičnom aktivnošću, postoji povećanje vrednosti FD u odnosu na
kontrolu, a na malom mozgu smanjenje. Suprotno, nakon administracije 1,8-sineola postoji smanjenje
vrednosti FD na velikom, odnosno povećanje na malom mozgu. Postojala je i dozna zavisnost odgovora
nakon administracije etarskog ulja kamforovog drveta, odnosno 1,8-sineola. Na velikom mozgu, povećanje
doze etarskog ulja kamforovog drveta, odnosno 1,8-sineola, u epohama sa epileptičnom aktivnošću, praćeno
je povećanjem relativne snage delta (0,1-4,0 Hz) frekventnog opsega, odnosno smanjenjem relativne snage
teta (4,1-8,0 Hz), alfa (8,1-15,0 Hz), beta (15,1-32,0 Hz) i gama (32,1-128,0 Hz) frekventnih opsega.
Suprotno, na malom mozgu, povećanje doze etarskog ulja kamforovog drveta u epohama sa epileptičnom
aktivnošću, praćeno je smanjenjem relativne snage delta (0,1-4,0 Hz), odnosno povećanjem relativne snage
teta (4,1-8,0 Hz), alfa (8,1-15,0 Hz) i beta (15,1-32,0 Hz) frekventnih opsega. Na malom mozgu, povećanje
doze 1,8-sineola u epohama sa epileptičnom aktivnošću, praćeno je povećanjem relativne snage teta (4,1-8,0
Hz), odnosno smanjenjem relativne snage gama (32,1-128,0 Hz) frekventnog opsega. I na velikom i na
malom mozgu pacova, promene vrednosti FD negativno su korelisane sa povećanjem doze kako etarskog ulja
kamforovog drveta tako i 1,8-sineola. Neophodno je dalje ispitati doznu zavisnost svakog konstituenta
etarskog ulja kamforovog drveta na aktivnost mozga kako bi se rasvetlila sigurna upotreba etarskih ulja
biljaka koje sadrže ove terpenoide., We investigated the rat brain activity in acute seizures evoked by camphor tree essential oil or its main
constituent 1,8-cineole. The experiments were performed on adult male Wistar rats. The surgery and acute
electrophysiological recordings were performed under pentobarbital sodium anesthesia. Local field potentials
of cerebral and cerebellar parietal cortex were recorded before and 1 h after intraperitoneal (i.p.) camphor
essential oil or 1,8-cineole administration. The rats were intraperitoneally injected with camphor essential oil
(150-750 μl/kg b.w., in 1 ml of saline, i.p.) or 1,8-cineole (300-500 μl/kg b.w., in 1 ml of saline, i.p.). The
digitized electrocortical signals (sampling frequency: 256 Hz) were analyzed by the Fast Fourier Transform,
and were calculated Fractal dimension (FD) and Hurst exponent (H) also. Camphor essential oil (≥450 μl/kg
b.w.) and 1,8-cineole (≥300 μl/kg b.w.) induced seizure-like activity with single and multiple spiking of high
amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions, 3-15 min after their
administration. On the cerebrum, after camphor essential oil and 1,8-cineole administration, in epochs with
epileptic activity, there was high increase in total power and an increase in relative power in delta (0,1-4,0
Hz) frequency range, as well as a decrease in relative power in theta (4,1-8,0 Hz), alpha (8,1-15,0 Hz), beta
(15,1-32,0 Hz) and gamma (32,1-128,0 Hz) frequency ranges. It was confirmed the dominant presence of the
delta (0,1- 4,0 Hz) frequency range and the values of the relative power ranged from 47 to 87 %. On the
cerebellum, in epochs with epileptic activity, the relative power of the frequency ranges were behaving
differently than cerebrum, as well as after administration of 1,8-cineole compared to the camphor essential
oil. The differences between the cerebrum and cerebellum, as well as differences in the activities of the
camphor essential oil and 1,8-cineole, were more pronounced in the parameters of fractal analysis. On the
cerebrum, after camphor essential oil aministration, in epochs with epileptic activity, there was an increase in
the FD value compared to the control, and the decrease on the cerebellum. In contrast, after 1,8-cineole
administration there was a decrease in FD value on the cerebrum, and increase on the cerebellum. There was
a dose dependence of response after the camphor essential oil and 1,8-cineole administration. On the
cerebrum, increasing the dose of the camphor essential oil and 1,8-cineole, in epochs with epileptic activity,
correlated with an increase in relative power in delta (0,1 to 4,0 Hz) frequency range and a decrease in
relative power in theta (4,1-8,0 Hz), alpha (8,1-15,0 Hz), beta (15,1-32,0 Hz) and gamma (32,1-128,0 Hz)
frequency ranges. In contrast, on the cerebellum, increasing the dose of the camphor essential oil in epochs
with epileptic activity, correlated with a decrease in relative power in delta (0,1 to 4,0 Hz) and increase in
relative power in theta (4,1 to 8,0 Hz), alpha (8,1 to 15,0 Hz) and beta (15,1 to 32,0 Hz) frequency ranges. On
the cerebellum, increasing the dose of 1,8-cineole, in epochs with epileptic activity, correlated with an
increase in relative power in theta (4,1-8,0 Hz) and a decrease in relative power in gamma (32,1-128,0 Hz)
frequency range. On the cerebrum and cerebellum, FD changes were negatively correlated with campor
essential oil and 1,8-cineole doses increasing. It is necessary to investigate further the dose dependent
effectiveness of each terpenoid constituent of camhor essential oil on the brain activity in order to elucidate
the relative safety of the usage of essential oils with these terpenoids.",
publisher = "Belgrade: University of Belgrade, Faculty of Biology",
journal = "University of Belgrade, Faculty of Biology",
title = "Spektralne i fraktalne karakteristike električne aktivnosti mozga pacova pod akutnim uticajem etarskog ulja kamforovog drveta, Spectral and fractal characteristics of rat brain electrical activity after acute camphor tree essential oil administration",
pages = "1-133",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2122"
}

Stojadinović, G.. (2013). Spektralne i fraktalne karakteristike električne aktivnosti mozga pacova pod akutnim uticajem etarskog ulja kamforovog drveta. in University of Belgrade, Faculty of Biology
Belgrade: University of Belgrade, Faculty of Biology., 1-133.
https://hdl.handle.net/21.15107/rcub_nardus_2122

Stojadinović G. Spektralne i fraktalne karakteristike električne aktivnosti mozga pacova pod akutnim uticajem etarskog ulja kamforovog drveta. in University of Belgrade, Faculty of Biology. 2013;:1-133.
https://hdl.handle.net/21.15107/rcub_nardus_2122 .

Stojadinović, Gordana, "Spektralne i fraktalne karakteristike električne aktivnosti mozga pacova pod akutnim uticajem etarskog ulja kamforovog drveta" in University of Belgrade, Faculty of Biology (2013):1-133,
https://hdl.handle.net/21.15107/rcub_nardus_2122 .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Soković, Marina
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1364
AB  - In this study, we investigated the presence of long-range correlation effects in the electrocortical activity of rats using the Hurst exponent (H) calculated by dispersion analysis (DA) and an aggregated variance method (AGV). A slow decline of the autocorrelation function during time expansion and the existence of a correlation between distant time points of electrocorticograms (ECoGs) were shown to be typical of various pathophysiological states. In these cases, the H values were within a 0.5 < H < 1 range. A particularly slow decay of the autocorrelation function is typical of a long-range dependence (LRD). We found that ECoGs after i.p. administrations of camphor essential oil or its main constituent, 1,8-cineole, included attacks of uncontrolled electrical discharges and showed the presence of long-range correlation effects. Such findings are in agreement with recent data obtained by other authors and suggest that initiation of seizures can be predicted by certain ECoG indices. We estimated the critical period where the H values for ECoGs containing uncontrolled electrical discharges continuously increased within a few minutes before the attack. We believe that the AGV demonstrates certain advantages over DA in calculations of the H.
T2  - Neurophysiology
T1  - Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole
IS  - 1
VL  - 42
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1364
ER  - 

@article{
author = "Ćulić, Milka and Stojadinović, Gordana and Martać, Ljiljana and Soković, Marina",
year = "2010",
abstract = "In this study, we investigated the presence of long-range correlation effects in the electrocortical activity of rats using the Hurst exponent (H) calculated by dispersion analysis (DA) and an aggregated variance method (AGV). A slow decline of the autocorrelation function during time expansion and the existence of a correlation between distant time points of electrocorticograms (ECoGs) were shown to be typical of various pathophysiological states. In these cases, the H values were within a 0.5 < H < 1 range. A particularly slow decay of the autocorrelation function is typical of a long-range dependence (LRD). We found that ECoGs after i.p. administrations of camphor essential oil or its main constituent, 1,8-cineole, included attacks of uncontrolled electrical discharges and showed the presence of long-range correlation effects. Such findings are in agreement with recent data obtained by other authors and suggest that initiation of seizures can be predicted by certain ECoG indices. We estimated the critical period where the H values for ECoGs containing uncontrolled electrical discharges continuously increased within a few minutes before the attack. We believe that the AGV demonstrates certain advantages over DA in calculations of the H.",
journal = "Neurophysiology",
title = "Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole",
number = "1",
volume = "42",
pages = "62",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1364"
}

Ćulić, M., Stojadinović, G., Martać, L.,& Soković, M.. (2010). Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole. in Neurophysiology, 42(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1364

Ćulić M, Stojadinović G, Martać L, Soković M. Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole. in Neurophysiology. 2010;42(1):null-62.
https://hdl.handle.net/21.15107/rcub_ibiss_1364 .

Ćulić, Milka, Stojadinović, Gordana, Martać, Ljiljana, Soković, Marina, "Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole" in Neurophysiology, 42, no. 1 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1364 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Keković, G.
AU  - Podgorac, Jelena
AU  - Ćulić, Milka
AU  - Sekulić, S.
AU  - Lalošević, D.
AU  - Čapo, I.
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/243
AB  - Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls.
AB  - Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.
T2  - Archives of Biological Sciences
T1  - Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije
T1  - Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation
IS  - 1
VL  - 62
SP  - 9
EP  - 13
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_243
ER  - 

@article{
author = "Martać, Ljiljana and Stojadinović, Gordana and Keković, G. and Podgorac, Jelena and Ćulić, Milka and Sekulić, S. and Lalošević, D. and Čapo, I.",
year = "2010, 2010",
abstract = "Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls., Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.",
journal = "Archives of Biological Sciences",
title = "Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije, Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation",
number = "1",
volume = "62",
pages = "9-13",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_243"
}

Martać, L., Stojadinović, G., Keković, G., Podgorac, J., Ćulić, M., Sekulić, S., Lalošević, D.,& Čapo, I.. (2010). Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije. in Archives of Biological Sciences, 62(1), 9-13.
https://hdl.handle.net/21.15107/rcub_ibiss_243

Martać L, Stojadinović G, Keković G, Podgorac J, Ćulić M, Sekulić S, Lalošević D, Čapo I. Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije. in Archives of Biological Sciences. 2010;62(1):9-13.
https://hdl.handle.net/21.15107/rcub_ibiss_243 .

Martać, Ljiljana, Stojadinović, Gordana, Keković, G., Podgorac, Jelena, Ćulić, Milka, Sekulić, S., Lalošević, D., Čapo, I., "Spektralne promene moždane aktivnosti kod mladunaca pacova izloženih dejstvu aluminijuma tokom gestacije i laktacije" in Archives of Biological Sciences, 62, no. 1 (2010):9-13,
https://hdl.handle.net/21.15107/rcub_ibiss_243 .

TY  - JOUR
AU  - Keković, Goran
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Sekulić, Slobodan R
AU  - Ćulić, Milka
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1127
AB  - The features of rat cerebral and cerebellar electrocortical activity (ECoG) under different types of anaesthesia (nembutal. ketamine or zoletil) were examined by the distribution of spectral entropy across frequency bands of ECoG and by calculation of fractal dimension determined on the basis of Higuchi's algorithm. Spectral entropy, as a measure of activity, in the case of cerebrum had greater values than the spectral entropy of cerebellum in low frequency ranges, regardless of the type or applied anesthetic. Various anesthetics evoked different effects on spectral entropy of electrocortical activity: spectral entropy of delta range greatly dominated under nembutal anesthesia, while ketamine or zoletil appeared to affect the spectral entropy of higher frequency ranges. The pronounced effect of ketamine or zoletil anesthesia on spectral entropy of higher frequency was confirmed by the higher values of Higucihi's fractal dimension (ED) of ECoGs, with a tendency of higher ED values in cerebellar activity than cerebral activity.
T2  - Acta Neurobiologiae Experimentalis
T1  - Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia
IS  - 1
VL  - 70
SP  - 173
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1127
ER  - 

@article{
author = "Keković, Goran and Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Sekulić, Slobodan R and Ćulić, Milka",
year = "2010",
abstract = "The features of rat cerebral and cerebellar electrocortical activity (ECoG) under different types of anaesthesia (nembutal. ketamine or zoletil) were examined by the distribution of spectral entropy across frequency bands of ECoG and by calculation of fractal dimension determined on the basis of Higuchi's algorithm. Spectral entropy, as a measure of activity, in the case of cerebrum had greater values than the spectral entropy of cerebellum in low frequency ranges, regardless of the type or applied anesthetic. Various anesthetics evoked different effects on spectral entropy of electrocortical activity: spectral entropy of delta range greatly dominated under nembutal anesthesia, while ketamine or zoletil appeared to affect the spectral entropy of higher frequency ranges. The pronounced effect of ketamine or zoletil anesthesia on spectral entropy of higher frequency was confirmed by the higher values of Higucihi's fractal dimension (ED) of ECoGs, with a tendency of higher ED values in cerebellar activity than cerebral activity.",
journal = "Acta Neurobiologiae Experimentalis",
title = "Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia",
number = "1",
volume = "70",
pages = "173-75",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1127"
}

Keković, G., Stojadinović, G., Martać, L., Podgorac, J., Sekulić, S. R.,& Ćulić, M.. (2010). Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia. in Acta Neurobiologiae Experimentalis, 70(1), 173-75.
https://hdl.handle.net/21.15107/rcub_ibiss_1127

Keković G, Stojadinović G, Martać L, Podgorac J, Sekulić SR, Ćulić M. Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia. in Acta Neurobiologiae Experimentalis. 2010;70(1):173-75.
https://hdl.handle.net/21.15107/rcub_ibiss_1127 .

Keković, Goran, Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Sekulić, Slobodan R, Ćulić, Milka, "Spectral and fractal measures of cerebellar and cerebral activity in various types of anesthesia" in Acta Neurobiologiae Experimentalis, 70, no. 1 (2010):173-75,
https://hdl.handle.net/21.15107/rcub_ibiss_1127 .

TY  - JOUR
AU  - Ćulić, Milka
AU  - Keković, Goran
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Soković, Marina
AU  - Podgorac, Jelena
AU  - Sekulić, Slobodan R
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1133
AB  - We investigated the rat brain activity in acute seizures evoked by camphor essential oil or its main constituent 1,8-cineole by wavelet (primarily) and fractal analysis. Experiments were performed on anesthetized animals before and after intraperitoneal camphor oil or cineole administration. The properties of frequency bands in pre-ictal, ictal and inter-ictal stages have been determined by wavelet analysis. The domination of 6 frequency band was confirmed in obtained brain activities, which participate with approximate to 45% of mean relative wavelet energy (MRWE) in control signals and arise up to approximate to 76% MRWE in energy spectrum during the ictal stage (after drug administration). Other frequency bands decreased during ictal stage and arised in inter-ictal stage. There was a dose-dependent response of cineole effect: increase in cineole concentration leaded to the higher values of relative wavelet energy (RWE) of delta frequency band while there were slight changes of the mean fractal dimension (FD) values as a measure of system complexity.
T2  - General Physiology and Biophysics
T1  - Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole
IS  - null
VL  - 28
SP  - 289
EP  - 40
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1133
ER  - 

@article{
author = "Ćulić, Milka and Keković, Goran and Stojadinović, Gordana and Martać, Ljiljana and Soković, Marina and Podgorac, Jelena and Sekulić, Slobodan R",
year = "2009",
abstract = "We investigated the rat brain activity in acute seizures evoked by camphor essential oil or its main constituent 1,8-cineole by wavelet (primarily) and fractal analysis. Experiments were performed on anesthetized animals before and after intraperitoneal camphor oil or cineole administration. The properties of frequency bands in pre-ictal, ictal and inter-ictal stages have been determined by wavelet analysis. The domination of 6 frequency band was confirmed in obtained brain activities, which participate with approximate to 45% of mean relative wavelet energy (MRWE) in control signals and arise up to approximate to 76% MRWE in energy spectrum during the ictal stage (after drug administration). Other frequency bands decreased during ictal stage and arised in inter-ictal stage. There was a dose-dependent response of cineole effect: increase in cineole concentration leaded to the higher values of relative wavelet energy (RWE) of delta frequency band while there were slight changes of the mean fractal dimension (FD) values as a measure of system complexity.",
journal = "General Physiology and Biophysics",
title = "Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole",
number = "null",
volume = "28",
pages = "289-40",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1133"
}

Ćulić, M., Keković, G., Stojadinović, G., Martać, L., Soković, M., Podgorac, J.,& Sekulić, S. R.. (2009). Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole. in General Physiology and Biophysics, 28(null), 289-40.
https://hdl.handle.net/21.15107/rcub_ibiss_1133

Ćulić M, Keković G, Stojadinović G, Martać L, Soković M, Podgorac J, Sekulić SR. Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole. in General Physiology and Biophysics. 2009;28(null):289-40.
https://hdl.handle.net/21.15107/rcub_ibiss_1133 .

Ćulić, Milka, Keković, Goran, Stojadinović, Gordana, Martać, Ljiljana, Soković, Marina, Podgorac, Jelena, Sekulić, Slobodan R, "Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole" in General Physiology and Biophysics, 28, no. null (2009):289-40,
https://hdl.handle.net/21.15107/rcub_ibiss_1133 .

TY  - JOUR
AU  - Sekulić, Slobodan R
AU  - Lukac, Damir D
AU  - Drapsin, Miodrag
AU  - Suknjaja, Vesna
AU  - Keković, Goran
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1477
AB  - The aim of this study was to examine the righting reflex from a supine to a prone position in the albino guinea pig fetus. Ultrasound examinations of one-fetus gestations were performed in the period from the 31st to the 66th day of gestation. The experimental and control group each encompassed 6 fetuses. Fetuses were brought into supine positions relative to the gravity vector by manipulating the pregnant females into the appropriate positions. The control group received 15 mg/kg of diazepam intraperitoneally before the examination to show whether changes in fetal position occurred as the result of passive rotation. In the experimental group, each fetus was examined every other day (summary results: absent 69 times, prone position 10 times, lateral position 29 times). In the control group, each fetus was examined every five days (summary results: absent 42 times). The absence of the righting reflex in the control group was statistically significant (chi(2) = 18.66, df = 1, p = 0.000, p < 0.05). The experimental group fetuses assumed a prone position more frequently in the period from the 51st to the 66th day of gestation than in the period from the 31st to the 50th day of gestation (chi(2) = 4.17, df = 1, p = 0.0412, p < 0.05), suggesting maturation of the righting reflex.
T2  - General Physiology and Biophysics
T1  - The righting reflex from a supine to a prone position in the guinea pig fetus
IS  - null
VL  - 28
EP  - 288
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1477
ER  - 

@article{
author = "Sekulić, Slobodan R and Lukac, Damir D and Drapsin, Miodrag and Suknjaja, Vesna and Keković, Goran and Stojadinović, Gordana and Martać, Ljiljana",
year = "2009",
abstract = "The aim of this study was to examine the righting reflex from a supine to a prone position in the albino guinea pig fetus. Ultrasound examinations of one-fetus gestations were performed in the period from the 31st to the 66th day of gestation. The experimental and control group each encompassed 6 fetuses. Fetuses were brought into supine positions relative to the gravity vector by manipulating the pregnant females into the appropriate positions. The control group received 15 mg/kg of diazepam intraperitoneally before the examination to show whether changes in fetal position occurred as the result of passive rotation. In the experimental group, each fetus was examined every other day (summary results: absent 69 times, prone position 10 times, lateral position 29 times). In the control group, each fetus was examined every five days (summary results: absent 42 times). The absence of the righting reflex in the control group was statistically significant (chi(2) = 18.66, df = 1, p = 0.000, p < 0.05). The experimental group fetuses assumed a prone position more frequently in the period from the 51st to the 66th day of gestation than in the period from the 31st to the 50th day of gestation (chi(2) = 4.17, df = 1, p = 0.0412, p < 0.05), suggesting maturation of the righting reflex.",
journal = "General Physiology and Biophysics",
title = "The righting reflex from a supine to a prone position in the guinea pig fetus",
number = "null",
volume = "28",
pages = "288",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1477"
}

Sekulić, S. R., Lukac, D. D., Drapsin, M., Suknjaja, V., Keković, G., Stojadinović, G.,& Martać, L.. (2009). The righting reflex from a supine to a prone position in the guinea pig fetus. in General Physiology and Biophysics, 28(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1477

Sekulić SR, Lukac DD, Drapsin M, Suknjaja V, Keković G, Stojadinović G, Martać L. The righting reflex from a supine to a prone position in the guinea pig fetus. in General Physiology and Biophysics. 2009;28(null):null-288.
https://hdl.handle.net/21.15107/rcub_ibiss_1477 .

Sekulić, Slobodan R, Lukac, Damir D, Drapsin, Miodrag, Suknjaja, Vesna, Keković, Goran, Stojadinović, Gordana, Martać, Ljiljana, "The righting reflex from a supine to a prone position in the guinea pig fetus" in General Physiology and Biophysics, 28, no. null (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1477 .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Ćulić, Milka
AU  - Martać, Ljiljana
AU  - Soković, M.
AU  - Spasić, S.
AU  - Đoković, D.
PY  - 2008
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/205
AB  - The aim of our study was to investigate the effect of camphor essential oil on rat cerebral cortex activity by fractal analysis. Fractal dimension (FD) values of the parietal electrocortical activity were calculated before and after intra-peritoneal administration of camphor essential oil (450-675 μl/kg) in anesthetized rats. Camphor oil induced seizure-like activity with single and multiple spiking of high amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions. The FD values of cortical activity after camphor oil administration increased on the average. Only FD values of cortical ECoG sequences were lower than those before camphor oil administration.
AB  - Cilj naše studije je bilo istraživanje efekta kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova pomoću fraktalne analize. Vrednosti fraktalne dimenzije parijetalne elektrokortikalne aktivnosti su izračunate pre i posle davanja kamforovog esencijalnog ulja (450-675 μl/kg,i.p.) anesteziranim pacovima. Kamforovo esencijalno ulje izazvalo je moždanu aktivnost nalik na napad sa pojedinačnim i višestrukim šiljak-talasima velike amplitude u parijetalnom elektrokortikogramu kao i povremene klonične konvulzije ekstremiteta. Posle davanja kamforovog ulja, srednje vrednosti fraktalne dimenzije kortikalne aktivnosti suse povećale u proseku. Jedino vrednosti fraktalne dimenzije iktalnih sekvenci elektrokortikograma su bile niže nego one pre davanja kamforovog ulja.
T2  - Archives of Biological Sciences
T1  - Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije
T1  - Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes
IS  - 4
VL  - 60
SP  - 547
EP  - 553
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_205
ER  - 

@article{
author = "Stojadinović, Gordana and Ćulić, Milka and Martać, Ljiljana and Soković, M. and Spasić, S. and Đoković, D.",
year = "2008, 2008",
abstract = "The aim of our study was to investigate the effect of camphor essential oil on rat cerebral cortex activity by fractal analysis. Fractal dimension (FD) values of the parietal electrocortical activity were calculated before and after intra-peritoneal administration of camphor essential oil (450-675 μl/kg) in anesthetized rats. Camphor oil induced seizure-like activity with single and multiple spiking of high amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions. The FD values of cortical activity after camphor oil administration increased on the average. Only FD values of cortical ECoG sequences were lower than those before camphor oil administration., Cilj naše studije je bilo istraživanje efekta kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova pomoću fraktalne analize. Vrednosti fraktalne dimenzije parijetalne elektrokortikalne aktivnosti su izračunate pre i posle davanja kamforovog esencijalnog ulja (450-675 μl/kg,i.p.) anesteziranim pacovima. Kamforovo esencijalno ulje izazvalo je moždanu aktivnost nalik na napad sa pojedinačnim i višestrukim šiljak-talasima velike amplitude u parijetalnom elektrokortikogramu kao i povremene klonične konvulzije ekstremiteta. Posle davanja kamforovog ulja, srednje vrednosti fraktalne dimenzije kortikalne aktivnosti suse povećale u proseku. Jedino vrednosti fraktalne dimenzije iktalnih sekvenci elektrokortikograma su bile niže nego one pre davanja kamforovog ulja.",
journal = "Archives of Biological Sciences",
title = "Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije, Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes",
number = "4",
volume = "60",
pages = "547-553",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_205"
}

Stojadinović, G., Ćulić, M., Martać, L., Soković, M., Spasić, S.,& Đoković, D.. (2008). Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije. in Archives of Biological Sciences, 60(4), 547-553.
https://hdl.handle.net/21.15107/rcub_ibiss_205

Stojadinović G, Ćulić M, Martać L, Soković M, Spasić S, Đoković D. Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije. in Archives of Biological Sciences. 2008;60(4):547-553.
https://hdl.handle.net/21.15107/rcub_ibiss_205 .

Stojadinović, Gordana, Ćulić, Milka, Martać, Ljiljana, Soković, M., Spasić, S., Đoković, D., "Efekat kamforovog esencijalnog ulja na aktivnost kore velikog mozga pacova u funkciji promena fraktalne dimenzije" in Archives of Biological Sciences, 60, no. 4 (2008):547-553,
https://hdl.handle.net/21.15107/rcub_ibiss_205 .