TY  - JOUR
AU  - Katanić Stanković, Jelena S.
AU  - Đorović Jovanović, Jelena
AU  - Mišić, Danijela
AU  - Gašić, Uroš
AU  - Nikles, Stefanie
AU  - Marković, Zoran
AU  - Bauer, Rudolf
PY  - 2023
UR  - https://www.mdpi.com/1420-3049/28/3/1274
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9921532
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5482
AB  - Rabelera holostea (L.) M. T. Sharples & E. A. Tripp (Greater Stitchwort), formerly known as Stellaria holostea L., is widespread in the warm temperate areas of Europe and Western Asia, the Caucasus region, as well as in some countries of North Africa. Nowadays it is considered as a weed, but earlier it was often used raw in salads or for the treatment of various inflammatory disorders. The goal of this study was to determine the constituents of the methanol extract of R. holostea aerial parts and its biological potential in terms of antioxidant, antimicrobial, and anti-inflammatory properties. Until now, the constituents and biological activities of this plant were not reported in detail. A comprehensive phytochemical profiling of the extract has shown that phenolic acids, such as ferulic, chlorogenic, and p-coumaric acid, flavonoids and flavonoid glucosides, such as chrysoeriol, rutin, and naringin, are the most abundant compounds. The antioxidant activity of R. holostea extract towards DPPH and ABTS radicals, but also the total antioxidant capacity and the inhibition of lipid peroxidation were moderate. The antimicrobial potential was pronounced mostly towards some fungi such as F. oxysporum (MIC 1.25 mg/mL), whereas the capacity of R. holostea to affect the growth of bacteria was much less pronounced. R. holostea extract was most inclined to anti-inflammatory activity. At a concentration of 50 µg/mL, it significantly inhibited both cyclooxygenase enzymes (COX-1 and COX-2) by 71.24% and 72.83%, respectively. Molecular docking studies indicated that chlorogenic acid and chrysoeriol are the main contributors to COX-1 and COX-2 inhibitory activity.
PB  - Basel: MDPI
T2  - Molecules (Basel, Switzerland)
T1  - UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract
IS  - 3
VL  - 28
DO  - 10.3390/molecules28031274
SP  - 1274
ER  - 

@article{
author = "Katanić Stanković, Jelena S. and Đorović Jovanović, Jelena and Mišić, Danijela and Gašić, Uroš and Nikles, Stefanie and Marković, Zoran and Bauer, Rudolf",
year = "2023",
abstract = "Rabelera holostea (L.) M. T. Sharples & E. A. Tripp (Greater Stitchwort), formerly known as Stellaria holostea L., is widespread in the warm temperate areas of Europe and Western Asia, the Caucasus region, as well as in some countries of North Africa. Nowadays it is considered as a weed, but earlier it was often used raw in salads or for the treatment of various inflammatory disorders. The goal of this study was to determine the constituents of the methanol extract of R. holostea aerial parts and its biological potential in terms of antioxidant, antimicrobial, and anti-inflammatory properties. Until now, the constituents and biological activities of this plant were not reported in detail. A comprehensive phytochemical profiling of the extract has shown that phenolic acids, such as ferulic, chlorogenic, and p-coumaric acid, flavonoids and flavonoid glucosides, such as chrysoeriol, rutin, and naringin, are the most abundant compounds. The antioxidant activity of R. holostea extract towards DPPH and ABTS radicals, but also the total antioxidant capacity and the inhibition of lipid peroxidation were moderate. The antimicrobial potential was pronounced mostly towards some fungi such as F. oxysporum (MIC 1.25 mg/mL), whereas the capacity of R. holostea to affect the growth of bacteria was much less pronounced. R. holostea extract was most inclined to anti-inflammatory activity. At a concentration of 50 µg/mL, it significantly inhibited both cyclooxygenase enzymes (COX-1 and COX-2) by 71.24% and 72.83%, respectively. Molecular docking studies indicated that chlorogenic acid and chrysoeriol are the main contributors to COX-1 and COX-2 inhibitory activity.",
publisher = "Basel: MDPI",
journal = "Molecules (Basel, Switzerland)",
title = "UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract",
number = "3",
volume = "28",
doi = "10.3390/molecules28031274",
pages = "1274"
}

Katanić Stanković, J. S., Đorović Jovanović, J., Mišić, D., Gašić, U., Nikles, S., Marković, Z.,& Bauer, R.. (2023). UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract. in Molecules (Basel, Switzerland)
Basel: MDPI., 28(3), 1274.
https://doi.org/10.3390/molecules28031274

Katanić Stanković JS, Đorović Jovanović J, Mišić D, Gašić U, Nikles S, Marković Z, Bauer R. UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract. in Molecules (Basel, Switzerland). 2023;28(3):1274.
doi:10.3390/molecules28031274 .

Katanić Stanković, Jelena S., Đorović Jovanović, Jelena, Mišić, Danijela, Gašić, Uroš, Nikles, Stefanie, Marković, Zoran, Bauer, Rudolf, "UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract" in Molecules (Basel, Switzerland), 28, no. 3 (2023):1274,
https://doi.org/10.3390/molecules28031274 . .

TY  - JOUR
AU  - Mihailović, Vladimir
AU  - Katanić Stanković, Jelena S.
AU  - Jurić, Tatjana
AU  - Srećković, Nikola
AU  - Mišić, Danijela
AU  - Šiler, Branislav
AU  - Monti, Daria Maria
AU  - Imbimbo, Paola
AU  - Nikles, Stefanie
AU  - Pan, San-Po
AU  - Bauer, Rudolf
PY  - 2020
UR  - https://www.sciencedirect.com/science/article/pii/S0926669019309847?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3562
AB  - Blackstonia perfoliata (L.) Huds. is known as a highly bitter secoiridoid glycosides-containing plant and as a possible substitute for some Gentianaceae plants in herbal preparations. Nevertheless, its bioactive properties are still unknown. The present study aimed to characterize both, secoiridoid glycosides and phenolic constituents, and to investigate antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities of B. perfoliata methanolic extract. The secoiridoid glycosides swertiamarin, gentiopicrin, and sweroside were found to be the dominant compounds of the extract, while 23 phenolic compounds were identified in much lower concentrations. Among phenolics, flavanols were the most abundant, which represents a unique feature among Gentianaceae species. The extract showed moderate to weak antioxidant activity with better performance in inhibition of lipid peroxidation than in free radical scavenging activities. The extract showed generally better antifungal properties compared with its antibacterial potential. Also, B. perfoliata demonstrated in vitro anti-inflammatory activity, the extract (50 μg/mL) showed inhibition of cyclooxigenases, COX-1 and COX-2, activities (19.65 and 48.02%, respectively). It also displayed biocompatibility on the immortalized and cancer cells, as no cytotoxic effect was observed. For the first time, the bioactive potential of this species was demonstrated, justifying its usage in pharmaceutical and food products as an alternative for some overexploited and endangered species from the Gentianaceae family.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds
VL  - 145
DO  - 10.1016/J.INDCROP.2019.111974
SP  - 111974
ER  - 

@article{
author = "Mihailović, Vladimir and Katanić Stanković, Jelena S. and Jurić, Tatjana and Srećković, Nikola and Mišić, Danijela and Šiler, Branislav and Monti, Daria Maria and Imbimbo, Paola and Nikles, Stefanie and Pan, San-Po and Bauer, Rudolf",
year = "2020",
abstract = "Blackstonia perfoliata (L.) Huds. is known as a highly bitter secoiridoid glycosides-containing plant and as a possible substitute for some Gentianaceae plants in herbal preparations. Nevertheless, its bioactive properties are still unknown. The present study aimed to characterize both, secoiridoid glycosides and phenolic constituents, and to investigate antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities of B. perfoliata methanolic extract. The secoiridoid glycosides swertiamarin, gentiopicrin, and sweroside were found to be the dominant compounds of the extract, while 23 phenolic compounds were identified in much lower concentrations. Among phenolics, flavanols were the most abundant, which represents a unique feature among Gentianaceae species. The extract showed moderate to weak antioxidant activity with better performance in inhibition of lipid peroxidation than in free radical scavenging activities. The extract showed generally better antifungal properties compared with its antibacterial potential. Also, B. perfoliata demonstrated in vitro anti-inflammatory activity, the extract (50 μg/mL) showed inhibition of cyclooxigenases, COX-1 and COX-2, activities (19.65 and 48.02%, respectively). It also displayed biocompatibility on the immortalized and cancer cells, as no cytotoxic effect was observed. For the first time, the bioactive potential of this species was demonstrated, justifying its usage in pharmaceutical and food products as an alternative for some overexploited and endangered species from the Gentianaceae family.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds",
volume = "145",
doi = "10.1016/J.INDCROP.2019.111974",
pages = "111974"
}

Mihailović, V., Katanić Stanković, J. S., Jurić, T., Srećković, N., Mišić, D., Šiler, B., Monti, D. M., Imbimbo, P., Nikles, S., Pan, S.,& Bauer, R.. (2020). Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds. in Industrial Crops and Products
Elsevier., 145, 111974.
https://doi.org/10.1016/J.INDCROP.2019.111974

Mihailović V, Katanić Stanković JS, Jurić T, Srećković N, Mišić D, Šiler B, Monti DM, Imbimbo P, Nikles S, Pan S, Bauer R. Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds. in Industrial Crops and Products. 2020;145:111974.
doi:10.1016/J.INDCROP.2019.111974 .

Mihailović, Vladimir, Katanić Stanković, Jelena S., Jurić, Tatjana, Srećković, Nikola, Mišić, Danijela, Šiler, Branislav, Monti, Daria Maria, Imbimbo, Paola, Nikles, Stefanie, Pan, San-Po, Bauer, Rudolf, "Blackstonia perfoliata (L.) Huds. (Gentianaceae): A promising source of useful bioactive compounds" in Industrial Crops and Products, 145 (2020):111974,
https://doi.org/10.1016/J.INDCROP.2019.111974 . .