TY  - JOUR
AU  - Radovanović, Marina
AU  - Lazarević, Nevena
AU  - Novaković, Jovana
AU  - Jeremić, Nevena
AU  - Jakovljević, Vladimir
AU  - Živković, Vladimir
AU  - Bradić, Jovana
AU  - Pecarski, Danijela
AU  - Tel-Çayan, Gülsen
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Gregori, Andrej
AU  - Petrović, Jovana
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5792
AB  - The present study aimed to examine the biological activity and cardioprotective potential of Trametes versicolor heteropolysaccharides (TVH) in a rat model of metabolic syndrome (MetS). This study included 40 Wistar rats divided into 5 groups: CTRL—healthy non-treated rats; MetS—non-treated rats; and H-TV, M-TV and L-TV-rats with MetS treated with either 300, 200 or 100 mg/kg TVH per os for 4 weeks. After finishing the treatment, we conducted an oral glucose tolerance test (OGTT), hemodynamic measurements and the animals were sacrificed, hearts isolated and subjected to the Langendorff technique. Blood samples were used for the determination of oxidative stress parameters, lipid status and insulin levels. We showed that α-amylase inhibition was not the mode of TVH antidiabetic action, while TVH showed a moderate inhibition of pathogenic microorganisms’ growth (MIC 8.00 mg·mL−1; MBC/MFC 16.00 mg·mL−1). H-TV and M-TV significantly reduced the level of prooxidants (O2−, H2O2, TBARS; p < 0.05), increased antioxidants activity (SOD, CAT, GSH; p < 0.05), reduced blood pressure (p < 0.05), improved glucose homeostasis in the OGTT test (p < 0.05), and ejection fraction (p < 0.05) and cardiac contractility (p < 0.05) compared to MetS (p < 0.05). Moreover, TVH treatment normalized the lipid status and decreased insulin levels compared to MetS rats (p < 0.05). The obtained results demonstrated that the TVH may be considered a useful agent for cardioprotection in MetS conditions.
PB  - Basel: MDPI
T2  - Pharmaceuticals
T1  - Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome
IS  - 6
VL  - 16
DO  - 10.3390/ph16060787
SP  - 787
ER  - 

@article{
author = "Radovanović, Marina and Lazarević, Nevena and Novaković, Jovana and Jeremić, Nevena and Jakovljević, Vladimir and Živković, Vladimir and Bradić, Jovana and Pecarski, Danijela and Tel-Çayan, Gülsen and Glamočlija, Jasmina and Soković, Marina and Gregori, Andrej and Petrović, Jovana",
year = "2023",
abstract = "The present study aimed to examine the biological activity and cardioprotective potential of Trametes versicolor heteropolysaccharides (TVH) in a rat model of metabolic syndrome (MetS). This study included 40 Wistar rats divided into 5 groups: CTRL—healthy non-treated rats; MetS—non-treated rats; and H-TV, M-TV and L-TV-rats with MetS treated with either 300, 200 or 100 mg/kg TVH per os for 4 weeks. After finishing the treatment, we conducted an oral glucose tolerance test (OGTT), hemodynamic measurements and the animals were sacrificed, hearts isolated and subjected to the Langendorff technique. Blood samples were used for the determination of oxidative stress parameters, lipid status and insulin levels. We showed that α-amylase inhibition was not the mode of TVH antidiabetic action, while TVH showed a moderate inhibition of pathogenic microorganisms’ growth (MIC 8.00 mg·mL−1; MBC/MFC 16.00 mg·mL−1). H-TV and M-TV significantly reduced the level of prooxidants (O2−, H2O2, TBARS; p < 0.05), increased antioxidants activity (SOD, CAT, GSH; p < 0.05), reduced blood pressure (p < 0.05), improved glucose homeostasis in the OGTT test (p < 0.05), and ejection fraction (p < 0.05) and cardiac contractility (p < 0.05) compared to MetS (p < 0.05). Moreover, TVH treatment normalized the lipid status and decreased insulin levels compared to MetS rats (p < 0.05). The obtained results demonstrated that the TVH may be considered a useful agent for cardioprotection in MetS conditions.",
publisher = "Basel: MDPI",
journal = "Pharmaceuticals",
title = "Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome",
number = "6",
volume = "16",
doi = "10.3390/ph16060787",
pages = "787"
}

Radovanović, M., Lazarević, N., Novaković, J., Jeremić, N., Jakovljević, V., Živković, V., Bradić, J., Pecarski, D., Tel-Çayan, G., Glamočlija, J., Soković, M., Gregori, A.,& Petrović, J.. (2023). Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome. in Pharmaceuticals
Basel: MDPI., 16(6), 787.
https://doi.org/10.3390/ph16060787

Radovanović M, Lazarević N, Novaković J, Jeremić N, Jakovljević V, Živković V, Bradić J, Pecarski D, Tel-Çayan G, Glamočlija J, Soković M, Gregori A, Petrović J. Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome. in Pharmaceuticals. 2023;16(6):787.
doi:10.3390/ph16060787 .

Radovanović, Marina, Lazarević, Nevena, Novaković, Jovana, Jeremić, Nevena, Jakovljević, Vladimir, Živković, Vladimir, Bradić, Jovana, Pecarski, Danijela, Tel-Çayan, Gülsen, Glamočlija, Jasmina, Soković, Marina, Gregori, Andrej, Petrović, Jovana, "Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome" in Pharmaceuticals, 16, no. 6 (2023):787,
https://doi.org/10.3390/ph16060787 . .

TY  - GEN
AU  - Piria, Marina
AU  - Simonović, Predrag
AU  - Kalogianni, Eleni
AU  - Vardakas, Leonidas
AU  - Koutsikos, Nicholas
AU  - Zanella, Davor
AU  - Ristovska, Milica
AU  - Apostolou, Apostolos
AU  - Adrović, Avdul
AU  - Mrdak, Danilo
AU  - Tarkan, Ali Serhan
AU  - Milošević, Dragana
AU  - Zanella, Linda N
AU  - Bakiu, Rigers
AU  - Ekmekçi, F Güler
AU  - Povž, Metka
AU  - Korro, Kastriot
AU  - Nikolić, Vera
AU  - Škrijelj, Rifat
AU  - Kostov, Vasil
AU  - Gregori, Andrej
AU  - Joy, Michael K
PY  - 2017
UR  - http://doi.wiley.com/10.1111/faf.12242
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2842
AB  - Fish introductions, particularly in areas of high biological diversity and endemism, represent a major threat for biodiversity. In the Balkan Peninsula, 60 fish species have been introduced to date, of which 36 have become naturalized in inland waters. Since the Balkans are one of the world's 35 biodiversity hot spots, this large presence of alien fish species poses a serious threat for the stability of freshwater ecosystems and the survival of the native ichthyofauna and of aquatic biodiversity in general. The motivation for the introductions, and the historical timeline, varies among the Balkan states. Despite recent attempts to implement and align legislation aimed at preventing the introduction of potentially invasive species, and the implementation of rigorous controls of introductions and increased protection of open waters, the majority of current introductions remain intentional, primarily via aquaculture. This review article provides a historical overview of freshwater fish introductions, the motivation behind them a nd the current distribution of alien freshwater fishes in the Balkans. The ecological implications and future perspectives concerning alien fish species in the region are also discussed.
T2  - Fish and Fisheries
T1  - Alien freshwater fish species in the Balkans-Vectors and pathways of introduction
DO  - 10.1111/faf.12242
ER  - 

@misc{
author = "Piria, Marina and Simonović, Predrag and Kalogianni, Eleni and Vardakas, Leonidas and Koutsikos, Nicholas and Zanella, Davor and Ristovska, Milica and Apostolou, Apostolos and Adrović, Avdul and Mrdak, Danilo and Tarkan, Ali Serhan and Milošević, Dragana and Zanella, Linda N and Bakiu, Rigers and Ekmekçi, F Güler and Povž, Metka and Korro, Kastriot and Nikolić, Vera and Škrijelj, Rifat and Kostov, Vasil and Gregori, Andrej and Joy, Michael K",
year = "2017",
abstract = "Fish introductions, particularly in areas of high biological diversity and endemism, represent a major threat for biodiversity. In the Balkan Peninsula, 60 fish species have been introduced to date, of which 36 have become naturalized in inland waters. Since the Balkans are one of the world's 35 biodiversity hot spots, this large presence of alien fish species poses a serious threat for the stability of freshwater ecosystems and the survival of the native ichthyofauna and of aquatic biodiversity in general. The motivation for the introductions, and the historical timeline, varies among the Balkan states. Despite recent attempts to implement and align legislation aimed at preventing the introduction of potentially invasive species, and the implementation of rigorous controls of introductions and increased protection of open waters, the majority of current introductions remain intentional, primarily via aquaculture. This review article provides a historical overview of freshwater fish introductions, the motivation behind them a nd the current distribution of alien freshwater fishes in the Balkans. The ecological implications and future perspectives concerning alien fish species in the region are also discussed.",
journal = "Fish and Fisheries",
title = "Alien freshwater fish species in the Balkans-Vectors and pathways of introduction",
doi = "10.1111/faf.12242"
}

Piria, M., Simonović, P., Kalogianni, E., Vardakas, L., Koutsikos, N., Zanella, D., Ristovska, M., Apostolou, A., Adrović, A., Mrdak, D., Tarkan, A. S., Milošević, D., Zanella, L. N., Bakiu, R., Ekmekçi, F. G., Povž, M., Korro, K., Nikolić, V., Škrijelj, R., Kostov, V., Gregori, A.,& Joy, M. K.. (2017). Alien freshwater fish species in the Balkans-Vectors and pathways of introduction. in Fish and Fisheries.
https://doi.org/10.1111/faf.12242

Piria M, Simonović P, Kalogianni E, Vardakas L, Koutsikos N, Zanella D, Ristovska M, Apostolou A, Adrović A, Mrdak D, Tarkan AS, Milošević D, Zanella LN, Bakiu R, Ekmekçi FG, Povž M, Korro K, Nikolić V, Škrijelj R, Kostov V, Gregori A, Joy MK. Alien freshwater fish species in the Balkans-Vectors and pathways of introduction. in Fish and Fisheries. 2017;.
doi:10.1111/faf.12242 .

Piria, Marina, Simonović, Predrag, Kalogianni, Eleni, Vardakas, Leonidas, Koutsikos, Nicholas, Zanella, Davor, Ristovska, Milica, Apostolou, Apostolos, Adrović, Avdul, Mrdak, Danilo, Tarkan, Ali Serhan, Milošević, Dragana, Zanella, Linda N, Bakiu, Rigers, Ekmekçi, F Güler, Povž, Metka, Korro, Kastriot, Nikolić, Vera, Škrijelj, Rifat, Kostov, Vasil, Gregori, Andrej, Joy, Michael K, "Alien freshwater fish species in the Balkans-Vectors and pathways of introduction" in Fish and Fisheries (2017),
https://doi.org/10.1111/faf.12242 . .