TY  - JOUR
AU  - Bensing, Christian
AU  - Mojić, Marija
AU  - Bulatović, Mirna
AU  - Edeler, David
AU  - Pérez-Quintanilla, Damian
AU  - Gómez-Ruiz, Santiago
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S2772950822003314
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5106
AB  - A series of nanostructured SBA-15-based materials functionalized with the tetraorganotin(IV) metallodrugs Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) are synthesized and structurally characterized by different techniques used in solid-state chemistry. The cytotoxicity of both the organotin(IV) compounds and the tin-functionalized SBA-15 materials are studied against different cancer cell lines observing that the materials have similar cytotoxic activity in comparison with the free organotin compounds in terms of mass. However, considering that the percentage of active metal compound loaded into material is low, the utilization of mesoporous silica as drug vehicle clearly improves the cytotoxic effectiveness of metal-based drugs against cancer cells. One of the most potent between all tested systems is material SBA-15~Cl|Ph3Sn(CH2)8OH. Its cytotoxicity seems to come from additional mechanisms apart from apoptosis provoking cell reprogram in B16 melanoma into more mature and less aggressive phenotype. Moderated production of ROS/RNS is probably in the background of observed phenomenon. Obtained results are further confirmed in syngeneic mouse model of melanoma in C57BL6 mice. The in vivo results show that SBA-15 do not disturb tumor growth, while both Ph3Sn(CH2)8OH and SBA-15~Cl|Ph3Sn(CH2)8OH significantly decreases tumor volume with an enhancement of the antitumor potential of the tetraorganotin(IV) compound upon immobilization in SBA-15.
PB  - Elsevier B.V.
T2  - Biomaterials Advances
T1  - Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.
VL  - 140
DO  - 10.1016/j.bioadv.2022.213054
SP  - 213054
ER  - 

@article{
author = "Bensing, Christian and Mojić, Marija and Bulatović, Mirna and Edeler, David and Pérez-Quintanilla, Damian and Gómez-Ruiz, Santiago and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2022",
abstract = "A series of nanostructured SBA-15-based materials functionalized with the tetraorganotin(IV) metallodrugs Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) are synthesized and structurally characterized by different techniques used in solid-state chemistry. The cytotoxicity of both the organotin(IV) compounds and the tin-functionalized SBA-15 materials are studied against different cancer cell lines observing that the materials have similar cytotoxic activity in comparison with the free organotin compounds in terms of mass. However, considering that the percentage of active metal compound loaded into material is low, the utilization of mesoporous silica as drug vehicle clearly improves the cytotoxic effectiveness of metal-based drugs against cancer cells. One of the most potent between all tested systems is material SBA-15~Cl|Ph3Sn(CH2)8OH. Its cytotoxicity seems to come from additional mechanisms apart from apoptosis provoking cell reprogram in B16 melanoma into more mature and less aggressive phenotype. Moderated production of ROS/RNS is probably in the background of observed phenomenon. Obtained results are further confirmed in syngeneic mouse model of melanoma in C57BL6 mice. The in vivo results show that SBA-15 do not disturb tumor growth, while both Ph3Sn(CH2)8OH and SBA-15~Cl|Ph3Sn(CH2)8OH significantly decreases tumor volume with an enhancement of the antitumor potential of the tetraorganotin(IV) compound upon immobilization in SBA-15.",
publisher = "Elsevier B.V.",
journal = "Biomaterials Advances",
title = "Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.",
volume = "140",
doi = "10.1016/j.bioadv.2022.213054",
pages = "213054"
}

Bensing, C., Mojić, M., Bulatović, M., Edeler, D., Pérez-Quintanilla, D., Gómez-Ruiz, S., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2022). Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.. in Biomaterials Advances
Elsevier B.V.., 140, 213054.
https://doi.org/10.1016/j.bioadv.2022.213054

Bensing C, Mojić M, Bulatović M, Edeler D, Pérez-Quintanilla D, Gómez-Ruiz S, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH.. in Biomaterials Advances. 2022;140:213054.
doi:10.1016/j.bioadv.2022.213054 .

Bensing, Christian, Mojić, Marija, Bulatović, Mirna, Edeler, David, Pérez-Quintanilla, Damian, Gómez-Ruiz, Santiago, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Effect of chain length on the cytotoxic activity of (alkyl-ω-ol)triphenyltin(IV) loaded into SBA-15 nanostructured silica and in vivo study of SBA-15~Cl|Ph3Sn(CH2)8OH." in Biomaterials Advances, 140 (2022):213054,
https://doi.org/10.1016/j.bioadv.2022.213054 . .

TY  - JOUR
AU  - Bensing, Christian
AU  - Mojić, Marija
AU  - Gómez-Ruiz, Santiago
AU  - Carralero, Sandra
AU  - Dojčinović, Biljana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2016
UR  - http://xlink.rsc.org/?DOI=C6DT03519A
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85000774313&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A11#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2481
AB  - SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.
T2  - Dalton Transactions
T1  - Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line
IS  - 47
VL  - 45
DO  - 10.1039/C6DT03519A
SP  - 18984
EP  - 18993
ER  - 

@article{
author = "Bensing, Christian and Mojić, Marija and Gómez-Ruiz, Santiago and Carralero, Sandra and Dojčinović, Biljana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2016",
abstract = "SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.",
journal = "Dalton Transactions",
title = "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line",
number = "47",
volume = "45",
doi = "10.1039/C6DT03519A",
pages = "18984-18993"
}

Bensing, C., Mojić, M., Gómez-Ruiz, S., Carralero, S., Dojčinović, B., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2016). Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions, 45(47), 18984-18993.
https://doi.org/10.1039/C6DT03519A

Bensing C, Mojić M, Gómez-Ruiz S, Carralero S, Dojčinović B, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions. 2016;45(47):18984-18993.
doi:10.1039/C6DT03519A .

Bensing, Christian, Mojić, Marija, Gómez-Ruiz, Santiago, Carralero, Sandra, Dojčinović, Biljana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line" in Dalton Transactions, 45, no. 47 (2016):18984-18993,
https://doi.org/10.1039/C6DT03519A . .

TY  - JOUR
AU  - Kaluđerović, Milena R.
AU  - Mojić, Marija
AU  - Gómez-Ruiz,  Santiago
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
PY  - 2016
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3826
AB  - In vitro antitumor activity of various organogallium(III) complexes (1-8) has been tested against CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used to assess on the antiproliferative effect of investigated organogallium(III) complexes. From the investigated complexes, the most active was found to be tetranuclear compound 8 against CT26CL25 cells. Flow cytometric analysis of the CT26CL25 cells upon the treatment with 8 was performed in order to determine the role of apoptosis, caspase activation, autophagy and proliferation rate on the cell death caused with this compound. Results indicate cytotoxic potential of the tetranuclear complex 8 by inducing caspase independent apoptosis and blocking most of the cells before first division.
PB  - Sharjah: Bentham Science Publishers
T2  - Anticancer Agents Med Chem
T1  - Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells
IS  - 3
VL  - 16
DO  - 10.2174/1871520615666151007160319
SP  - 359
EP  - 364
ER  - 

@article{
author = "Kaluđerović, Milena R. and Mojić, Marija and Gómez-Ruiz,  Santiago and Mijatović, Sanja and Maksimović-Ivanić, Danijela",
year = "2016",
abstract = "In vitro antitumor activity of various organogallium(III) complexes (1-8) has been tested against CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used to assess on the antiproliferative effect of investigated organogallium(III) complexes. From the investigated complexes, the most active was found to be tetranuclear compound 8 against CT26CL25 cells. Flow cytometric analysis of the CT26CL25 cells upon the treatment with 8 was performed in order to determine the role of apoptosis, caspase activation, autophagy and proliferation rate on the cell death caused with this compound. Results indicate cytotoxic potential of the tetranuclear complex 8 by inducing caspase independent apoptosis and blocking most of the cells before first division.",
publisher = "Sharjah: Bentham Science Publishers",
journal = "Anticancer Agents Med Chem",
title = "Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells",
number = "3",
volume = "16",
doi = "10.2174/1871520615666151007160319",
pages = "359-364"
}

Kaluđerović, M. R., Mojić, M., Gómez-Ruiz,  ., Mijatović, S.,& Maksimović-Ivanić, D.. (2016). Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells. in Anticancer Agents Med Chem
Sharjah: Bentham Science Publishers., 16(3), 359-364.
https://doi.org/10.2174/1871520615666151007160319

Kaluđerović MR, Mojić M, Gómez-Ruiz  , Mijatović S, Maksimović-Ivanić D. Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells. in Anticancer Agents Med Chem. 2016;16(3):359-364.
doi:10.2174/1871520615666151007160319 .

Kaluđerović, Milena R., Mojić, Marija, Gómez-Ruiz,  Santiago, Mijatović, Sanja, Maksimović-Ivanić, Danijela, "Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells" in Anticancer Agents Med Chem, 16, no. 3 (2016):359-364,
https://doi.org/10.2174/1871520615666151007160319 . .