TY  - JOUR
AU  - Rosić, Gvozden
AU  - Selaković, Dragica
AU  - Joksimović, Jovana
AU  - Srejović, Ivan
AU  - Živković, Vladimir
AU  - Tatalović, Nikola
AU  - Oreščanin Dušić, Zorana
AU  - Mitrović, Slobodanka
AU  - Ilić, Milena
AU  - Jakovljević, Vladimir
PY  - 2016
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0378427415301223
UR  - http://www.ncbi.nlm.nih.gov/pubmed/26656795
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2612
AB  - The aim of this study was to evaluate the effects of chronic NAC administration along with cisplatin on cisplatin-induced cardiotoxicity by means of coronary flow (CF), cardiodynamic parameters, oxidative stress markers and morphological changes in isolated rat heart. Isolated hearts of Wistar albino rats (divided into four groups: control, cisplatin, NAC and cisplatin+NAC group) were perfused according to Langendorff technique at constant coronary perfusion pressure starting at 50 and gradually increased to 65, 80, 95 and 110 cm H2O to evaluate cardiodynamic parameters within autoregulation range. Samples of coronary venous effluent (CVE) were collected for determination of CF and biochemical assays, and heart tissue samples for biochemical assays and histopathological examination. Cisplatin treatment decreased CF and heart rate, and increased left ventricular systolic pressure and maximum left ventricular pressure development rate. Cisplatin increased H2O2 and TBARS, but decreased NO2(-) levels in CVE. In tissue samples, cisplatin reduced pathological alterations in myocardium and coronary vessels, with no changes in the amount of total glutathione, as well as in activity of glutathione peroxidase and glutathione reductase. NAC coadministration, by reducing oxidative damage, attenuated cisplatin-induced changes of cardiodynamic and oxidative stress parameters, as well as morphological changes in myocardium and coronary vasculature.
T2  - Toxicology letters
T1  - The effects of N-acetylcysteine on cisplatin-induced changes of cardiodynamic parameters within coronary autoregulation range in isolated rat hearts.
VL  - 242
DO  - 10.1016/j.toxlet.2015.11.028
SP  - 34
EP  - 46
ER  - 

@article{
author = "Rosić, Gvozden and Selaković, Dragica and Joksimović, Jovana and Srejović, Ivan and Živković, Vladimir and Tatalović, Nikola and Oreščanin Dušić, Zorana and Mitrović, Slobodanka and Ilić, Milena and Jakovljević, Vladimir",
year = "2016",
abstract = "The aim of this study was to evaluate the effects of chronic NAC administration along with cisplatin on cisplatin-induced cardiotoxicity by means of coronary flow (CF), cardiodynamic parameters, oxidative stress markers and morphological changes in isolated rat heart. Isolated hearts of Wistar albino rats (divided into four groups: control, cisplatin, NAC and cisplatin+NAC group) were perfused according to Langendorff technique at constant coronary perfusion pressure starting at 50 and gradually increased to 65, 80, 95 and 110 cm H2O to evaluate cardiodynamic parameters within autoregulation range. Samples of coronary venous effluent (CVE) were collected for determination of CF and biochemical assays, and heart tissue samples for biochemical assays and histopathological examination. Cisplatin treatment decreased CF and heart rate, and increased left ventricular systolic pressure and maximum left ventricular pressure development rate. Cisplatin increased H2O2 and TBARS, but decreased NO2(-) levels in CVE. In tissue samples, cisplatin reduced pathological alterations in myocardium and coronary vessels, with no changes in the amount of total glutathione, as well as in activity of glutathione peroxidase and glutathione reductase. NAC coadministration, by reducing oxidative damage, attenuated cisplatin-induced changes of cardiodynamic and oxidative stress parameters, as well as morphological changes in myocardium and coronary vasculature.",
journal = "Toxicology letters",
title = "The effects of N-acetylcysteine on cisplatin-induced changes of cardiodynamic parameters within coronary autoregulation range in isolated rat hearts.",
volume = "242",
doi = "10.1016/j.toxlet.2015.11.028",
pages = "34-46"
}

Rosić, G., Selaković, D., Joksimović, J., Srejović, I., Živković, V., Tatalović, N., Oreščanin Dušić, Z., Mitrović, S., Ilić, M.,& Jakovljević, V.. (2016). The effects of N-acetylcysteine on cisplatin-induced changes of cardiodynamic parameters within coronary autoregulation range in isolated rat hearts.. in Toxicology letters, 242, 34-46.
https://doi.org/10.1016/j.toxlet.2015.11.028

Rosić G, Selaković D, Joksimović J, Srejović I, Živković V, Tatalović N, Oreščanin Dušić Z, Mitrović S, Ilić M, Jakovljević V. The effects of N-acetylcysteine on cisplatin-induced changes of cardiodynamic parameters within coronary autoregulation range in isolated rat hearts.. in Toxicology letters. 2016;242:34-46.
doi:10.1016/j.toxlet.2015.11.028 .

Rosić, Gvozden, Selaković, Dragica, Joksimović, Jovana, Srejović, Ivan, Živković, Vladimir, Tatalović, Nikola, Oreščanin Dušić, Zorana, Mitrović, Slobodanka, Ilić, Milena, Jakovljević, Vladimir, "The effects of N-acetylcysteine on cisplatin-induced changes of cardiodynamic parameters within coronary autoregulation range in isolated rat hearts." in Toxicology letters, 242 (2016):34-46,
https://doi.org/10.1016/j.toxlet.2015.11.028 . .