TY  - JOUR
AU  - Figueira, Inês
AU  - Fernandes, Adelaide
AU  - Mladenović, Aleksandra
AU  - Lopez-Contreras, Andres
AU  - Henriques, Catarina M.
AU  - Selman, Colin
AU  - Ferreiro, Elisabete
AU  - Gonos, Efstathios S.
AU  - Trejo, José Luis
AU  - Misra, Juhi
AU  - Rasmussen, Lene Juel
AU  - Xapelli, Sara
AU  - Ellam, Timothy
AU  - Bellantuono, Ilaria
PY  - 2016
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0047637416301816
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-84999035290&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=BC81928C1802E221B1A9A8D8F9963BDB.wsnAw8kcdt7IPYLO0V48gA%3A1#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2479
AB  - Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.
T2  - Mechanisms of Ageing and Development
T1  - Interventions for age-related diseases: Shifting the paradigm
VL  - 160
DO  - 10.1016/j.mad.2016.09.009
SP  - 69
EP  - 92
ER  - 

@article{
author = "Figueira, Inês and Fernandes, Adelaide and Mladenović, Aleksandra and Lopez-Contreras, Andres and Henriques, Catarina M. and Selman, Colin and Ferreiro, Elisabete and Gonos, Efstathios S. and Trejo, José Luis and Misra, Juhi and Rasmussen, Lene Juel and Xapelli, Sara and Ellam, Timothy and Bellantuono, Ilaria",
year = "2016",
abstract = "Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.",
journal = "Mechanisms of Ageing and Development",
title = "Interventions for age-related diseases: Shifting the paradigm",
volume = "160",
doi = "10.1016/j.mad.2016.09.009",
pages = "69-92"
}

Figueira, I., Fernandes, A., Mladenović, A., Lopez-Contreras, A., Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, L. J., Xapelli, S., Ellam, T.,& Bellantuono, I.. (2016). Interventions for age-related diseases: Shifting the paradigm. in Mechanisms of Ageing and Development, 160, 69-92.
https://doi.org/10.1016/j.mad.2016.09.009

Figueira I, Fernandes A, Mladenović A, Lopez-Contreras A, Henriques CM, Selman C, Ferreiro E, Gonos ES, Trejo JL, Misra J, Rasmussen LJ, Xapelli S, Ellam T, Bellantuono I. Interventions for age-related diseases: Shifting the paradigm. in Mechanisms of Ageing and Development. 2016;160:69-92.
doi:10.1016/j.mad.2016.09.009 .

Figueira, Inês, Fernandes, Adelaide, Mladenović, Aleksandra, Lopez-Contreras, Andres, Henriques, Catarina M., Selman, Colin, Ferreiro, Elisabete, Gonos, Efstathios S., Trejo, José Luis, Misra, Juhi, Rasmussen, Lene Juel, Xapelli, Sara, Ellam, Timothy, Bellantuono, Ilaria, "Interventions for age-related diseases: Shifting the paradigm" in Mechanisms of Ageing and Development, 160 (2016):69-92,
https://doi.org/10.1016/j.mad.2016.09.009 . .