TY  - JOUR
AU  - Čukuranović Kokoris, Jovana
AU  - Jovanović, Ivan
AU  - Pantović, Vukica
AU  - Krstić, Miljan
AU  - Stanojković, Milica
AU  - Milošević, Verica
AU  - Ugrenović, Slađana
AU  - Stojanović, Vesna
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0040816616302464
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27884532
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2684
AB  - The aim of this research was to quantify the changes in the morphology and density of the anterior pituitary folliculostellate (FS) and luteinizing hormone (LH) cells. Material was tissue of the pituitary gland of the 14 male cadavers. Tissue slices were immunohistochemically stained with monoclonal anti-LH antibody and polyclonal anti-S100 antibody for the detection of LH and FS cells, respectively. Digital images of the stained slices were afterwards morphometrically analyzed by ImageJ. Results of the morphometric analysis showed significant increase of the FS cells volume density in cases older than 70 years. Volume density of the LH cells did not significantly change, whereas their area significantly increased with age. Nucleocytoplasmic ratio of the LH cells gradually decreased and became significant after the age of 70. Finally, volume density of the FS cell significantly correlated with LH cells area and nucleocytoplasmic ratio. From all above cited, we concluded that in men, density and size of the FS cells increase with age. Long-term hypertrophy of the LH cells results in their functional decline after the age of 70. Strong correlation between FS cells and LH cells morphometric parameters might point to age-related interaction between these two cell groups.
T2  - Tissue & Cell
T1  - Morphometric analysis of the folliculostellate cells and luteinizing hormone gonadotropic cells of the anterior pituitary of the men during the aging process.
IS  - 1
VL  - 49
DO  - 10.1016/j.tice.2016.11.006
SP  - 78
EP  - 85
ER  - 

@article{
author = "Čukuranović Kokoris, Jovana and Jovanović, Ivan and Pantović, Vukica and Krstić, Miljan and Stanojković, Milica and Milošević, Verica and Ugrenović, Slađana and Stojanović, Vesna",
year = "2017",
abstract = "The aim of this research was to quantify the changes in the morphology and density of the anterior pituitary folliculostellate (FS) and luteinizing hormone (LH) cells. Material was tissue of the pituitary gland of the 14 male cadavers. Tissue slices were immunohistochemically stained with monoclonal anti-LH antibody and polyclonal anti-S100 antibody for the detection of LH and FS cells, respectively. Digital images of the stained slices were afterwards morphometrically analyzed by ImageJ. Results of the morphometric analysis showed significant increase of the FS cells volume density in cases older than 70 years. Volume density of the LH cells did not significantly change, whereas their area significantly increased with age. Nucleocytoplasmic ratio of the LH cells gradually decreased and became significant after the age of 70. Finally, volume density of the FS cell significantly correlated with LH cells area and nucleocytoplasmic ratio. From all above cited, we concluded that in men, density and size of the FS cells increase with age. Long-term hypertrophy of the LH cells results in their functional decline after the age of 70. Strong correlation between FS cells and LH cells morphometric parameters might point to age-related interaction between these two cell groups.",
journal = "Tissue & Cell",
title = "Morphometric analysis of the folliculostellate cells and luteinizing hormone gonadotropic cells of the anterior pituitary of the men during the aging process.",
number = "1",
volume = "49",
doi = "10.1016/j.tice.2016.11.006",
pages = "78-85"
}

Čukuranović Kokoris, J., Jovanović, I., Pantović, V., Krstić, M., Stanojković, M., Milošević, V., Ugrenović, S.,& Stojanović, V.. (2017). Morphometric analysis of the folliculostellate cells and luteinizing hormone gonadotropic cells of the anterior pituitary of the men during the aging process.. in Tissue & Cell, 49(1), 78-85.
https://doi.org/10.1016/j.tice.2016.11.006

Čukuranović Kokoris J, Jovanović I, Pantović V, Krstić M, Stanojković M, Milošević V, Ugrenović S, Stojanović V. Morphometric analysis of the folliculostellate cells and luteinizing hormone gonadotropic cells of the anterior pituitary of the men during the aging process.. in Tissue & Cell. 2017;49(1):78-85.
doi:10.1016/j.tice.2016.11.006 .

Čukuranović Kokoris, Jovana, Jovanović, Ivan, Pantović, Vukica, Krstić, Miljan, Stanojković, Milica, Milošević, Verica, Ugrenović, Slađana, Stojanović, Vesna, "Morphometric analysis of the folliculostellate cells and luteinizing hormone gonadotropic cells of the anterior pituitary of the men during the aging process." in Tissue & Cell, 49, no. 1 (2017):78-85,
https://doi.org/10.1016/j.tice.2016.11.006 . .