TY  - JOUR
AU  - Petković, Branka
AU  - Selaković, Vesna
AU  - Radenović, Lidija
PY  - 2008
UR  - https://www.sciencedirect.com/science/article/pii/S0166432808003252?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3795
AB  - The purpose of this study was to investigate the temporal pattern of NMDA receptors antagonist-MK-801 on motor behaviour parameters in gerbils submitted to different duration of global cerebral ischemia. The common carotid arteries of gerbils were occluded for 5, 10 or 15 min. Gerbils were given MK-801 (3 mg/kg i.p.) or saline immediately after the occlusion in normothermic conditions prior to testing. Motor activity was registered 1, 2, 4, 7,14,21 and 28 days after reperfusion during 60 min by open field test. At the same time, the effect of NMDA receptor blockade was followed in vivo by monitoring the neurological status of whole animals or at the cellular level by standard light and confocal microscopy on brain slices. Postischemic gerbils quickly developed hypermotor response with the most intensity in animals submitted to 15 min ischemia. MK-801 administrated immediately after ischemia significantly decreased this hyperactivity. In all ischemic-treated animals, behavioural suppression by MK-801 was observed already 1 day after occlusion and was lasting as far as observed ischemia-dependent hypermotor responses. Beneficial effect of MK-801 was also confirmed by morphological and neurological status data. These findings suggest that sustained ischemia-induced hyperactivity is related to abnormalities in NMDA glutamatergic function, as well as its manifestation could be completely abolished by NMDA receptor blockade immediately after ischemic insult.
PB  - Elsevier Science BV
T2  - Behavioural Brain Research
T1  - Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia
IS  - 1
VL  - 194
DO  - 10.1016/j.bbr.2008.06.031
SP  - 72
EP  - 78
ER  - 

@article{
author = "Petković, Branka and Selaković, Vesna and Radenović, Lidija",
year = "2008",
abstract = "The purpose of this study was to investigate the temporal pattern of NMDA receptors antagonist-MK-801 on motor behaviour parameters in gerbils submitted to different duration of global cerebral ischemia. The common carotid arteries of gerbils were occluded for 5, 10 or 15 min. Gerbils were given MK-801 (3 mg/kg i.p.) or saline immediately after the occlusion in normothermic conditions prior to testing. Motor activity was registered 1, 2, 4, 7,14,21 and 28 days after reperfusion during 60 min by open field test. At the same time, the effect of NMDA receptor blockade was followed in vivo by monitoring the neurological status of whole animals or at the cellular level by standard light and confocal microscopy on brain slices. Postischemic gerbils quickly developed hypermotor response with the most intensity in animals submitted to 15 min ischemia. MK-801 administrated immediately after ischemia significantly decreased this hyperactivity. In all ischemic-treated animals, behavioural suppression by MK-801 was observed already 1 day after occlusion and was lasting as far as observed ischemia-dependent hypermotor responses. Beneficial effect of MK-801 was also confirmed by morphological and neurological status data. These findings suggest that sustained ischemia-induced hyperactivity is related to abnormalities in NMDA glutamatergic function, as well as its manifestation could be completely abolished by NMDA receptor blockade immediately after ischemic insult.",
publisher = "Elsevier Science BV",
journal = "Behavioural Brain Research",
title = "Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia",
number = "1",
volume = "194",
doi = "10.1016/j.bbr.2008.06.031",
pages = "72-78"
}

Petković, B., Selaković, V.,& Radenović, L.. (2008). Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia. in Behavioural Brain Research
Elsevier Science BV., 194(1), 72-78.
https://doi.org/10.1016/j.bbr.2008.06.031

Petković B, Selaković V, Radenović L. Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia. in Behavioural Brain Research. 2008;194(1):72-78.
doi:10.1016/j.bbr.2008.06.031 .

Petković, Branka, Selaković, Vesna, Radenović, Lidija, "Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia" in Behavioural Brain Research, 194, no. 1 (2008):72-78,
https://doi.org/10.1016/j.bbr.2008.06.031 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Radenović, Lidija
AU  - Selaković, Vesna
AU  - Prolić, Zlatko
PY  - 2006
UR  - https://www.sciencedirect.com/science/article/pii/S0166432806005158?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3803
AB  - In addition to morphological changes, global cerebral ischemia leads to functional changes that can be assessed by behavioral examination. The purpose of this study was to investigate the impact of the duration of global cerebral ischemia on the time course of a comprehensive set of motor behaviors in Mongolian gerbils. The common carotid arteries of gerbils were occluded either for 5 min, 10 min, or 15 min. Gerbil motor behavior was recorded in the open field at 24 h, 48 h, 4 days, 7 days, 14 days, 21 days, and 28 days after reperfusion. Each session lasted for 60 min and was composed of six intervals of 10 min. Our results revealed that ischemic gerbils quickly develop locomotor and stereotypic hyperactivity, with the expected decrease of resting time. The most evident effect was observed in gerbils submitted to a 15 min ischemia, whose locomotor activity returned to nearly normal values after 7 days. In contrast, the duration of global cerebral ischemia had no effects on rearing, clockwise, or counter-clockwise rotation. These findings indicate that exposure to global cerebral ischernia induces changes in locomotion, stereotypy, and resting time. The magnitude and duration of these effects depend on the duration of ischernia.
PB  - Elsevier Science BV
T2  - Behavioural Brain Research
T1  - Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia
IS  - 2
VL  - 175
DO  - 10.1016/j.bbr.2006.09.008
SP  - 362
EP  - 373
ER  - 

@article{
author = "Petković, Branka and Radenović, Lidija and Selaković, Vesna and Prolić, Zlatko",
year = "2006",
abstract = "In addition to morphological changes, global cerebral ischemia leads to functional changes that can be assessed by behavioral examination. The purpose of this study was to investigate the impact of the duration of global cerebral ischemia on the time course of a comprehensive set of motor behaviors in Mongolian gerbils. The common carotid arteries of gerbils were occluded either for 5 min, 10 min, or 15 min. Gerbil motor behavior was recorded in the open field at 24 h, 48 h, 4 days, 7 days, 14 days, 21 days, and 28 days after reperfusion. Each session lasted for 60 min and was composed of six intervals of 10 min. Our results revealed that ischemic gerbils quickly develop locomotor and stereotypic hyperactivity, with the expected decrease of resting time. The most evident effect was observed in gerbils submitted to a 15 min ischemia, whose locomotor activity returned to nearly normal values after 7 days. In contrast, the duration of global cerebral ischemia had no effects on rearing, clockwise, or counter-clockwise rotation. These findings indicate that exposure to global cerebral ischernia induces changes in locomotion, stereotypy, and resting time. The magnitude and duration of these effects depend on the duration of ischernia.",
publisher = "Elsevier Science BV",
journal = "Behavioural Brain Research",
title = "Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia",
number = "2",
volume = "175",
doi = "10.1016/j.bbr.2006.09.008",
pages = "362-373"
}

Petković, B., Radenović, L., Selaković, V.,& Prolić, Z.. (2006). Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia. in Behavioural Brain Research
Elsevier Science BV., 175(2), 362-373.
https://doi.org/10.1016/j.bbr.2006.09.008

Petković B, Radenović L, Selaković V, Prolić Z. Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia. in Behavioural Brain Research. 2006;175(2):362-373.
doi:10.1016/j.bbr.2006.09.008 .

Petković, Branka, Radenović, Lidija, Selaković, Vesna, Prolić, Zlatko, "Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia" in Behavioural Brain Research, 175, no. 2 (2006):362-373,
https://doi.org/10.1016/j.bbr.2006.09.008 . .