TY  - JOUR
AU  - Petković, Branka
AU  - Tovilović-Kovačević, Gordana
AU  - Tomić, Mirko
AU  - Prolić, Zlatko M.
AU  - Radenović, Lidija Lj
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1472
UR  - http://www.gpb.sav.sk/2009-Special-Issue.htm
AB  - External magnetic fields (MFs) have the ability to modify motor activity of animals, complex type of behaviour connected with dopaminergic and serotonergic neurotransmissions in the brain. Thus, the purpose of this study was to examine MF-induced changes in the activity of serotonin 5-HT(2A) receptors in the prefrontal cortex, as well as dopamine D(1) and D(2) receptors in the striatum of adult Wistar rats, considering their involvement in motor behavior regulation. Experimental animals were continuously exposed to extremely low frequency MF (ELF-MF, 50 Hz, 0.5 mT) for 1, 3, and 7 days. Subsequently, binding properties (K(d) and B(max)) of receptors were determined by in vitro radioligand receptor binding assays. It was shown that the affinity of serotonin 5-HT(2A) receptors decreased and their density increased in the prefrontal cortex of rats after ELF-MF exposure. Regarding affinity, this effect was duration-dependent and most prominent after 7-day of ELF-MF exposure. In contrast to serotonin 5-HT(2A) receptors in the prefrontal cortex, ELF-MF had no significant effect on the affinity and density of dopamine D(1) and D(2) receptors in the striatum. We can conclude that continuous exposure to ELF-MF up to 7 days affects cortical serotonergic neurotransmission, whereby intensity of these changes depends on ELF-MF exposure duration.
PB  - Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
T2  - General Physiology and Biophysics
T1  - Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain
IS  - Special Issue
VL  - 28
SP  - 41
EP  - 46
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1472
ER  - 

@article{
author = "Petković, Branka and Tovilović-Kovačević, Gordana and Tomić, Mirko and Prolić, Zlatko M. and Radenović, Lidija Lj",
year = "2009",
abstract = "External magnetic fields (MFs) have the ability to modify motor activity of animals, complex type of behaviour connected with dopaminergic and serotonergic neurotransmissions in the brain. Thus, the purpose of this study was to examine MF-induced changes in the activity of serotonin 5-HT(2A) receptors in the prefrontal cortex, as well as dopamine D(1) and D(2) receptors in the striatum of adult Wistar rats, considering their involvement in motor behavior regulation. Experimental animals were continuously exposed to extremely low frequency MF (ELF-MF, 50 Hz, 0.5 mT) for 1, 3, and 7 days. Subsequently, binding properties (K(d) and B(max)) of receptors were determined by in vitro radioligand receptor binding assays. It was shown that the affinity of serotonin 5-HT(2A) receptors decreased and their density increased in the prefrontal cortex of rats after ELF-MF exposure. Regarding affinity, this effect was duration-dependent and most prominent after 7-day of ELF-MF exposure. In contrast to serotonin 5-HT(2A) receptors in the prefrontal cortex, ELF-MF had no significant effect on the affinity and density of dopamine D(1) and D(2) receptors in the striatum. We can conclude that continuous exposure to ELF-MF up to 7 days affects cortical serotonergic neurotransmission, whereby intensity of these changes depends on ELF-MF exposure duration.",
publisher = "Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences",
journal = "General Physiology and Biophysics",
title = "Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain",
number = "Special Issue",
volume = "28",
pages = "41-46",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1472"
}

Petković, B., Tovilović-Kovačević, G., Tomić, M., Prolić, Z. M.,& Radenović, L. L.. (2009). Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain. in General Physiology and Biophysics
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences., 28(Special Issue), 41-46.
https://hdl.handle.net/21.15107/rcub_ibiss_1472

Petković B, Tovilović-Kovačević G, Tomić M, Prolić ZM, Radenović LL. Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain. in General Physiology and Biophysics. 2009;28(Special Issue):41-46.
https://hdl.handle.net/21.15107/rcub_ibiss_1472 .

Petković, Branka, Tovilović-Kovačević, Gordana, Tomić, Mirko, Prolić, Zlatko M., Radenović, Lidija Lj, "Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain" in General Physiology and Biophysics, 28, no. Special Issue (2009):41-46,
https://hdl.handle.net/21.15107/rcub_ibiss_1472 .