TY  - JOUR
AU  - Milošević, Milena
AU  - Milićević, Katarina
AU  - Božić, Iva
AU  - Lavrnja, Irena
AU  - Stevanović, Ivana
AU  - Bijelić, Dunja
AU  - Dubaić, Marija
AU  - Živković, Irena
AU  - Stević, Zorica
AU  - Giniatullin, Rashid
AU  - Andjus, Pavle
PY  - 2017
UR  - http://journal.frontiersin.org/article/10.3389/fimmu.2017.01619/full
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2928
AB  - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with a very fast progression, no diagnostic tool for the presymptomatic phase, and still no effective treatment of the disease. Although ALS affects motor neurons, the overall pathophysiological condition points out to the non-cell autonomous mechanisms, where astrocytes and microglia play crucial roles in the disease progression. We have already shown that IgG from sera of ALS patients (ALS IgG) induce calcium transients and an increase in the mobility of acidic vesicles in cultured rat astrocytes. Having in mind the role of microglia in neurodegeneration, and a well-documented fact that oxidative stress is one of the many components contributing to the disease, we decided to examine the effect of ALS IgG on activation, oxidative stress and antioxidative system of BV-2 microglia, and to evaluate their acute effect on cytosolic peroxide, pH, and on reactive oxygen species (ROS) generation. All tested ALS IgGs (compared to control IgG) induced oxidative stress (rise in nitric oxide and the index of lipid peroxidation) followed by release of TNF-α and higher antioxidative defense (elevation of Mn- and CuZn-superoxide dismutase, catalase, and glutathione reductase with a decrease of glutathione peroxidase and glutathione) after 24 h treatment. Both ALS IgG and control IgG showed same localization on the membrane of BV-2 cells following 24 h treatment. Cytosolic peroxide and pH alteration were evaluated with fluorescent probes HyPer and SypHer, respectively, having in mind that HyPer also reacts to pH changes. Out of 11 tested IgGs from ALS patients, 4 induced slow exponential rise of HyPer signal, with maximal normalized fluorescence in the range 0.2–0.5, also inducing similar increase of SypHer intensity, but of a lower amplitude. None of the control IgGs induced changes with neither of the indicators. Acute ROS generation was detected in one out of three tested ALS samples with carboxy-H2DCFDA. The observed phenomena demonstrate the potential role of inflammatory humoral factors, IgGs, as potential triggers of the activation in microglia, known to occur in later stages of ALS. Therefore, revealing the ALS IgG signaling cascade in microglial cells could offer a valuable molecular biomarker and/or a potential therapeutic target.
T2  - Frontiers in Immunology
T1  - Immunoglobulins G from Sera of Amyotrophic Lateral Sclerosis Patients Induce Oxidative Stress and Upregulation of Antioxidative System in BV-2 Microglial Cell Line
IS  - NOV
VL  - 8
DO  - 10.3389/fimmu.2017.01619
SP  - 1619
ER  - 

@article{
author = "Milošević, Milena and Milićević, Katarina and Božić, Iva and Lavrnja, Irena and Stevanović, Ivana and Bijelić, Dunja and Dubaić, Marija and Živković, Irena and Stević, Zorica and Giniatullin, Rashid and Andjus, Pavle",
year = "2017",
abstract = "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with a very fast progression, no diagnostic tool for the presymptomatic phase, and still no effective treatment of the disease. Although ALS affects motor neurons, the overall pathophysiological condition points out to the non-cell autonomous mechanisms, where astrocytes and microglia play crucial roles in the disease progression. We have already shown that IgG from sera of ALS patients (ALS IgG) induce calcium transients and an increase in the mobility of acidic vesicles in cultured rat astrocytes. Having in mind the role of microglia in neurodegeneration, and a well-documented fact that oxidative stress is one of the many components contributing to the disease, we decided to examine the effect of ALS IgG on activation, oxidative stress and antioxidative system of BV-2 microglia, and to evaluate their acute effect on cytosolic peroxide, pH, and on reactive oxygen species (ROS) generation. All tested ALS IgGs (compared to control IgG) induced oxidative stress (rise in nitric oxide and the index of lipid peroxidation) followed by release of TNF-α and higher antioxidative defense (elevation of Mn- and CuZn-superoxide dismutase, catalase, and glutathione reductase with a decrease of glutathione peroxidase and glutathione) after 24 h treatment. Both ALS IgG and control IgG showed same localization on the membrane of BV-2 cells following 24 h treatment. Cytosolic peroxide and pH alteration were evaluated with fluorescent probes HyPer and SypHer, respectively, having in mind that HyPer also reacts to pH changes. Out of 11 tested IgGs from ALS patients, 4 induced slow exponential rise of HyPer signal, with maximal normalized fluorescence in the range 0.2–0.5, also inducing similar increase of SypHer intensity, but of a lower amplitude. None of the control IgGs induced changes with neither of the indicators. Acute ROS generation was detected in one out of three tested ALS samples with carboxy-H2DCFDA. The observed phenomena demonstrate the potential role of inflammatory humoral factors, IgGs, as potential triggers of the activation in microglia, known to occur in later stages of ALS. Therefore, revealing the ALS IgG signaling cascade in microglial cells could offer a valuable molecular biomarker and/or a potential therapeutic target.",
journal = "Frontiers in Immunology",
title = "Immunoglobulins G from Sera of Amyotrophic Lateral Sclerosis Patients Induce Oxidative Stress and Upregulation of Antioxidative System in BV-2 Microglial Cell Line",
number = "NOV",
volume = "8",
doi = "10.3389/fimmu.2017.01619",
pages = "1619"
}

Milošević, M., Milićević, K., Božić, I., Lavrnja, I., Stevanović, I., Bijelić, D., Dubaić, M., Živković, I., Stević, Z., Giniatullin, R.,& Andjus, P.. (2017). Immunoglobulins G from Sera of Amyotrophic Lateral Sclerosis Patients Induce Oxidative Stress and Upregulation of Antioxidative System in BV-2 Microglial Cell Line. in Frontiers in Immunology, 8(NOV), 1619.
https://doi.org/10.3389/fimmu.2017.01619

Milošević M, Milićević K, Božić I, Lavrnja I, Stevanović I, Bijelić D, Dubaić M, Živković I, Stević Z, Giniatullin R, Andjus P. Immunoglobulins G from Sera of Amyotrophic Lateral Sclerosis Patients Induce Oxidative Stress and Upregulation of Antioxidative System in BV-2 Microglial Cell Line. in Frontiers in Immunology. 2017;8(NOV):1619.
doi:10.3389/fimmu.2017.01619 .

Milošević, Milena, Milićević, Katarina, Božić, Iva, Lavrnja, Irena, Stevanović, Ivana, Bijelić, Dunja, Dubaić, Marija, Živković, Irena, Stević, Zorica, Giniatullin, Rashid, Andjus, Pavle, "Immunoglobulins G from Sera of Amyotrophic Lateral Sclerosis Patients Induce Oxidative Stress and Upregulation of Antioxidative System in BV-2 Microglial Cell Line" in Frontiers in Immunology, 8, no. NOV (2017):1619,
https://doi.org/10.3389/fimmu.2017.01619 . .

TY  - JOUR
AU  - Momčilović, Miljana
AU  - Stamenković, Vera
AU  - Jovanović, Miloš
AU  - Anđus, Pavle R.
AU  - Jakovčevski, Igor
AU  - Schachner, Melitta
AU  - Miljković, Đorđe
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0165572816302077
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2497
AB  - The extracellular matrix glycoprotein tenascin-C (TnC) has been increasingly appreciated as a molecule susceptibly reacting to abnormalities in the mammalian immune system. TnC expression is elevated in inflamed tissues outside the immune system, but also in lymphoid organs. It participates in the promotion of inflammatory responses. Here, the role of TnC in a paradigm of CNS autoimmunity was investigated. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, was induced in mice deficient in TnC (TnC−/− mice). Amelioration of EAE was observed in these mice in comparison to their wild-type (TnC+/+) littermates. Since T helper (Th)1 and Th17 cells play a dominant role in the pathogenesis of EAE, these cells were investigated in addition to analyzing locomotor functions and pro-inflammatory cytokine levels. Smaller numbers of interferon-gamma-producing Th1 cells and reduced ability of Th17 cells to produce interleukin-17 were observed in spleens of TnC−/− mice challenged by immunization with the myelin associated glycoprotein (MOG) when compared to TnC+/+ mice. There was no difference in Th1 and Th17 responses in non-immunized TnC−/− and TnC+/+ mice, thus excluding generalized immunosuppression in TnC−/− mice. These results show that TnC is important for the pathogenesis of CNS autoimmunity and that its deficiency interferes with Th1 and Th17 encephalitogenic potentials.
T2  - Journal of Neuroimmunology
T1  - Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis
VL  - 302
DO  - 10.1016/j.jneuroim.2016.12.001
SP  - 1
EP  - 6
ER  - 

@article{
author = "Momčilović, Miljana and Stamenković, Vera and Jovanović, Miloš and Anđus, Pavle R. and Jakovčevski, Igor and Schachner, Melitta and Miljković, Đorđe",
year = "2017",
abstract = "The extracellular matrix glycoprotein tenascin-C (TnC) has been increasingly appreciated as a molecule susceptibly reacting to abnormalities in the mammalian immune system. TnC expression is elevated in inflamed tissues outside the immune system, but also in lymphoid organs. It participates in the promotion of inflammatory responses. Here, the role of TnC in a paradigm of CNS autoimmunity was investigated. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, was induced in mice deficient in TnC (TnC−/− mice). Amelioration of EAE was observed in these mice in comparison to their wild-type (TnC+/+) littermates. Since T helper (Th)1 and Th17 cells play a dominant role in the pathogenesis of EAE, these cells were investigated in addition to analyzing locomotor functions and pro-inflammatory cytokine levels. Smaller numbers of interferon-gamma-producing Th1 cells and reduced ability of Th17 cells to produce interleukin-17 were observed in spleens of TnC−/− mice challenged by immunization with the myelin associated glycoprotein (MOG) when compared to TnC+/+ mice. There was no difference in Th1 and Th17 responses in non-immunized TnC−/− and TnC+/+ mice, thus excluding generalized immunosuppression in TnC−/− mice. These results show that TnC is important for the pathogenesis of CNS autoimmunity and that its deficiency interferes with Th1 and Th17 encephalitogenic potentials.",
journal = "Journal of Neuroimmunology",
title = "Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis",
volume = "302",
doi = "10.1016/j.jneuroim.2016.12.001",
pages = "1-6"
}

Momčilović, M., Stamenković, V., Jovanović, M., Anđus, P. R., Jakovčevski, I., Schachner, M.,& Miljković, Đ.. (2017). Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis. in Journal of Neuroimmunology, 302, 1-6.
https://doi.org/10.1016/j.jneuroim.2016.12.001

Momčilović M, Stamenković V, Jovanović M, Anđus PR, Jakovčevski I, Schachner M, Miljković Đ. Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis. in Journal of Neuroimmunology. 2017;302:1-6.
doi:10.1016/j.jneuroim.2016.12.001 .

Momčilović, Miljana, Stamenković, Vera, Jovanović, Miloš, Anđus, Pavle R., Jakovčevski, Igor, Schachner, Melitta, Miljković, Đorđe, "Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis" in Journal of Neuroimmunology, 302 (2017):1-6,
https://doi.org/10.1016/j.jneuroim.2016.12.001 . .

TY  - CONF
AU  - Novaković, Lazar
AU  - Živković, Suzana
AU  - Popović-Bijelić, Ana
AU  - Mišić, Danijela
AU  - Mojović, Miloš
PY  - 2015
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6189
AB  - Electron paramagnetic resonance spectroscopy (EPR) was applied for in vivo detection of oxidative stress induced by high ionic strengths in Centaurium erythraea Rafn (Gentianaceae), a herbaceous perennial often found on saline soils. Shoots of C. erythraea were cultured in vitro for 4 weeks on solid 1/2 MS medium, or 1/2 MS medium supplemented with 200 mM NaCl to induce salt stress and thus stimulate the production of reactive oxygen species (ROS), which is a common response of plant cells subjected to various types of biotic or abiotic stresses. The reduction of a stable cell-permeable aminoxyl radical spin probe, Tempo, was measured to assess the oxidative status of the control and salt-treated samples. In both types of samples, the reduction of Tempo showed zero-order kinetics. After one hour, the control reduced only 9% of the initial amount of the spin probe, whereas the sample grown with 200 mM NaCl reduced it by 20%. This may indicate that the plants grown in the presence of 200 mM NaCl produced higher amounts of ROS which are able to reduce the aminoxyl radical. The obtained results indicate that EPR can be used as a method for in vivo evaluation of the redox state of plants under stress conditions, and could also be useful in determining the salt-stress tolerance of plants. Further
studies, including different salt concentrations, and plant species, have to be conducted to verify these findings.
PB  - Belgrade: Serbian Plant Physiology Society
C3  - Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia
T1  - Application of Tempo EPR spin probe for in vivo detection of salt-induced oxidative stress in Centaurium erythraea Rafn
SP  - 178
EP  - 179
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6189
ER  - 

@conference{
author = "Novaković, Lazar and Živković, Suzana and Popović-Bijelić, Ana and Mišić, Danijela and Mojović, Miloš",
year = "2015",
abstract = "Electron paramagnetic resonance spectroscopy (EPR) was applied for in vivo detection of oxidative stress induced by high ionic strengths in Centaurium erythraea Rafn (Gentianaceae), a herbaceous perennial often found on saline soils. Shoots of C. erythraea were cultured in vitro for 4 weeks on solid 1/2 MS medium, or 1/2 MS medium supplemented with 200 mM NaCl to induce salt stress and thus stimulate the production of reactive oxygen species (ROS), which is a common response of plant cells subjected to various types of biotic or abiotic stresses. The reduction of a stable cell-permeable aminoxyl radical spin probe, Tempo, was measured to assess the oxidative status of the control and salt-treated samples. In both types of samples, the reduction of Tempo showed zero-order kinetics. After one hour, the control reduced only 9% of the initial amount of the spin probe, whereas the sample grown with 200 mM NaCl reduced it by 20%. This may indicate that the plants grown in the presence of 200 mM NaCl produced higher amounts of ROS which are able to reduce the aminoxyl radical. The obtained results indicate that EPR can be used as a method for in vivo evaluation of the redox state of plants under stress conditions, and could also be useful in determining the salt-stress tolerance of plants. Further
studies, including different salt concentrations, and plant species, have to be conducted to verify these findings.",
publisher = "Belgrade: Serbian Plant Physiology Society",
journal = "Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia",
title = "Application of Tempo EPR spin probe for in vivo detection of salt-induced oxidative stress in Centaurium erythraea Rafn",
pages = "178-179",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6189"
}

Novaković, L., Živković, S., Popović-Bijelić, A., Mišić, D.,& Mojović, M.. (2015). Application of Tempo EPR spin probe for in vivo detection of salt-induced oxidative stress in Centaurium erythraea Rafn. in Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia
Belgrade: Serbian Plant Physiology Society., 178-179.
https://hdl.handle.net/21.15107/rcub_ibiss_6189

Novaković L, Živković S, Popović-Bijelić A, Mišić D, Mojović M. Application of Tempo EPR spin probe for in vivo detection of salt-induced oxidative stress in Centaurium erythraea Rafn. in Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia. 2015;:178-179.
https://hdl.handle.net/21.15107/rcub_ibiss_6189 .

Novaković, Lazar, Živković, Suzana, Popović-Bijelić, Ana, Mišić, Danijela, Mojović, Miloš, "Application of Tempo EPR spin probe for in vivo detection of salt-induced oxidative stress in Centaurium erythraea Rafn" in Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia (2015):178-179,
https://hdl.handle.net/21.15107/rcub_ibiss_6189 .

TY  - CONF
AU  - Mandić-Kovačević, Nebojša
AU  - Živković, Suzana
AU  - Rakić, Tamara
AU  - Popović-Bijelić, Ana
PY  - 2014
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6393
AB  - The resurrection plant Ramonda serbica was completely dehydrated for 14 days, reaching 4.2 % of the relative water content, and then fully rehydrated for 24 h. During dehydration, the total phenolic and flavonoid contents of leaf extracts significantly increased, and then gradually decreased upon rehydration. These changes directly correspond to the observed antioxidant activity of extracts towards
the hydrophobic free radical DPPH. The scavenging potential towards the hydrophilic radical Tempone was maximal after 3 h of rehydration, indicating a strong oxidative burst upon water uptake.
PB  - Belgrade: Society of Physical Chemists of Serbia
C3  - Proceedings: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2014. Vol. 1; 2014 Sep 22-26; Belgrade, Serbia
T1  - Antioxidant potential of the resurrection plant Ramonda serbica
SP  - 506
EP  - 509
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6393
ER  - 

@conference{
author = "Mandić-Kovačević, Nebojša and Živković, Suzana and Rakić, Tamara and Popović-Bijelić, Ana",
year = "2014",
abstract = "The resurrection plant Ramonda serbica was completely dehydrated for 14 days, reaching 4.2 % of the relative water content, and then fully rehydrated for 24 h. During dehydration, the total phenolic and flavonoid contents of leaf extracts significantly increased, and then gradually decreased upon rehydration. These changes directly correspond to the observed antioxidant activity of extracts towards
the hydrophobic free radical DPPH. The scavenging potential towards the hydrophilic radical Tempone was maximal after 3 h of rehydration, indicating a strong oxidative burst upon water uptake.",
publisher = "Belgrade: Society of Physical Chemists of Serbia",
journal = "Proceedings: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2014. Vol. 1; 2014 Sep 22-26; Belgrade, Serbia",
title = "Antioxidant potential of the resurrection plant Ramonda serbica",
pages = "506-509",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6393"
}

Mandić-Kovačević, N., Živković, S., Rakić, T.,& Popović-Bijelić, A.. (2014). Antioxidant potential of the resurrection plant Ramonda serbica. in Proceedings: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2014. Vol. 1; 2014 Sep 22-26; Belgrade, Serbia
Belgrade: Society of Physical Chemists of Serbia., 506-509.
https://hdl.handle.net/21.15107/rcub_ibiss_6393

Mandić-Kovačević N, Živković S, Rakić T, Popović-Bijelić A. Antioxidant potential of the resurrection plant Ramonda serbica. in Proceedings: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2014. Vol. 1; 2014 Sep 22-26; Belgrade, Serbia. 2014;:506-509.
https://hdl.handle.net/21.15107/rcub_ibiss_6393 .

Mandić-Kovačević, Nebojša, Živković, Suzana, Rakić, Tamara, Popović-Bijelić, Ana, "Antioxidant potential of the resurrection plant Ramonda serbica" in Proceedings: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2014. Vol. 1; 2014 Sep 22-26; Belgrade, Serbia (2014):506-509,
https://hdl.handle.net/21.15107/rcub_ibiss_6393 .

TY  - JOUR
AU  - Radenović, Lidija
AU  - Selaković, Vesna
AU  - Olivan, Sara
AU  - Calvo, Ana Cristina
AU  - Rando, Amaya
AU  - Petković, Branka
AU  - Osta, Rosario
PY  - 2014
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0361923013001871
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3787
AB  - The tetanus toxin C (TTC) fragment capacity of being transported in a retrograde way through motoneurons and its nontoxic nature opens the door to a new promising therapeutic strategy for neurodegenerative diseases. In this study, the TTC effect was tested for the first time in animal model of global cerebral ischemia induced by 10-min occlusion of both common carotid arteries. The aim was to evaluate the effect of TTC gene therapy treatment on the development and expression of global cerebral ischemia/reperfusion-induced oxidative stress and motor hyperactivity in Mongolian gerbils. Several oxidative stress and motor behavioral parameters were investigated between 2 h and 14 days after reperfusion. Neuroprotective efficiency of TTC was observed in the forebrain cortex, striatum, hippocampus, and cerebellum at the level of each examined oxidative stress parameter (nitric oxide level, superoxide production, superoxide dismutase activity, and index of lipid peroxidation). Additionally, TTC significantly decreased ischemia-induced motor hyperactivity based on tested parameters (locomotion, stereotypy, and rotations). As judged by biochemical as well as behavioral data, treatment with TTC for the first time showed neuroprotective efficiency by reduction of ischemia-induced oxidative stress and motor hyperactivity and can be a promising strategy for ischemia-induced neuronal damage treatment.
PB  - Pergamon-Elsevier Science Ltd
T2  - Brain Research Bulletin
T1  - Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils
VL  - 101
DO  - 10.1016/j.brainresbull.2013.11.006
SP  - 37
EP  - 44
ER  - 

@article{
author = "Radenović, Lidija and Selaković, Vesna and Olivan, Sara and Calvo, Ana Cristina and Rando, Amaya and Petković, Branka and Osta, Rosario",
year = "2014",
abstract = "The tetanus toxin C (TTC) fragment capacity of being transported in a retrograde way through motoneurons and its nontoxic nature opens the door to a new promising therapeutic strategy for neurodegenerative diseases. In this study, the TTC effect was tested for the first time in animal model of global cerebral ischemia induced by 10-min occlusion of both common carotid arteries. The aim was to evaluate the effect of TTC gene therapy treatment on the development and expression of global cerebral ischemia/reperfusion-induced oxidative stress and motor hyperactivity in Mongolian gerbils. Several oxidative stress and motor behavioral parameters were investigated between 2 h and 14 days after reperfusion. Neuroprotective efficiency of TTC was observed in the forebrain cortex, striatum, hippocampus, and cerebellum at the level of each examined oxidative stress parameter (nitric oxide level, superoxide production, superoxide dismutase activity, and index of lipid peroxidation). Additionally, TTC significantly decreased ischemia-induced motor hyperactivity based on tested parameters (locomotion, stereotypy, and rotations). As judged by biochemical as well as behavioral data, treatment with TTC for the first time showed neuroprotective efficiency by reduction of ischemia-induced oxidative stress and motor hyperactivity and can be a promising strategy for ischemia-induced neuronal damage treatment.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Brain Research Bulletin",
title = "Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils",
volume = "101",
doi = "10.1016/j.brainresbull.2013.11.006",
pages = "37-44"
}

Radenović, L., Selaković, V., Olivan, S., Calvo, A. C., Rando, A., Petković, B.,& Osta, R.. (2014). Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils. in Brain Research Bulletin
Pergamon-Elsevier Science Ltd., 101, 37-44.
https://doi.org/10.1016/j.brainresbull.2013.11.006

Radenović L, Selaković V, Olivan S, Calvo AC, Rando A, Petković B, Osta R. Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils. in Brain Research Bulletin. 2014;101:37-44.
doi:10.1016/j.brainresbull.2013.11.006 .

Radenović, Lidija, Selaković, Vesna, Olivan, Sara, Calvo, Ana Cristina, Rando, Amaya, Petković, Branka, Osta, Rosario, "Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils" in Brain Research Bulletin, 101 (2014):37-44,
https://doi.org/10.1016/j.brainresbull.2013.11.006 . .