TY  - JOUR
AU  - Nenadić, Marija
AU  - Soković, Marina
AU  - Calhelha, Ricardo C.
AU  - Ferreira, Isabel C. F. R.
AU  - Ćirić, Ana
AU  - Vesović, Nikola
AU  - Ćurčić, Srećko
PY  - 2018
UR  - http://link.springer.com/10.2478/s11756-018-0082-x
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3092
AB  - Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study. The sulphorhodamine B (SRB) assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasis is put on the secretion of Abax parallelepipedus, which showed the highest antitumour potential and weakest inhibition of non-tumour cell proliferation. The antitumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time. It is suggested that certain organic acids are responsible for the action. Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity.
T2  - Biologia
T1  - Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)
DO  - 10.2478/s11756-018-0082-x
ER  - 

@article{
author = "Nenadić, Marija and Soković, Marina and Calhelha, Ricardo C. and Ferreira, Isabel C. F. R. and Ćirić, Ana and Vesović, Nikola and Ćurčić, Srećko",
year = "2018",
abstract = "Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study. The sulphorhodamine B (SRB) assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasis is put on the secretion of Abax parallelepipedus, which showed the highest antitumour potential and weakest inhibition of non-tumour cell proliferation. The antitumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time. It is suggested that certain organic acids are responsible for the action. Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity.",
journal = "Biologia",
title = "Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)",
doi = "10.2478/s11756-018-0082-x"
}

Nenadić, M., Soković, M., Calhelha, R. C., Ferreira, I. C. F. R., Ćirić, A., Vesović, N.,& Ćurčić, S.. (2018). Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae). in Biologia.
https://doi.org/10.2478/s11756-018-0082-x

Nenadić M, Soković M, Calhelha RC, Ferreira ICFR, Ćirić A, Vesović N, Ćurčić S. Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae). in Biologia. 2018;.
doi:10.2478/s11756-018-0082-x .

Nenadić, Marija, Soković, Marina, Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Ćirić, Ana, Vesović, Nikola, Ćurčić, Srećko, "Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)" in Biologia (2018),
https://doi.org/10.2478/s11756-018-0082-x . .