TY  - JOUR
AU  - Pergal, Marija V.
AU  - Brkljačić, Jelena
AU  - Tovilović-Kovačević, Gordana
AU  - Jovančić, Petar
AU  - Pezo, Lato
AU  - Vasiljević-Radović, Dana
AU  - Djonlagić, Jasna
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2125
AB  - Segmented polyurethanes based on poly(dimethylsiloxane), currently used
   for biomedical applications, have sub-optimal biocompatibility which
   reduces their efficacy. Improving the endothelial cell attachment and
   blood-contacting properties of PDMS-based copolymers would substantially
   improve their clinical applications. We have studied the surface
   properties and in vitro biocompatibility of two series of segmented
   poly(urethane-dimethylsiloxane)s (SPU-PDMS) based on hydroxypropyl-and
   hydroxyethoxypropyl-terminated PDMS with potential applications in
   blood-contacting medical devices. SPU-PDMS copolymers were characterized
   by contact angle measurements, surface free energy determination
   (calculated using the van Oss-Chaudhury-Good and Owens-Wendt methods),
   and atomic force microscopy. The biocompatibility of copolymers was
   evaluated using an endothelial EA.hy926 cell line by direct contact
   assay, before and after pre-treatment of copolymers with multicomponent
   protein mixture, as well as by a competitive blood-protein adsorption
   assay. The obtained results suggested good blood compatibility of
   synthesized copolymers. All copolymers exhibited good resistance to
   fibrinogen adsorption and all favored albumin adsorption. Copolymers
   based on hydroxyethoxypropyl-PDMS had lower hydrophobicity, higher
   surface free energy and better microphase separation in comparison with
   hydroxypropyl-PDMS-based copolymers, which promoted better endothelial
   cell attachment and growth on the surface of these polymers as compared
   to hydroxypropyl-PDMS-based copolymers. The results showed that SPU-PDMS
   copolymers display good surface properties, depending on the type of
   soft PDMS segments, which can be tailored for biomedical application
   requirements such as biomedical devices for short-and long-term uses.
T2  - Hemijska Industrija
T1  - Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes
IS  - 6
VL  - 68
DO  - 10.2298/HEMIND141103082P
SP  - 731
EP  - 741
ER  - 

@article{
author = "Pergal, Marija V. and Brkljačić, Jelena and Tovilović-Kovačević, Gordana and Jovančić, Petar and Pezo, Lato and Vasiljević-Radović, Dana and Djonlagić, Jasna",
year = "2014",
abstract = "Segmented polyurethanes based on poly(dimethylsiloxane), currently used
   for biomedical applications, have sub-optimal biocompatibility which
   reduces their efficacy. Improving the endothelial cell attachment and
   blood-contacting properties of PDMS-based copolymers would substantially
   improve their clinical applications. We have studied the surface
   properties and in vitro biocompatibility of two series of segmented
   poly(urethane-dimethylsiloxane)s (SPU-PDMS) based on hydroxypropyl-and
   hydroxyethoxypropyl-terminated PDMS with potential applications in
   blood-contacting medical devices. SPU-PDMS copolymers were characterized
   by contact angle measurements, surface free energy determination
   (calculated using the van Oss-Chaudhury-Good and Owens-Wendt methods),
   and atomic force microscopy. The biocompatibility of copolymers was
   evaluated using an endothelial EA.hy926 cell line by direct contact
   assay, before and after pre-treatment of copolymers with multicomponent
   protein mixture, as well as by a competitive blood-protein adsorption
   assay. The obtained results suggested good blood compatibility of
   synthesized copolymers. All copolymers exhibited good resistance to
   fibrinogen adsorption and all favored albumin adsorption. Copolymers
   based on hydroxyethoxypropyl-PDMS had lower hydrophobicity, higher
   surface free energy and better microphase separation in comparison with
   hydroxypropyl-PDMS-based copolymers, which promoted better endothelial
   cell attachment and growth on the surface of these polymers as compared
   to hydroxypropyl-PDMS-based copolymers. The results showed that SPU-PDMS
   copolymers display good surface properties, depending on the type of
   soft PDMS segments, which can be tailored for biomedical application
   requirements such as biomedical devices for short-and long-term uses.",
journal = "Hemijska Industrija",
title = "Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes",
number = "6",
volume = "68",
doi = "10.2298/HEMIND141103082P",
pages = "731-741"
}

Pergal, M. V., Brkljačić, J., Tovilović-Kovačević, G., Jovančić, P., Pezo, L., Vasiljević-Radović, D.,& Djonlagić, J.. (2014). Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes. in Hemijska Industrija, 68(6), 731-741.
https://doi.org/10.2298/HEMIND141103082P

Pergal MV, Brkljačić J, Tovilović-Kovačević G, Jovančić P, Pezo L, Vasiljević-Radović D, Djonlagić J. Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes. in Hemijska Industrija. 2014;68(6):731-741.
doi:10.2298/HEMIND141103082P .

Pergal, Marija V., Brkljačić, Jelena, Tovilović-Kovačević, Gordana, Jovančić, Petar, Pezo, Lato, Vasiljević-Radović, Dana, Djonlagić, Jasna, "Surface characterization, hemo-and cytocompatibility of segmented
 poly(dimethylsiloxane)-based polyurethanes" in Hemijska Industrija, 68, no. 6 (2014):731-741,
https://doi.org/10.2298/HEMIND141103082P . .