TY  - JOUR
AU  - Bensing, Christian
AU  - Mojić, Marija
AU  - Gómez-Ruiz, Santiago
AU  - Carralero, Sandra
AU  - Dojčinović, Biljana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2016
UR  - http://xlink.rsc.org/?DOI=C6DT03519A
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85000774313&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A11#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2481
AB  - SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.
T2  - Dalton Transactions
T1  - Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line
IS  - 47
VL  - 45
DO  - 10.1039/C6DT03519A
SP  - 18984
EP  - 18993
ER  - 

@article{
author = "Bensing, Christian and Mojić, Marija and Gómez-Ruiz, Santiago and Carralero, Sandra and Dojčinović, Biljana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2016",
abstract = "SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.",
journal = "Dalton Transactions",
title = "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line",
number = "47",
volume = "45",
doi = "10.1039/C6DT03519A",
pages = "18984-18993"
}

Bensing, C., Mojić, M., Gómez-Ruiz, S., Carralero, S., Dojčinović, B., Maksimović-Ivanić, D., Mijatović, S.,& Kaluđerović, G. N.. (2016). Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions, 45(47), 18984-18993.
https://doi.org/10.1039/C6DT03519A

Bensing C, Mojić M, Gómez-Ruiz S, Carralero S, Dojčinović B, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. in Dalton Transactions. 2016;45(47):18984-18993.
doi:10.1039/C6DT03519A .

Bensing, Christian, Mojić, Marija, Gómez-Ruiz, Santiago, Carralero, Sandra, Dojčinović, Biljana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line" in Dalton Transactions, 45, no. 47 (2016):18984-18993,
https://doi.org/10.1039/C6DT03519A . .