TY  - JOUR
AU  - Trifunović, Svetlana
AU  - Šošić-Jurjević, Branka 
AU  - Ristić, Nataša
AU  - Nestorović, Nataša
AU  - Filipović, Branko
AU  - Stevanović, Ivana
AU  - Begović-Kuprešanin, Vesna
AU  - Manojlović-Stojanoski, Milica
PY  - 2023
UR  - https://www.mdpi.com/1422-0067/24/1/540
UR  - http://www.ncbi.nlm.nih.gov/pubmed/36613982
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9820254
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5402
AB  - As the mediator between the mother and fetus, the placenta allows the most appropriate environment and optimal fetal growth. The placenta of one sex sometimes has a greater ability over the other to respond to and protect against possible maternal insults. Here, we characterized sex differences in the placenta's morphological features and antioxidant status following dexamethasone (Dx) exposure. Pregnant rats were exposed to Dx or saline. The placenta was histologically and stereologically analyzed. The activity of the antioxidant enzymes, lipid peroxides (TBARS), superoxide anion and nitric oxide (NO) was measured. The decrease in placental zone volumes was more pronounced (p < 0.05) in female placentas. The volume density of PCNA-immunopositive nuclei was reduced (p < 0.05) in both sexes. The reduced (p < 0.05) antioxidant enzyme activities, enhanced TBARS and NO concentration indicate that Dx exposure triggered oxidative stress in the placenta of both fetal sexes, albeit stronger in the placenta of female fetuses. In conclusion, maternal Dx treatment reduced the size and volume of placental zones, altered placental histomorphology, decreased cell proliferation and triggered oxidative stress; however, the placentas of female fetuses exerted more significant responses to the treatment effects. The reduced placental size most probably reduced the transport of nutrients and oxygen, thus resulting in the reduced weight of fetuses, similar in both sexes. The lesser ability of the male placenta to detect and react to maternal exposure to environmental challenges may lead to long-standing health effects.
PB  - Basel: MDPI
T2  - International Journal of Molecular Sciences
T1  - Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta
IS  - 1
VL  - 24
DO  - 10.3390/ijms24010540
SP  - 540
ER  - 

@article{
author = "Trifunović, Svetlana and Šošić-Jurjević, Branka  and Ristić, Nataša and Nestorović, Nataša and Filipović, Branko and Stevanović, Ivana and Begović-Kuprešanin, Vesna and Manojlović-Stojanoski, Milica",
year = "2023",
abstract = "As the mediator between the mother and fetus, the placenta allows the most appropriate environment and optimal fetal growth. The placenta of one sex sometimes has a greater ability over the other to respond to and protect against possible maternal insults. Here, we characterized sex differences in the placenta's morphological features and antioxidant status following dexamethasone (Dx) exposure. Pregnant rats were exposed to Dx or saline. The placenta was histologically and stereologically analyzed. The activity of the antioxidant enzymes, lipid peroxides (TBARS), superoxide anion and nitric oxide (NO) was measured. The decrease in placental zone volumes was more pronounced (p < 0.05) in female placentas. The volume density of PCNA-immunopositive nuclei was reduced (p < 0.05) in both sexes. The reduced (p < 0.05) antioxidant enzyme activities, enhanced TBARS and NO concentration indicate that Dx exposure triggered oxidative stress in the placenta of both fetal sexes, albeit stronger in the placenta of female fetuses. In conclusion, maternal Dx treatment reduced the size and volume of placental zones, altered placental histomorphology, decreased cell proliferation and triggered oxidative stress; however, the placentas of female fetuses exerted more significant responses to the treatment effects. The reduced placental size most probably reduced the transport of nutrients and oxygen, thus resulting in the reduced weight of fetuses, similar in both sexes. The lesser ability of the male placenta to detect and react to maternal exposure to environmental challenges may lead to long-standing health effects.",
publisher = "Basel: MDPI",
journal = "International Journal of Molecular Sciences",
title = "Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta",
number = "1",
volume = "24",
doi = "10.3390/ijms24010540",
pages = "540"
}

Trifunović, S., Šošić-Jurjević, B., Ristić, N., Nestorović, N., Filipović, B., Stevanović, I., Begović-Kuprešanin, V.,& Manojlović-Stojanoski, M.. (2023). Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta. in International Journal of Molecular Sciences
Basel: MDPI., 24(1), 540.
https://doi.org/10.3390/ijms24010540

Trifunović S, Šošić-Jurjević B, Ristić N, Nestorović N, Filipović B, Stevanović I, Begović-Kuprešanin V, Manojlović-Stojanoski M. Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta. in International Journal of Molecular Sciences. 2023;24(1):540.
doi:10.3390/ijms24010540 .

Trifunović, Svetlana, Šošić-Jurjević, Branka , Ristić, Nataša, Nestorović, Nataša, Filipović, Branko, Stevanović, Ivana, Begović-Kuprešanin, Vesna, Manojlović-Stojanoski, Milica, "Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta" in International Journal of Molecular Sciences, 24, no. 1 (2023):540,
https://doi.org/10.3390/ijms24010540 . .