TY  - JOUR
AU  - Zubenko, Alexander
AU  - Kartsev, Victor
AU  - Petrou, Anthi
AU  - Geronikaki, Athina
AU  - Ivanov, Marija
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Divaeva, Lyudmila
AU  - Morkovnik, Anatolii
AU  - Klimenko, Alexander
PY  - 2022
UR  - https://www.mdpi.com/2079-6382/11/11/1654
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9686863
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5399
AB  - In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed that these compounds showed moderate antibacterial activity. Compound 2j was found to be the most potent (MIC/MBC at 0.23-0.94 mg/mL and 0.47-1.88 mg/mL) On the other hand, compounds showed good antifungal activity (MIC/MFC at 0.06-0.47 and 0.11-0.94 mg/mL respectively) with 2d being the most active one. The docking studies revealed that inhibition of E. coli MurB and 14-lanosterol demethylase probably represent the mechanism of antibacterial and antifungal activities.
PB  - Basel: MDPI
T2  - Antibiotics
T1  - Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents
IS  - 11
VL  - 11
DO  - 10.3390/antibiotics11111654
SP  - 1654
ER  - 

@article{
author = "Zubenko, Alexander and Kartsev, Victor and Petrou, Anthi and Geronikaki, Athina and Ivanov, Marija and Glamočlija, Jasmina and Soković, Marina and Divaeva, Lyudmila and Morkovnik, Anatolii and Klimenko, Alexander",
year = "2022",
abstract = "In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed that these compounds showed moderate antibacterial activity. Compound 2j was found to be the most potent (MIC/MBC at 0.23-0.94 mg/mL and 0.47-1.88 mg/mL) On the other hand, compounds showed good antifungal activity (MIC/MFC at 0.06-0.47 and 0.11-0.94 mg/mL respectively) with 2d being the most active one. The docking studies revealed that inhibition of E. coli MurB and 14-lanosterol demethylase probably represent the mechanism of antibacterial and antifungal activities.",
publisher = "Basel: MDPI",
journal = "Antibiotics",
title = "Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents",
number = "11",
volume = "11",
doi = "10.3390/antibiotics11111654",
pages = "1654"
}

Zubenko, A., Kartsev, V., Petrou, A., Geronikaki, A., Ivanov, M., Glamočlija, J., Soković, M., Divaeva, L., Morkovnik, A.,& Klimenko, A.. (2022). Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents. in Antibiotics
Basel: MDPI., 11(11), 1654.
https://doi.org/10.3390/antibiotics11111654

Zubenko A, Kartsev V, Petrou A, Geronikaki A, Ivanov M, Glamočlija J, Soković M, Divaeva L, Morkovnik A, Klimenko A. Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents. in Antibiotics. 2022;11(11):1654.
doi:10.3390/antibiotics11111654 .

Zubenko, Alexander, Kartsev, Victor, Petrou, Anthi, Geronikaki, Athina, Ivanov, Marija, Glamočlija, Jasmina, Soković, Marina, Divaeva, Lyudmila, Morkovnik, Anatolii, Klimenko, Alexander, "Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents" in Antibiotics, 11, no. 11 (2022):1654,
https://doi.org/10.3390/antibiotics11111654 . .

TY  - JOUR
AU  - Kartsev, Victor
AU  - Geronikaki, Athina
AU  - Zubenko, Alexander
AU  - Petrou, Anthi
AU  - Ivanov, Marija
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Divaeva, Lyudmila
AU  - Morkovnik, Anatolii
AU  - Klimenko, Alexander
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9658463
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5173
AB  - Herein, we report the design, synthesis, and evaluation of the antimicrobial activity of new heteroaryl (aryl) thiazole derivatives. The design was based on a molecular hybridization approach. The in vitro evaluation revealed that these compounds demonstrated moderate antibacterial activity. The best activity was achieved for compound 3, with MIC and MBC in the range of 0.23-0.7 and 0.47-0.94 mg/mL, respectively. Three compounds (2, 3, and 4) were tested against three resistant strains, namely methicillin resistant Staphylococcus aureus, P. aeruginosa, and E. coli, which showed higher potential than the reference drug ampicillin. Antifungal activity of the compounds was better with MIC and MFC in the range of 0.06-0.47 and 0.11-0.94 mg/mL, respectively. The best activity was observed for compound 9, with MIC at 0.06-0.23 mg/mL and MFC at 0.11-0.47 mg/mL. According to docking studies, the predicted inhibition of the E. coli MurB enzyme is a putative mechanism of the antibacterial activity of the compounds, while inhibition of 14a-lanosterol demethylase is probably the mechanism of their antifungal activity.
PB  - Basel: MDPI
T2  - Antibiotics
T1  - Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies
IS  - 10
VL  - 11
DO  - 10.3390/antibiotics11101337
SP  - 1337
ER  - 

@article{
author = "Kartsev, Victor and Geronikaki, Athina and Zubenko, Alexander and Petrou, Anthi and Ivanov, Marija and Glamočlija, Jasmina and Soković, Marina and Divaeva, Lyudmila and Morkovnik, Anatolii and Klimenko, Alexander",
year = "2022",
abstract = "Herein, we report the design, synthesis, and evaluation of the antimicrobial activity of new heteroaryl (aryl) thiazole derivatives. The design was based on a molecular hybridization approach. The in vitro evaluation revealed that these compounds demonstrated moderate antibacterial activity. The best activity was achieved for compound 3, with MIC and MBC in the range of 0.23-0.7 and 0.47-0.94 mg/mL, respectively. Three compounds (2, 3, and 4) were tested against three resistant strains, namely methicillin resistant Staphylococcus aureus, P. aeruginosa, and E. coli, which showed higher potential than the reference drug ampicillin. Antifungal activity of the compounds was better with MIC and MFC in the range of 0.06-0.47 and 0.11-0.94 mg/mL, respectively. The best activity was observed for compound 9, with MIC at 0.06-0.23 mg/mL and MFC at 0.11-0.47 mg/mL. According to docking studies, the predicted inhibition of the E. coli MurB enzyme is a putative mechanism of the antibacterial activity of the compounds, while inhibition of 14a-lanosterol demethylase is probably the mechanism of their antifungal activity.",
publisher = "Basel: MDPI",
journal = "Antibiotics",
title = "Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies",
number = "10",
volume = "11",
doi = "10.3390/antibiotics11101337",
pages = "1337"
}

Kartsev, V., Geronikaki, A., Zubenko, A., Petrou, A., Ivanov, M., Glamočlija, J., Soković, M., Divaeva, L., Morkovnik, A.,& Klimenko, A.. (2022). Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies. in Antibiotics
Basel: MDPI., 11(10), 1337.
https://doi.org/10.3390/antibiotics11101337

Kartsev V, Geronikaki A, Zubenko A, Petrou A, Ivanov M, Glamočlija J, Soković M, Divaeva L, Morkovnik A, Klimenko A. Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies. in Antibiotics. 2022;11(10):1337.
doi:10.3390/antibiotics11101337 .

Kartsev, Victor, Geronikaki, Athina, Zubenko, Alexander, Petrou, Anthi, Ivanov, Marija, Glamočlija, Jasmina, Soković, Marina, Divaeva, Lyudmila, Morkovnik, Anatolii, Klimenko, Alexander, "Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies" in Antibiotics, 11, no. 10 (2022):1337,
https://doi.org/10.3390/antibiotics11101337 . .