TY  - JOUR
AU  - Đurašević, Siniša
AU  - Nikolić, Gorana
AU  - Todorović, Ana
AU  - Drakulić, Dunja
AU  - Pejić, Snežana
AU  - Martinović, Vesna
AU  - Mitić-Ćulafić, Dragana
AU  - Milić, Dragana
AU  - Kop, Tatjana J.
AU  - Jasnić, Nebojša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3645
AB  - The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.
T2  - Food and Chemical Toxicology
T1  - Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
VL  - 140
DO  - 10.1016/j.fct.2020.111302
SP  - 111302
ER  - 

@article{
author = "Đurašević, Siniša and Nikolić, Gorana and Todorović, Ana and Drakulić, Dunja and Pejić, Snežana and Martinović, Vesna and Mitić-Ćulafić, Dragana and Milić, Dragana and Kop, Tatjana J. and Jasnić, Nebojša and Đorđević, Jelena and Todorović, Zoran",
year = "2020",
abstract = "The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.",
journal = "Food and Chemical Toxicology",
title = "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats",
volume = "140",
doi = "10.1016/j.fct.2020.111302",
pages = "111302"
}

Đurašević, S., Nikolić, G., Todorović, A., Drakulić, D., Pejić, S., Martinović, V., Mitić-Ćulafić, D., Milić, D., Kop, T. J., Jasnić, N., Đorđević, J.,& Todorović, Z.. (2020). Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. in Food and Chemical Toxicology, 140, 111302.
https://doi.org/10.1016/j.fct.2020.111302

Đurašević S, Nikolić G, Todorović A, Drakulić D, Pejić S, Martinović V, Mitić-Ćulafić D, Milić D, Kop TJ, Jasnić N, Đorđević J, Todorović Z. Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. in Food and Chemical Toxicology. 2020;140:111302.
doi:10.1016/j.fct.2020.111302 .

Đurašević, Siniša, Nikolić, Gorana, Todorović, Ana, Drakulić, Dunja, Pejić, Snežana, Martinović, Vesna, Mitić-Ćulafić, Dragana, Milić, Dragana, Kop, Tatjana J., Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran, "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats" in Food and Chemical Toxicology, 140 (2020):111302,
https://doi.org/10.1016/j.fct.2020.111302 . .

TY  - JOUR
AU  - Đorđević, Jelena
AU  - Kolarević, Stoimir
AU  - Jovanović, Jovana
AU  - Kostić-Vuković, Jovana
AU  - Novaković, Irena
AU  - Jeremić, Marko
AU  - Sladić, Dušan
AU  - Vuković-Gačić, Branka
PY  - 2020
UR  - https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1514043
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3214
AB  - Tert-butylquinone (TBQ) and its alkylamino and aralkylamino derivatives are of high interest as a potential antitumor agent. Therefore, it was necessary to investigate if the compounds exert undesirable activities such as interaction with DNA molecule which could result in negative side effects in the case of their use in the diseases treatment. The major aim of this study was to investigate genotoxic potential of TBQ and selected derivatives in an acellular model by using plasmid DNA, in the prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002 and in eukaryotic models by using comet assay in human fetal lung cell line (MRC-5) and human liver cancer cell line (HepG2). Results indicated that in the acellular model TBQ and its derivatives do not interact with plasmid pUC19. In the prokaryotic model, only TBQ exerted weak genotoxic potential and only at highly cytotoxic concentrations. In eukaryotic models, genotoxic potential was detected mainly at the highest concentrations of the tested substances but the effect was lower in both cell lines in comparison with benzo[a]pyrene and etoposide which were used as positive controls. Weak genotoxic potential of tested compounds recommends them as good candidates for further testing in development of new antitumor agents.
T2  - Drug and Chemical Toxicology
T1  - Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models.
IS  - 5
VL  - 43
DO  - 10.1080/01480545.2018.1514043
SP  - 522
EP  - 530
ER  - 

@article{
author = "Đorđević, Jelena and Kolarević, Stoimir and Jovanović, Jovana and Kostić-Vuković, Jovana and Novaković, Irena and Jeremić, Marko and Sladić, Dušan and Vuković-Gačić, Branka",
year = "2020",
abstract = "Tert-butylquinone (TBQ) and its alkylamino and aralkylamino derivatives are of high interest as a potential antitumor agent. Therefore, it was necessary to investigate if the compounds exert undesirable activities such as interaction with DNA molecule which could result in negative side effects in the case of their use in the diseases treatment. The major aim of this study was to investigate genotoxic potential of TBQ and selected derivatives in an acellular model by using plasmid DNA, in the prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002 and in eukaryotic models by using comet assay in human fetal lung cell line (MRC-5) and human liver cancer cell line (HepG2). Results indicated that in the acellular model TBQ and its derivatives do not interact with plasmid pUC19. In the prokaryotic model, only TBQ exerted weak genotoxic potential and only at highly cytotoxic concentrations. In eukaryotic models, genotoxic potential was detected mainly at the highest concentrations of the tested substances but the effect was lower in both cell lines in comparison with benzo[a]pyrene and etoposide which were used as positive controls. Weak genotoxic potential of tested compounds recommends them as good candidates for further testing in development of new antitumor agents.",
journal = "Drug and Chemical Toxicology",
title = "Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models.",
number = "5",
volume = "43",
doi = "10.1080/01480545.2018.1514043",
pages = "522-530"
}

Đorđević, J., Kolarević, S., Jovanović, J., Kostić-Vuković, J., Novaković, I., Jeremić, M., Sladić, D.,& Vuković-Gačić, B.. (2020). Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models.. in Drug and Chemical Toxicology, 43(5), 522-530.
https://doi.org/10.1080/01480545.2018.1514043

Đorđević J, Kolarević S, Jovanović J, Kostić-Vuković J, Novaković I, Jeremić M, Sladić D, Vuković-Gačić B. Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models.. in Drug and Chemical Toxicology. 2020;43(5):522-530.
doi:10.1080/01480545.2018.1514043 .

Đorđević, Jelena, Kolarević, Stoimir, Jovanović, Jovana, Kostić-Vuković, Jovana, Novaković, Irena, Jeremić, Marko, Sladić, Dušan, Vuković-Gačić, Branka, "Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models." in Drug and Chemical Toxicology, 43, no. 5 (2020):522-530,
https://doi.org/10.1080/01480545.2018.1514043 . .

TY  - JOUR
AU  - Nikolić, Biljana
AU  - Vasilijević, Bojana
AU  - Ćirić, Ana
AU  - Mitić-Ćulafić, Dragana
AU  - Cvetković, Stefana
AU  - Džamić, Ana
AU  - Knežević-Vukčević, Jelena
PY  - 2019
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641900005N
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/3760
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3401
AB  - Previously chemically characterized Juniperus communis essential oil (EO) and post-distillation waste (PDW) were tested for cytotoxicity and antimicrobial activity against food contaminants. Microdilution assay showed that PDW induced moderate antifungal (minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values, ranging between 0.118-0.900 mg mL-1), and an antibacterial effect against Listeria monocytogenes (MIC and minimum bactericidal concentration (MBC) were 0.39 and 0.74 mg mL-1, respectively). Combinations of EO/PDW with selected antibiotics induced synergistic antilisterial activity in the checkerboard assay. The MTT assay determined that cytotoxicity against colon cancer cells was high for the EO but negligible for PDW (IC50 values were 0.087-0.106 and 1.450-6.840 mg mL-1, respectively). The selectivity indices indicated high selectivity of PDW against tested fungi and L. monocytogenes. In the adhesion-inhibition assay, PDW reduced in vitro adhesion of L. monocytogenes to colon cells (29-62% of inhibition). In conclusion, PDW exhibited an antimicrobial effect against important food spoilage and poisoning fungi and L. monocytogenes, and also reduced in vitro adhesion of L. monocytogenes to colon cells. The results indicate that J. communis PDW could be considered as natural preservative against food spoilage and poisonous fungi, and as an adjuvant to conventional therapy of listeriosis
T2  - Archives of Biological Sciences
T1  - Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants
IS  - 2
VL  - 71
DO  - 10.2298/ABS181217005N
SP  - 235
EP  - 244
ER  - 

@article{
author = "Nikolić, Biljana and Vasilijević, Bojana and Ćirić, Ana and Mitić-Ćulafić, Dragana and Cvetković, Stefana and Džamić, Ana and Knežević-Vukčević, Jelena",
year = "2019",
abstract = "Previously chemically characterized Juniperus communis essential oil (EO) and post-distillation waste (PDW) were tested for cytotoxicity and antimicrobial activity against food contaminants. Microdilution assay showed that PDW induced moderate antifungal (minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values, ranging between 0.118-0.900 mg mL-1), and an antibacterial effect against Listeria monocytogenes (MIC and minimum bactericidal concentration (MBC) were 0.39 and 0.74 mg mL-1, respectively). Combinations of EO/PDW with selected antibiotics induced synergistic antilisterial activity in the checkerboard assay. The MTT assay determined that cytotoxicity against colon cancer cells was high for the EO but negligible for PDW (IC50 values were 0.087-0.106 and 1.450-6.840 mg mL-1, respectively). The selectivity indices indicated high selectivity of PDW against tested fungi and L. monocytogenes. In the adhesion-inhibition assay, PDW reduced in vitro adhesion of L. monocytogenes to colon cells (29-62% of inhibition). In conclusion, PDW exhibited an antimicrobial effect against important food spoilage and poisoning fungi and L. monocytogenes, and also reduced in vitro adhesion of L. monocytogenes to colon cells. The results indicate that J. communis PDW could be considered as natural preservative against food spoilage and poisonous fungi, and as an adjuvant to conventional therapy of listeriosis",
journal = "Archives of Biological Sciences",
title = "Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants",
number = "2",
volume = "71",
doi = "10.2298/ABS181217005N",
pages = "235-244"
}

Nikolić, B., Vasilijević, B., Ćirić, A., Mitić-Ćulafić, D., Cvetković, S., Džamić, A.,& Knežević-Vukčević, J.. (2019). Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants. in Archives of Biological Sciences, 71(2), 235-244.
https://doi.org/10.2298/ABS181217005N

Nikolić B, Vasilijević B, Ćirić A, Mitić-Ćulafić D, Cvetković S, Džamić A, Knežević-Vukčević J. Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants. in Archives of Biological Sciences. 2019;71(2):235-244.
doi:10.2298/ABS181217005N .

Nikolić, Biljana, Vasilijević, Bojana, Ćirić, Ana, Mitić-Ćulafić, Dragana, Cvetković, Stefana, Džamić, Ana, Knežević-Vukčević, Jelena, "Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants" in Archives of Biological Sciences, 71, no. 2 (2019):235-244,
https://doi.org/10.2298/ABS181217005N . .

TY  - JOUR
AU  - Vlaisavljević, Sanja
AU  - Jelača, Sanja
AU  - Zengin, Gökhan
AU  - Mimica-Dukić, Neda
AU  - Berežni, Sanja
AU  - Miljić, Milorad
AU  - Dajić Stevanović, Zora
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C9RA08231J
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3547
AB  - The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.
T2  - RSC Advances
T1  - Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties
IS  - 64
VL  - 9
DO  - 10.1039/C9RA08231J
SP  - 37474
EP  - 37483
ER  - 

@article{
author = "Vlaisavljević, Sanja and Jelača, Sanja and Zengin, Gökhan and Mimica-Dukić, Neda and Berežni, Sanja and Miljić, Milorad and Dajić Stevanović, Zora",
year = "2019",
abstract = "The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.",
journal = "RSC Advances",
title = "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties",
number = "64",
volume = "9",
doi = "10.1039/C9RA08231J",
pages = "37474-37483"
}

Vlaisavljević, S., Jelača, S., Zengin, G., Mimica-Dukić, N., Berežni, S., Miljić, M.,& Dajić Stevanović, Z.. (2019). Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances, 9(64), 37474-37483.
https://doi.org/10.1039/C9RA08231J

Vlaisavljević S, Jelača S, Zengin G, Mimica-Dukić N, Berežni S, Miljić M, Dajić Stevanović Z. Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances. 2019;9(64):37474-37483.
doi:10.1039/C9RA08231J .

Vlaisavljević, Sanja, Jelača, Sanja, Zengin, Gökhan, Mimica-Dukić, Neda, Berežni, Sanja, Miljić, Milorad, Dajić Stevanović, Zora, "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties" in RSC Advances, 9, no. 64 (2019):37474-37483,
https://doi.org/10.1039/C9RA08231J . .

TY  - CONF
AU  - Tubić, Ljiljana
AU  - Simin, Nataša
AU  - Živković, Sanja
AU  - Bekvalac, Kristina
AU  - Savić, Jelena
AU  - Momčilović, Miloš
PY  - 2018
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5453
AB  - Chive (Allium schoenoprasum L.) is a small bulbous perennial which is used as a spice plant and
as a culinary herb. This plant contains compounds with potent antioxidant activity and has beneficial
effect on human health. Chive can be easily grown without special care. Accordingly, it would
be the best that people grow spice and healthy plants on their own balconies and terraces to have
fresh raw plant like chive every day. The objective of this study was to determine the impact of urban
environmental factors on the quality of chives planted at 5 different locations in Belgrade. The parameters of quality were phenolics profile and heavy metals content, while exposure to stress
was determined by measuring the activity of antioxidant enzymes, peroxidases (POX) and superoxide
dismutases (SOD) in fresh plants. The phenolics profile of plant aerial parts was characterized
by LC-MS/MS. Twelve phenolic compounds were quantified, among which kaempferol 3-O-glucoside
and quercetin 3-O-glucoside were dominant. Positive correlation between POX/SOD activity
and concentrations of the forementioned compounds was observed. The concentrations of Cd,
Cr, Cu, Pb and Zn in the leaves of investigated chives were measured using ICP-OES technique.
The levels of Cd in edible parts of chive at all investigated locations were higher than permissible
limit. Mean Cr concentration in leaves of chive was high only in central urban zone. The process of
urbanization has been expanded with the negative consequences on plants, which can be seen
from increased POX activity and high levels of heavy metals in leaves of chives.
PB  - Belgrade: Serbian Plant Physiology Society; Institute for Biological Research "Siniša Stanković"; Faculty of Biology
C3  - 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia
T1  - Fresh chives in pots on the Belgrade’s balconies and terraces How do the urban environmental factors affect their quality?
SP  - 53
EP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5453
ER  - 

@conference{
author = "Tubić, Ljiljana and Simin, Nataša and Živković, Sanja and Bekvalac, Kristina and Savić, Jelena and Momčilović, Miloš",
year = "2018",
abstract = "Chive (Allium schoenoprasum L.) is a small bulbous perennial which is used as a spice plant and
as a culinary herb. This plant contains compounds with potent antioxidant activity and has beneficial
effect on human health. Chive can be easily grown without special care. Accordingly, it would
be the best that people grow spice and healthy plants on their own balconies and terraces to have
fresh raw plant like chive every day. The objective of this study was to determine the impact of urban
environmental factors on the quality of chives planted at 5 different locations in Belgrade. The parameters of quality were phenolics profile and heavy metals content, while exposure to stress
was determined by measuring the activity of antioxidant enzymes, peroxidases (POX) and superoxide
dismutases (SOD) in fresh plants. The phenolics profile of plant aerial parts was characterized
by LC-MS/MS. Twelve phenolic compounds were quantified, among which kaempferol 3-O-glucoside
and quercetin 3-O-glucoside were dominant. Positive correlation between POX/SOD activity
and concentrations of the forementioned compounds was observed. The concentrations of Cd,
Cr, Cu, Pb and Zn in the leaves of investigated chives were measured using ICP-OES technique.
The levels of Cd in edible parts of chive at all investigated locations were higher than permissible
limit. Mean Cr concentration in leaves of chive was high only in central urban zone. The process of
urbanization has been expanded with the negative consequences on plants, which can be seen
from increased POX activity and high levels of heavy metals in leaves of chives.",
publisher = "Belgrade: Serbian Plant Physiology Society; Institute for Biological Research "Siniša Stanković"; Faculty of Biology",
journal = "3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia",
title = "Fresh chives in pots on the Belgrade’s balconies and terraces How do the urban environmental factors affect their quality?",
pages = "53-54",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5453"
}

Tubić, L., Simin, N., Živković, S., Bekvalac, K., Savić, J.,& Momčilović, M.. (2018). Fresh chives in pots on the Belgrade’s balconies and terraces How do the urban environmental factors affect their quality?. in 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia
Belgrade: Serbian Plant Physiology Society; Institute for Biological Research "Siniša Stanković"; Faculty of Biology., 53-54.
https://hdl.handle.net/21.15107/rcub_ibiss_5453

Tubić L, Simin N, Živković S, Bekvalac K, Savić J, Momčilović M. Fresh chives in pots on the Belgrade’s balconies and terraces How do the urban environmental factors affect their quality?. in 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia. 2018;:53-54.
https://hdl.handle.net/21.15107/rcub_ibiss_5453 .

Tubić, Ljiljana, Simin, Nataša, Živković, Sanja, Bekvalac, Kristina, Savić, Jelena, Momčilović, Miloš, "Fresh chives in pots on the Belgrade’s balconies and terraces How do the urban environmental factors affect their quality?" in 3rd International Conference on Plant Biology (22nd SPPS Meeting); 2018 Jun 9-12; Belgrade, Serbia (2018):53-54,
https://hdl.handle.net/21.15107/rcub_ibiss_5453 .

TY  - JOUR
AU  - Kolarević, Stoimir
AU  - Milovanović, Dragana
AU  - Kračun-Kolarević, Margareta
AU  - Kostić, Jovana
AU  - Sunjog, Karolina
AU  - Martinović, Rajko
AU  - Đorđević, Jelena
AU  - Novaković, Irena
AU  - Sladić, Dušan
AU  - Vuković-Gačić, Branka
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/01480545.2017.1413108
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2966
AB  - In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3'-methoxyavarone, 4'-(methylamino)avarone and 3'-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3'-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3'-methoxyavarone and 3'-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells.
T2  - Drug and Chemical Toxicology
T1  - Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models.
IS  - 2
VL  - 42
DO  - 10.1080/01480545.2017.1413108
SP  - 130
EP  - 139
ER  - 

@article{
author = "Kolarević, Stoimir and Milovanović, Dragana and Kračun-Kolarević, Margareta and Kostić, Jovana and Sunjog, Karolina and Martinović, Rajko and Đorđević, Jelena and Novaković, Irena and Sladić, Dušan and Vuković-Gačić, Branka",
year = "2018",
abstract = "In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3'-methoxyavarone, 4'-(methylamino)avarone and 3'-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3'-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3'-methoxyavarone and 3'-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells.",
journal = "Drug and Chemical Toxicology",
title = "Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models.",
number = "2",
volume = "42",
doi = "10.1080/01480545.2017.1413108",
pages = "130-139"
}

Kolarević, S., Milovanović, D., Kračun-Kolarević, M., Kostić, J., Sunjog, K., Martinović, R., Đorđević, J., Novaković, I., Sladić, D.,& Vuković-Gačić, B.. (2018). Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models.. in Drug and Chemical Toxicology, 42(2), 130-139.
https://doi.org/10.1080/01480545.2017.1413108

Kolarević S, Milovanović D, Kračun-Kolarević M, Kostić J, Sunjog K, Martinović R, Đorđević J, Novaković I, Sladić D, Vuković-Gačić B. Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models.. in Drug and Chemical Toxicology. 2018;42(2):130-139.
doi:10.1080/01480545.2017.1413108 .

Kolarević, Stoimir, Milovanović, Dragana, Kračun-Kolarević, Margareta, Kostić, Jovana, Sunjog, Karolina, Martinović, Rajko, Đorđević, Jelena, Novaković, Irena, Sladić, Dušan, Vuković-Gačić, Branka, "Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models." in Drug and Chemical Toxicology, 42, no. 2 (2018):130-139,
https://doi.org/10.1080/01480545.2017.1413108 . .