TY  - JOUR
AU  - Petrova, Detelina
AU  - Gašić, Uroš
AU  - Yocheva, Lyubomira
AU  - Hinkov, Anton
AU  - Yordanova, Zhenya
AU  - Chaneva, Ganka
AU  - Mantovska, Desislava
AU  - Paunov, Momchil
AU  - Ivanova, Lyubomira
AU  - Rogova, Mariya
AU  - Shishkova, Kalina
AU  - Todorov, Daniel
AU  - Tosheva, Anita
AU  - Kapchina-Toteva, Veneta
AU  - Vassileva, Valya
AU  - Atanassov, Atanas
AU  - Mišić, Danijela
AU  - Bonchev, Georgi
AU  - Zhiponova, Miroslava
PY  - 2022
UR  - https://www.frontiersin.org/articles/10.3389/fpls.2022.866777/full
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9150856
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5003
AB  - Nepeta nuda (catmint; Lamiaceae) is a perennial medicinal plant with a wide geographic distribution in Europe and Asia. This study first characterized the taxonomic position of N. nuda using DNA barcoding technology. Since medicinal plants are rich in secondary metabolites contributing to their adaptive immune response, we explored the N. nuda metabolic adjustment operating under variable environments. Through comparative analysis of wild-grown and in vitro cultivated plants, we assessed the change in phenolic and iridoid compounds, and the associated immune activities. The wild-grown plants from different Bulgarian locations contained variable amounts of phenolic compounds manifested by a general increase in flowers, as compared to leaves, while a strong reduction was observed in the in vitro plants. A similar trend was noted for the antioxidant and anti-herpesvirus activity of the extracts. The antimicrobial potential, however, was very similar, regardless the growth conditions. Analysis of the N. nuda extracts led to identification of 63 compounds including phenolic acids and derivatives, flavonoids, and iridoids. Quantification of the content of 21 target compounds indicated their general reduction in the extracts from in vitro plants, and only the ferulic acid (FA) was specifically increased. Cultivation of in vitro plants under different light quality and intensity indicated that these variable light conditions altered the content of bioactive compounds, such as aesculin, FA, rosmarinic acid, cirsimaritin, naringenin, rutin, isoquercetin, epideoxyloganic acid, chlorogenic acid. Thus, this study generated novel information on the regulation of N. nuda productivity using light and other cultivation conditions, which could be exploited for biotechnological purposes.
T2  - Frontiers in Plant Science
T1  - Catmint (Nepeta nuda L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.
VL  - 13
DO  - 10.3389/fpls.2022.866777
SP  - 866777
ER  - 

@article{
author = "Petrova, Detelina and Gašić, Uroš and Yocheva, Lyubomira and Hinkov, Anton and Yordanova, Zhenya and Chaneva, Ganka and Mantovska, Desislava and Paunov, Momchil and Ivanova, Lyubomira and Rogova, Mariya and Shishkova, Kalina and Todorov, Daniel and Tosheva, Anita and Kapchina-Toteva, Veneta and Vassileva, Valya and Atanassov, Atanas and Mišić, Danijela and Bonchev, Georgi and Zhiponova, Miroslava",
year = "2022",
abstract = "Nepeta nuda (catmint; Lamiaceae) is a perennial medicinal plant with a wide geographic distribution in Europe and Asia. This study first characterized the taxonomic position of N. nuda using DNA barcoding technology. Since medicinal plants are rich in secondary metabolites contributing to their adaptive immune response, we explored the N. nuda metabolic adjustment operating under variable environments. Through comparative analysis of wild-grown and in vitro cultivated plants, we assessed the change in phenolic and iridoid compounds, and the associated immune activities. The wild-grown plants from different Bulgarian locations contained variable amounts of phenolic compounds manifested by a general increase in flowers, as compared to leaves, while a strong reduction was observed in the in vitro plants. A similar trend was noted for the antioxidant and anti-herpesvirus activity of the extracts. The antimicrobial potential, however, was very similar, regardless the growth conditions. Analysis of the N. nuda extracts led to identification of 63 compounds including phenolic acids and derivatives, flavonoids, and iridoids. Quantification of the content of 21 target compounds indicated their general reduction in the extracts from in vitro plants, and only the ferulic acid (FA) was specifically increased. Cultivation of in vitro plants under different light quality and intensity indicated that these variable light conditions altered the content of bioactive compounds, such as aesculin, FA, rosmarinic acid, cirsimaritin, naringenin, rutin, isoquercetin, epideoxyloganic acid, chlorogenic acid. Thus, this study generated novel information on the regulation of N. nuda productivity using light and other cultivation conditions, which could be exploited for biotechnological purposes.",
journal = "Frontiers in Plant Science",
title = "Catmint (Nepeta nuda L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.",
volume = "13",
doi = "10.3389/fpls.2022.866777",
pages = "866777"
}

Petrova, D., Gašić, U., Yocheva, L., Hinkov, A., Yordanova, Z., Chaneva, G., Mantovska, D., Paunov, M., Ivanova, L., Rogova, M., Shishkova, K., Todorov, D., Tosheva, A., Kapchina-Toteva, V., Vassileva, V., Atanassov, A., Mišić, D., Bonchev, G.,& Zhiponova, M.. (2022). Catmint (Nepeta nuda L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.. in Frontiers in Plant Science, 13, 866777.
https://doi.org/10.3389/fpls.2022.866777

Petrova D, Gašić U, Yocheva L, Hinkov A, Yordanova Z, Chaneva G, Mantovska D, Paunov M, Ivanova L, Rogova M, Shishkova K, Todorov D, Tosheva A, Kapchina-Toteva V, Vassileva V, Atanassov A, Mišić D, Bonchev G, Zhiponova M. Catmint (Nepeta nuda L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.. in Frontiers in Plant Science. 2022;13:866777.
doi:10.3389/fpls.2022.866777 .

Petrova, Detelina, Gašić, Uroš, Yocheva, Lyubomira, Hinkov, Anton, Yordanova, Zhenya, Chaneva, Ganka, Mantovska, Desislava, Paunov, Momchil, Ivanova, Lyubomira, Rogova, Mariya, Shishkova, Kalina, Todorov, Daniel, Tosheva, Anita, Kapchina-Toteva, Veneta, Vassileva, Valya, Atanassov, Atanas, Mišić, Danijela, Bonchev, Georgi, Zhiponova, Miroslava, "Catmint (Nepeta nuda L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions." in Frontiers in Plant Science, 13 (2022):866777,
https://doi.org/10.3389/fpls.2022.866777 . .