@article{
author = "Zubenko, Alexander and Kartsev, Victor and Petrou, Anthi and Geronikaki, Athina and Ivanov, Marija and Glamočlija, Jasmina and Soković, Marina and Divaeva, Lyudmila and Morkovnik, Anatolii and Klimenko, Alexander",
year = "2022",
abstract = "In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed that these compounds showed moderate antibacterial activity. Compound 2j was found to be the most potent (MIC/MBC at 0.23-0.94 mg/mL and 0.47-1.88 mg/mL) On the other hand, compounds showed good antifungal activity (MIC/MFC at 0.06-0.47 and 0.11-0.94 mg/mL respectively) with 2d being the most active one. The docking studies revealed that inhibition of E. coli MurB and 14-lanosterol demethylase probably represent the mechanism of antibacterial and antifungal activities.",
publisher = "Basel: MDPI",
journal = "Antibiotics",
title = "Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents",
number = "11",
volume = "11",
doi = "10.3390/antibiotics11111654",
pages = "1654"
}