dc.creator | Mihailović, Mirjana | |
dc.creator | Dobrić, Silva Lj | |
dc.creator | Poznanović, Goran | |
dc.creator | Petrović, Miodrag V | |
dc.creator | Uskoković, Aleksandra | |
dc.creator | Arambašić Jovanović, Jelena | |
dc.creator | Bogojević, Desanka | |
dc.date.accessioned | 2017-11-23T11:04:51Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2009 | sr |
dc.identifier.issn | 1073-2322 | sr |
dc.identifier.other | Rad_konverzija_3444 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1449 | |
dc.description.abstract | The importance of alpha(2)-macroglobulin (alpha(2)M) in natural radioprotection was studied by examining its radioprotective effectiveness in rat models of exogenously and endogenously, preexposure-increased alpha(2)M. Radioprotective efficacy was ascertained by the postirradiation survival rate, the restoration of body weight, and the leukocyte count, which were monitored during a 4-week follow-up period. The results were compared with the effects of a pretreatment with the synthetic radioprotective agent amifostine (Ami), which provides 100% protection in rats whole-body-irradiated by x-rays given in a dose of 6.7 Gy (LD(50/30)). Raising the plasma concentration of alpha(2)M 15-fold in male rats by a single intraperitoneal injection of purified protein provided 100% survival of irradiated animals. Female rats on the 19th day of pregnancy with endogenously elevated levels of alpha(2)M displayed improved survival (80%) compared with untreated rats (50% survival). After alpha(2)M administration, the pregnant, irradiated rats exhibited 100% survival. In both males and pregnant females, alpha(2)M administration promoted body weight and leukocyte postirradiation recovery as in Ami-pretreated rats. These findings, together with our observation that Ami administration induced a 45-fold increase in alpha(2)M in the circulation, led us to conclude that alpha(2)M has an essential role in both natural and amifostine-mediated radioprotection in the rat. | en |
dc.description.sponsorship | Ministry for Science and Technological Development of the Republic of Serbia [143002B] | sr |
dc.language.iso | English | sr |
dc.publisher | Wolters Kluwer Health, Inc. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143002/RS// | |
dc.rights | restrictedAccess | |
dc.source | Shock | sr |
dc.title | The Acute-Phase Protein Alpha(2)-Macroglobulin Plays An Important Role in Radioprotection in the Rat | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Добрић, Силва Љ; Михаиловић, Мирјана В.; Aрамбашић, Јелена; Богојевић, Десанка Б.; Познановић, Горан; Петровић, Миодраг В; Ускоковић, Aлександра; | |
dc.rights.holder | @ 2009 by the Shock Society | |
dc.citation.issue | 6 | sr |
dc.citation.volume | 31 | sr |
dc.identifier.doi | 10.1097/SHK.0b013e31818bb625 | |
dc.identifier.pmid | 18838941 | |
dc.identifier.scopus | 2-s2.0-67650692384 | |
dc.identifier.wos | 000267437900011 | |
dc.citation.spage | 607 | |
dc.citation.epage | 614 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1449 | |