dc.creator | Ognjanović, Branka I | |
dc.creator | Marković, Snezana D | |
dc.creator | Pavlović, Slađan | |
dc.creator | Žikić, Radoslav V. | |
dc.creator | Stajn, Andras S | |
dc.creator | Saičić, Zorica | |
dc.date.accessioned | 2017-11-23T11:15:11Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2008 | sr |
dc.identifier.issn | 0862-8408 | sr |
dc.identifier.other | Rad_konverzija_3557 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1562 | |
dc.identifier.uri | http://www.biomed.cas.cz/physiolres/pdf/57/57_403.pdf | |
dc.description.abstract | The effects of selenium ( Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl2 for 4 weeks) resulted in increased lipid peroxidation ( LP) in both organs (p < 0.005 and p < 0.01). Vitamin C (Vit C) was decreased in the liver ( p < 0.005), whereas vitamin E ( Vit E) was increased in the liver and kidneys ( p < 0.005 and p < 0.05) of Cd-exposed animals. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were decreased in both tissues ( p < 0.05 and p < 0.005), whereas catalase (CAT) activity was decreased only in liver ( p < 0.005). Glutathione S-transferase (GST) increased in both tissues ( p < 0.005 and p<0.01). Treatment with Se (0.5 mg Se/kg b.m./day as Na2SeO3 for 4 weeks) significantly increased liver and kidneys SOD and GSH-Px activities ( p < 0.05 to p < 0.005), as well as CAT and GST activities only in the liver ( p < 0.01). In animals exposed to Se, both the concentrations of Vit C ( p < 0.01) and Vit E (p < 0.005) were increased in both tissues. Co-treatment with Se resulted in reversal of oxidative stress with significant decline in analyzed tissues Cd burden. Our results show that Se may ameliorate Cd-induced oxidative stress by decreasing LP and altering antioxidant defense system in rat liver and kidneys and that Se demonstrates the protective effect from cadmium-induced oxidative damage. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Physiological Research | sr |
dc.subject | Antioxidant defense system | |
dc.subject | Cadmium | |
dc.subject | Lipid peroxides | |
dc.subject | Rat | |
dc.subject | Selenium | |
dc.title | Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саичић, Зорица; Павловић, Слађан З.; Огњановић, Бранка И; Марковић, Снезана Д; Жикић, Радослав В.; Стајн, Aндрас С; | |
dc.rights.holder | © 2008 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 57 | sr |
dc.identifier.pmid | 17465690 | |
dc.identifier.scopus | 2-s2.0-45949089424 | |
dc.identifier.wos | 000257270900011 | |
dc.citation.epage | 411 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1562 | |