Prikaz osnovnih podataka o dokumentu
The effects of cold acclimation and nitric oxide on antioxidative enzymes in rat pancreas
dc.creator | Vasilijević, Ana | |
dc.creator | Buzadžić, Biljana J. | |
dc.creator | Korać, Aleksandra B | |
dc.creator | Otašević, Vesna | |
dc.creator | Janković, Aleksandra | |
dc.creator | Micunović, Ksenija | |
dc.creator | Korać, Bato | |
dc.date.accessioned | 2017-11-23T11:15:01Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2007 | sr |
dc.identifier.issn | 1532-0456 | sr |
dc.identifier.other | Rad_konverzija_3598 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1603 | |
dc.description.abstract | Alterations of pancreatic antioxidative defense (AD) and possible nitric oxide (NO) role in AD organization of adult rats receiving L-arginine-HCl (2.25%) or N-omega-nitro-L-arginine methyl ester (L-NAME-HCl, 0.01%) as drinking liquids and maintained at room (22 +/- 1 degrees C) or low (4 +/- 1 degrees C) temperature for 45 days were studied. For that purpose, copper, zinc- and manganese superoxide dismutase (CuZnSOD, MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and glutathione reductase (GR) activities were determined. Cold-induced decrease of CuZnSOD was inhibited with L-NAME, while L-arginine produced the same effect as cold in both supplemented groups. Cold acclimation elevated GSH-Px activity. L-Arginine and L-NAME expressed no effect on GSH-Px in rats kept at room temperature. L-NAME additionally elevated cold-induced GSH-Px activity, L-arginine expressing a similar trend. Cold-induced increase in GST activity was inhibited by L-NAME, while L-arginine inhibited this enzyme in both supplemented groups. Cold acclimation increased GR activity in control and L-NAME-treated group and L-arginine expressed a similar trend. Neither of the treatments affected MnSOD and CAT activities. Cold-induced changes of pancreatic AD were additionally affected by the alterations in L-arginine-NO-producing pathway. Some AD changes in the same direction with L-arginine or L-NAME point to the complexity of nitrogen compounds metabolism and function, accompanied by tissue-specific response. (C) 2007 Elsevier Inc. All rights reserved. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.publisher | Elsevier | |
dc.rights | restrictedAccess | |
dc.source | Comparative Biochemistry and Physiology C-Toxicology & Pharmacology | sr |
dc.title | The effects of cold acclimation and nitric oxide on antioxidative enzymes in rat pancreas | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јанковић, Aлександра; Василијевић, Aна; Кораћ, Бато М.; Мицуновић, Ксенија; Бузаджић, Биљана Ј.; Корац, Aлександра Б; Петровић, Весна; | |
dc.rights.holder | © 2007 Elsevier Inc. | |
dc.citation.issue | 4 | sr |
dc.citation.volume | 145 | sr |
dc.identifier.doi | 10.1016/j.cbpc.2007.02.013 | |
dc.identifier.pmid | 17395542 | |
dc.identifier.scopus | 2-s2.0-34247632249 | |
dc.identifier.wos | 000246935300016 | |
dc.citation.spage | 641 | |
dc.citation.epage | 647 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1603 |