dc.creator | Oreščanin Dušić, Zorana | |
dc.creator | Milovanović, Slobodan R | |
dc.creator | Spasić, Snezana D | |
dc.creator | Jones, David R | |
dc.creator | Spasić, Mihajlo | |
dc.date.accessioned | 2017-11-23T11:15:01Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2007 | sr |
dc.identifier.issn | 1734-1140 | sr |
dc.identifier.other | Rad_konverzija_3600 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1605 | |
dc.description.abstract | The conversion of nitric oxide (NO*) into its congeners nitrosonium (NO+) and nitroxyl (HNO/NO-) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO* into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNPinduced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO--mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth muscles. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Pharmacological Reports | sr |
dc.title | Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Спасић, Михајло Б.; Спасић, Снезана Д; Јонес, Давид Р; Миловановић, Слободан Р; Орешчанин-Душић, Зорана С.; | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 59 | sr |
dc.citation.epage | 322 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1605 | |