Приказ основних података о документу
Immunoreactive TSH cells in juvenile and peripubertal rats after estradiol and human chorionic gonadotropin treatment
dc.creator | Sekulić, Milka I. | |
dc.creator | Šošić-Jurjević, Branka | |
dc.creator | Filipović, Branko | |
dc.creator | Manojlović-Stojanoski, Milica | |
dc.creator | Milošević, Verica | |
dc.date.accessioned | 2017-11-23T11:15:16Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2006 | sr |
dc.identifier.issn | 0065-1281 | sr |
dc.identifier.other | Rad_konverzija_3653 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1658 | |
dc.description.abstract | Different hormones and growth factors control the homeostasis of the anterior pituitary gland. We examined the morphological features of pituitary thyroid stimulating hormone (TSH)-producing cells in juvenile and peripubertal female rats after treatments with estradiol-dipropionate (EDP), human chorionic gonadotropin (hCG) and a combination of both hormones (EDP+hCG). TSH-producing cells were labelled using a peroxidase-antiperoxidase immunohistochemical procedure for binding of a rabbit anti-rat beta-thyrotropic polyclonal antisera. Morphometric differences in the cytoplasmic and nuclear volume densities in thyrotropes after the treatments were determined using a stereological method. The relative weights of the pituitary glands were significantly higher in the EDP- and EDP+hCG-treated juvenile and peripubertal rats than in untreated age-matched controls. Treatment with EDP promoted a decrease, and treatment with hCG an increase, of the cellular and nuclear volumes in TSH cells in both juvenile and peripubertal females in comparison with the respective controls. Treatment with a combination of EDP+hCG did not induce any significant changes. The cytoplasmic and nuclear volume densities in TSH cells in the EDP+hCG-treated group were significantly higher than in the EDP-treated, and significantly lower than in hCG-treated rats at both growth stages. These findings suggest that estradiol and hCG exerted opposite effects on pituitary TSH-immunoreactive cells. The observed effects on thyrotrope morphology were apparently independent of the stage of development. (C) 2006 Elsevier GmbH. All rights reserved. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.publisher | Elsevier GmbH | |
dc.rights | restrictedAccess | |
dc.source | Acta Histochemica | sr |
dc.title | Immunoreactive TSH cells in juvenile and peripubertal rats after estradiol and human chorionic gonadotropin treatment | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Манојловић-Стојаноски, Милица; Милошевић, Верица Љ.; Шошић-Јурјевић, Бранка Т.; Секулић, Милка И.; Филиповић, Бранко; | |
dc.rights.holder | © 2006 Elsevier GmbH. | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 108 | sr |
dc.identifier.doi | 10.1016/j.acthis.2006.03.004 | |
dc.identifier.pmid | 16714054 | |
dc.identifier.scopus | 2-s2.0-33745008999 | |
dc.identifier.wos | 000239188000005 | |
dc.citation.spage | 117 | |
dc.citation.epage | 123 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1658 |