dc.creator | Kataranovski, Milena | |
dc.creator | Kataranovski, Dragan S. | |
dc.creator | Savić, D | |
dc.creator | Jovcić, G | |
dc.creator | Bogdanović, Z | |
dc.creator | Jovanović, T | |
dc.date.accessioned | 2017-11-23T11:15:48Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 1998 | sr |
dc.identifier.issn | 0862-8408 | sr |
dc.identifier.other | Rad_konverzija_3863 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1868 | |
dc.description.abstract | Changes in the number and ex vivo function of peripheral blood neutrophils were investigated following intraperitoneal administration of cadmium-chloride in rats. Besides a dose-dependent increase in the number of peripheral blood neutrophils, changes were found in the functional state of isolated polymorphonuclear leukocytes (PMNs). Increased spontaneous adhesion and activation, and TNF activity in a conditioned medium were observed in cultures of granulocytes in comparison to granulocytes from control (saline-treated) animals. Increased levels of plasma activity of inflammatory cytokines, tumor necrosis factor (TNF) and interleukin-6 (IL-6) were noted following cadmium administration. Cytological signs of pulmonary inflammation were revealed histologically and the majority of neutrophils recovered from the lungs by enzyme digestion exhibited a capacity of nitroblue tetrazolium (NBT) reduction. Our data demonstrate that acute cadmium intoxication leads to a systemic inflammatory response characterized by numerical and functional changes in the granulocyte compartment and to increased levels of inflammation-related cytokine activity in the circulation. Correlations between the increased number of peripheral blood neutrophils and IL-6 plasma activity (r = 0.776, p < 0.00001) and the number of neutrophils recovered from the lung tissue (r = 0.893, p < 0.00001) suggested that systemic cadmium-induced inflammation might be involved in the pulmonary toxicity of cadmium. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Physiological Research | sr |
dc.title | Granulocyte and plasma cytokine activity in acute cadmium intoxication in rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Катарановски, Драган С.; Јовцић, Г; Савић, Д; Јовановић, Т; Богдановић, З; Катарановски, Милена В.; | |
dc.citation.issue | 6 | sr |
dc.citation.volume | 47 | sr |
dc.citation.epage | 461 | sr |
dc.type.version | publishedVersion | en |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1868 | |