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Activity of antioxidant defense enzymes and glutathione content in some tissues of the Belgrade (b/b) laboratory rat
dc.creator | Saičić, Zorica | |
dc.creator | Simović, MO | |
dc.creator | Korać, Bato | |
dc.creator | Blagojević, Duško | |
dc.creator | Buzadžić, Biljana J. | |
dc.creator | Spasić, Mihajlo | |
dc.creator | Petrović, Vojislav M. | |
dc.date.accessioned | 2017-11-23T11:17:24Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 1997 | sr |
dc.identifier.issn | 0742-8413 | sr |
dc.identifier.other | Rad_konverzija_3869 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1874 | |
dc.description.abstract | The activity of antioxidant defense (AD) enzymes-superoxide dismutase (SOD, EC 1.15.1.1.), catalase (CAT, EC 1.11.1.6.), glutathione peroxidase (GSH-Px, EC 1.11.1.9.), glutathione-S-transferase (GST, EC 2.5.1.18), glutathione reductase (GR, EC 1.6.4.2) and glutathione (GSH) content of the anemic Belgrade (b/b) laboratory rats-were measured and analyzed in liver, spleen, lung, heart, brain and testes in comparison with nonanemic controls. The activities of hepatic Mn SOD, CAT, GSH-Px and GST (P < 0.02, P < 0.01 and P < 0.005) were decreased in anemic, comparing with nonanemic animals, whereas the spleen CuZn SOD, Mn SOD, CAT and GSH-Px (P < 0.005, P < 0.02, P < 0.005 and P < 0.01) activities were increased. In the lung of anemic rats, Mn SOD, GSH-Px and GR (P < 0.005, P < 0.01, P < 0.05) activities were higher, whereas GST (P < 0.01) activity was lower in relation to nonanemic ones. In anemic rats, heart Mn SOD (P < 0.05) activity was increased, brain GSH-Px (P < 0.005) activity was lower, whereas GR (P < 0.02) activity was higher compared with nonanemic controls. CuZn SOD (P < 0.05) activity in the testes was elevated and GSH-Px (P < 0.05) reduced in anemic animals. GSH content was decreased in the liver (P < 0.01), lung and brain (P < 0.005) and increased in the spleen (P < 0.02) of anemic rats in relation to the controls. Our data suggest phenotype specific differences in the AD system of the Belgrade (b/b) rat tissues in comparison with nonanemic controls. (C) 1997 Elsevier Science Inc. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology | sr |
dc.title | Activity of antioxidant defense enzymes and glutathione content in some tissues of the Belgrade (b/b) laboratory rat | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Благојевић, Душко П.; Спасић, МБ; Саичић, Зорица; Кораћ, Бато М.; Бузаджић, Биљана Ј.; Петровић, Војислав М.; Симовић, МО; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 117 | sr |
dc.citation.epage | 179 | sr |
dc.type.version | publishedVersion | en |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1874 |
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