dc.creator | Bulatović, Mirna Z. | |
dc.creator | Kaluderovic, Milena R. | |
dc.creator | Mojić, Marija | |
dc.creator | Zmejkovski, Bojana B. | |
dc.creator | Hey-Hawkins, Evamarie | |
dc.creator | Vidaković, Melita | |
dc.creator | Grdović, Nevena | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.date.accessioned | 2016-05-23T10:59:40Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1879-0712 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1916 | |
dc.description.abstract | (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
profile in comparison to cisplatin. This is manifested through
accelerated dying process led by necrotic cell death, reflected through
mitochondrial collapse, strong ATP depletion and reactive oxygen species
production. Loss of mitochondrial potential was further followed with
intensive apoptosis that finalized with DNA fragmentation.
Different dynamic of tumoricidal action could be partly ascribed to less
affected repair mechanisms in comparison to cisplatin. Importantly,
{[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
suggesting different intracellular response of normal vs. tumor cells.
This selectivity toward malignant phenotype is further confirmed by
retained tumoricidal potential in hypoxic conditions, while cisplatin
became completely inefficient. (C) 2015 Published by Elsevier B.V. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of the Republic of
Serbia {[}173013, 173020, 172035]; SMWK {[}33707045]; SAB (ESF)
{[}100147954]; Free State of Saxony {[}100099597] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Pharmacology | |
dc.subject | Platinum(IV) complex | |
dc.subject | Cisplatin | |
dc.subject | Mitochondrial collapse | |
dc.subject | Oxidative stress | |
dc.subject | Hypoxic conditions | |
dc.title | Improved in vitro antitumor potential of
(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
num(IV) complex under normoxic and hypoxic conditions | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Змејковски, Бојана Б.; Максимовић, Данијела Д.; Грдовић, Невена; Калудеровиц, Милена Р.; Хеy-Хаwкинс, Евамарие; Булатовић, Мирна З.; Калуђеровић, Горан Н.; Мојић, Марија К.; Мијатовић, Сања A.; Видаковиц, Мелита; | |
dc.citation.volume | 760 | |
dc.identifier.doi | 10.1016/j.ejphar.2015.04.012 | |
dc.identifier.scopus | 2-s2.0-84929457797 | |
dc.identifier.wos | 000355664200017 | |
dc.citation.spage | 136 | |
dc.citation.epage | 144 | |
dc.type.version | publishedVersion | en |