dc.creator | Ajdžanović, Vladimir | |
dc.creator | Jarić, Ivana | |
dc.creator | Živanović, Jasmina | |
dc.creator | Mojić, Marija | |
dc.creator | Milošević, Verica | |
dc.date.accessioned | 2016-05-23T10:59:55Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1432-1424 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2010 | |
dc.description.abstract | Soy isoflavone's (genistein and daidzein in particular) biological
significance has been thoroughly studied for decades, so we started from
the premise that refreshed investigation approach in this field should
consider identification of their new molecular targets. In addition to
recently described epigenetic aspects of polyphenole action, the cell
membrane constituents-mediated effects of soy isoflavones are worthy of
special attention. Accordingly, the expanding concept of membrane
steroid receptors and rapid signaling from the cell surface may include
the prominent role of these steroid-like compounds. It was observed that
daidzein strongly interacts with membrane estrogen receptors in adrenal
medullary cells. At low doses, daidzein was found to stimulate
catecholamine synthesis through extracellular signal-regulated kinase
1/2 or protein kinase A pathways, but at high doses, it inhibited
catecholamine synthesis and secretion induced by acetylcholine. Keeping
in mind that catecholamine excess can contribute to the cardiovascular
pathologies and that catecholamine lack may lead to depression, daidzein
application promises to have a wide range of therapeutic effects. On the
other hand, it was shown in vitro that genistein inhibits LNCaP prostate
cancer cells invasiveness by decreasing the membrane fluidity along with
immobilization of the androgen receptor containing membrane lipid rafts,
with down regulation of the androgen receptors and Akt signaling. These
data are promising in development of the molecular pharmacotherapy
pertinent to balanced soy isoflavone treatment of cardiovascular,
psychiatric, and steroid-related malignant diseases. | en |
dc.description.sponsorship | Ministry of Science, Education and Technological Development of the
Republic of Serbia {[}173009] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Journal of Membrane Biology | |
dc.subject | Cell membrane | |
dc.subject | Membrane steroid receptor | |
dc.subject | Soy isoflavones | |
dc.title | Membrane Steroid Receptor-Mediated Action of Soy Isoflavones: Tip of the
Iceberg | en |
dc.type | review | |
dc.rights.license | ARR | |
dcterms.abstract | Aјджановић, Владимир; Зивановиц, Јасмина; Мојић, Марија К.; Милосевиц, Верица; Медиговиц, Ивана; | |
dc.citation.issue | 1 | |
dc.citation.volume | 248 | |
dc.identifier.doi | 10.1007/s00232-014-9745-x | |
dc.identifier.scopus | 2-s2.0-84922006763 | |
dc.identifier.wos | 000348279300001 | |
dc.citation.spage | 1 | |
dc.citation.epage | 6 | |
dc.type.version | publishedVersion | en |