dc.creator | Markovic, Violeta | |
dc.creator | Debeljak, Nevena | |
dc.creator | Stanojkovic, Tatjana | |
dc.creator | Kolundzija, Branka | |
dc.creator | Sladic, Dusan | |
dc.creator | Vujcic, Miroslava | |
dc.creator | Janovic, Barbara | |
dc.creator | Tanić, Nikola | |
dc.creator | Perovic, Milka | |
dc.creator | Tesic, Vesna | |
dc.creator | Antic, Jadranka | |
dc.creator | Joksovic, Milan D. | |
dc.date.accessioned | 2016-05-23T10:59:57Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1768-3254 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2021 | |
dc.description.abstract | Novel anthraquinone based chalcone compounds were synthesized starting
from 1-acetylanthraquinone in a Claisen-Schmidt reaction and evaluated
for their anticancer potential against three human cancer cell lines.
Compounds 4a, 4b and 4j showed promising activity in inhibition of HeLa
cells with IC50 values ranging from 2.36 to 2.73 mu M and low
cytotoxicity against healthy MRC-5 cell lines. The effects that
compounds produces on the cell cycle were investigated by flow
cytometry. It was found that 4a, 4b and 4j cause the accumulation of
cells in the S and G2/M phases in a dose-dependent manner and induce
caspase-dependent apoptosis. All of three compounds exhibit calf thymus
DNA-binding activity. The determined binding constants by absorption
titrations (2.65 x 10(3) M-1, 1.36 x 10(3) M(-1)and 2.51 x 10(3) M-1 of
4a/CT-DNA, 4b/CT-DNA and 4j/CT-DNA, respectively) together with
fluorescence displacement analysis designate 4a, 4b and 4j as strong
minor groove binders, but no cleavage of plasmid DNA was observed. (C)
2014 Elsevier Masson SAS. All rights reserved. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of the Republic of
Serbia {[}172016, 172055, 173056, 175011] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Medicinal Chemistry | |
dc.subject | Chalcone | |
dc.subject | Anthraquinone | |
dc.subject | Cytotoxicity | |
dc.subject | Apoptosis | |
dc.title | Anthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative
evaluation and DNA-interaction studies | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јоксовиц, Милан Д.; Aнтиц, Јадранка; Тесиц, Весна; Перовиц, Милка; Таниц, Никола; Јановиц, Барбара; Вујциц, Мирослава; Сладиц, Дусан; Колундзија, Бранка; Станојковиц, Татјана; Дебељак, Невена; Марковиц, Виолета; | |
dc.citation.volume | 89 | |
dc.identifier.doi | 10.1016/j.ejmech.2014.10.055 | |
dc.identifier.scopus | 2-s2.0-84908368917 | |
dc.identifier.wos | 000348003500036 | |
dc.citation.spage | 401 | |
dc.citation.epage | 410 | |
dc.type.version | publishedVersion | en |