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The influence of combined oral contraceptives containing drospirenone on hypothalamic-pituitary-adrenocortical axis activity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome
dc.creator | Macut, Djuro | |
dc.creator | Bozic-Antic, Ivana | |
dc.creator | Brkljačić, Jelena | |
dc.creator | Topalovic, Vladanka | |
dc.creator | Macut, Jelica Bjekic | |
dc.creator | Panidis, Dimitrios | |
dc.creator | Kotlica, Biljana Kastratovic | |
dc.creator | Papadakis, Efstathios | |
dc.creator | Matić, Gordana | |
dc.creator | Vojnović-Milutinović, Danijela | |
dc.date.accessioned | 2016-05-23T11:00:06Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1109-3099 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2069 | |
dc.description.abstract | OBJECTIVE: Most women with PCOS have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevation in urinary excretion of its metabolites. Increased cortisol clearance in PCOS is followed by a compensatory overdrive of the hypothalamic-pituitary-adrenocortical (HPA) axis. We hypothesized that oral contraceptives containing ethinylestradiol and drospirenone (EE-DRSP) could modulate glucocorticoid receptor (GR) expression and function and thus affect HPA axis activity in PCOS patients. DESIGN: We analyzed 12 women with PCOS (age 24.17 +/- 4.88 years; body mass index 22.05 +/- 3.97 kg/m(2)) treated for 12 months with EE-DRSP and 20 BMI matched controls. In all subjects testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone binding globulin (SHBG), cortisol (basal and after dexamethasone), concentrations of GR protein, phospo-GR211 protein, number of GR per cell (B-max) and its equilibrium dissociation constant (K-D) were measured. RESULTS: Before treatment, increased concentrations of testosterone and DHEAS (p<0.001, respectively), unaltered basal cortisol and an increased sensitivity (p<0.05) of the HPA axis to dexamethasone were observed in PCOS women in comparison to controls. After treatment, testosterone (p<0.01), DHEAS (p<0.05) and cortisol suppression after dexamethasone (p<0.01) were decreased in PCOS women. There were no changes in GR protein concentration, GR phosphorylation nor in the receptor functional parameters B-max and K-D in women with PCOS before and after the therapy, and in comparison to controls. CONCLUSIONS: Prolonged treatment with EE-DRSP in PCOS women decreased serum androgens and increased cortisol in the presence of decreased sensitivity of the HPA axis and did not exert changes in GR expression and function. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the Republic of Serbia {[}11141009] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Hormones-International Journal of Endocrinology and Metabolism | |
dc.subject | Combined oral contraceptives | |
dc.subject | Cortisol | |
dc.subject | Drospirenone | |
dc.subject | Glucocorticoid receptor | |
dc.subject | Polycystic ovary syndrome | |
dc.title | The influence of combined oral contraceptives containing drospirenone on hypothalamic-pituitary-adrenocortical axis activity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Котлица, Биљана Кастратовиц; Матић, Гордана М.; Војновић-Милутиновић, Данијела; Пападакис, Ефстатхиос; Панидис, Димитриос; Мацут, Јелица Бјекиц; Топаловиц, Владанка; Бозиц-Aнтиц, Ивана; Мацут, Дјуро; Несторов, Јелена; | |
dc.citation.issue | 1 | |
dc.citation.volume | 14 | |
dc.identifier.wos | 000354590900010 | |
dc.citation.spage | 109 | |
dc.citation.epage | 117 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_2069 |
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